{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T22:03:41Z","timestamp":1769810621514,"version":"3.49.0"},"reference-count":59,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DNND"],"DOI":"10.2147\/dnnd.s574901","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T11:40:14Z","timestamp":1769773214000},"page":"1-10","source":"Crossref","is-referenced-by-count":0,"title":["Advancements in Therapy for Alzheimer\u2019s Disease Based on the Cerebral Lymphatic System"],"prefix":"10.2147","volume":"Volume 16","author":[{"given":"Feiyue","family":"Mi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongfeng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changyin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2026,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1002\/alz.13809","volume":"20","author":"Better","year":"2024","journal-title":"Alzheimer Dementia"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"147ra111","DOI":"10.1126\/scitranslmed.3003748","volume":"4","author":"Iliff","year":"2012","journal-title":"Sci Trans Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature14432","volume":"523","author":"Louveau","year":"2015","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1084\/jem.20142290","volume":"212","author":"Aspelund","year":"2015","journal-title":"J Exp Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"711","DOI":"10.3233\/JAD-2011-110725","volume":"27","author":"Yang","year":"2011","journal-title":"J Alzheimer Dis"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/s41586-018-0368-8","volume":"560","author":"Da Mesquita","year":"2018","journal-title":"Nature"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.nbd.2016.05.015","volume":"93","author":"Peng","year":"2016","journal-title":"Neurobiol Dis"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1093\/brain\/awae329","volume":"148","author":"Al-Diwani","year":"2025","journal-title":"Brain"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"189ra177","DOI":"10.1126\/scitranslmed.3005615","volume":"5","author":"Potter","year":"2013","journal-title":"Sci Trans Med"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nrneurol.2015.119","volume":"11","author":"Tarasoff-Conway","year":"2015","journal-title":"Nat Rev Neurol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/s41586-023-06993-7","volume":"627","author":"Smyth","year":"2024","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"16073","DOI":"10.1038\/s41598-020-72621-3","volume":"10","author":"Giannetto","year":"2020","journal-title":"Sci Rep"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"3645","DOI":"10.1084\/jem.20170391","volume":"214","author":"Antila","year":"2017","journal-title":"J Exp Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1038\/s41586-023-06899-4","volume":"625","author":"Yoon","year":"2024","journal-title":"Nature"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1002\/ana.24271","volume":"76","author":"Kress","year":"2014","journal-title":"Ann Neurol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"2705","DOI":"10.1016\/j.cell.2025.02.022","volume":"188","author":"Kim","year":"2025","journal-title":"Cell"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.bjps.2024.10.002","volume":"99","author":"Chao","year":"2024","journal-title":"JPRAS"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abc0836","volume":"14","author":"Kataru","year":"2021","journal-title":"Sci Signaling"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"156041","DOI":"10.1016\/j.phymed.2024.156041","volume":"135","author":"Liu","year":"2024","journal-title":"Phytomedicine"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"605814","DOI":"10.3389\/fphar.2021.605814","volume":"12","author":"Zheng","year":"2021","journal-title":"Front Pharmacol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.cell.2020.06.039","volume":"182","author":"Oliver","year":"2020","journal-title":"Cell"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"155753","DOI":"10.1016\/j.phymed.2024.155753","volume":"130","author":"Ye","year":"2024","journal-title":"Phytomedicine"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"109119","DOI":"10.1016\/j.clim.2022.109119","volume":"244","author":"Li","year":"2022","journal-title":"Clin Immunol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1080\/10717544.2018.1482973","volume":"25","author":"Ye","year":"2018","journal-title":"Drug Delivery"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"106","DOI":"10.7150\/thno.76133","volume":"13","author":"Wu","year":"2023","journal-title":"Theranostics"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"34431","DOI":"10.1021\/acsami.4c09059","volume":"16","author":"Ye","year":"2024","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.bbrc.2020.04.046","volume":"528","author":"Takahashi","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"4331","DOI":"10.7150\/thno.98587","volume":"14","author":"Ye","year":"2024","journal-title":"Theranostics"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"16036","DOI":"10.1074\/jbc.M700641200","volume":"282","author":"Michaluk","year":"2007","journal-title":"J Biol Chem"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/s41467-024-55678-w","volume":"16","author":"Wu","year":"2025","journal-title":"Nat Commun"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/s41421-024-00701-z","volume":"10","author":"Sun","year":"2024","journal-title":"Cell Discovery"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/nature20587","volume":"540","author":"Iaccarino","year":"2016","journal-title":"Nature"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.cell.2019.02.014","volume":"177","author":"Martorell","year":"2019","journal-title":"Cell"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1038\/s41586-024-07132-6","volume":"627","author":"Murdock","year":"2024","journal-title":"Nature"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"137","DOI":"10.3233\/JAD-180253","volume":"65","author":"Sobol","year":"2018","journal-title":"J Alzheimer Dis"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"113003","DOI":"10.1016\/j.physbeh.2020.113003","volume":"223","author":"Bashiri","year":"2020","journal-title":"Physiol Behav"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"111263","DOI":"10.1016\/j.brainresbull.2025.111263","volume":"222","author":"Liang","year":"2025","journal-title":"Brain Res Bull"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"121074","DOI":"10.1016\/j.neuroimage.2025.121074","volume":"308","author":"Kong","year":"2025","journal-title":"NeuroImage"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.arr.2016.05.006","volume":"29","author":"Tatti","year":"2016","journal-title":"Ageing Res Rev"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1136\/jnnp-2020-323870","volume":"92","author":"Chu","year":"2021","journal-title":"J Neurol Neurosurg"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.neuroimage.2017.12.048","volume":"169","author":"Koch","year":"2018","journal-title":"NeuroImage"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s40478-021-01198-3","volume":"9","author":"Lin","year":"2021","journal-title":"Acta Neuropathol Commun"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"e2401039","DOI":"10.1002\/advs.202401039","volume":"11","author":"Wu","year":"2024","journal-title":"Adv Sci"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jare.2020.06.012","volume":"26","author":"Liao","year":"2020","journal-title":"J Adv Res"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"3025","DOI":"10.1093\/hmg\/dds134","volume":"21","author":"Martin","year":"2012","journal-title":"Human Molecular Genetics"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.ydbio.2003.10.036","volume":"266","author":"Lange","year":"2004","journal-title":"Dev Biol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1182\/blood-2008-05-156331","volume":"112","author":"Shin","year":"2008","journal-title":"Blood"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1084\/jem.20041896","volume":"201","author":"Hirakawa","year":"2005","journal-title":"J Exp Med"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1002\/path.5767","volume":"255","author":"Choi","year":"2021","journal-title":"J Pathol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1101\/gad.282400.116","volume":"30","author":"Cha","year":"2016","journal-title":"Genes Dev"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.celrep.2018.09.049","volume":"25","author":"Cha","year":"2018","journal-title":"Cell Rep"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1055\/a-2513-4313","volume":"52","author":"Hong","year":"2025","journal-title":"Archi Plastic Surg"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"494e","DOI":"10.1097\/PRS.0000000000010933","volume":"153","author":"Xie","year":"2024","journal-title":"Plastic Reconstruct Surg"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"73","DOI":"10.29063\/ajrh2024\/v28i12.8","volume":"28","author":"Yu","year":"2024","journal-title":"Afr J Reproduct Health"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"144","DOI":"10.5582\/bst.2025.01108","volume":"19","author":"Ma","year":"2025","journal-title":"Biosci Trends"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/00003086-198902000-00029","volume":"1989","author":"Ilizarov","year":"1989","journal-title":"Clin Orthopaedics Related Res"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1161\/STROKEAHA.121.037912","volume":"53","author":"Bai","year":"2022","journal-title":"Stroke"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1097\/00006534-200203000-00046","volume":"109","author":"Bouletreau","year":"2002","journal-title":"Plastic Reconstruct Surg"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"e14518","DOI":"10.1002\/alz.14518","volume":"21","author":"Lu","year":"2025","journal-title":"Alzheimer Dement"}],"container-title":["Degenerative Neurological and Neuromuscular Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/111477","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/111477","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T11:40:15Z","timestamp":1769773215000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/advancements-in-therapy-for-alzheimers-disease-based-on-the-cerebral-l-peer-reviewed-fulltext-article-DNND"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":59,"URL":"https:\/\/doi.org\/10.2147\/dnnd.s574901","relation":{},"ISSN":["1179-9900"],"issn-type":[{"value":"1179-9900","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]}}}