{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:02:00Z","timestamp":1767175320814,"version":"3.48.0"},"reference-count":37,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DMSO"],"DOI":"10.2147\/dmso.s549884","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:00:26Z","timestamp":1767175226000},"page":"4931-4942","source":"Crossref","is-referenced-by-count":0,"title":["miR-199a Knockdown Alleviates Insulin Resistance and Inflammation by Targeting DDIT4 via the PI3K\/AKT Pathway in vitro and in vivo"],"prefix":"10.2147","volume":"Volume 18","author":[{"given":"Ya-Wei","family":"Cai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling-Jia","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen-Sen","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong-En","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2025,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s12902-018-0280-0","volume":"18","author":"Wolde","year":"2018","journal-title":"BMC Endocr Disord"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e0184645","DOI":"10.1371\/journal.pone.0184645","volume":"12","author":"Calle-Bustos","year":"2017","journal-title":"PLoS One"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1625677","DOI":"10.1080\/20013078.2019.1625677","volume":"8","author":"Xiao","year":"2019","journal-title":"J Extracell Vesicles"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2517","DOI":"10.2147\/PPA.S170144","volume":"12","author":"Zheng","year":"2018","journal-title":"Patient Prefer Adherence"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"36034","DOI":"10.1039\/C8RA05092A","volume":"8","author":"Teng","year":"2018","journal-title":"RSC Adv"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s12920-018-0373-7","volume":"11","author":"Woo","year":"2018","journal-title":"BMC Med Genomics"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1038\/nature05482","volume":"444","author":"Kahn","year":"2006","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/nm.2627","volume":"18","author":"Osborn","year":"2012","journal-title":"Nature Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/s41392-021-00805-y","volume":"6","author":"Wang","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e0177928","DOI":"10.1371\/journal.pone.0177928","volume":"12","author":"Krauskopf","year":"2017","journal-title":"PLoS One"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.3892\/or.2020.7547","volume":"43","author":"Huang","year":"2020","journal-title":"Oncol Rep"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"4453","DOI":"10.7150\/jca.44441","volume":"11","author":"Wei","year":"2020","journal-title":"J Cancer"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/s41419-019-1417-4","volume":"10","author":"Wu","year":"2019","journal-title":"Cell Death Dis"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"8171989","DOI":"10.1155\/2019\/8171989","volume":"2019","author":"Huang","year":"2019","journal-title":"Biomed Res Int"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1002\/cbin.11129","volume":"43","author":"Dong","year":"2019","journal-title":"Cell Biol Int"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.3390\/ijms17101729","volume":"17","author":"Feng","year":"2016","journal-title":"Int J Mol Sci"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"4115","DOI":"10.18632\/aging.202378","volume":"13","author":"Zhou","year":"2021","journal-title":"Aging"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.ygeno.2019.04.019","volume":"112","author":"Lynch","year":"2020","journal-title":"Genomics"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"384","DOI":"10.3892\/ijmm.2020.4602","volume":"46","author":"Song","year":"2020","journal-title":"Int J Mol Med"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s11010-014-2170-8","volume":"397","author":"Yan","year":"2014","journal-title":"Mol Cell Biochem"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3892\/mmr.2023.13068","volume":"28","author":"Pan","year":"2023","journal-title":"Mol Med Rep"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.7150\/ijbs.27173","volume":"14","author":"Huang","year":"2018","journal-title":"Int J Biol Sci"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.bbrc.2018.04.097","volume":"500","author":"Wang","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.3389\/fimmu.2019.01637","volume":"10","author":"Santos","year":"2019","journal-title":"Front Immunol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"4504","DOI":"10.1016\/j.febslet.2014.09.047","volume":"588","author":"Wang","year":"2014","journal-title":"FEBS Lett"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1161\/CIRCRESAHA.108.193102","volume":"104","author":"Rane","year":"2009","journal-title":"Circ Res"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1186\/s12885-018-4460-0","volume":"18","author":"Lei","year":"2018","journal-title":"BMC Cancer"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1093\/biolre\/ioy038","volume":"98","author":"Yang","year":"2018","journal-title":"Biol Reprod"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1038\/s41419-021-03899-y","volume":"12","author":"Perez-Sisques","year":"2021","journal-title":"Cell Death Dis"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"418","DOI":"10.18632\/oncotarget.23063","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1007\/s12020-016-0999-1","volume":"54","author":"Wang","year":"2016","journal-title":"Endocrine"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.mce.2015.07.023","volume":"414","author":"Yang","year":"2015","journal-title":"Mol Cell Endocrinol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/etm.2022.11602","volume":"24","author":"Pan","year":"2022","journal-title":"Exp Ther Med"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"17150","DOI":"10.18632\/aging.103658","volume":"12","author":"Zhong","year":"2020","journal-title":"Aging"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.bbrc.2017.05.160","volume":"489","author":"Wang","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"5384","DOI":"10.1038\/s41598-017-05541-4","volume":"7","author":"Wang","year":"2017","journal-title":"Sci Rep"},{"key":"ref37","volume":"41","author":"Zhang","year":"2021","journal-title":"Biosci Rep"}],"container-title":["Diabetes, Metabolic Syndrome and Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/110604","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/110604","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:00:27Z","timestamp":1767175227000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/mir-199a-knockdown-alleviates-insulin-resistance-and-inflammation-by-t-peer-reviewed-fulltext-article-DMSO"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":37,"URL":"https:\/\/doi.org\/10.2147\/dmso.s549884","relation":{},"ISSN":["1178-7007"],"issn-type":[{"value":"1178-7007","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]}}}