{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:08:24Z","timestamp":1770750504863,"version":"3.50.0"},"reference-count":91,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJGM"],"DOI":"10.2147\/ijgm.s364954","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T16:21:18Z","timestamp":1654014078000},"page":"5349-5360","source":"Crossref","is-referenced-by-count":6,"title":["Putative Involvement of Cytokine Modulation in the Development of Perioperative Neurocognitive Disorders"],"prefix":"10.2147","volume":"Volume 15","author":[{"given":"Christopher","family":"Pereira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Dani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8811-1834","authenticated-orcid":true,"given":"Simon D","family":"Taylor-Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4023-1156","authenticated-orcid":true,"given":"Michael","family":"Fertleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2022,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"752","DOI":"10.3389\/fpsyt.2018.00752","volume":"9","author":"Safavynia","year":"2019","journal-title":"Front Psychiatry"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1001\/jama.2012.6857","volume":"308","author":"Marcantonio","year":"2012","journal-title":"J Am Med Assoc"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1038\/s41590-020-00812-1","volume":"21","author":"Yang","year":"2020","journal-title":"Nat Immunol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/S0140-6736(13)60688-1","volume":"383","author":"Inouye","year":"2014","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/jnc.13607","volume":"139","author":"DiSabato","year":"2016","journal-title":"J Neurochem"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1038\/s41590-018-0212-1","volume":"19","author":"Song","year":"2018","journal-title":"Nat Immunol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1007\/s12035-014-9070-5","volume":"53","author":"Tang","year":"2016","journal-title":"Mol Neurobiol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.671499","volume":"13","author":"Saxena","year":"2021","journal-title":"Front Aging Neurosci"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1159\/000328989","volume":"33","author":"Czeh","year":"2011","journal-title":"Dev Neurosci"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/NAN.12011","volume":"39","author":"Boche","year":"2013","journal-title":"Neuropathol Appl Neurobiol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.3389\/fimmu.2017.01520","volume":"8","author":"Amici","year":"2017","journal-title":"Front Immunol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.12703\/P6-13","volume":"6","author":"Martinez","year":"2014","journal-title":"F1000Prime Rep"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.nurt.2010.05.014","volume":"7","author":"Lull","year":"2010","journal-title":"Neurotherapeutics"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1213\/ANE.0b013e318215217e","volume":"112","author":"Evered","year":"2011","journal-title":"Anesth Analg"},{"key":"ref15","unstructured":"Johansen A, Wakeman R, Boulton C, Plant F, Roberts J, Williams A. National hip fracture database; 2013:1\u201396. Available from: https:\/\/www.nhfd.co.uk\/20\/hipfractureR.nsf\/docs\/2018Report. Accessed August 28, 2021."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"746","DOI":"10.7326\/0003-4819-154-11-201106070-00006","volume":"154","author":"O\u2019Mahony","year":"2011","journal-title":"Ann Intern Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1097\/SLA.0b013e31818e4776","volume":"249","author":"Robinson","year":"2009","journal-title":"Ann Surg"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.jagp.2016.10.008","volume":"25","author":"Lee","year":"2017","journal-title":"Am J Geriatr Psychiatry"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1001\/archinte.162.4.457","volume":"162","author":"McCusker","year":"2002","journal-title":"Arch Intern Med"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1111\/j.1532-5415.2000.tb04718.x","volume":"48","author":"Marcantonio","year":"2000","journal-title":"J Am Geriatr Soc"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"2809","DOI":"10.1093\/brain\/aws190","volume":"135","author":"Davis","year":"2012","journal-title":"Brain"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1002\/bjs.11148","volume":"106","author":"Fowler","year":"2019","journal-title":"Br J Surg"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.2147\/CIA.S133896","volume":"13","author":"Kotekar","year":"2018","journal-title":"Clin Interv Aging"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1093\/bja\/aeu163","volume":"113","author":"Silbert","year":"2014","journal-title":"Br J Anaesth"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1136\/jnnp.74.9.1200","volume":"74","author":"Tarkowski","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1096\/fj.09-141754","volume":"24","author":"Chakrabarty","year":"2010","journal-title":"FASEB J"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-6-16","volume":"6","author":"Chakrabarty","year":"2011","journal-title":"Mol Neurodegener"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1002\/ana.22082","volume":"68","author":"Cibelli","year":"2010","journal-title":"Ann Neurol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1159\/000356526","volume":"21","author":"Cerejeira","year":"2014","journal-title":"Neuroimmunomodulation"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"110791","DOI":"10.1016\/j.exger.2019.110791","volume":"130","author":"Lin","year":"2020","journal-title":"Exp Gerontol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1002\/gps.4720","volume":"33","author":"Hall","year":"2018","journal-title":"Int J Geriatr Psychiatry"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.15406\/moji.2016.04.00121","volume":"4","author":"Ray","year":"2016","journal-title":"MOJ Immunol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.bbi.2019.06.015","volume":"81","author":"Enache","year":"2019","journal-title":"Brain Behav Immun"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/7854_2018_88","volume":"44","author":"Upthegrove","year":"2020","journal-title":"Curr Top Behav Neurosci"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"S34","DOI":"10.1002\/eji.200737772","volume":"37","author":"Dinarello","year":"2007","journal-title":"Eur J Immunol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/0753-3322(94)90005-1","volume":"48","author":"Cavaillon","year":"1994","journal-title":"Biomed Pharmacother"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3389\/fphar.2012.00120","volume":"3","author":"Wiese","year":"2012","journal-title":"Front Pharmacol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.bbi.2007.05.005","volume":"21","author":"Quan","year":"2007","journal-title":"Brain Behav Immun"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"139","DOI":"10.31887\/dcns.2003.5.2\/mschwarz","volume":"5","author":"Schwarz","year":"2003","journal-title":"Dialogues Clin Neurosci"},{"key":"ref41","doi-asserted-by":"publisher","volume-title":"Annals of the New York Academy of Sciences","year":"1998","DOI":"10.1111\/j.1749-6632.1998.tb09569.x"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1007\/s00401-010-0743-5","volume":"120","author":"Sis\u00f3","year":"2010","journal-title":"Acta Neuropathol"},{"key":"ref43","first-page":"37","volume":"37","author":"Westhoff","year":"2012","journal-title":"Shock"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s12265-018-9835-8","volume":"11","author":"Lindblom","year":"2018","journal-title":"J Cardiovasc Transl Res"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1111\/jgs.14238","volume":"64","author":"Neerland","year":"2016","journal-title":"J Am Geriatr Soc"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1093\/bja\/85.1.109","volume":"85","author":"Desborough","year":"2000","journal-title":"Br J Anaesth"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1172\/JCI104426","volume":"40","author":"Christy","year":"1961","journal-title":"J Clin Invest"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1186\/1742-2094-9-242","volume":"9","author":"Bromander","year":"2012","journal-title":"J Neuroinflammation"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/nrneurol.2010.4","volume":"6","author":"Blennow","year":"2010","journal-title":"Nat Rev Neurol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.it.2015.08.006","volume":"36","author":"Louveau","year":"2015","journal-title":"Trends Immunol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/nrneurol.2017.188","volume":"14","author":"Sweeney","year":"2018","journal-title":"Nat Rev Neurol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.athoracsur.2012.04.044","volume":"94","author":"Reinsfelt","year":"2012","journal-title":"Ann Thorac Surg"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1080\/00365517709091496","volume":"37","author":"Tibbling","year":"1977","journal-title":"Scand J Clin Lab Invest"},{"key":"ref54","doi-asserted-by":"publisher","volume-title":"Albumin in Medicine: Pathological and Clinical Applications","year":"2016","DOI":"10.1007\/978-981-10-2116-9_1"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1038\/jcbfm.2015.76","volume":"35","author":"Sweeney","year":"2015","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1159\/000443789","volume":"41","author":"Hov","year":"2016","journal-title":"Dement Geriatr Cogn Disord"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-019-0693-y","volume":"19","author":"Ayob","year":"2019","journal-title":"BMC Anesthesiol"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12871-020-01166-9","volume":"20","author":"Lin","year":"2020","journal-title":"BMC Anesthesiol"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1111\/j.1445-2197.2005.03530.x","volume":"75","author":"Chuang","year":"2005","journal-title":"ANZ J Surg"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.3233\/JAD-190941","volume":"73","author":"Sajjad","year":"2020","journal-title":"J Alzheimers Dis"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1186\/s12974-016-0681-9","volume":"13","author":"Hirsch","year":"2016","journal-title":"J Neuroinflammation"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1111\/j.1532-5415.2011.03428.x","volume":"59","author":"MacLullich","year":"2011","journal-title":"J Am Geriatr Soc"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.jpsychores.2014.06.014","volume":"77","author":"Cape","year":"2014","journal-title":"J Psychosom Res"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1007\/s00540-012-1506-3","volume":"27","author":"Ji","year":"2013","journal-title":"J Anesth"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1038\/s41598-022-06034-9","volume":"12","author":"Fertleman","year":"2022","journal-title":"Sci Rep"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/j.1399-6576.2012.02769.x","volume":"57","author":"Reinsfelt","year":"2013","journal-title":"Acta Anaesthesiol Scand"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1002\/ana.25678","volume":"87","author":"Danielson","year":"2020","journal-title":"Ann Neurol"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12974-021-02145-8","volume":"18","author":"Vasunilashorn","year":"2021","journal-title":"J Neuroinflammation"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1007\/s00540-018-2504-x","volume":"32","author":"Kawano","year":"2018","journal-title":"J Anesth"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/s1098-7339(99)90049-4","volume":"24","author":"Yeager","year":"1999","journal-title":"Reg Anesth Pain Med"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1002\/alz.12064","volume":"16","author":"Wang","year":"2020","journal-title":"Alzheimers Dement"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/j.drudis.2021.01.019","volume":"26","author":"Granger","year":"2021","journal-title":"Drug Discov Today"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/clpt.2011.278","volume":"91","author":"Scott","year":"2012","journal-title":"Clin Pharmacol Ther"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1007\/s00535-018-1479-6","volume":"53","author":"Shi","year":"2018","journal-title":"J Gastroenterol"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1097\/00000542-200603000-00005","volume":"104","author":"Buvanendran","year":"2006","journal-title":"Anesthesiology"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s00210-011-0617-y","volume":"383","author":"Renner","year":"2011","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"273","DOI":"10.2147\/CIA.S1847","volume":"3","author":"Chau","year":"2008","journal-title":"Clin Interv Aging"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1213\/00000539-200108000-00026","volume":"93","author":"Nader","year":"2001","journal-title":"Anesth Analg"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1186\/s12974-018-1318-y","volume":"15","author":"Danielson","year":"2018","journal-title":"J Neuroinflammation"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1097\/ALN.0000000000001433","volume":"126","author":"Royse","year":"2017","journal-title":"Anesthesiology"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/S0140-6736(15)00273-1","volume":"386","author":"Whitlock","year":"2015","journal-title":"Lancet"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"e0152308","DOI":"10.1371\/journal.pone.0152308","volume":"11","author":"Valentin","year":"2016","journal-title":"PLoS One"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.amjsurg.2012.11.018","volume":"206","author":"Wang","year":"2013","journal-title":"Am J Surg"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"260","DOI":"10.12788\/fp.003","volume":"37","author":"Cole","year":"2020","journal-title":"Fed Pract"},{"key":"ref85","unstructured":"Meso Scale Discovery. Proinflammatory Panel 1 (human) Kits; 2020. Available from: https:\/\/www.mesoscale.com\/~\/media\/files\/product%20inserts\/proinflammatory%20panel%201%20human%20insert.pdf. Accessed May 26, 2022."},{"key":"ref86","doi-asserted-by":"publisher","first-page":"48","DOI":"10.4103\/sni.sni_433_17","volume":"9","author":"Epstein","year":"2018","journal-title":"Surg Neurol Int"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1212\/WNL.55.7.909","volume":"55","author":"Evans","year":"2000","journal-title":"Neurology"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1136\/pgmj.2006.044792","volume":"82","author":"Ahmed","year":"2006","journal-title":"Postgrad Med J"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1111\/jgs.15770","volume":"67","author":"Berger","year":"2019","journal-title":"J Am Geriatr Soc"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.knee.2017.12.001","volume":"25","author":"Azim","year":"2018","journal-title":"The Knee"},{"key":"ref91","volume":"27","author":"Wang","year":"2013","journal-title":"FASEB J"}],"container-title":["International Journal of General Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=81181","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=81181","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T16:21:24Z","timestamp":1654014084000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/putative-involvement-of-cytokine-modulation-in-the-development-of-peri-peer-reviewed-fulltext-article-IJGM"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":91,"URL":"https:\/\/doi.org\/10.2147\/ijgm.s364954","relation":{},"ISSN":["1178-7074"],"issn-type":[{"value":"1178-7074","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6]]}}}