{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T03:39:23Z","timestamp":1786765163908,"version":"build-2736575974"},"reference-count":41,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DMSO"],"DOI":"10.2147\/dmso.s539555","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T12:25:25Z","timestamp":1762259125000},"page":"4059-4072","source":"Crossref","is-referenced-by-count":2,"title":["Rapamycin and Chloroquine Modulate Insulin Resistance and Hepatic Steatosis in a High-Fat\/High-Cholesterol Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease Mouse Model"],"prefix":"10.2147","volume":"Volume 18","author":[{"given":"Qi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1097\/hep.0000000000000520","volume":"78","author":"Rinella","year":"2023","journal-title":"Hepatology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1016\/j.cmet.2023.10.018","volume":"35","author":"Pan","year":"2023","journal-title":"Cell Metab"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/s2213-8587(24)00318-8","volume":"13","author":"Stefan","year":"2025","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/s41575-021-00448-y","volume":"18","author":"Targher","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"48968","DOI":"10.1074\/jbc.M407841200","volume":"279","author":"Jenkins","year":"2004","journal-title":"J Biol Chem"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"47066","DOI":"10.1074\/jbc.M403855200","volume":"279","author":"Villena","year":"2004","journal-title":"J Biol Chem"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1126\/science.1100747","volume":"306","author":"Zimmermann","year":"2004","journal-title":"Science"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s12944-017-0521-7","volume":"16","author":"Onal","year":"2017","journal-title":"Lipids Health Dis"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/s41580-018-0085-z","volume":"20","author":"Olzmann","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1080\/15548627.2020.1834711","volume":"17","author":"Park","year":"2021","journal-title":"Autophagy"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/j.jhep.2013.01.011","volume":"58","author":"Lin","year":"2013","journal-title":"J Hepatol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1080\/15548627.2018.1490850","volume":"14","author":"Zhang","year":"2018","journal-title":"Autophagy"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1038\/nature07976","volume":"458","author":"Singh","year":"2009","journal-title":"Nature"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1126\/science.1221365","volume":"335","author":"Hughes","year":"2012","journal-title":"Science"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"100663","DOI":"10.1016\/j.crfs.2023.100663","volume":"8","author":"Seo","year":"2024","journal-title":"Curr Res Food Sci"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1080\/15548627.2018.1474314","volume":"14","author":"Mauthe","year":"2018","journal-title":"Autophagy"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1002\/hep.25789","volume":"57","author":"Savard","year":"2013","journal-title":"Hepatology"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1254\/jphs.08215fp","volume":"109","author":"Chang","year":"2009","journal-title":"J Pharmacol Sci"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"112074","DOI":"10.1016\/j.mce.2023.112074","volume":"578","author":"Ortiz-Silva","year":"2023","journal-title":"Mol Cellular Endocrinol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1001\/jama.2020.2298","volume":"323","author":"Sheka","year":"2020","journal-title":"JAMA"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"H76","DOI":"10.1152\/ajpheart.00708.2019","volume":"319","author":"Muscella","year":"2020","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1001\/jama.2018.20045","volume":"321","author":"Ference","year":"2019","journal-title":"JAMA"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1111\/j.1365-2796.2005.01556.x","volume":"258","author":"Olofsson","year":"2005","journal-title":"J Internal Med"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"708959","DOI":"10.3389\/fimmu.2021.708959","volume":"12","author":"Fontes-Cal","year":"2021","journal-title":"Front Immunol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"880298","DOI":"10.3389\/fimmu.2022.880298","volume":"13","author":"Duan","year":"2022","journal-title":"Front Immunol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s10238-015-0347-4","volume":"16","author":"Paredes-Turrubiarte","year":"2016","journal-title":"Clin Exp Med"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1038\/s41586-024-07372-6","volume":"629","author":"Miyamoto","year":"2024","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1002\/hep.31236","volume":"72","author":"Chen","year":"2020","journal-title":"Hepatology"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"e0218971","DOI":"10.1371\/journal.pone.0218971","volume":"14","author":"Pedroza","year":"2019","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.ebiom.2019.04.036","volume":"43","author":"Lambrecht","year":"2019","journal-title":"EBioMedicine"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1080\/15548627.2019.1635383","volume":"16","author":"Zhang","year":"2020","journal-title":"Autophagy"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.2337\/db09-1324","volume":"59","author":"Houde","year":"2010","journal-title":"Diabetes"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s00109-011-0834-3","volume":"90","author":"Yang","year":"2012","journal-title":"J Mol Med"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1194\/jlr.M100392-JLR200","volume":"43","author":"Morrisett","year":"2002","journal-title":"J Lipid Res"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1126\/science.1215135","volume":"335","author":"Lamming","year":"2012","journal-title":"Science"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"31189","DOI":"10.1073\/pnas.2017152117","volume":"117","author":"Yi","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.molcel.2010.06.022","volume":"39","author":"D\u00fcvel","year":"2010","journal-title":"Mol Cell"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"e12476","DOI":"10.15252\/emmm.202012476","volume":"12","author":"Nirk","year":"2020","journal-title":"EMBO Mol Med"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.1007\/s00125-015-3689-2","volume":"58","author":"Wasko","year":"2015","journal-title":"Diabetologia"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1002\/acr.20393","volume":"63","author":"Morris","year":"2011","journal-title":"Arthritis Care Res"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.ejphar.2015.11.012","volume":"770","author":"Chen","year":"2016","journal-title":"Eur J Pharmacol"}],"container-title":["Diabetes, Metabolic Syndrome and Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/108545","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/108545","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T12:25:27Z","timestamp":1762259127000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/rapamycin-and-chloroquine-modulate-insulin-resistance-and-hepatic-stea-peer-reviewed-fulltext-article-DMSO"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":41,"URL":"https:\/\/doi.org\/10.2147\/dmso.s539555","relation":{},"ISSN":["1178-7007"],"issn-type":[{"value":"1178-7007","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]}}}