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Accessed March 30, 2021."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"e13651","DOI":"10.7759\/cureus.13651","volume":"13","author":"Boivin","year":"2021","journal-title":"Cureus"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"e139","DOI":"10.1161\/cir.0000000000000757","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"key":"ref41","unstructured":"Villarroel MA, Blackwell DL, Jen A. Tables of Summary Health Statistics for U.S. Adults: 2018 National Health Interview Survey. NCHS, National Center for Health Statistics. 2019. Available from: http:\/\/www.cdc.gov\/nchs\/nhis\/SHS\/tables.htm. Accessed May 29, 2021."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"e254","DOI":"10.1161\/cir.0000000000000950","volume":"143","author":"Virani","year":"2021","journal-title":"Circulation"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"67","DOI":"10.5334\/aogh.2591","volume":"86","author":"Zeng","year":"2020","journal-title":"Ann Glob Health"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1161\/circulationaha.110.009035","volume":"123","author":"Huxley","year":"2011","journal-title":"Circulation"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"e006273","DOI":"10.1161\/circep.118.006273","volume":"11","author":"Khurshid","year":"2018","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1001\/archinte.1995.00430050045005","volume":"155","author":"Feinberg","year":"1995","journal-title":"Arch Intern Med"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"2333721419859687","DOI":"10.1177\/2333721419859687","volume":"5","author":"Lindberg","year":"2019","journal-title":"Gerontol Geriatr Med"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1177\/1747493019897870","volume":"16","author":"Lippi","year":"2021","journal-title":"Int J Stroke"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"e9349","DOI":"10.7759\/cureus.9349","volume":"12","author":"Khan","year":"2020","journal-title":"Cureus"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1101\/2021.05.03.21256482","author":"Quer","year":"2021","journal-title":"medRxiv [Preprint]"},{"key":"ref51","unstructured":"World Health Organization. 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