{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T09:09:21Z","timestamp":1774429761572,"version":"3.50.1"},"reference-count":42,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJGM"],"DOI":"10.2147\/ijgm.s572889","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:45:21Z","timestamp":1774421121000},"page":"1-14","source":"Crossref","is-referenced-by-count":0,"title":["Immunological and Inflammatory Characteristics of Severe Cutaneous Adverse Drug Reactions: A Retrospective Study"],"prefix":"10.2147","volume":"Volume 19","author":[{"given":"Qing","family":"Luo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu-Dong","family":"Mou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Hao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2026,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1007\/s12016-021-08859-0","volume":"61","author":"Zhang","year":"2021","journal-title":"Clin Rev Allergy Immunol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10092105","volume":"10","author":"Chang","year":"2022","journal-title":"Biomedicines"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13030645","volume":"13","author":"Kliniec","year":"2024","journal-title":"J Clin Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e1969","DOI":"10.1002\/hsr2.1969","volume":"7","author":"Moshayedi","year":"2024","journal-title":"Health Sci Rep"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1187937","DOI":"10.3389\/fmed.2023.1187937","volume":"10","author":"Chen","year":"2023","journal-title":"Front Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/all.16316","volume":"80","author":"Cadot","year":"2025","journal-title":"Allergy"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1213889","DOI":"10.3389\/fmed.2023.1213889","volume":"10","author":"Marks","year":"2023","journal-title":"Front Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"8722","DOI":"10.1038\/s41467-024-52990-3","volume":"15","author":"Gibson","year":"2024","journal-title":"Nat Commun"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"R234","DOI":"10.1186\/cc2877","volume":"8","author":"Castelli","year":"2004","journal-title":"Crit Care"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e170","DOI":"10.15190\/d.2023.9","volume":"11","author":"Bhatt","year":"2023","journal-title":"Discoveries"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.ijid.2020.08.078","volume":"100","author":"Mizukawa","year":"2020","journal-title":"Int J Infect Dis"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57090895","volume":"57","author":"Frantz","year":"2021","journal-title":"Medicina"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1001\/archderm.1993.01680220104023","volume":"129","author":"Bastuji-Garin","year":"1993","journal-title":"Arch Dermatol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"263","DOI":"10.3343\/alm.2014.34.4.263","volume":"34","author":"Meisner","year":"2014","journal-title":"Ann Lab Med"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1001\/archderm.140.2.183","volume":"140","author":"Kano","year":"2004","journal-title":"Arch Dermatol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1108345","DOI":"10.3389\/fmed.2023.1108345","volume":"10","author":"Manieri","year":"2023","journal-title":"Front Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"547","DOI":"10.2147\/ccid.s356450","volume":"15","author":"Primisawitri","year":"2022","journal-title":"Clin Cosmet Invest Dermatol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1007\/s40257-024-00889-6","volume":"25","author":"Shah","year":"2024","journal-title":"Am J Clin Dermatol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.alit.2025.05.002","volume":"74","author":"Justice","year":"2025","journal-title":"Allergol Int"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"18433","DOI":"10.1038\/s41598-021-97575-y","volume":"11","author":"Koduri","year":"2021","journal-title":"Sci Rep"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.jaad.2020.08.122","volume":"84","author":"Tsai","year":"2021","journal-title":"J Am Acad Dermatol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aax2398","volume":"13","author":"Kinoshita","year":"2021","journal-title":"Sci Transl Med"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"102979","DOI":"10.1016\/j.jaut.2022.102979","volume":"137","author":"Coss","year":"2023","journal-title":"J Autoimmun"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.ad.2015.08.006","volume":"107","author":"Horcajada-Reales","year":"2016","journal-title":"Actas Dermosifiliogr"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"901401","DOI":"10.3389\/fmed.2022.901401","volume":"9","author":"Lehloenya","year":"2022","journal-title":"Front Med"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"22","DOI":"10.25259\/ijdvl_1284_2024","volume":"92","author":"Thara","year":"2026","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"832048","DOI":"10.3389\/fphar.2022.832048","volume":"13","author":"Tempark","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1001\/archderm.143.12.1591-a","volume":"143","author":"Sfia","year":"2007","journal-title":"Arch Dermatol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1002\/hep.30508","volume":"70","author":"Thorgersen","year":"2019","journal-title":"Hepatology"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.3389\/fimmu.2020.01648","volume":"11","author":"Bhaskar","year":"2020","journal-title":"Front Immunol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"754","DOI":"10.3389\/fimmu.2018.00754","volume":"9","author":"Sproston","year":"2018","journal-title":"Front Immunol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"65","DOI":"10.2147\/oarrr.s318826","volume":"15","author":"Triggianese","year":"2023","journal-title":"Open Access Rheumatol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"e2404542121","DOI":"10.1073\/pnas.2404542121","volume":"121","author":"Noone","year":"2024","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"e23043","DOI":"10.1002\/jcla.23043","volume":"34","author":"Pan","year":"2020","journal-title":"J Clin Lab Anal"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1097\/der.0000000000000890","volume":"34","author":"Fadhel","year":"2023","journal-title":"Dermatitis"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.eplepsyres.2017.05.015","volume":"135","author":"Wang","year":"2017","journal-title":"Epilepsy Res"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/1547691x.2019.1695985","volume":"17","author":"Wang","year":"2020","journal-title":"J Immunotoxicol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1001\/jamadermatol.2023.4450","volume":"160","author":"Br\u00fcggen","year":"2024","journal-title":"JAMA Dermatol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1073\/pnas.1508920113","volume":"113","author":"Fay","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"135","DOI":"10.2147\/jir.s160964","volume":"11","author":"Ng","year":"2018","journal-title":"J Inflamm Res"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/j.jaci.2013.04.038","volume":"132","author":"Yoon","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1414136","DOI":"10.3389\/fimmu.2024.1414136","volume":"15","author":"Zhou","year":"2024","journal-title":"Front Immunol"}],"container-title":["International Journal of General Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/113445","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/113445","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:45:23Z","timestamp":1774421123000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/immunological-and-inflammatory-characteristics-of-severe-cutaneous-adv-peer-reviewed-fulltext-article-IJGM"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":42,"URL":"https:\/\/doi.org\/10.2147\/ijgm.s572889","relation":{},"ISSN":["1178-7074"],"issn-type":[{"value":"1178-7074","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]}}}