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Age-adjusted percent distribution (with standard errors) of work-loss days in the past 12 months among employed adults aged 18 and over, and age-adjusted percent distribution (with standard errors) of bed days in the past 12 months among all adults aged 18 and over, by selected characteristics: United States; 2018. Availabe from: https:\/\/ftp.cdc.gov\/pub\/Health_Statistics\/NCHS\/NHIS\/SHS\/2018_SHS_Table_A-9.pdf. Accessed September 29, 2022."},{"key":"ref30","unstructured":"Kaiser Family Foundation. Adult self-reported health status analysis of the centers for disease control and prevention (CDC)\u2019s 2020 Behavioral Risk Factor Surveillance System (BRFSS). Timeframe; 2020. Availabe from: https:\/\/www.kff.org\/other\/state-indicator\/adult-self-reported-healthstatus\/?currentTimeframe=0&sortModel=%7B%22colId%22:%22Location%22,%22sort%22:%22asc%22%7D. Accessed September 23, 2022."},{"key":"ref31","unstructured":"S.C. Department of Health and Environmental Control (DHEC). 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