{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:57:57Z","timestamp":1791903477747,"version":"4.3.4"},"reference-count":40,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s241324","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T21:58:31Z","timestamp":1588283911000},"page":"3087-3098","source":"Crossref","is-referenced-by-count":8,"title":["<p>A Mansonone Derivative Coupled with Monoclonal Antibody 4D5-Modified Chitosan Inhibit AKR1C3 to Treat Castration-Resistant Prostate Cancer<\/p>"],"prefix":"10.2147","volume":"Volume 15","author":[{"given":"Meng","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5005-3069","authenticated-orcid":true,"given":"Jie","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lichun","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Bei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8879-3273","authenticated-orcid":true,"given":"Yadong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiliang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21551","volume":"69","author":"Siegel","year":"2019","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/s41391-018-0079-0","volume":"22","author":"Crawford","year":"2019","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1016\/j.juro.2018.07.090","volume":"200","author":"Lowrance","year":"2018","journal-title":"J Urol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.1038\/onc.2013.235","volume":"33","author":"Yuan","year":"2014","journal-title":"Oncogene"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"3876","DOI":"10.1158\/1078-0432.CCR-10-2815","volume":"17","author":"Massard","year":"2011","journal-title":"Clin Cancer Res"},{"key":"ref6","first-page":"1273","volume":"7","author":"Buchanan","year":"2001","journal-title":"Clin Cancer Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/978-0-387-69080-3_53","volume":"617","author":"Lapouge","year":"2008","journal-title":"Advan Exp Med Biol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"365","DOI":"10.3978\/j.issn.2223-4683.2015.05.02","volume":"4","author":"Chandrasekar","year":"2015","journal-title":"Transl Androl Urol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3390\/jcm8050601","volume":"8","author":"Miyazaki","year":"2019","journal-title":"J Clin Med"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.jsbmb.2013.05.012","volume":"137","author":"Adeniji","year":"2013","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1158\/0008-5472.CAN-09-2092","volume":"70","author":"Hofland","year":"2010","journal-title":"Cancer Res"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"e77407","DOI":"10.1371\/journal.pone.0077407","volume":"8","author":"Jernberg","year":"2013","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"6142","DOI":"10.1158\/0008-5472.CAN-12-1335","volume":"72","author":"Mitsiades","year":"2012","journal-title":"Cancer Res"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.mce.2018.07.002","volume":"489","author":"Penning","year":"2019","journal-title":"Mol Cell Endocrinol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1002\/pros.23875","volume":"79","author":"Zhao","year":"2019","journal-title":"Prostate"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1158\/1535-7163.MCT-16-0186","volume":"16","author":"Liu","year":"2017","journal-title":"Mol Cancer Ther"},{"key":"ref17","first-page":"1833","volume":"17","author":"Kshitij","year":"2017","journal-title":"mol Cancer Ther"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"3339","DOI":"10.1016\/j.ejmech.2011.04.059","volume":"46","author":"Wu","year":"2011","journal-title":"Eur J Med Chem"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1248\/bpb.27.1025","volume":"27","author":"Wang","year":"2004","journal-title":"Biol Pharm Bull"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/s41416-019-0496-4","volume":"121","author":"Jathal","year":"2019","journal-title":"Br J Cancer"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.1016\/j.cellsig.2015.08.002","volume":"27","author":"Muniyan","year":"2015","journal-title":"Cell Signal"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/j.biochi.2012.04.011","volume":"94","author":"Ivanova","year":"2012","journal-title":"Biochimie"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"6403","DOI":"10.1007\/s00253-016-7487-7","volume":"100","author":"Lv","journal-title":"Appl Microbiol Biotechnol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1021\/acs.bioconjchem.8b00091","volume":"29","author":"Herve-Aubert","year":"2018","journal-title":"Bioconjug Chem"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/s00253-011-3306-3","volume":"91","author":"Silvia","year":"2011","journal-title":"Appl Microbiol Biotechnol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"115004","DOI":"10.1016\/j.carbpol.2019.115004","volume":"222","author":"Zhang","year":"2019","journal-title":"Carbohydr Polym"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1002\/pros.23874","volume":"79","author":"Kaipainen","year":"2019","journal-title":"Prostate"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"472e411","DOI":"10.1016\/j.urolonc.2018.07.005","volume":"36","author":"Wang","year":"2018","journal-title":"Urol Oncol"},{"key":"ref29","first-page":"6","volume":"2018","author":"Kumar","year":"2018","journal-title":"Cold Spring Harb Protoc"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1136\/jcp.2007.050906","volume":"61","author":"Wako","year":"2008","journal-title":"J Clin Pathol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1158\/0008-5472.CAN-15-1233","volume":"76","author":"Tobrain","year":"2016","journal-title":"Cancer Res"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.jconrel.2010.04.009","volume":"146","author":"Tai","year":"2010","journal-title":"J Controlled Release off J Controlled Release Soc"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1021\/mp800049w","volume":"5","author":"Li","year":"2008","journal-title":"Mol Pharm"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-17-1023","volume":"17","author":"Verma","year":"2018","journal-title":"Mol Cancer Ther"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jsbmb.2011.12.012","volume":"130","author":"Byrns","year":"2012","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.bcp.2016.07.015","volume":"116","author":"Mowday","year":"2016","journal-title":"Biochem Pharmacol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"7431","DOI":"10.1021\/acs.jmedchem.6b00160","volume":"59","author":"Adeniji","year":"2016","journal-title":"J Med Chem"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"7119","DOI":"10.1074\/jbc.M307649200","volume":"279","author":"Gregory","year":"2004","journal-title":"J Biol Chem"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1158\/1078-0432.CCR-04-1158","volume":"11","author":"Gregory","year":"2005","journal-title":"Clin Cancer Res"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"14584","DOI":"10.1038\/s41598-017-14607-2","volume":"7","author":"He","year":"2017","journal-title":"Sci Rep"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=57788","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=57788","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T21:58:36Z","timestamp":1588283916000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/a-mansonone-derivative-coupled-with-monoclonal-antibody-4d5-modified-c-peer-reviewed-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":40,"URL":"https:\/\/doi.org\/10.2147\/ijn.s241324","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5]]}}}