{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:32:02Z","timestamp":1784302322539,"version":"3.55.0"},"reference-count":47,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IDR"],"DOI":"10.2147\/idr.s340652","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T14:12:59Z","timestamp":1640182379000},"page":"5639-5650","source":"Crossref","is-referenced-by-count":21,"title":["Impact of Carbapenem Heteroresistance Among Multidrug-Resistant ESBL\/AmpC-Producing Klebsiella pneumoniae Clinical Isolates on Antibiotic Treatment in Experimentally Infected Mice"],"prefix":"10.2147","volume":"Volume 14","author":[{"given":"Yilin","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8187-8151","authenticated-orcid":true,"given":"Yuqiao","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zinan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0348-412X","authenticated-orcid":true,"given":"Shiyu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9023-1010","authenticated-orcid":true,"given":"Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,12]]},"reference":[{"key":"ref1","unstructured":"O\u2019Neill J. Tackling drug-resistant infections globally: final report and recommendations. The Review on Antimicrobial Resistance London, United Kingdom; 2016."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3109\/23744235.2015.1109135","volume":"48","author":"Martelius","year":"2016","journal-title":"Infect Dis"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1093\/cid\/cix270","volume":"65","author":"Gorrie","year":"2017","journal-title":"Clin Infect Dis"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"397","DOI":"10.2174\/138920309789351994","volume":"10","author":"Livermore","year":"2009","journal-title":"Curr Protein Pept Sci"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1038\/nrmicro2693","volume":"9","author":"Bush","year":"2011","journal-title":"Nat Rev Microbiol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1097\/MD.0000000000000111","volume":"93","author":"Girometti","year":"2014","journal-title":"Medicine"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1517\/14656566.2014.914172","volume":"15","author":"Karaiskos","year":"2014","journal-title":"Expert Opin Pharmacother"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2377","DOI":"10.1056\/NEJMp1011715","volume":"363","author":"Moellering","year":"2010","journal-title":"N Engl J Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/S1473-3099(09)70054-4","volume":"9","author":"Nordmann","year":"2009","journal-title":"Lancet Infect Dis"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S1473-3099(16)30257-2","volume":"17","author":"Grundmann","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s13756-019-0545-z","volume":"8","author":"Tian","year":"2019","journal-title":"Antimicrob Resist Infect Control"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"3957","DOI":"10.1038\/s41467-019-11756-y","volume":"10","author":"Wong","year":"2019","journal-title":"Nat Commun"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1128\/CMR.00001-07","volume":"20","author":"Queenan","year":"2007","journal-title":"Clin Microbiol Rev"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics8030122","volume":"8","author":"Suay-Garcia","year":"2019","journal-title":"Antibiotics"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1592\/phco.29.11.1326","volume":"29","author":"Kuper","year":"2009","journal-title":"Pharmacotherapy"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"e1007726","DOI":"10.1371\/journal.ppat.1007726","volume":"15","author":"Band","year":"2019","journal-title":"PLoS Pathog"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/s41579-019-0218-1","volume":"17","author":"Andersson","year":"2019","journal-title":"Nat Rev Microbiol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02448-17","volume":"9","author":"Band","year":"2018","journal-title":"mBio"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"16053","DOI":"10.1038\/nmicrobiol.2016.53","volume":"1","author":"Band","year":"2016","journal-title":"Nat Microbiol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1093\/jac\/dkaa048","volume":"75","author":"Tan","year":"2020","journal-title":"J Antimicrob Chemother"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","volume":"18","author":"Magiorakos","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"ref22","unstructured":"CLSI. Performance Standards for Antimicrobial Susceptibility Testing. 27th ed. CLSI Supplement M100. Wayne, PA: Clinical and Laboratory Standards Institute; 2017"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1007\/s10096-011-1537-y","volume":"31","author":"Gude","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1128\/JCM.40.6.2153-2162.2002","volume":"40","author":"Perez-Perez","year":"2002","journal-title":"J Clin Microbiol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"33","DOI":"10.2147\/IDR.S189494","volume":"12","author":"Xu","year":"2019","journal-title":"Infect Drug Resist"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1128\/AAC.01051-08","volume":"53","author":"Kim","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.ijantimicag.2010.12.018","volume":"37","author":"Luo","year":"2011","journal-title":"Int J Antimicrob Agents"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"4377","DOI":"10.1128\/JCM.02316-14","volume":"52","author":"Compain","year":"2014","journal-title":"J Clin Microbiol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1099\/jmm.0.015198-0","volume":"59","author":"Turton","year":"2010","journal-title":"J Med Microbiol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.ijantimicag.2017.10.014","volume":"51","author":"He","year":"2018","journal-title":"Int J Antimicrob Agents"},{"key":"ref31","unstructured":"U.S. Department of Health and Human Services. Centers for Disease Control and Prevention. Antibiotic Resistance Threats in the United States. Atlanta, GA: Centers for Disease Control and Prevention; 2013."},{"key":"ref32","unstructured":"World Health Organization. WHO Publishes List of Bacteria for Which New Antibiotics are Urgently Needed. Geneva, Switzerland: World Health Organization; 2017."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"4089","DOI":"10.1128\/JCM.01130-10","volume":"48","author":"Tato","year":"2010","journal-title":"J Clin Microbiol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.1128\/JCM.02134-09","volume":"48","author":"Pournaras","year":"2010","journal-title":"J Clin Microbiol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1128\/CMR.00058-14","volume":"28","author":"El-Halfawy","year":"2015","journal-title":"Clin Microbiol Rev"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/s41564-018-0342-0","volume":"4","author":"Nicoloff","year":"2019","journal-title":"Nat Microbiol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/j.1574-6968.2007.00997.x","volume":"279","author":"Ikonomidis","year":"2008","journal-title":"FEMS Microbiol Lett"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.ijantimicag.2010.12.015","volume":"37","author":"Lee","year":"2011","journal-title":"Int J Antimicrob Agents"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"e0139116","DOI":"10.1371\/journal.pone.0139116","volume":"10","author":"Netikul","year":"2015","journal-title":"PLoS One"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0076-6879(83)97122-7","volume":"97","author":"Nikaido","year":"1983","journal-title":"Methods Enzymol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"3926","DOI":"10.1128\/AAC.46.12.3926-3932.2002","volume":"46","author":"Martinez-Martinez","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1007\/s00284-009-9364-4","volume":"58","author":"Yang","year":"2009","journal-title":"Curr Microbiol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1099\/jmm.0.012575-0","volume":"58","author":"Landman","year":"2009","journal-title":"J Med Microbiol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.ijantimicag.2018.03.020","volume":"52","author":"Hamzaoui","year":"2018","journal-title":"Int J Antimicrob Agents"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"107","DOI":"10.4161\/viru.22718","volume":"4","author":"Shon","year":"2013","journal-title":"Virulence"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1128\/AAC.47.4.1262-1266.2003","volume":"47","author":"Moore","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"105162","DOI":"10.1016\/j.micpath.2021.105162","volume":"160","author":"Zhang","year":"2021","journal-title":"Microb Pathog"}],"container-title":["Infection and Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=77052","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=77052","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T14:13:06Z","timestamp":1640182386000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/impact-of-carbapenem-heteroresistance-among-multidrug-resistant-esblam-peer-reviewed-fulltext-article-IDR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":47,"URL":"https:\/\/doi.org\/10.2147\/idr.s340652","relation":{},"ISSN":["1178-6973"],"issn-type":[{"value":"1178-6973","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12]]}}}