{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T23:32:52Z","timestamp":1790465572672,"version":"4.1.0"},"reference-count":60,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IDR"],"DOI":"10.2147\/idr.s260258","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T21:28:16Z","timestamp":1595366896000},"page":"2521-2535","source":"Crossref","is-referenced-by-count":23,"title":["&lt;p&gt;Ribaxamase, an Orally Administered \u03b2-Lactamase, Diminishes Changes to Acquired Antimicrobial Resistance of the Gut Resistome in Patients Treated with Ceftriaxone&lt;\/p&gt;"],"prefix":"10.2147","volume":"Volume 13","author":[{"given":"John F","family":"Kokai-Kun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxiong","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Trout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4600-5600","authenticated-orcid":true,"given":"Julia L","family":"Cope","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3808-8576","authenticated-orcid":true,"given":"Nadim J","family":"Ajami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"Degar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0951-3593","authenticated-orcid":true,"given":"Sheila","family":"Connelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/gm228","volume":"3","author":"Kinross","year":"2011","journal-title":"Genome Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1053\/j.gastro.2014.01.059","volume":"146","author":"Britton","year":"2014","journal-title":"Gastroenterology"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"16020","DOI":"10.1038\/nrdp.2016.20","volume":"2","author":"Smits","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"333","DOI":"10.2147\/IDR.S87224","volume":"8","author":"Crowther","year":"2015","journal-title":"Infect Drug Resist"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e89417","DOI":"10.1371\/journal.pone.0089417","volume":"9","author":"Knecht","year":"2014","journal-title":"PLoS One"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e95476","DOI":"10.1371\/journal.pone.0095476","volume":"9","author":"Panda","year":"2014","journal-title":"PLoS One"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e0146822","DOI":"10.1371\/journal.pone.0146822","volume":"11","author":"Dubberke","year":"2016","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"20","DOI":"10.7812\/TPP\/15-049","volume":"20","author":"Kuntz","year":"2016","journal-title":"Perm J"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1093\/jac\/dkt477","volume":"69","author":"Slimings","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1093\/cid\/cir301","volume":"53","author":"Stevens","year":"2011","journal-title":"Clin Infect Dis"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"230","DOI":"10.3390\/antibiotics4030230","volume":"4","author":"Vincent","year":"2015","journal-title":"Antibiotics (Basel)"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1128\/AAC.01820-15","volume":"60","author":"Wieczorkiewicz","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1159\/000069712","volume":"48","author":"Karachalios","year":"2002","journal-title":"Chemotherapy"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1128\/AAC.02197-16","volume":"61","author":"Kokai-Kun","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.3390\/genes6041347","volume":"6","author":"Johanesen","year":"2015","journal-title":"Genes (Basel)"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"20140087","DOI":"10.1098\/rstb.2014.0087","volume":"370","author":"van Schaik","year":"2015","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/nrmicro3380","volume":"13","author":"Blair","year":"2015","journal-title":"Nat Rev Microbiol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1586\/14787210.2014.956092","volume":"12","author":"Miller","year":"2014","journal-title":"Expert Rev Anti Infect Ther"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1179\/107902610x12883422813822","volume":"34","author":"Dumford","year":"2011","journal-title":"J Spinal Cord Med"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.ajic.2010.10.024","volume":"39","author":"Fujitani","year":"2011","journal-title":"Am J Infect Control"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1182\/blood-2014-02-554725","volume":"124","author":"Taur","year":"2014","journal-title":"Blood"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1016\/j.bbmt.2010.05.008","volume":"16","author":"Kamboj","year":"2010","journal-title":"Biol Blood Marrow Transplant"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.ucl.2015.05.005","volume":"42","author":"Boyle","year":"2015","journal-title":"Urol Clin North Am"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/S1473-3099(11)70056-1","volume":"11","author":"Cornaglia","year":"2011","journal-title":"Lancet Infect Dis"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/S1473-3099(09)70054-4","volume":"9","author":"Nordmann","year":"2009","journal-title":"Lancet Infect Dis"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"297","DOI":"10.2147\/IDR.S39186","volume":"8","author":"Zmarlicka","year":"2015","journal-title":"Infect Drug Resist"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.ijmm.2013.02.001","volume":"303","author":"Carattoli","year":"2013","journal-title":"Int J Med Microbiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.1128\/AAC.01103-16","volume":"60","author":"McGann","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.anaerobe.2016.05.015","volume":"41","author":"Kaleko","year":"2016","journal-title":"Anaerobe"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1111\/jam.13432","volume":"123","author":"Connelly","year":"2017","journal-title":"J Appl Microbiol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/S1473-3099(18)30731-X","volume":"19","author":"Kokai-Kun","year":"2019","journal-title":"Lancet Infect Dis"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.anaerobe.2018.07.002","volume":"53","author":"Kokai-Kun","year":"2018","journal-title":"Anaerobe"},{"key":"ref33","first-page":"1","volume":"6","author":"Kokai-Kun","year":"2019","journal-title":"J Trans Sci"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jinf.2016.04.008","volume":"73","author":"Chalmers","year":"2016","journal-title":"J Infect"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1136\/gutjnl-2015-310376","volume":"65","author":"Imhann","year":"2016","journal-title":"Gut"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1136\/gutjnl-2015-310861","volume":"65","author":"Jackson","year":"2016","journal-title":"Gut"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1056\/NEJMoa1408913","volume":"372","author":"Lessa","year":"2015","journal-title":"N Engl J Med"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1111\/jgs.13310","volume":"63","author":"Zapata","year":"2015","journal-title":"J Am Geriatr Soc"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1128\/CMR.00043-12","volume":"25","author":"Fernandez","year":"2012","journal-title":"Clin Microbiol Rev"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1128\/AAC.37.5.1028","volume":"37","author":"Parker","year":"1993","journal-title":"Antimicrob Agents Chemother"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.1128\/AAC.45.8.2386-2389.2001","volume":"45","author":"Madinier","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1128\/JCM.42.2.888-890.2004","volume":"42","author":"Jolivet-Gougeon","year":"2004","journal-title":"J Clin Microbiol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.anaerobe.2014.11.003","volume":"32","author":"Meggersee","year":"2015","journal-title":"Anaerobe"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1089\/mdr.2013.0180","volume":"20","author":"Molina","year":"2014","journal-title":"Microb Drug Resist"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"S25","DOI":"10.1086\/491711","volume":"42 Suppl 1","author":"Courvalin","year":"2006","journal-title":"Clin Infect Dis"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"2492","DOI":"10.1093\/jac\/dkr339","volume":"66","author":"Soki","year":"2011","journal-title":"J Antimicrob Chemother"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.anaerobe.2019.03.003","volume":"56","author":"Kierzkowska","year":"2019","journal-title":"Anaerobe"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1128\/AAC.47.1.148-153.2003","volume":"47","author":"Aldridge","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1007\/s00284-006-0411-0","volume":"54","author":"Ferreira","year":"2007","journal-title":"Curr Microbiol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1590\/S1415-47572004000400020","volume":"27","author":"Novais","year":"2004","journal-title":"Genet Mol Biol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1093\/jac\/dkn347","volume":"62","author":"Garcia","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1128\/JCM.44.1.172-176.2006","volume":"44","author":"Iwahara","year":"2006","journal-title":"J Clin Microbiol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"3644","DOI":"10.1128\/JB.181.12.3644-3648.1999","volume":"181","author":"Casadewall","year":"1999","journal-title":"J Bacteriol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1128\/AAC.01348-08","volume":"53","author":"Depardieu","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nature08821","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1001\/jamainternmed.2017.0212","volume":"177","author":"Tariq","year":"2017","journal-title":"JAMA Intern Med"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1590\/1678-775720150469","volume":"24","author":"Binta","year":"2016","journal-title":"J Appl Oral Sci"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"4203","DOI":"10.1128\/AAC.49.10.4203-4209.2005","volume":"49","author":"Ambrose","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"257","DOI":"10.2478\/v10042-008-0056-x","volume":"46","author":"Wieczorek","year":"2008","journal-title":"Folia Histochem Cytobiol"}],"container-title":["Infection and Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=59927","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=59927","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T21:28:21Z","timestamp":1595366901000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/ribaxamase-an-orally-administered-beta-lactamase-diminishes-changes-to-peer-reviewed-article-IDR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":60,"URL":"https:\/\/doi.org\/10.2147\/idr.s260258","relation":{},"ISSN":["1178-6973"],"issn-type":[{"value":"1178-6973","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7]]}}}