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Accessed September 4, 2025."},{"key":"ref112","doi-asserted-by":"publisher","first-page":"e91","DOI":"10.1016\/j.amjmed.2019.10.005","volume":"133","author":"Amaral","year":"2020","journal-title":"Am J Med"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"64","DOI":"10.33696\/immunology.6.191","volume":"6","author":"Chang","year":"2024","journal-title":"J Cell Immunol"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"e1007993","DOI":"10.1371\/journal.ppat.1007993","volume":"15","author":"Young","year":"2019","journal-title":"PLoS Pathog"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"5914","DOI":"10.4049\/jimmunol.0900255","volume":"184","author":"Hoarau","year":"2010","journal-title":"J Immunol"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1002\/art.40383","volume":"70","author":"Chang","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1002\/art.40384","volume":"70","author":"Chang","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3390\/diseases6040095","volume":"6","author":"Chang","year":"2018","journal-title":"Diseases"},{"key":"ref119","doi-asserted-by":"publisher","first-page":"e2357","DOI":"10.1002\/rmv.2357","volume":"33","author":"Costa","year":"2023","journal-title":"Rev Med Virol"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1093\/infdis\/jis033","volume":"205","author":"Kam","year":"2012","journal-title":"J Infect Dis"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/s41426-017-0010-0","volume":"7","author":"Auerswald","year":"2018","journal-title":"Emerg Microbes Infect"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"e0010152","DOI":"10.1371\/journal.pntd.0010152","volume":"16","author":"Andrew","year":"2022","journal-title":"PLoS Negl Trop Dis"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"e0013250","DOI":"10.1371\/journal.pntd.0013250","volume":"19","author":"Malik","year":"2025","journal-title":"PLoS Negl Trop Dis"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1038\/s41467-018-03772-1","volume":"9","author":"Santiago","year":"2018","journal-title":"Nat Commun"},{"key":"ref125","doi-asserted-by":"publisher","first-page":"2528","DOI":"10.1002\/jmv.27658","volume":"94","author":"Xu","year":"2022","journal-title":"J Med Virol"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.medmal.2015.05.007","volume":"45","author":"Simon","year":"2015","journal-title":"M\u00e9decine et Maladies Infectieuses"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"e0006510","DOI":"10.1371\/journal.pntd.0006510","volume":"12","author":"Contopoulos-Ioannidis","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"key":"ref128","doi-asserted-by":"publisher","first-page":"e2996","DOI":"10.1371\/journal.pntd.0002996","volume":"8","author":"G\u00e9rardin","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref129","doi-asserted-by":"publisher","first-page":"e60","DOI":"10.1371\/journal.pmed.0050060","volume":"5","author":"G\u00e9rardin","year":"2008","journal-title":"PLoS Med"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1093\/jpids\/piae102","volume":"13","author":"Ferreira","year":"2024","journal-title":"J Pediatric Infect Dis Soc"},{"key":"ref131","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/s0368-2315(06)76447-x","volume":"35","author":"Lenglet","year":"2006","journal-title":"J Gynecol Obstet Biol Reprod"},{"key":"ref132","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.3201\/eid2311.170480","volume":"23","author":"Escobar","year":"2017","journal-title":"Emerg Infect Dis"},{"key":"ref133","unstructured":"Commissioner O of the. FDA approves first vaccine to prevent disease caused by chikungunya virus. FDA. 2024. Available from: https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-first-vaccine-prevent-disease-caused-chikungunya-virus. Accessed September 2, 2025."},{"key":"ref134","unstructured":"Commission authorises chikungunya vaccine and funds new mosquito eradication programme*. European Commission - European Commission. Available from: https:\/\/ec.europa.eu\/commission\/presscorner\/detail\/en\/https:\\\/\\\/ec.europa.eu\\\/commission\\\/presscorner\\\/detail\\\/en\\\/ip_24_3502. Accessed September 2, 2025."},{"key":"ref135","doi-asserted-by":"publisher","first-page":"2342","DOI":"10.1038\/s41591-025-03703-w","volume":"31","author":"Ribeiro Dos Santos","year":"2025","journal-title":"Nat Med"},{"key":"ref136","unstructured":"Research C for BE and. FDA update on the safety of ixchiq (Chikungunya Vaccine, Live). FDA. 2025. Available from: https:\/\/www.fda.gov\/vaccines-blood-biologics\/safety-availability-biologics\/fda-update-safety-ixchiq-chikungunya-vaccine-live. Accessed September 2, 2025."},{"key":"ref137","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1016\/S0140-6736(25)00345-9","volume":"405","author":"Richardson","year":"2025","journal-title":"Lancet"},{"key":"ref138","unstructured":"CDC. Chikungunya vaccine information for healthcare providers. Chikungunya Virus. 2025. Available from: https:\/\/www.cdc.gov\/chikungunya\/hcp\/vaccines\/index.html. Accessed September 2, 2025."},{"key":"ref139","doi-asserted-by":"publisher","first-page":"e0281612","DOI":"10.1371\/journal.pone.0281612","volume":"18","author":"Troj\u00e1nek","year":"2023","journal-title":"PLoS One"},{"key":"ref140","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.3201\/eid2606.190490","volume":"26","author":"Gossner","year":"2020","journal-title":"Emerg Infect Dis"},{"key":"ref141","doi-asserted-by":"publisher","first-page":"e0012904","DOI":"10.1371\/journal.pntd.0012904","volume":"19","author":"Liu","year":"2025","journal-title":"PLoS Negl Trop Dis"},{"key":"ref142","doi-asserted-by":"publisher","first-page":"taad008","DOI":"10.1093\/jtm\/taad008","volume":"30","author":"Simon","year":"2023","journal-title":"J Travel Med"},{"key":"ref143","doi-asserted-by":"publisher","first-page":"100911","DOI":"10.1016\/S2666-5247(24)00150-2","volume":"5","author":"Monteiro","year":"2024","journal-title":"Lancet Microbe"}],"container-title":["Infection and Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/110933","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/110933","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T15:25:27Z","timestamp":1768231527000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/chikungunya-virus-in-2025-epidemiology-immunopathogenesis-and-vaccine--peer-reviewed-fulltext-article-IDR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":143,"URL":"https:\/\/doi.org\/10.2147\/idr.s567134","relation":{},"ISSN":["1178-6973"],"issn-type":[{"value":"1178-6973","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]}}}