{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:18:07Z","timestamp":1790194687392,"version":"4.1.0"},"reference-count":71,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJGM"],"DOI":"10.2147\/ijgm.s547865","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T07:30:15Z","timestamp":1755847815000},"page":"4635-4645","source":"Crossref","is-referenced-by-count":7,"title":["The Pathogenesis and Treatment of Insomnia Combined with Depression"],"prefix":"10.2147","volume":"Volume 18","author":[{"given":"Yifan","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"166","DOI":"10.5935\/1984-0063.20180031","volume":"11","author":"Khan","year":"2018","journal-title":"Sleep Sci"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.ypmed.2019.02.001","volume":"123","author":"Dong","year":"2019","journal-title":"Prev Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"230","DOI":"10.5694\/mja2.51200","volume":"215","author":"Sweetman","year":"2021","journal-title":"Med J Aust"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.sleep.2017.07.016","volume":"38","author":"Chen","year":"2017","journal-title":"Sleep Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1093\/schbul\/sby129","volume":"45","author":"Reeve","year":"2019","journal-title":"Schizophr Bull"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/s11920-023-01455-3","volume":"25","author":"Nielson","year":"2023","journal-title":"Curr Psychiatry Rep"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e12858","DOI":"10.1111\/jsr.12858","volume":"28","author":"Emamian","year":"2019","journal-title":"J Sleep Res"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s12888-018-1623-0","volume":"18","author":"Hung","year":"2018","journal-title":"BMC Psychiatry"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.smrv.2018.10.006","volume":"43","author":"Hertenstein","year":"2019","journal-title":"Sleep Med Rev"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"104532","DOI":"10.1016\/j.neubiorev.2022.104532","volume":"134","author":"Zhang","year":"2022","journal-title":"Neurosci Biobehav Rev"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.jad.2019.08.094","volume":"260","author":"Mason","year":"2020","journal-title":"J Affect Disord"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"112514","DOI":"10.1016\/j.psychres.2019.112514","volume":"282","author":"Sun","year":"2019","journal-title":"Psychiatry Res"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1017\/S1041610217001454","volume":"30","author":"Li","year":"2018","journal-title":"Int Psychogeriatr"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"578252","DOI":"10.1016\/j.jneuroim.2023.578252","volume":"386","author":"Zhang","year":"2024","journal-title":"J Neuroimmunol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"175149","DOI":"10.1016\/j.ejphar.2022.175149","volume":"930","author":"Li","year":"2022","journal-title":"Eur J Pharmacol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.brainresbull.2021.09.019","volume":"177","author":"Moriya","year":"2021","journal-title":"Brain Res Bull"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/s41583-019-0151-3","volume":"20","author":"Okaty","year":"2019","journal-title":"Nat Rev Neurosci"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1378\/chest.14-1617","volume":"147","author":"Levenson","year":"2015","journal-title":"Chest"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/978-3-030-61663-2_6","volume":"1297","author":"M\u00e9ndez-D\u00edaz","year":"2021","journal-title":"Adv Exp Med Biol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.beth.2021.06.006","volume":"53","author":"Wieman","year":"2022","journal-title":"Behav Ther"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jpsychires.2016.09.016","volume":"84","author":"Gong","year":"2017","journal-title":"J Psychiatr Res"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1007\/s11682-020-00310-w","volume":"15","author":"Gong","year":"2021","journal-title":"Brain Imaging Behav"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.neuron.2015.02.018","volume":"86","author":"Berridge","year":"2015","journal-title":"Neuron"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.sleep.2023.09.026","volume":"112","author":"Gong","year":"2023","journal-title":"Sleep Med"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.jad.2020.05.026","volume":"274","author":"Benson","year":"2020","journal-title":"J Affect Disord"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"101588","DOI":"10.1016\/j.smrv.2022.101588","volume":"62","author":"Dressle","year":"2022","journal-title":"Sleep Med Rev"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3389\/fnbeh.2020.00044","volume":"14","author":"Santiago","year":"2020","journal-title":"Front Behav Neurosci"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/jsr.12570","volume":"27","author":"van Neijenhof","year":"2018","journal-title":"J Sleep Res"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"8437","DOI":"10.3390\/ijms24098437","volume":"24","author":"Drin\u010di\u0107","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.copsyc.2019.12.002","volume":"34","author":"Asarnow","year":"2020","journal-title":"Curr Opin Psychol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"e14008","DOI":"10.1097\/MD.0000000000014008","volume":"98","author":"Zhou","year":"2019","journal-title":"Medicine"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s11064-019-02914-1","volume":"45","author":"Rahmani","year":"2020","journal-title":"Neurochem Res"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3109\/07853890.2015.1131327","volume":"48","author":"Schmitt","year":"2016","journal-title":"Ann Med"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.pnpbp.2018.07.025","volume":"88","author":"Zaki","year":"2019","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s11920-017-0816-4","volume":"19","author":"Wichniak","year":"2017","journal-title":"Curr Psychiatry Rep"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaa092","volume":"43","author":"Mi","year":"2020","journal-title":"Sleep"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1016\/j.clinthera.2022.07.004","volume":"44","author":"Pochiero","year":"2022","journal-title":"Clin Ther"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"Cd010753","DOI":"10.1002\/14651858.CD010753.pub2","volume":"5","author":"Everitt","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s13034-020-00316-8","volume":"14","author":"Boafo","year":"2020","journal-title":"Child Adolesc Psychiatr Ment Health"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1055\/s-0032-1331702","volume":"46","author":"Goerke","year":"2013","journal-title":"Pharmacopsychiatry"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.5665\/SLEEP.1294","volume":"34","author":"Krystal","year":"2011","journal-title":"Sleep"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/pcn.12565","volume":"72","author":"Nishimura","year":"2018","journal-title":"Psychiatry Clin Neurosci"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/bcp.13772","volume":"85","author":"Liguori","year":"2019","journal-title":"Br J Clin Pharmacol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"627","DOI":"10.3390\/clockssleep5040042","volume":"5","author":"Mlyncekova","year":"2023","journal-title":"Clocks Sleep"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"291","DOI":"10.2147\/NSS.S220947","volume":"11","author":"Hao","year":"2019","journal-title":"Nat Sci Sleep"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"568","DOI":"10.3390\/ph16040568","volume":"16","author":"Kwa\u015bny","year":"2023","journal-title":"Pharmaceuticals"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsy104","volume":"41","author":"Sadler","year":"2018","journal-title":"Sleep"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1080\/16506073.2017.1359206","volume":"47","author":"Sadler","year":"2018","journal-title":"Cogn Behav Ther"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1093\/sleep\/31.4.489","volume":"31","author":"Manber","year":"2008","journal-title":"Sleep"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"e1316","DOI":"10.4088\/JCP.15m10244","volume":"77","author":"Manber","year":"2016","journal-title":"J Clin Psychiatry"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsad104","volume":"46","author":"Boland","year":"2023","journal-title":"Sleep"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jpsychores.2017.12.012","volume":"106","author":"Cunningham","year":"2018","journal-title":"J Psychosom Res"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1001\/jamapsychiatry.2021.3422","volume":"79","author":"Irwin","year":"2022","journal-title":"JAMA Psychiatry"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"101597","DOI":"10.1016\/j.smrv.2022.101597","volume":"62","author":"Hertenstein","year":"2022","journal-title":"Sleep Med Rev"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1159\/000520282","volume":"91","author":"Leerssen","year":"2022","journal-title":"Psychother Psychosom"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.5664\/jcsm.10514","volume":"19","author":"Edinger","year":"2023","journal-title":"J Clin Sleep Med"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1017\/S0033291718001113","volume":"49","author":"Cheng","year":"2019","journal-title":"Psychol Med"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.sleep.2023.12.014","volume":"114","author":"Spina","year":"2024","journal-title":"Sleep Med"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.sleep.2020.02.003","volume":"70","author":"Zhou","year":"2020","journal-title":"Sleep Med"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.jad.2022.11.062","volume":"323","author":"Pu","year":"2023","journal-title":"J Affect Disord"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"863134","DOI":"10.3389\/fpsyt.2022.863134","volume":"13","author":"Zhao","year":"2022","journal-title":"Front Psychiatry"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1120567","DOI":"10.3389\/fpubh.2023.1120567","volume":"11","author":"Zhao","year":"2023","journal-title":"Front Public Health"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.2147\/NSS.S332474","volume":"13","author":"Zhao","year":"2021","journal-title":"Nat Sci Sleep"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"e2220563","DOI":"10.1001\/jamanetworkopen.2022.20563","volume":"5","author":"Yin","year":"2022","journal-title":"JAMA Netw Open"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"497","DOI":"10.2147\/NSS.S253320","volume":"12","author":"Yin","year":"2020","journal-title":"Nat Sci Sleep"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.smrv.2018.09.003","volume":"43","author":"Perach","year":"2019","journal-title":"Sleep Med Rev"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"1124344","DOI":"10.3389\/fpsyt.2023.1124344","volume":"14","author":"Li","year":"2023","journal-title":"Front Psychiatry"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"1231040","DOI":"10.3389\/fpsyt.2023.1231040","volume":"14","author":"Evanger","year":"2023","journal-title":"Front Psychiatry"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.genhosppsych.2021.09.004","volume":"73","author":"Huberty","year":"2021","journal-title":"Gen Hosp Psychiatry"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"636","DOI":"10.5498\/wjp.v12.i4.636","volume":"12","author":"Chan","year":"2022","journal-title":"World J Psychiatry"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s11920-022-01370-z","volume":"24","author":"Peters","year":"2022","journal-title":"Curr Psychiatry Rep"}],"container-title":["International Journal of General Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/106083","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/106083","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T07:30:16Z","timestamp":1755847816000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/the-pathogenesis-and-treatment-of-insomnia-combined-with-depression-peer-reviewed-fulltext-article-IJGM"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":71,"URL":"https:\/\/doi.org\/10.2147\/ijgm.s547865","relation":{},"ISSN":["1178-7074"],"issn-type":[{"value":"1178-7074","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]}}}