{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:43:01Z","timestamp":1773114181166,"version":"3.50.1"},"reference-count":45,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJGM"],"DOI":"10.2147\/ijgm.s331178","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T10:30:37Z","timestamp":1638786637000},"page":"9419-9431","source":"Crossref","is-referenced-by-count":3,"title":["Integrative Analysis of DNA Methylation and Gene Expression Profiling Data Reveals Candidate Methylation-Regulated Genes in Hepatoblastoma"],"prefix":"10.2147","volume":"Volume 14","author":[{"given":"Jian-Yao","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Lao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Jie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Peng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2021,12]]},"reference":[{"key":"ref1","volume-title":"WHO Classification of Tumours of the Digestive System","year":"2010"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1002\/pbc.24215","volume":"59","author":"Spector","year":"2012","journal-title":"Pediatr Blood Cancer"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e85599","DOI":"10.1371\/journal.pone.0085599","volume":"9","author":"Dong","year":"2014","journal-title":"PLoS One"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.clinimag.2018.08.009","volume":"52","author":"Baheti","year":"2018","journal-title":"Clin Imaging"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.leukres.2008.07.027","volume":"33","author":"Jost","year":"2009","journal-title":"Leuk Res"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s00277-005-0005-0","volume":"84","author":"Galm","year":"2005","journal-title":"Ann Hematol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1007\/s00383-016-3960-8","volume":"32","author":"Liu","year":"2016","journal-title":"Pediatr Surg Int"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1101\/gad.947102","volume":"16","author":"Bird","year":"2002","journal-title":"Genes Dev"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.drup.2012.01.008","volume":"15","author":"Wilting","year":"2012","journal-title":"Drug Resist Updat"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.yexmp.2011.08.004","volume":"91","author":"Huang","year":"2011","journal-title":"Exp Mol Pathol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/j.jhep.2010.07.027","volume":"54","author":"Lambert","year":"2011","journal-title":"J Hepatol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1093\/bib\/bbw063","volume":"18","author":"Yang","year":"2017","journal-title":"Brief Bioinform"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1056\/NEJMra072067","volume":"358","author":"Esteller","year":"2008","journal-title":"N Engl J Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.cell.2017.09.007","volume":"171","author":"Robertson","year":"2017","journal-title":"Cell"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1158\/1055-9965.EPI-11-0067","volume":"20","author":"Chung","year":"2011","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"35","DOI":"10.2217\/epi.10.71","volume":"3","author":"Dudziec","year":"2011","journal-title":"Epigenomics"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1158\/1078-0432.CCR-03-0127","volume":"10","author":"Dulaimi","year":"2004","journal-title":"Clin Cancer Res"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.2147\/CMAR.S188415","volume":"11","author":"Zhu","year":"2019","journal-title":"Cancer Manag Res"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1111\/cas.12928","volume":"107","author":"Honda","year":"2016","journal-title":"Cancer Sci"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1203\/PDR.0b013e3181d01863","volume":"67","author":"Sakamoto","year":"2010","journal-title":"Pediatr Res"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41698-020-0125-y","volume":"4","author":"Sekiguchi","year":"2020","journal-title":"NPJ Precis Oncol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.jhep.2020.03.025","volume":"73","author":"Carrillo-Reixach","year":"2020","journal-title":"J Hepatol"},{"key":"ref23","volume-title":"The NCBI Handbook [Internet]","year":"2003"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1002\/mpo.10171","volume":"39","author":"Rowland","year":"2002","journal-title":"Med Pediatr Oncol"},{"key":"ref25","volume-title":"Neoplasms of the Liver","year":"1987"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1097\/MOP.0000000000000081","volume":"26","author":"Kremer","year":"2014","journal-title":"Curr Opin Pediatr"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1097\/MOP.0000000000000046","volume":"26","author":"Czauderna","year":"2014","journal-title":"Curr Opin Pediatr"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1002\/pbc.24221","volume":"59","author":"McCarville","year":"2012","journal-title":"Pediatr Blood Cancer"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1016\/j.ejca.2011.12.011","volume":"48","author":"Maibach","year":"2012","journal-title":"Eur J Cancer"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1200\/JCO.2005.07.145","volume":"23","author":"Aronson","year":"2005","journal-title":"J Clin Oncol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"7251","DOI":"10.7150\/thno.31155","volume":"9","author":"Long","year":"2019","journal-title":"Theranostics"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.7150\/ijbs.41587","volume":"16","author":"Bai","year":"2020","journal-title":"Int J Biol Sci"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1089\/dna.2020.5789","volume":"40","author":"Cui","year":"2021","journal-title":"DNA Cell Biol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"97871","DOI":"10.18632\/oncotarget.14208","volume":"8","author":"Maschietto","year":"2016","journal-title":"Oncotarget"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.3892\/ol.2016.4789","volume":"12","author":"Cui","year":"2016","journal-title":"Oncol Lett"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1016\/j.biopha.2017.05.056","volume":"91","author":"Xu","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"8797","DOI":"10.1002\/jcb.27129","volume":"119","author":"Tu","year":"2018","journal-title":"J Cell Biochem"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"553","DOI":"10.3389\/fgene.2019.00553","volume":"10","author":"Rivas","year":"2019","journal-title":"Front Genet"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13148-018-0462-7","volume":"10","author":"Beck","year":"2018","journal-title":"Clin Epigenetics"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"44398","DOI":"10.18632\/oncotarget.17897","volume":"8","author":"Tsung","year":"2017","journal-title":"Oncotarget"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1007\/s10585-020-10060-0","volume":"37","author":"Park","year":"2020","journal-title":"Clin Exp Metastasis"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/(SICI)1098-2264(199603)15:3<187::AID-GCC8>3.0.CO;2-Z","volume":"15","author":"Ohnishi","year":"1996","journal-title":"Genes Chromosomes Cancer"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"2967","DOI":"10.1038\/s41598-021-82542-4","volume":"11","author":"Woodfield","year":"2021","journal-title":"Sci Rep"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"7388","DOI":"10.1158\/1078-0432.CCR-17-1004","volume":"23","author":"Mart\u00ednez","year":"2017","journal-title":"Clin Cancer Res"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1158\/0008-5472.CAN-19-0743","volume":"80","author":"Eckhardt","year":"2020","journal-title":"Cancer Res"}],"container-title":["International Journal of General Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=76507","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=76507","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T10:30:40Z","timestamp":1638786640000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/integrative-analysis-of-dna-methylation-and-gene-expression-profiling--peer-reviewed-fulltext-article-IJGM"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":45,"URL":"https:\/\/doi.org\/10.2147\/ijgm.s331178","relation":{},"ISSN":["1178-7074"],"issn-type":[{"value":"1178-7074","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12]]}}}