{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T03:15:16Z","timestamp":1780974916871,"version":"3.54.1"},"reference-count":42,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s240953","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T19:22:30Z","timestamp":1594322550000},"page":"4919-4932","source":"Crossref","is-referenced-by-count":55,"title":["&lt;p&gt;Multifunctional Superparamagnetic Iron Oxide Nanoparticles Conjugated with A\u03b2 Oligomer-Specific scFv Antibody and Class A Scavenger Receptor Activator Show Early Diagnostic Potentials for Alzheimer\u2019s Disease&lt;\/p&gt;"],"prefix":"10.2147","volume":"Volume 15","author":[{"given":"Xiao-Ge","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Qun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7066-6065","authenticated-orcid":true,"given":"Ling-Xiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Lin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Tian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1038\/d41586-018-05718-5","volume":"559","author":"Drew","year":"2018","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.cell.2019.09.001","volume":"179","author":"Long","year":"2019","journal-title":"Cell"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1073\/pnas.0409336102","volume":"102","author":"Georganopoulou","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s00401-013-1151-4","volume":"126","author":"Toledo","year":"2013","journal-title":"Acta Neuropathol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/j.1471-4159.2011.07553.x","volume":"120","author":"Slemmon","year":"2012","journal-title":"J Neurochem"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1093\/brain\/awr038","volume":"134","author":"Fodero-Tavoletti","year":"2011","journal-title":"Brain"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"3336","DOI":"10.1093\/brain\/awq277","volume":"133","author":"Jack","year":"2010","journal-title":"Brain"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1038\/d41586-018-05721-w","volume":"559","author":"Dolgin","year":"2018","journal-title":"Nature"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"645","DOI":"10.3233\/JAD-160907","volume":"57","author":"Hane","year":"2017","journal-title":"J Alzheimer\u2019s Dis"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1038\/d41586-018-05717-6","volume":"559","author":"Hodson","year":"2018","journal-title":"Nature"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/ene.13439","volume":"25","author":"Lane","year":"2018","journal-title":"Eur J Neurol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"S567","DOI":"10.3233\/JAD-179941","volume":"64","author":"Cline","year":"2018","journal-title":"J Alzheimer\u2019s Dis"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"11938","DOI":"10.1523\/JNEUROSCI.2357-10.2010","volume":"30","author":"Zempel","year":"2010","journal-title":"J Neurosci"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.neurobiolaging.2009.05.012","volume":"32","author":"Poon","year":"2011","journal-title":"Neurobiol Aging"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"5907","DOI":"10.1073\/pnas.0901229106","volume":"106","author":"Pigino","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1126\/science.aad8373","volume":"352","author":"Hong","year":"2016","journal-title":"Science"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"595","DOI":"10.15252\/emmm.201606210","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s00401-015-1386-3","volume":"129","author":"Viola","year":"2015","journal-title":"Acta Neuropathol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.neuropharm.2017.11.016","volume":"136","author":"Santos","year":"2018","journal-title":"Neuropharmacology"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.3233\/JAD-170819","volume":"62","author":"Forloni","year":"2018","journal-title":"J Alzheimer\u2019s Dis"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"10191","DOI":"10.1523\/JNEUROSCI.3432-04.2004","volume":"24","author":"Lacor","year":"2004","journal-title":"J Neurosci"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1056\/NEJMoa1202753","volume":"367","author":"Bateman","year":"2012","journal-title":"N Engl J Med"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1038\/nature08538","volume":"461","author":"Perrin","year":"2009","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.brainres.2018.11.034","volume":"1707","author":"Liu","year":"2019","journal-title":"Brain Res"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"e94197","DOI":"10.1371\/journal.pone.0094197","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1097\/WCO.0000000000000570","volume":"31","author":"Whitwell","year":"2018","journal-title":"Curr Opin Neurol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.febslet.2008.12.064","volume":"583","author":"Wang","year":"2009","journal-title":"FEBS Lett"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1016\/j.bbapap.2011.09.005","volume":"1814","author":"Zhang","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1515\/revneuro-2017-0063","volume":"29","author":"Reiss","year":"2018","journal-title":"Rev Neurosci"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1083\/jcb.201709069","volume":"217","author":"Hansen","year":"2018","journal-title":"J Cell Biol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"3240","DOI":"10.1172\/JCI90606","volume":"127","author":"Sarlus","year":"2017","journal-title":"J Clin Invest"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1038\/nm.4397","volume":"23","author":"Salter","year":"2017","journal-title":"Nat Med"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1002\/glia.10148","volume":"40","author":"Husemann","year":"2002","journal-title":"Glia"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.1523\/JNEUROSCI.23-07-02665.2003","volume":"23","author":"Bamberger","year":"2003","journal-title":"J Neurosci"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"30406","DOI":"10.1074\/jbc.M414686200","volume":"280","author":"Alarcon","year":"2005","journal-title":"J Biol Chem"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"27392","DOI":"10.1074\/jbc.M702887200","volume":"282","author":"Stuart","year":"2007","journal-title":"J Biol Chem"},{"key":"ref37","first-page":"489456","volume":"2012","author":"Wilkinson","year":"2012","journal-title":"Int J Alzheimers Dis"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/nri3515","volume":"13","author":"Canton","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nnano.2014.254","volume":"10","author":"Viola","year":"2015","journal-title":"Nat Nanotechnol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1016\/j.addr.2011.07.001","volume":"63","author":"De","year":"2011","journal-title":"Adv Drug Deliv Rev"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1073\/pnas.1620145114","volume":"114","author":"Wei","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.18632\/aging.101818","volume":"11","author":"Puzzo","year":"2019","journal-title":"Aging (Albany NY)"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=59592","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=59592","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T19:22:32Z","timestamp":1594322552000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/multifunctional-superparamagnetic-iron-oxide-nanoparticles-conjugated--peer-reviewed-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":42,"URL":"https:\/\/doi.org\/10.2147\/ijn.s240953","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7]]}}}