{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:06:52Z","timestamp":1788257212292,"version":"build-2803163510"},"reference-count":272,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DNND"],"DOI":"10.2147\/dnnd.s203406","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T08:30:07Z","timestamp":1641371407000},"page":"1-21","source":"Crossref","is-referenced-by-count":10,"title":["Updated Perspectives on the Challenges of Managing Multiple Sclerosis During Pregnancy"],"prefix":"10.2147","volume":"Volume 12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0064-8910","authenticated-orcid":true,"given":"Ram\u00f3n","family":"Villaverde-Gonz\u00e1lez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1177\/1756285616631897","volume":"9","author":"Coyle","year":"2016","journal-title":"Ther Adv Neurol Disord"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1177\/1756285613488434","volume":"6","author":"Harbo","year":"2013","journal-title":"Ther Adv Neurol Disord"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1016\/S0140-6736(18)30481-1","volume":"391","author":"Thompson","year":"2018","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1212\/01.wnl.0000316802.35974.34","volume":"71","author":"Alonso","year":"2008","journal-title":"Neurology"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e48078","DOI":"10.1371\/journal.pone.0048078","volume":"7","author":"Trojano","year":"2012","journal-title":"PLoS One"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.msard.2016.06.003","volume":"9","author":"Candeliere-Merlicco","year":"2016","journal-title":"Mult Scler Relat Disord"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.msard.2019.05.022","volume":"33","author":"Perez-Carmona","year":"2019","journal-title":"Mult Scler Relat Disord"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","volume":"17","author":"Thompson","year":"2018","journal-title":"Lancet Neurol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.msard.2018.06.006","volume":"24","author":"Rasmussen","year":"2018","journal-title":"Mult Scler Relat Disord"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1093\/brain\/118.1.253","volume":"118","author":"Runmarker","year":"1995","journal-title":"Brain"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1212\/WNL.39.11.1438","volume":"39","author":"Weinshenker","year":"1989","journal-title":"Neurology"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1177\/1352458512452920","volume":"19","author":"Alwan","year":"2013","journal-title":"Mult Scler"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1177\/1352458519851245","volume":"26","author":"Moberg","year":"2020","journal-title":"Mult Scler"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1007\/s10072-017-2999-1","volume":"38","author":"Ferraro","year":"2017","journal-title":"Neurol Sci"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e1559","DOI":"10.1212\/WNL.0000000000006384","volume":"91","author":"Houtchens","year":"2018","journal-title":"Neurology"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.msard.2019.01.003","volume":"28","author":"Nguyen","year":"2019","journal-title":"Mult Scler Relat Disord"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1016\/S1474-4422(06)70581-6","volume":"5","author":"Orton","year":"2006","journal-title":"Lancet Neurol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s00281-018-0723-8","volume":"41","author":"Gold","year":"2019","journal-title":"Semin Immunopathol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.autrev.2011.02.006","volume":"10","author":"Sellner","year":"2011","journal-title":"Autoimmun Rev"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"3609","DOI":"10.1093\/brain\/awt281","volume":"136","author":"Kalincik","year":"2013","journal-title":"Brain"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1046\/j.1468-1331.2003.00519.x","volume":"10","author":"Pozzilli","year":"2003","journal-title":"Eur J Neurol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1093\/brain\/114.2.1045","volume":"114","author":"Weinshenker","year":"1991","journal-title":"Brain"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1093\/brain\/awg081","volume":"126","author":"Confavreux","year":"2003","journal-title":"Brain"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1212\/WNL.0b013e3181e3973f","volume":"74","author":"Tremlett","year":"2010","journal-title":"Neurology"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1212\/WNL.0b013e3182703f46","volume":"79","author":"Schoonheim","year":"2012","journal-title":"Neurology"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1136\/jnnp.2010.208173","volume":"81","author":"Koch","year":"2010","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nrneurol.2012.43","volume":"8","author":"Voskuhl","year":"2012","journal-title":"Nat Rev Neurol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1111\/ane.12433","volume":"132","author":"Airas","year":"2015","journal-title":"Acta Neurol Scand"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1177\/1352458512438236","volume":"18","author":"Bove","year":"2012","journal-title":"Mult Scler"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1001\/archneur.62.9.1362","volume":"62","author":"Alonso","year":"2005","journal-title":"Arch Neurol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"3441","DOI":"10.1001\/jama.1988.03720230051029","volume":"259","author":"Nelson","year":"1988","journal-title":"JAMA"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1111\/j.1600-0404.1991.tb04977.x","volume":"84","author":"Bernardi","year":"1991","journal-title":"Acta Neurol Scand"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/0010-7824(93)90088-O","volume":"47","author":"Villard-Mackintosh","year":"1993","journal-title":"Contraception"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1212\/WNL.55.6.848","volume":"55","author":"Hern\u00e1n","year":"2000","journal-title":"Neurology"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1111\/j.1471-0528.1998.tb10008.x","volume":"105","author":"Thorogood","year":"1998","journal-title":"Br J Obstet Gynaecol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1212\/WNL.0000000000004207","volume":"89","author":"Langer-Gould","year":"2017","journal-title":"Neurology"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/ane.12426","volume":"132","author":"Magyari","year":"2015","journal-title":"Acta Neurol Scand"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1212\/WNL.0b013e31824c4648","volume":"78","author":"Ponsonby","year":"2012","journal-title":"Neurology"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1001\/jamaneurol.2020.3324","volume":"77","author":"Nguyen","year":"2020","journal-title":"JAMA Neurol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1756286420936166","DOI":"10.1177\/1756286420936166","volume":"13","author":"Krysko","year":"2020","journal-title":"Ther Adv Neurol Disord"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/S1474-4422(17)30076-5","volume":"16","author":"Wijnands","year":"2017","journal-title":"Lancet Neurol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s40120-014-0024-7","volume":"3","author":"Lebrun","year":"2014","journal-title":"Neurol Ther"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/j.1365-2796.1989.tb01387.x","volume":"226","author":"Grinsted","year":"1989","journal-title":"J Int Med"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1177\/1352458514540843","volume":"21","author":"Thone","year":"2014","journal-title":"Mult Scler"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1177\/1352458515602339","volume":"22","author":"Sep\u00falveda","year":"2016","journal-title":"Mult Scler"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s40263-015-0238-y","volume":"29","author":"Amato","year":"2015","journal-title":"CNS Drugs"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1159\/000367640","volume":"72","author":"Hellwig","year":"2014","journal-title":"Eur Neurol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.clim.2013.02.001","volume":"149","author":"Hellwig","year":"2013","journal-title":"Clin Immunol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1007\/s00415-015-7663-1","volume":"262","author":"Roux","year":"2015","journal-title":"J Neurol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"102682","DOI":"10.1016\/j.msard.2020.102682","volume":"48","author":"Soler","year":"2021","journal-title":"Mult Scler Relat Disord"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1177\/1352458508101937","volume":"15","author":"Chen","year":"2009","journal-title":"Mult Scler"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.neurol.2013.09.010","volume":"170","author":"Bodiguel","year":"2014","journal-title":"Rev Neurol (Paris)"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1093\/aje\/kwy197","volume":"188","author":"MacDonald","year":"2019","journal-title":"Am J Epidemiol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1097\/AOG.0000000000000541","volume":"124","author":"Bove","year":"2014","journal-title":"Obstet Gynecol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1002\/ana.22483","volume":"70","author":"van der Kop","year":"2011","journal-title":"Ann Neurol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1177\/1352458510372629","volume":"16","author":"Jalkanen","year":"2010","journal-title":"Mult Scler"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1007\/s10072-017-3081-8","volume":"38","author":"Amato","year":"2017","journal-title":"Neurol Sci"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1002\/pds.4735","volume":"28","author":"MacDonald","year":"2019","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1056\/NEJM199807303390501","volume":"339","author":"Confavreux","year":"1998","journal-title":"N Engl J Med"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.clineuro.2005.11.016","volume":"108","author":"Vukusic","year":"2006","journal-title":"Clin Neurol Neurosurg"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/nrneurol.2015.53","volume":"11","author":"Vukusic","year":"2015","journal-title":"Nat Rev Neurol"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1177\/1352458509102366","volume":"15","author":"Fernandez Liguori","year":"2009","journal-title":"Mult Scler"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.clineuro.2010.11.016","volume":"113","author":"Finkelsztejn","year":"2011","journal-title":"Clin Neurol Neurosurg"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1177\/1756285612453192","volume":"5","author":"Hellwig","year":"2012","journal-title":"Ther Adv Neurol Disord"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.msard.2017.07.002","volume":"17","author":"Jesus-Ribeiro","year":"2017","journal-title":"Mult Scler Relat Disord"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"102241","DOI":"10.1016\/j.msard.2020.102241","volume":"44","author":"Dobson","year":"2020","journal-title":"Mult Scler Relat Disord"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1111\/j.1471-0528.2011.02931.x","volume":"118","author":"Finkelsztejn","year":"2011","journal-title":"BJOG"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"175","DOI":"10.2217\/cer-2020-0211","volume":"10","author":"Modrego","year":"2021","journal-title":"J Comp Eff Res"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1111\/j.1468-1331.2007.01927.x","volume":"14","author":"Paavilainen","year":"2007","journal-title":"Eur J Neurol"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1212\/WNL.44.2.327","volume":"44","author":"van Walderveen","year":"1994","journal-title":"Neurology"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1111\/j.1468-1331.2006.01108.x","volume":"13","author":"Saraste","year":"2006","journal-title":"Eur J Neurol"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1212\/CON.0000000000000328","volume":"22","author":"Fabian","year":"2016","journal-title":"Continuum (Minneap Minn)"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.jri.2012.10.005","volume":"97","author":"Patas","year":"2013","journal-title":"J Reprod Immunol"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1093\/humupd\/dmi008","volume":"11","author":"Bouman","year":"2005","journal-title":"Hum Reprod Update"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.imlet.2004.10.007","volume":"97","author":"Phiel","year":"2005","journal-title":"Immunol Lett"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.yhbeh.2012.02.023","volume":"62","author":"Robinson","year":"2012","journal-title":"Horm Behav"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1111\/j.1365-2249.2007.03555.x","volume":"151","author":"Airas","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3389\/fimmu.2017.00196","volume":"8","author":"de Andr\u00e9s","year":"2017","journal-title":"Front Immunol"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1177\/1352458510389628","volume":"17","author":"Neuteboom","year":"2011","journal-title":"Mult Scler"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.imlet.2004.09.004","volume":"96","author":"S\u00e1nchez-Ram\u00f3n","year":"2005","journal-title":"Immunol Lett"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.pneurobio.2013.09.004","volume":"113","author":"Schumacher","year":"2014","journal-title":"Prog Neurobiol"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1002\/glia.22736","volume":"63","author":"El-Etr","year":"2015","journal-title":"Glia"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1212\/WNL.0000000000003036","volume":"87","author":"Benoit","year":"2016","journal-title":"Neurology"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/j.1600-0404.2007.00978.x","volume":"118","author":"Hellwig","year":"2008","journal-title":"Acta Neurol Scand"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1177\/1352458515623366","volume":"22","author":"Herbstritt","year":"2016","journal-title":"Mult Scler"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S1550-8579(07)80008-8","volume":"4","author":"Saraste","year":"2007","journal-title":"Gend Med"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1093\/brain\/awh152","volume":"127","author":"Vukusic","year":"2004","journal-title":"Brain"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1177\/1352458518816614","volume":"26","author":"Bsteh","year":"2020","journal-title":"Mult Scler"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1177\/1352458516634872","volume":"22","author":"Thiel","year":"2016","journal-title":"Mult Scler"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"e2989","DOI":"10.1212\/WNL.0000000000012084","volume":"96","author":"Yeh","year":"2021","journal-title":"Neurology"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.msard.2019.06.007","volume":"34","author":"Alroughani","year":"2019","journal-title":"Mult Scler Relat Disord"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"102518","DOI":"10.1016\/j.msard.2020.102518","volume":"46","author":"Villaverde-Gonz\u00e1lez","year":"2020","journal-title":"Mult Scler Relat Disord"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1212\/WNL.0b013e3181eb5860","volume":"75","author":"Airas","year":"2010","journal-title":"Neurology"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"e1939","DOI":"10.1212\/WNL.0000000000009374","volume":"94","author":"Langer-Gould","year":"2020","journal-title":"Neurology"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1136\/jnnp.56.10.1062","volume":"56","author":"Roullet","year":"1993","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1007\/BF00863773","volume":"241","author":"Worthington","year":"1994","journal-title":"J Neurol"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/1471-2377-12-165","volume":"12","author":"Past\u00f2","year":"2012","journal-title":"BMC Neurol"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1212\/WNL.0b013e318224afc9","volume":"77","author":"Portaccio","year":"2011","journal-title":"Neurology"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1177\/1352458513507816","volume":"20","author":"Hughes","year":"2014","journal-title":"Mult Scler"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1001\/jamaneurol.2015.1806","volume":"72","author":"Hellwig","year":"2015","journal-title":"JAMA Neurol"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1136\/jnnp.2008.160911","volume":"80","author":"Koch","year":"2009","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.annepidem.2014.04.007","volume":"24","author":"Karp","year":"2014","journal-title":"Ann Epidemiol"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1136\/jnnp.2008.163816","volume":"81","author":"D\u2019Hooghe","year":"2010","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1177\/1352458514561907","volume":"21","author":"Masera","year":"2015","journal-title":"Mult Scler"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"fcaa185","DOI":"10.1093\/braincomms\/fcaa185","volume":"2","author":"Zeydan","year":"2020","journal-title":"Brain Commun"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1001\/jamaneurol.2015.4800","volume":"73","author":"Munger","year":"2016","journal-title":"JAMA Neurol"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1002\/ana.22456","volume":"70","author":"Mirzaei","year":"2011","journal-title":"Ann Neurol"},{"key":"ref108","doi-asserted-by":"crossref","unstructured":"Drug and Therapeutic Bulletin. Vitamin supplementation in pregnancy. Drug Ther Bull. 2016;54(7):81\u201384. doi:10.1136\/dtb.2016.7.0414","DOI":"10.1136\/dtb.2016.7.0414"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.msard.2019.04.003","volume":"32","author":"Coyle","year":"2019","journal-title":"Mult Scler Relat Disord"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.parkreldis.2017.05.007","volume":"40","author":"Seier","year":"2017","journal-title":"Parkinsonism Relat Disord"},{"key":"ref111","unstructured":"Baclofen and pregnancy: birth defects and withdrawal symptoms. Prescrire Int. 2015;24(163):214."},{"key":"ref112","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1258\/om.2010.100016","volume":"3","author":"Tandon","year":"2010","journal-title":"Obstet Med"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.jns.2016.09.033","volume":"370","author":"Maillart","year":"2016","journal-title":"J Neurol Sci"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.nrl.2014.12.015","volume":"32","author":"Cuello","year":"2017","journal-title":"Neurologia"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1177\/1352458520904545","volume":"27","author":"Mahlanza","year":"2021","journal-title":"Mult Scler"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1212\/01.wnl.0000208521.10685.a6","volume":"66","author":"Laplaud","year":"2006","journal-title":"Neurology"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1007\/s00415-008-0607-2","volume":"255","author":"Hellwig","year":"2008","journal-title":"J Neurol"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1136\/jnnp-2012-302235","volume":"83","author":"Michel","year":"2012","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref119","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1002\/ana.23745","volume":"72","author":"Correale","year":"2012","journal-title":"Ann Neurol"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1177\/1352458519865118","volume":"26","author":"Bove","year":"2020","journal-title":"Mult Scler"},{"key":"ref121","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.90.15_supplement.P4.356","volume":"90","author":"Brzosko","year":"2018","journal-title":"Neurology"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1212\/WNL.0000000000005347","volume":"90","author":"Rae-Grant","year":"2018","journal-title":"Neurology"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.1016\/j.msard.2016.07.003","volume":"9","author":"Giovannoni","year":"2016","journal-title":"Mult Scler Relat Disord"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3390\/brainsci7070078","volume":"7","author":"Dargahi","year":"2017","journal-title":"Brain Sci"},{"key":"ref125","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.clineuro.2012.04.024","volume":"115","author":"Fragoso","year":"2013","journal-title":"Clin Neurol Neurosurg"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s40120-020-00201-8","volume":"9","author":"Alroughani","year":"2020","journal-title":"Neurol Ther"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1080\/21556660.2020.1721507","volume":"9","author":"Caniba\u00f1o","year":"2020","journal-title":"J Drug Asses"},{"key":"ref128","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1177\/1352458517701314","volume":"23","author":"Houtchens","year":"2017","journal-title":"Mult Scler"},{"key":"ref129","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/j.1728-4465.2010.00250.x","volume":"41","author":"Singh","year":"2010","journal-title":"Stud Fam Plann"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0010-7824(02)00325-6","volume":"66","author":"Rasch","year":"2002","journal-title":"Contraception"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"1756286420951072","DOI":"10.1177\/1756286420951072","volume":"13","author":"Hakkarainen","year":"2020","journal-title":"Ther Adv Neurol Disord"},{"key":"ref132","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1007\/s00415-020-09762-y","volume":"267","author":"Hellwig","year":"2020","journal-title":"J Neurol"},{"key":"ref133","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1177\/1352458510394610","volume":"17","author":"Sandberg-Wollheim","year":"2011","journal-title":"Mult Scler"},{"key":"ref134","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.80.7_supplement.S30.006","volume":"80","author":"Tomczyk","year":"2013","journal-title":"Neurology"},{"key":"ref135","doi-asserted-by":"publisher","first-page":"e004536","DOI":"10.1136\/bmjopen-2013-004536","volume":"4","author":"Coyle","year":"2014","journal-title":"BMJ Open"},{"key":"ref136","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.1212\/WNL.0b013e3181fd62bb","volume":"75","author":"Amato","year":"2010","journal-title":"Neurology"},{"key":"ref137","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1212\/01.wnl.0000180575.77021.c4","volume":"65","author":"Boskovic","year":"2005","journal-title":"Neurology"},{"key":"ref138","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1212\/WNL.0b013e3182698c64","volume":"79","author":"Lu","year":"2012","journal-title":"Neurology"},{"key":"ref139","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1177\/1352458509106543","volume":"15","author":"Weber-Schoendorfer","year":"2009","journal-title":"Mult Scler"},{"key":"ref140","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1007\/s00415-008-0909-4","volume":"255","author":"Patti","year":"2008","journal-title":"J Neurol"},{"key":"ref141","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1136\/jnnp-2014-308113","volume":"86","author":"Romero","year":"2015","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref142","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1001\/jamaneurol.2019.4173","volume":"12","author":"Giannini","year":"2012","journal-title":"BMC Neurol"},{"key":"ref143","doi-asserted-by":"publisher","first-page":"9","DOI":"10.7224\/1537-2073.2016-079","volume":"20","author":"Sandberg-Wollheim","year":"2018","journal-title":"Int J MS Care"},{"key":"ref144","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1590\/S0004-282X2009000400015","volume":"67","author":"Fragoso","year":"2009","journal-title":"Arq Neuropsiquiatr"},{"key":"ref145","doi-asserted-by":"publisher","first-page":"969","DOI":"10.2165\/11538960-000000000-00000","volume":"24","author":"Fragoso","year":"2010","journal-title":"CNS Drugs"},{"key":"ref146","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.1007\/s00415-010-5652-y","volume":"257","author":"Salminen","year":"2010","journal-title":"J Neurol"},{"key":"ref147","doi-asserted-by":"publisher","first-page":"bcr2013201273","DOI":"10.1136\/bcr-2013-201273","volume":"2014","author":"Dung","year":"2014","journal-title":"BMJ Case Rep"},{"key":"ref148","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1007\/s00415-010-5758-2","volume":"258","author":"Hellwig","year":"2011","journal-title":"J Neurol"},{"key":"ref149","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1177\/1352458514537013","volume":"21","author":"Gold","year":"2015","journal-title":"Mult Scler"},{"key":"ref150","unstructured":"Hellwig K, Rog D, McGuigan C, Chen K, Parks B, Jones C An international registry tracking pregnancy outcomes in women treated with dimethyl fumarate. Abstract (P1147) at the ECTRIMS 2019 congress; September 11\u201313, 2019; Stockholm, Sweden. Available from: https:\/\/onlinelibrary.ectrims-congress.eu\/. Accessed December 22, 2021."},{"key":"ref151","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s40263-018-0496-6","volume":"32","author":"Vaughn","year":"2018","journal-title":"CNS Drugs"},{"key":"ref152","unstructured":"The European Medicines Agency - EMA. Tecfidera. Summary of product characteristics. (Online). Available from: https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/tecfidera-epar-product-information_en.pdf. Accessed August 2, 2021."},{"key":"ref153","unstructured":"The European Medicines Agency - EMA. Mayzent. Summary of product characteristics. (Online). Available from: https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/mayzent-epar-product-information_en.pdf. Accessed August 2, 2021."},{"key":"ref154","unstructured":"The European Medicines Agency - EMA. Gilenya. Summary of product characteristics. (Online). Available from: https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/gilenya-epar-product-information_es.pdf. Accessed August 2, 2021."},{"key":"ref155","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1080\/17512433.2018.1425615","volume":"11","author":"Koren","year":"2018","journal-title":"Expert Rev Clin Pharmacol"},{"key":"ref156","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1177\/1352458520912637","volume":"27","author":"Demortiere","year":"2021","journal-title":"Mult Scler"},{"key":"ref157","doi-asserted-by":"publisher","first-page":"e832","DOI":"10.1212\/WNL.0000000000005068","volume":"90","author":"Portaccio","year":"2018","journal-title":"Neurology"},{"key":"ref158","doi-asserted-by":"publisher","first-page":"e823","DOI":"10.1212\/WNL.0000000000005067","volume":"90","author":"Portaccio","year":"2018","journal-title":"Neurology"},{"key":"ref159","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1177\/1352458511401944","volume":"17","author":"Hellwig","year":"2011","journal-title":"Mult Scler"},{"key":"ref160","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1177\/1352458514546790","volume":"21","author":"Ebrahimi","year":"2015","journal-title":"Mult Scler"},{"key":"ref161","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s12883-016-0674-4","volume":"16","author":"Friend","year":"2016","journal-title":"BMC Neurol"},{"key":"ref162","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1177\/1352458517751049","volume":"24","author":"Montalban","year":"2018","journal-title":"Mult Scler"},{"key":"ref163","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1055\/s-0037-1608925","volume":"37","author":"Houtchens","year":"2017","journal-title":"Semin Neurol"},{"key":"ref164","unstructured":"The European Medicines Agency - EMA. Mavenclad. Summary of product characteristics. (Online). Available from: https:\/\/ec.europa.eu\/health\/documents\/community-register\/2017\/20170822138481\/anx_138481_es.pdf. Accessed August 2, 2021."},{"key":"ref165","unstructured":"The European Medicines Agency - EMA. Lemtrada. Summary of product characteristics. (Online). Available from: https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/lemtrada-epar-product-information_en.pdf. Accessed August 2, 2021."},{"key":"ref166","doi-asserted-by":"publisher","first-page":"271363","DOI":"10.1155\/2008\/271363","volume":"2008","author":"Klink","year":"2008","journal-title":"Clin Dev Immunol"},{"key":"ref167","unstructured":"U.S. Food and Drug Administration \u2013 FDA. Ocrevus (ocrelizumab). Prescribing information. Available from: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2017\/761053lbl.pdf. Accessed August 2, 2021."},{"key":"ref168","unstructured":"The European Medicines Agency - EMA. Ocrevus. Summary of product characteristics. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/ocrevus-epar-product-information_en.pdf. Accessed August 2, 2021."},{"key":"ref169","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1177\/1060028017747635","volume":"52","author":"Stahnke","year":"2018","journal-title":"Ann Pharmacother"},{"key":"ref170","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1212\/CON.0000000000000745","volume":"25","author":"Langer-Gould","year":"2019","journal-title":"Continuum (Minneap Minn)"},{"key":"ref171","doi-asserted-by":"publisher","first-page":"e840","DOI":"10.1212\/WNL.0000000000005065","volume":"90","author":"Alroughani","year":"2018","journal-title":"Neurology"},{"key":"ref172","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1177\/1352458517708672","volume":"23","author":"Oreja-Guevara","year":"2017","journal-title":"Mult Scler"},{"key":"ref173","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1212\/WNL.0000000000002887","volume":"87","author":"Wang","year":"2016","journal-title":"Neurology"},{"key":"ref174","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1177\/1352458509345920","volume":"15","author":"Freedman","year":"2009","journal-title":"Mult Scler"},{"key":"ref175","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1212\/WNL.0b013e3182535cf6","volume":"78","author":"Goodin","year":"2012","journal-title":"Neurology"},{"key":"ref176","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1002\/ana.21757","volume":"66","author":"Trojano","year":"2009","journal-title":"Ann Neurol"},{"key":"ref177","doi-asserted-by":"publisher","first-page":"545","DOI":"10.12998\/wjcc.v3.i7.545","volume":"3","author":"Gajofatto","year":"2015","journal-title":"World J Clin Cases"},{"key":"ref178","doi-asserted-by":"publisher","first-page":"e380","DOI":"10.1016\/S2214-109X(18)30029-9","volume":"6","author":"Bearak","year":"2018","journal-title":"Lancet Glob Health"},{"key":"ref179","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1056\/NEJMsa1506575","volume":"374","author":"Finer","year":"2016","journal-title":"New Engl J Med"},{"key":"ref180","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1177\/1352458511402114","volume":"17","author":"Hutchinson","year":"2011","journal-title":"Mult Scler"},{"key":"ref181","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1016\/j.jocn.2014.01.017","volume":"21","author":"Broadley","year":"2014","journal-title":"J Clin Neurosci"},{"key":"ref182","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1177\/1352458513519840","volume":"20","author":"Miller","year":"2014","journal-title":"Mult Scler"},{"key":"ref183","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1080\/14740338.2017.1311321","volume":"16","author":"Th\u00f6ne","year":"2017","journal-title":"Expert Opin Drug Saf"},{"key":"ref184","doi-asserted-by":"publisher","first-page":"e1570","DOI":"10.1212\/WNL.0000000000006382","volume":"91","author":"Houtchens","year":"2018","journal-title":"Neurology"},{"key":"ref185","doi-asserted-by":"publisher","first-page":"2512","DOI":"10.1007\/s00415-019-09450-6","volume":"266","author":"Berenguer-Ruiz","year":"2019","journal-title":"J Neurol"},{"key":"ref186","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.jns.2018.06.025","volume":"392","author":"Khalid","year":"2018","journal-title":"J Neurol Sci"},{"key":"ref187","unstructured":"The European Medicines Agency - EMA. Aubagio. Summary of product characteristics. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/aubagio-epar-product-information_en.pdf. Accessed August 2, 2021."},{"key":"ref188","doi-asserted-by":"publisher","first-page":"101483","DOI":"10.1016\/j.msard.2019.101483","volume":"38","author":"Sep\u00falveda","year":"2020","journal-title":"Mult Scler Relat Disord"},{"key":"ref189","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s40120-019-00160-9","volume":"8","author":"Barry","year":"2019","journal-title":"Neurol Ther"},{"key":"ref190","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1177\/1352458517731913","volume":"24","author":"Meinl","year":"2018","journal-title":"Mult Scler"},{"key":"ref191","doi-asserted-by":"publisher","first-page":"e377","DOI":"10.1212\/NXI.0000000000000377","volume":"4","author":"Novi","year":"2017","journal-title":"Neurol Neuroimmunol NeuroInflamm"},{"key":"ref192","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/ene.12195","volume":"20","author":"Sempere","year":"2013","journal-title":"Eur J Neurol"},{"key":"ref193","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.pjnns.2017.10.001","volume":"52","author":"Litwin","year":"2018","journal-title":"Neurol Neurochir Pol"},{"key":"ref194","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1007\/s40265-020-01319-7","volume":"80","author":"Lamb","year":"2020","journal-title":"Drugs"},{"key":"ref195","unstructured":"The European Medicines Agency - EMA. Zeposia. Summary of product characteristics. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/zeposia-epar-product-information_en.pdf. Accessed August 2, 2021."},{"key":"ref196","unstructured":"The European Medicines Agency - EMA. Tysabri. Summary of product characteristics. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/tysabri-epar-product-information_en.pdf. Accessed August 2, 2021."},{"key":"ref197","unstructured":"Food and Drug Administration- FDA. Tysabri (Natalizumab) prescribing information. Available from: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2012\/125104s0576lbl.pdf. Accessed August 2, 2021."},{"key":"ref198","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1111\/ane.12364","volume":"131","author":"de Giglio","year":"2015","journal-title":"Acta Neurol Scand"},{"key":"ref199","doi-asserted-by":"publisher","first-page":"e903","DOI":"10.1212\/NXI.0000000000000903","volume":"7","author":"Razaz","year":"2020","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"ref200","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1177\/1352458514554056","volume":"21","author":"Vukusic","year":"2015","journal-title":"Mult Scler"},{"key":"ref201","doi-asserted-by":"publisher","first-page":"e424","DOI":"10.1212\/NXI.0000000000000424","volume":"5","author":"Kleerekooper","year":"2017","journal-title":"Neurol Neuroimmunol NeuroInflamm"},{"key":"ref202","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1159\/000500881","volume":"8","author":"Muller","year":"2019","journal-title":"Eur Thyroid J"},{"key":"ref203","doi-asserted-by":"publisher","first-page":"102146","DOI":"10.1016\/j.msard.2020.102146","volume":"43","author":"Oh","year":"2020","journal-title":"Mult Scler Relat Disord"},{"key":"ref204","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1515\/jpm-2016-0060","volume":"45","author":"Yalcin","year":"2017","journal-title":"J Perinatal Med"},{"key":"ref205","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1136\/practneurol-2018-002060","volume":"19","author":"Dobson","year":"2019","journal-title":"Pract Neurol"},{"key":"ref206","doi-asserted-by":"publisher","first-page":"CD008873","DOI":"10.1002\/14651858.CD008873.pub4","volume":"7","author":"Palacios","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"ref207","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3174\/ajnr.A4539","volume":"37","author":"Traboulsee","year":"2016","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref208","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1001\/jama.2016.12126","volume":"316","author":"Ray","year":"2016","journal-title":"JAMA"},{"key":"ref209","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.clinimag.2020.02.007","volume":"62","author":"Lum","year":"2020","journal-title":"Clin Imaging"},{"key":"ref210","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1002\/jmri.26317","volume":"49","author":"Mervak","year":"2019","journal-title":"J Magn Reson Imaging"},{"key":"ref211","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1001\/jamaneurol.2014.209","volume":"71","author":"Haghikia","year":"2014","journal-title":"JAMA Neurol"},{"key":"ref212","doi-asserted-by":"publisher","first-page":"101961","DOI":"10.1016\/j.msard.2020.101961","volume":"40","author":"Triplett","year":"2020","journal-title":"Mult Scler Relat Disord"},{"key":"ref213","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.jogoh.2017.02.008","volume":"46","author":"Guilloton","year":"2017","journal-title":"J Gynecol Obstet Hum Reprod"},{"key":"ref214","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1097\/WCO.0000000000000922","volume":"34","author":"Dobson","year":"2021","journal-title":"Curr Opin Neurol"},{"key":"ref215","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1177\/1756285614540224","volume":"7","author":"Bomprezzi","year":"2014","journal-title":"Ther Adv Neurol Disord"},{"key":"ref216","doi-asserted-by":"publisher","first-page":"614715","DOI":"10.3389\/fimmu.2021.614715","volume":"12","author":"Riancho","year":"2021","journal-title":"Front Immunol"},{"key":"ref217","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1136\/jnnp-2015-312940","volume":"87","author":"Zhovtis Ryerson","year":"2016","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref218","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.msard.2018.06.015","volume":"24","author":"Yamout","year":"2018","journal-title":"Mult Scler Relat Disord"},{"key":"ref219","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1111\/j.1651-2227.2010.02074.x","volume":"100","author":"Norberg","year":"2011","journal-title":"Acta Paediatr"},{"key":"ref220","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.05.046","volume":"197","author":"Carmichael","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"ref221","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1002\/1096-9926(200012)62:6<385::AID-TERA5>3.0.CO;2-Z","volume":"62","author":"Park-Wyllie","year":"2000","journal-title":"Teratology"},{"key":"ref222","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1002\/bdra.23248","volume":"100","author":"Skuladottir","year":"2014","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"ref223","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.rdc.2017.04.013","volume":"43","author":"Bandoli","year":"2017","journal-title":"Rheum Dis Clin North Am"},{"key":"ref224","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1001\/jama.2020.3937","volume":"323","author":"R\u00e4ikk\u00f6nen","year":"2020","journal-title":"JAMA"},{"key":"ref225","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1007\/s00415-012-6653-9","volume":"260","author":"Houtchens","year":"2013","journal-title":"J Neurol"},{"key":"ref226","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s40120-018-0110-3","volume":"7","author":"Fragoso","year":"2018","journal-title":"Neurol Ther"},{"key":"ref227","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.3390\/jcm8101623","volume":"8","author":"Rolfes","year":"2019","journal-title":"J Clin Med"},{"key":"ref228","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1136\/practneurol-2020-002527","volume":"20","author":"Reyes","year":"2020","journal-title":"Pract Neurol"},{"key":"ref229","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.nrl.2020.02.006","volume":"36","author":"Otero-Romero","year":"2021","journal-title":"Neurologia (Engl Ed)"},{"key":"ref230","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1056\/NEJMoa2104983","volume":"384","author":"Shimabukuro","year":"2021","journal-title":"N Engl J Med"},{"key":"ref231","unstructured":"Acog.org (homepage on the Internet). American College of Obstetricians and Gynecologists. COVID-19 Vaccination Considerations for Obstetric\u2013Gynecologic Care. [updated July 30, 2021]. Available from: https:\/\/www.acog.org\/clinical\/clinical-guidance\/practice-advisory\/articles\/2020\/12\/covid-19-vaccination-considerations-for-obstetric-gynecologic-care. Accessed December 22, 2021."},{"key":"ref232","unstructured":"Canada.ca (homepage on the Internet). National Advisory Committee on Immunization. Public Health Agency of Canada. Recommendations on the use of COVID-19 Vaccines; July 22, 2021. Available from: https:\/\/www.canada.ca\/en\/public-health\/services\/immunization\/national-advisory-committee-on-immunization-naci\/recommendations-use-covid-19-vaccines.html. Accessed December 22, 2021."},{"key":"ref233","unstructured":"Australian Technical Advisory Group on Immunisation (ATAGI). Clinical guidance on use of COVID-19 vaccine in Australia in 2021. Version 6.0; July 30, 2021. Available from: https:\/\/www.health.gov.au\/sites\/default\/files\/documents\/2021\/08\/covid-19-vaccination-atagi-clinical-guidance-on-covid-19-vaccine-in-australia-in-2021_0.pdf. Accessed August 2, 2021."},{"key":"ref234","unstructured":"Limia Sanchez A, Navarro JA, Armona Aquerreta JM Vaccination working group in the adult population and risk groups of the Vaccination Program and Registry Report. Vaccination in risk groups of all ages and in certain situations. Public Health Commission of the Interterritorial Council of the National Health System. Ministry of Health, Consumption and Social Welfare, July 2018.: 137\u2013145. Available from: http:\/\/www.ffis.es\/ups\/prl\/vacunacion_grupos_riesgo.pdf. Accessed December 22, 2021."},{"key":"ref235","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1136\/jnnp-2013-306054","volume":"85","author":"Portaccio","year":"2014","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref236","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1007\/s00415-004-0495-z","volume":"251","author":"Achiron","year":"2004","journal-title":"J Neurol"},{"key":"ref237","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.ijgo.2016.01.008","volume":"134","author":"Brandt-Wouters","year":"2016","journal-title":"Int J Gynecol Obstet"},{"key":"ref238","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1177\/1352458506075654","volume":"13","author":"Haas","year":"2007","journal-title":"Mult Scler"},{"key":"ref239","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1177\/1756285608100416","volume":"2","author":"Hellwig","year":"2009","journal-title":"Ther Adv Neurol Disord"},{"key":"ref240","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0301-2115(98)00231-0","volume":"82","author":"Orvieto","year":"1999","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref241","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1080\/07399332.2014.948627","volume":"36","author":"Fragoso","year":"2015","journal-title":"Health Care Women Int"},{"key":"ref242","doi-asserted-by":"publisher","first-page":"101519","DOI":"10.1016\/j.msard.2019.101519","volume":"38","author":"Horvat Ledinek","year":"2020","journal-title":"Mult Scler Related Disord"},{"key":"ref243","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1590\/0004-282x20180041","volume":"76","author":"Rosa","year":"2018","journal-title":"Arq Neuropsiquiatr"},{"key":"ref244","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1191\/1352458504ms1079sr","volume":"10","author":"de Seze","year":"2004","journal-title":"Mult Scler"},{"key":"ref245","doi-asserted-by":"publisher","first-page":"91","DOI":"10.7224\/1537-2073-13.2.91","volume":"13","author":"Avila-Ornelas","year":"2011","journal-title":"Int J MS Care"},{"key":"ref246","unstructured":"Durand-Dubief F, El-Etr M, Ionescu I, et al. The POPARTMUS French-Italian multicentric trial of postpartum progestin and estradiol in multiple sclerosis: MRI findings. Abstract (P063) at the ECTRIMS 2014 congress; September 10\u201313, 2014; Boston, USA. Available from: https:\/\/onlinelibrary.ectrims-congress.eu. Accessed December 22, 2021."},{"key":"ref247","doi-asserted-by":"publisher","first-page":"9","DOI":"10.7812\/TPP\/13-090","volume":"18","author":"Beaber","year":"2014","journal-title":"Perm J"},{"key":"ref248","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1177\/1352458519830588","volume":"25","author":"Portaccio","year":"2019","journal-title":"Mult Scler"},{"key":"ref249","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1001\/jamaneurol.2019.4173","volume":"77","author":"Krysko","year":"2020","journal-title":"JAMA Neurol"},{"key":"ref250","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1001\/archneurol.2009.132","volume":"66","author":"Langer-Gould","year":"2009","journal-title":"Arch Neurol"},{"key":"ref251","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/S0140-6736(15)01024-7","volume":"387","author":"Victora","year":"2016","journal-title":"Lancet"},{"key":"ref252","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.pcl.2012.09.010","volume":"60","author":"Dieterich","year":"2013","journal-title":"Pediatr Clin North Am"},{"key":"ref253","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1016\/j.amjmed.2019.02.021","volume":"132","author":"Sattari","year":"2019","journal-title":"Am J Med"},{"key":"ref254","first-page":"6527458","volume":"2016","author":"Almas","year":"2016","journal-title":"Multiple Scler Int"},{"key":"ref255","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1089\/bfm.2011.0044","volume":"7","author":"Hale","year":"2012","journal-title":"Breastfeed Med"},{"key":"ref256","unstructured":"The European Medicines Agency - EMA. Rebif. Summary of product characteristics. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/rebif-epar-product-information_en.pdf. Accessed August 2, 2021."},{"key":"ref257","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1177\/1352458520912173","volume":"27","author":"Datta","year":"2021","journal-title":"Mult Scler"},{"key":"ref258","unstructured":"Drugs and Lactation Database (LactMed) [Internet]. Ocrelizumab. Bethesda (MD): National Library of Medicine (US); 2006 [updated July 20, 2020]. https:\/\/www.ncbi.nlm.nih.gov\/books\/. Accessed December 22, 2021."},{"key":"ref259","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1177\/1352458517728813","volume":"24","author":"Proschmann","year":"2018","journal-title":"Mult Scler"},{"key":"ref260","doi-asserted-by":"publisher","first-page":"e769","DOI":"10.1212\/NXI.0000000000000769","volume":"7","author":"LaHue","year":"2020","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"ref261","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1177\/0890334414566237","volume":"31","author":"Baker","year":"2015","journal-title":"J Hum Lact"},{"key":"ref262","doi-asserted-by":"crossref","first-page":"e723","DOI":"10.1212\/NXI.0000000000000723","volume":"7","author":"Ciplea","year":"2020","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"ref263","unstructured":"Tailor K, Bove R, Oreja-Guevara C, et al. Pregnancy outcomes in patients treated with ocrelizumab. ePoster (P1132) at the MSVirtual\/Virtual 8th Joint ACTRIMS-ECTRIMS Meeting; September 11\u201313, 2020."},{"key":"ref264","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1177\/0890334415570970","volume":"31","author":"Cooper","year":"2015","journal-title":"J Hum Lact"},{"key":"ref265","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ncl.2018.09.007","volume":"37","author":"Kaplan","year":"2019","journal-title":"Neurol Clin"},{"key":"ref266","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1177\/1352458515600249","volume":"21","author":"Kraemer","year":"2015","journal-title":"Mult Scler"},{"key":"ref267","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1007\/s13311-017-0562-7","volume":"14","author":"Voskuhl","year":"2017","journal-title":"Neurotherapeutics"},{"key":"ref268","doi-asserted-by":"crossref","unstructured":"ACOG Committee on Obstetric Practice. Committee Opinion No. 723: guidelines for diagnostic imaging during pregnancy and lactation. Obstet Gynecol. 2017;130(4):e210\u2013e216. doi:10.1097\/AOG.0000000000002355","DOI":"10.1097\/AOG.0000000000002355"},{"key":"ref269","doi-asserted-by":"publisher","first-page":"e453","DOI":"10.1212\/NXI.0000000000000453","volume":"5","author":"Das","year":"2018","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"ref270","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1182\/blood-2010-07-295444","volume":"117","author":"Chakravarty","year":"2011","journal-title":"Blood"},{"key":"ref271","unstructured":"The European Medicines Agency - EMA. Kesimpta. Summary of product characteristics. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/kesimpta-epar-product-information_en.pdf. Accessed November 20, 2021."},{"key":"ref272","unstructured":"The European Medicines Agency - EMA. Ponvory. Summary of product characteristics. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/ponvory-epar-product-information_en.pdf. Accessed November 20, 2021."}],"container-title":["Degenerative Neurological and Neuromuscular Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=77340","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=77340","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T18:39:40Z","timestamp":1726425580000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/updated-perspectives-on-the-challenges-of-managing-multiple-sclerosis--peer-reviewed-fulltext-article-DNND"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":272,"URL":"https:\/\/doi.org\/10.2147\/dnnd.s203406","relation":{},"ISSN":["1179-9900"],"issn-type":[{"value":"1179-9900","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}