{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:35:46Z","timestamp":1785551746164,"version":"3.56.0"},"reference-count":48,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s241492","type":"journal-article","created":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T22:53:21Z","timestamp":1589151201000},"page":"3303-3318","source":"Crossref","is-referenced-by-count":32,"title":["&lt;p&gt;Induction of Robust Immune Responses by CpG-ODN-Loaded Hollow Polymeric Nanoparticles for Antiviral and Vaccine Applications in Chickens&lt;\/p&gt;"],"prefix":"10.2147","volume":"Volume 15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4244-7842","authenticated-orcid":true,"given":"Shu-Yi","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-Yu","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0988-7029","authenticated-orcid":true,"given":"Che-Ming Jack","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0595-3420","authenticated-orcid":true,"given":"Hui-Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"3554","DOI":"10.1016\/j.vaccine.2007.01.083","volume":"25","author":"Ninomiya","year":"2007","journal-title":"Vaccine"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/S0169-409X(98)00008-8","volume":"32","author":"Gupta","year":"1998","journal-title":"Adv Drug Deliv Rev"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1084\/jem.186.10.1623","volume":"186","author":"Chu","year":"1997","journal-title":"J Exp Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1111\/j.0105-2896.2004.00148.x","volume":"199","author":"Klinman","year":"2004","journal-title":"Immunol Rev"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nri1391","volume":"4","author":"Akira","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"3163","DOI":"10.1016\/j.molimm.2009.06.002","volume":"46","author":"Brownlie","year":"2009","journal-title":"Mol Immunol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"76","DOI":"10.2174\/156720109787048221","volume":"6","author":"Taghavi","year":"2009","journal-title":"Curr Drug Deliv"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1637\/8196-121907-Reg","volume":"52","author":"Taghavi","year":"2008","journal-title":"Avian Dis"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1089\/vim.2013.0124","volume":"27","author":"St. Paul","year":"2014","journal-title":"Viral Immunol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1637\/8560-121808-Reg.1","volume":"53","author":"Dar","year":"2009","journal-title":"Avian Dis"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.rvsc.2008.02.006","volume":"85","author":"Zhang","year":"2008","journal-title":"Res Vet Sci"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1146\/annurev.immunol.20.100301.064842","volume":"20","author":"Krieg","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.4049\/jimmunol.175.3.1619","volume":"175","author":"Roda","year":"2005","journal-title":"J Immunol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"4524","DOI":"10.1016\/j.vaccine.2012.04.033","volume":"30","author":"Paul","year":"2012","journal-title":"Vaccine"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1016\/j.addr.2013.05.013","volume":"65","author":"Hafner","year":"2013","journal-title":"Adv Drug Deliv Rev"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jconrel.2017.06.026","volume":"261","author":"Kumar","year":"2017","journal-title":"J Control Release"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"27589","DOI":"10.1021\/acsami.8b02019","volume":"10","author":"Rajput","year":"2018","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1807616","DOI":"10.1002\/adfm.201807616","volume":"29","author":"Lin","year":"2019","journal-title":"Adv Funct Mater"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"244","DOI":"10.7150\/ntno.19796","volume":"1","author":"Chattopadhyay","year":"2017","journal-title":"Nanotheranostics"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"4807","DOI":"10.1016\/j.vaccine.2016.08.009","volume":"34","author":"Singh","year":"2016","journal-title":"Vaccine"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.antiviral.2013.06.014","volume":"99","author":"Chen","year":"2013","journal-title":"Antiviral Res"},{"key":"ref22","author":"Li","year":"2019","journal-title":"Transbound Emerg Dis"},{"key":"ref23","first-page":"15","author":"Tsai","year":"2016","journal-title":"J Vet Med Sci"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/j.1365-2567.2009.03129.x","volume":"129","author":"Wu","year":"2010","journal-title":"Immunology"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"8579","DOI":"10.2147\/IJN.S185806","volume":"13","author":"Hu","year":"2018","journal-title":"Int J Nanomedicine"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"39953","DOI":"10.1021\/acsami.7b09931","volume":"9","author":"Chen","year":"2017","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.virol.2013.09.018","volume":"448","author":"Promkuntod","year":"2014","journal-title":"Virology"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.jim.2018.06.001","volume":"459","author":"Hsieh","year":"2018","journal-title":"J Immunol Methods"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"2216","DOI":"10.3390\/ijms20092216","volume":"20","author":"Liu","year":"2019","journal-title":"Int J Mol Sci"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.dci.2016.05.016","volume":"63","author":"Van Goor","year":"2016","journal-title":"Dev Comp Immunol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1002\/jlb.64.4.484","volume":"64","author":"Grassi","year":"1998","journal-title":"J Leukoc Biol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1002\/eji.200737984","volume":"38","author":"Manolova","year":"2008","journal-title":"Eur J Immunol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1146\/annurev.iy.09.040191.001415","volume":"9","author":"Steinman","year":"1991","journal-title":"Annu Rev Immunol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"2760","DOI":"10.1002\/(SICI)1521-4141(199809)28:09<2760::AID-IMMU2760>3.0.CO;2-N","volume":"28","author":"Sallusto","year":"1998","journal-title":"Eur J Immunol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.dci.2010.12.015","volume":"35","author":"Wu","year":"2011","journal-title":"Dev Comp Immunol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1084\/jem.20081571","volume":"206","author":"Dienz","year":"2009","journal-title":"J Exp Med"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1002\/eji.201040391","volume":"40","author":"Kimura","year":"2010","journal-title":"Eur J Immunol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1084\/jem.177.4.1199","volume":"177","author":"Manetti","year":"1993","journal-title":"J Exp Med"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"10188","DOI":"10.1073\/pnas.90.21.10188","volume":"90","author":"Seder","year":"1993","journal-title":"Proc Natl Acad Sci"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"3231","DOI":"10.1002\/(SICI)1521-4141(199810)28:10<3231::AID-IMMU3231>3.0.CO;2-Q","volume":"28","author":"Stoll","year":"1998","journal-title":"Eur J Immunol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1002\/eji.1830270526","volume":"27","author":"De Smedt","year":"1997","journal-title":"Eur J Immunol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.dci.2004.09.001","volume":"29","author":"Tregaskes","year":"2005","journal-title":"Dev Comp Immunol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/B978-012370634-8.50017-2","volume":"1","author":"Kothlow","year":"2008","journal-title":"Avian Immunol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"6141","DOI":"10.4049\/jimmunol.162.10.6141","volume":"162","author":"Staats","year":"1999","journal-title":"J Immunol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"37725","DOI":"10.1038\/srep37725","volume":"6","author":"Lin","year":"2016","journal-title":"Sci Rep"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1631\/jzus.B1700506","volume":"19","author":"Wang","year":"2018","journal-title":"J Zhejiang Univ Sci B"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1186\/1743-422X-8-447","volume":"8","author":"Jiang","year":"2011","journal-title":"Virol J"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1186\/1743-422X-7-364","volume":"7","author":"Liu","year":"2010","journal-title":"Virol J"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=57984","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=57984","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T21:38:48Z","timestamp":1696109928000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/induction-of-robust-immune-responses-by-cpg-odn-loaded-hollow-polymeri-peer-reviewed-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":48,"URL":"https:\/\/doi.org\/10.2147\/ijn.s241492","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5]]}}}