{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T07:35:33Z","timestamp":1782372933888,"version":"3.54.5"},"reference-count":75,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IDR"],"DOI":"10.2147\/idr.s547635","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T15:40:11Z","timestamp":1767973211000},"page":"1-11","source":"Crossref","is-referenced-by-count":4,"title":["The Current and Future Impact of WHO Guidance on Global HIV Pre-Exposure Prophylaxis Programs: A Narrative Review"],"prefix":"10.2147","volume":"Volume 19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1947-1721","authenticated-orcid":true,"given":"Fady","family":"Mishriky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,1]]},"reference":[{"key":"ref1","unstructured":"Global HIV & AIDS statistics \u2014 fact sheet | UNAIDS. Available from: https:\/\/www.unaids.org\/en\/resources\/fact-sheet. Accessed August 13, 2025."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1056\/NEJMoa1011205","volume":"363","author":"Grant","year":"2010","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1001\/jama.2024.16984","volume":"332","author":"Spinelli","year":"2024","journal-title":"JAMA"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.1056\/NEJMoa1506273","volume":"373","author":"Molina","year":"2015","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S0140-6736(20)31065-5","volume":"396","author":"Mayer","year":"2020","journal-title":"Lancet Lond Engl"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1056\/NEJMoa2101016","volume":"385","author":"Landovitz","year":"2021","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1056\/NEJMoa2407001","volume":"391","author":"Bekker","year":"2024","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1056\/NEJMoa2411858","volume":"392","author":"Kelley","year":"2025","journal-title":"N Engl J Med"},{"key":"ref9","unstructured":"Guidance on pre-exposure oral prophylaxis (PrEP) for serodiscordant couples, men and transgender women who have sex with men at high risk of HIV: recommendations for use in the context of demonstration projects. World Health Organization; 2012. Available from: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK132003\/. Accessed August 14, 2025."},{"key":"ref10","unstructured":"Global State of PrEP. Available from: https:\/\/www.who.int\/groups\/global-prep-network\/global-state-of-prep. Accessed September 1, 2025."},{"key":"ref11","first-page":"1","volume":"2","author":"Ruger","year":"2009","journal-title":"Glob Health Gov Sch J New Health Secur Paradigm"},{"key":"ref12","unstructured":"Periscopic. A map-based tool to explore trends in PrEP use globally as countries introduce and scale up PrEP programs. Available from: https:\/\/data.prepwatch.org\/. Accessed November 17, 2025."},{"key":"ref13","unstructured":"World Health Organization. Basic documents, 49th Ed. World Health Organization; 2020. Available from: https:\/\/iris.who.int\/handle\/10665\/339554. Accessed August 20, 2025."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1097\/QAD.0000000000003824","volume":"38","author":"Kebede","year":"2024","journal-title":"AIDS Lond Engl"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s12961-022-00899-y","volume":"20","author":"Saluja","year":"2022","journal-title":"Health Res Policy Syst"},{"key":"ref16","unstructured":"Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV. World Health Organization; 2015. Available from: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK327115\/. Accessed August 15, 2025."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1071\/SH18125","volume":"15","author":"Hodges-Mameletzis","year":"2018","journal-title":"Sexual Health"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"e502","DOI":"10.1016\/S2352-3018(21)00127-2","volume":"8","author":"Schaefer","year":"2021","journal-title":"Lancet HIV"},{"key":"ref19","unstructured":"World Health Organization. Consolidated Guidelines on HIV Prevention, Testing, Treatment, Service Delivery and Monitoring: Recommendations for a Public Health Approach. World Health Organization; 2021."},{"key":"ref20","unstructured":"The top 10 causes of death. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/the-top-10-causes-of-death. Accessed September 4, 2025."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1097\/QAD.0000000000002790","volume":"35","author":"Estcourt","year":"2021","journal-title":"AIDS Lond Engl"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e629","DOI":"10.1016\/S2352-3018(18)30215-7","volume":"5","author":"Grulich","year":"2018","journal-title":"Lancet HIV"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"e26110","DOI":"10.1002\/jia2.26110","volume":"26","author":"Castor","year":"2023","journal-title":"J Int AIDS Soc"},{"key":"ref24","unstructured":"PrEP demonstration projects: a framework for country level protocol development. Available from: https:\/\/www.who.int\/publications\/i\/item\/9789241507172. Accessed August 15, 2025."},{"key":"ref25","unstructured":"Consolidated guidelines on HIV prevention, diagnosis, treatment and care for key populations. World Health Organization; 2014. Available from: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK294008\/. Accessed August 15, 2025."},{"key":"ref26","unstructured":"World Health Organization. Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection. 2nd. World Health Organization; 2016."},{"key":"ref27","unstructured":"Preventing HIV during pregnancy and breastfeeding in the context of PrEP. Available from: https:\/\/www.who.int\/publications\/i\/item\/WHO-HIV-2017.09. Accessed August 15, 2025."},{"key":"ref28","unstructured":"Implementation tool for pre-exposure prophylaxis of HIV infection - clinical. Available from: https:\/\/www.who.int\/publications\/i\/item\/WHO-HIV-2017.17-1. Accessed August 17, 2025."},{"key":"ref29","unstructured":"What\u2019s the 2+1+1? Event-driven oral pre-exposure prophylaxis to prevent HIV for men who have sex with men: update to WHO\u2019s recommendation on oral PrEP. Available from: https:\/\/www.who.int\/publications\/i\/item\/what-s-the-2-1-1-event-driven-oral-pre-exposure-prophylaxis-to-prevent-hiv-for-men-who-have-sex-with-men. Accessed August 17, 2025."},{"key":"ref30","unstructured":"Differentiated and simplified pre-exposure prophylaxis for HIV prevention: update to WHO implementation guidance. Available from: https:\/\/www.who.int\/publications\/i\/item\/9789240053694. Accessed August 18, 2025."},{"key":"ref31","unstructured":"WHO recommends the dapivirine vaginal ring as a new choice for HIV prevention for women at substantial risk of HIV infection. Available from: https:\/\/www.who.int\/news\/item\/26-01-2021-who-recommends-the-dapivirine-vaginal-ring-as-a-new-choice-for-hiv-prevention-for-women-at-substantial-risk-of-hiv-infection. Accessed August 17, 2025."},{"key":"ref32","unstructured":"WHO implementation tool for pre-exposure prophylaxis of HIV infection: provider module for oral and long-acting PrEP. Available from: https:\/\/www.who.int\/publications\/i\/item\/9789240097230. Accessed August 22, 2025."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1056\/NEJMoa1602046","volume":"375","author":"Nel","year":"2016","journal-title":"N Engl J Med"},{"key":"ref34","unstructured":"Guidelines on long-acting injectable cabotegravir for HIV prevention. World Health Organization; 2022. Available from: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK586584\/. Accessed August 18, 2025."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1016\/S0140-6736(22)00538-4","volume":"399","author":"Delany-Moretlwe","year":"2022","journal-title":"Lancet Lond Engl"},{"key":"ref36","unstructured":"Guidelines on lenacapavir for HIV prevention and testing strategies for long-acting injectable pre-exposure prophylaxis. World Health Organization; 2025. Accessed August 18, 2025. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK616669\/."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/S0140-6736(25)00405-2","volume":"405","author":"Jogiraju","year":"2025","journal-title":"Lancet Lond Engl"},{"key":"ref38","unstructured":"HIV prevention 2025 road map \u2014 getting on track to end AIDS as a public health threat by 2030 | UNAIDS. Available from: https:\/\/www.unaids.org\/en\/resources\/documents\/2022\/prevention-2025-roadmap. Accessed August 20, 2025."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"102416","DOI":"10.1016\/j.eclinm.2023.102416","volume":"68","author":"Zia","year":"2024","journal-title":"eClinicalMedicine"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"e0259738","DOI":"10.1371\/journal.pone.0259738","volume":"17","author":"Atkins","year":"2022","journal-title":"PLoS One"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1186\/s12913-021-06832-3","volume":"21","author":"Peebles","year":"2021","journal-title":"BMC Health Serv Res"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1097\/QAD.0000000000001385","volume":"31","author":"Nunn","year":"2017","journal-title":"AIDS Lond Engl"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"e20210963","DOI":"10.1590\/0034-7167-2021-0963","volume":"76","author":"Antonini","year":"2023","journal-title":"Revista brasileira de enfermagem"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1089\/apc.2023.0117","volume":"38","author":"Nagai","year":"2024","journal-title":"AIDS Patient Care and STDs"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"e076545","DOI":"10.1136\/bmjopen-2023-076545","volume":"14","author":"Mpirirwe","year":"2024","journal-title":"BMJ Open"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1186\/s12879-018-3463-4","volume":"18","author":"Sidebottom","year":"2018","journal-title":"BMC Infect Dis"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1097\/QAI.0000000000003488","volume":"97","author":"Wulandari","year":"2024","journal-title":"JAIDS J Acquir Immune Defic Syndr"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1186\/s12889-024-19168-4","volume":"24","author":"Liu","year":"2024","journal-title":"BMC Public Health"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"e25866","DOI":"10.1002\/jia2.25866","volume":"25","author":"Joseph Davey","year":"2022","journal-title":"J Int AIDS Soc"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"e38","DOI":"10.1016\/S2352-3018(19)30335-2","volume":"7","author":"Kinuthia","year":"2020","journal-title":"Lancet HIV"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"102532","DOI":"10.1016\/j.eclinm.2024.102532","volume":"70","author":"Erlwanger","year":"2024","journal-title":"EClinicalMedicine"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"107874","DOI":"10.1016\/j.ijid.2025.107874","volume":"154","author":"Zhao","year":"2025","journal-title":"Int J Infect Dis"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"e25883","DOI":"10.1002\/jia2.25883","volume":"25","author":"Sun","year":"2022","journal-title":"J Int AIDS Soc"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"e254","DOI":"10.1016\/S2352-3018(22)00030-3","volume":"9","author":"Zhang","year":"2022","journal-title":"Lancet HIV"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1146\/annurev-psych-032620-035725","volume":"75","author":"Mustanski","year":"2024","journal-title":"Annu Rev Psychol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"e746","DOI":"10.1016\/S2352-3018(24)00240-6","volume":"11","author":"Davey","year":"2024","journal-title":"Lancet HIV"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/QAI.0000000000003635","volume":"99","author":"Wang","year":"2025","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"e048478","DOI":"10.1136\/bmjopen-2020-048478","volume":"12","author":"O Murchu","year":"2022","journal-title":"BMJ Open"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.jadohealth.2021.04.001","volume":"70","author":"Allison","year":"2022","journal-title":"J Adolesc Health"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"e1730","DOI":"10.1016\/S2214-109X(21)00391-0","volume":"9","author":"Irungu","year":"2021","journal-title":"Lancet Glob Health"},{"key":"ref61","unstructured":"Consolidated guidelines on differentiated HIV testing services. Available from: https:\/\/www.who.int\/publications\/i\/item\/9789240096394. Accessed August 22, 2025."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"e2318590","DOI":"10.1001\/jamanetworkopen.2023.18590","volume":"6","author":"Ortblad","year":"2023","journal-title":"JAMA Netw Open"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"e464","DOI":"10.1016\/S2352-3018(22)00126-6","volume":"9","author":"Ngure","year":"2022","journal-title":"Lancet HIV"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"2534","DOI":"10.1007\/s10461-024-04365-4","volume":"28","author":"Garcia","year":"2024","journal-title":"AIDS Behav"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1097\/QAD.0000000000003447","volume":"37","author":"Pintye","year":"2023","journal-title":"AIDS Lond Engl"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"e061503","DOI":"10.1136\/bmjopen-2022-061503","volume":"13","author":"Ramraj","year":"2023","journal-title":"BMJ Open"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"ciaf116","DOI":"10.1093\/cid\/ciaf116","author":"Baeten","year":"2025","journal-title":"Clin Infect Dis"},{"key":"ref68","unstructured":"Sadam R, Rigby J, Rigby J. Indian drugmakers Dr Reddy\u2019s, Hetero to sell generic HIV prevention drug for $40 a year. Reuters. 2025. Available from: https:\/\/www.reuters.com\/business\/healthcare-pharmaceuticals\/indian-drugmakers-dr-reddys-hetero-sell-generic-hiv-prevention-drug-40-year-2025-09-24\/. Accessed September 26, 2025."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"e26092","DOI":"10.1002\/jia2.26092","volume":"26","author":"Gaayeb","year":"2023","journal-title":"J Int AIDS Soc"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"ofac673","DOI":"10.1093\/ofid\/ofac673","volume":"10","author":"Pepperrell","year":"2023","journal-title":"Open Forum Infect Dis"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1002\/cpdd.1538","volume":"14","author":"Han","year":"2025","journal-title":"Clin Pharmacol Drug Dev"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1097\/QAI.0000000000003135","volume":"92","author":"Matthews","year":"2023","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"jiaf222","DOI":"10.1093\/infdis\/jiaf222","author":"Hillier","year":"2025","journal-title":"J Infect Dis"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"e0312957","DOI":"10.1371\/journal.pone.0312957","volume":"20","author":"Friedland","year":"2025","journal-title":"PLoS One"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"e0304552","DOI":"10.1371\/journal.pone.0304552","volume":"19","author":"Achilles","year":"2024","journal-title":"PLoS One"}],"container-title":["Infection and Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/110862","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/110862","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T15:40:15Z","timestamp":1767973215000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/the-current-and-future-impact-of-who-guidance-on-global-hiv-pre-exposu-peer-reviewed-fulltext-article-IDR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":75,"URL":"https:\/\/doi.org\/10.2147\/idr.s547635","relation":{},"ISSN":["1178-6973"],"issn-type":[{"value":"1178-6973","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]}}}