{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:30:17Z","timestamp":1781587817389,"version":"3.54.5"},"reference-count":180,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s254792","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T22:16:56Z","timestamp":1596665816000},"page":"5745-5765","source":"Crossref","is-referenced-by-count":50,"title":["<p>Potential Therapeutic Usage of Nanomedicine for Glaucoma Treatment<\/p>"],"prefix":"10.2147","volume":"Volume 15","author":[{"given":"Song","family":"Kwon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2353-8017","authenticated-orcid":true,"given":"Dongwoo","family":"Khang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5629-5117","authenticated-orcid":true,"given":"Jong Yeon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1136\/bjo.2005.081224","volume":"90","author":"Quigley","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2014.3192","volume":"311","author":"Weinreb","year":"2014","journal-title":"Jama"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"189","DOI":"10.2147\/OPTH.S80490","volume":"10","author":"Richter","year":"2016","journal-title":"Clin Ophthalmol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.exer.2015.03.021","volume":"142","author":"Schlunck","year":"2016","journal-title":"Exp Eye Res"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"5611","DOI":"10.1167\/iovs.16-19389","volume":"57","author":"Bengtsson","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/1471-2415-14-127","volume":"14","author":"Song","year":"2014","journal-title":"BMC Ophthalmol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/S0161-6420(82)34675-8","volume":"89","author":"Grant","year":"1982","journal-title":"Ophthalmology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1167\/tvst.4.2.1","volume":"4","author":"Susanna","year":"2015","journal-title":"Trans vision sci technol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.clae.2018.10.005","volume":"42","author":"Asiedu","year":"2019","journal-title":"Contact Lens Anterior Eye"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1038\/nri3488","volume":"13","author":"Smith","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"216rv214","DOI":"10.1126\/scitranslmed.3005872","volume":"5","author":"Chow","year":"2013","journal-title":"Sci Transl Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/nnano.2016.6","volume":"11","author":"Butcher","year":"2016","journal-title":"Nat Nanotechnol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"R183","DOI":"10.1088\/1361-6579\/aa7182","volume":"38","author":"Bayford","year":"2017","journal-title":"Physiol Meas"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"524","DOI":"10.5301\/ijao.5000533","volume":"39","author":"Johari","year":"2016","journal-title":"Int J Artif Organs"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1002\/jbm.a.35731","volume":"104","author":"Samadikuchaksaraei","year":"2016","journal-title":"J Biomed Mater Res A"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/jbm.b.33814","volume":"106","author":"Kargozar","year":"2018","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"16067","DOI":"10.1038\/nrdp.2016.67","volume":"2","author":"Weinreb","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"100840","DOI":"10.1016\/j.preteyeres.2020.100840","author":"Lee","year":"2020","journal-title":"Prog Retin Eye Res"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1001\/jamaophthalmol.2019.1173","volume":"137","author":"Walsh","year":"2019","journal-title":"JAMA Ophthalmol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"S43","DOI":"10.1016\/j.ophtha.2020.01.024","volume":"127","author":"Levkovitch-Verbin","year":"2020","journal-title":"Ophthalmology"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"750","DOI":"10.3980\/j.issn.2222-3959.2012.06.18","volume":"5","author":"Chen","year":"2012","journal-title":"Int J Ophthalmol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1038\/s41467-017-01913-6","volume":"8","author":"Choquet","year":"2017","journal-title":"Nat Commun"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.exer.2016.01.017","volume":"158","author":"Johnson","year":"2017","journal-title":"Exp Eye Res"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"165560","DOI":"10.1016\/j.bbadis.2019.165560","volume":"1866","author":"Ho","year":"2020","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"52","DOI":"10.2174\/1874364101004010052","volume":"4","author":"Goel","year":"2010","journal-title":"Open Ophthalmol J"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"4733","DOI":"10.1167\/iovs.16-19475","volume":"57","author":"Yan","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1038\/sj.eye.6702880","volume":"21","author":"Vrabec","year":"2007","journal-title":"Eye (Lond)"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1016\/S0140-6736(04)16257-0","volume":"363","author":"Weinreb","year":"2004","journal-title":"Lancet"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1097\/WCO.0b013e3283344461","volume":"23","author":"Bessero","year":"2010","journal-title":"Curr Opin Neurol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1471-2202-11-31","volume":"11","author":"Fang","year":"2010","journal-title":"BMC Neurosci"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.preteyeres.2006.07.003","volume":"25","author":"Tezel","year":"2006","journal-title":"Prog Retin Eye Res"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1097\/IJG.0b013e318181284f","volume":"18","author":"Kong","year":"2009","journal-title":"J Glaucoma"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Group, C.N.T.G.S. Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures. Collaborative Normal-Tension Glaucoma Study Group. Am J Ophthalmol. 1998;126(4):487\u2013497. doi:10.1016\/S0002-9394(98)00223-2","DOI":"10.1016\/S0002-9394(98)00223-2"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"8639","DOI":"10.1038\/s41598-017-09379-8","volume":"7","author":"Fedorchak","year":"2017","journal-title":"Sci Rep"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1177\/2040622313511286","volume":"5","author":"Sambhara","year":"2014","journal-title":"Ther Adv Chronic Dis"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3109\/08820539909061464","volume":"14","author":"Hejkal","year":"1999","journal-title":"Semin Ophthalmol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.survophthal.2008.08.013","volume":"53","author":"Camras","year":"2008","journal-title":"Surv Ophthalmol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1097\/IJG.0000000000000849","volume":"27","author":"Alizadeh","year":"2018","journal-title":"J Glaucoma"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"711","DOI":"10.2105\/AJPH.83.5.711","volume":"83","author":"Gurwitz","year":"1993","journal-title":"Am J Public Health"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.ejps.2012.05.007","volume":"47","author":"Loch","year":"2012","journal-title":"Eur J Pharm Sci"},{"key":"ref41","first-page":"267","volume":"10","author":"Scruggs","year":"1978","journal-title":"Ann Ophthalmol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1021\/js9802594","volume":"87","author":"Prausnitz","year":"1998","journal-title":"J Pharm Sci"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/j.addr.2006.07.027","volume":"58","author":"Urtti","year":"2006","journal-title":"Adv Drug Deliv Rev"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"659","DOI":"10.3109\/02713688109001870","volume":"1","author":"Bito","year":"1981","journal-title":"Curr Eye Res"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0168-3659(02)00175-X","volume":"83","author":"Wei","year":"2002","journal-title":"J Control Release"},{"key":"ref46","first-page":"627","volume":"38","author":"Hamalainen","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1038\/eye.2011.82","volume":"25","author":"Lavik","year":"2011","journal-title":"Eye (Lond)"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"47","DOI":"10.5497\/wjp.v2.i2.47","volume":"2","author":"Patel","year":"2013","journal-title":"World J Pharmacol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1208\/s12248-010-9183-3","volume":"12","author":"Gaudana","year":"2010","journal-title":"AAPS J"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/bmc.529","volume":"20","author":"Wei","year":"2006","journal-title":"Biomed Chromatogr"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1080\/02713683.2018.1536218","volume":"44","author":"Cardigos","year":"2019","journal-title":"Curr Eye Res"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"265","DOI":"10.3109\/08820538.2010.518840","volume":"25","author":"Patel","year":"2010","journal-title":"Semin Ophthalmol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.ajo.2008.04.008","volume":"146","author":"Alvarado","year":"2008","journal-title":"Am J Ophthalmol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1097\/IJG.0b013e318294869b","volume":"23","author":"Ponnusamy","year":"2014","journal-title":"J Glaucoma"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/S0002-9394(99)00369-4","volume":"128","author":"Sommer","year":"1999","journal-title":"Am J Ophthalmol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.ajo.2010.09.026","volume":"151","author":"Krupin","year":"2011","journal-title":"Am J Ophthalmol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1602\/neurorx.2.1.99","volume":"2","author":"Schnyder","year":"2005","journal-title":"NeuroRx"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/s11051-008-9491-z","volume":"11","author":"Li","year":"2009","journal-title":"J Nanopart Res"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1038\/nbt1006-1211","volume":"24","author":"Wagner","year":"2006","journal-title":"Nat Biotechnol"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"457","DOI":"10.3129\/i10-090","volume":"45","author":"Zarbin","year":"2010","journal-title":"Can J Ophthalmol"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"188","DOI":"10.3389\/fphar.2012.00188","volume":"3","author":"Bucolo","year":"2012","journal-title":"Front Pharmacol"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.ajo.2010.03.019","volume":"150","author":"Zarbin","year":"2010","journal-title":"Am J Ophthalmol"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.drudis.2007.10.021","volume":"13","author":"Sahoo","year":"2008","journal-title":"Drug Discov Today"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"5762431","DOI":"10.1155\/2016\/5762431","volume":"2016","author":"Lu","year":"2016","journal-title":"J Nanomater"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"2998","DOI":"10.1021\/nn5002968","volume":"8","author":"Kim","year":"2014","journal-title":"ACS Nano"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1615\/CritRevTherDrugCarrierSyst.2014010123","volume":"31","author":"Goyal","year":"2014","journal-title":"Crit Rev Ther Drug Carrier Syst"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1097\/ICU.0b013e32835cfe92","volume":"24","author":"Pita-Thomas","year":"2013","journal-title":"Curr Opin Ophthalmol"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"204","DOI":"10.3109\/08982104.2014.881850","volume":"24","author":"Gaafar","year":"2014","journal-title":"J Liposome Res"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.addr.2017.04.001","volume":"122","author":"Janagam","year":"2017","journal-title":"Adv Drug Deliv Rev"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3109\/10717544.2014.903011","volume":"23","author":"Puglia","year":"2016","journal-title":"Drug Deliv"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"8238","DOI":"10.1038\/s41598-017-08843-9","volume":"7","author":"Kim","year":"2017","journal-title":"Sci Rep"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1021\/nn4046024","volume":"8","author":"Natarajan","year":"2014","journal-title":"ACS Nano"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1111\/jcmm.13110","volume":"21","author":"Salatin","year":"2017","journal-title":"J Cell Mol Med"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.2147\/IJN.S196681","volume":"14","author":"Nagai","year":"2019","journal-title":"Int J Nanomedicine"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"1802289","DOI":"10.1002\/advs.201802289","volume":"6","author":"Zhu","year":"2019","journal-title":"Adv Sci"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1002\/wnan.65","volume":"2","author":"Prow","year":"2010","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1093\/toxsci\/kft081","volume":"133","author":"Kim","year":"2013","journal-title":"Toxicol Sci"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2217\/17435889.1.3.297","volume":"1","author":"Immordino","year":"2006","journal-title":"Int J Nanomedicine"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"27135","DOI":"10.1074\/jbc.M200429200","volume":"277","author":"Mastrobattista","year":"2002","journal-title":"J Biol Chem"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0378-5173(99)00348-8","volume":"198","author":"Monem","year":"2000","journal-title":"Int J Pharm"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v26.i6.10","volume":"26","author":"Puri","year":"2009","journal-title":"Crit Rev Ther Drug Carrier Syst"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"35","DOI":"10.4103\/2230-973X.76727","volume":"1","author":"Jain","year":"2011","journal-title":"Int J Pharm Investig"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.ijpharm.2015.01.032","volume":"480","author":"Yu","year":"2015","journal-title":"Int J Pharm"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0168-3659(99)00192-3","volume":"63","author":"Law","year":"2000","journal-title":"J Control Release"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1208\/pt0801001","volume":"8","author":"Hathout","year":"2007","journal-title":"AAPS PharmSciTech"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1080\/026520499289211","volume":"16","author":"Velpandian","year":"1999","journal-title":"J Microencapsul"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3109\/03639040903099751","volume":"36","author":"Mehanna","year":"2010","journal-title":"Drug Dev Ind Pharm"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.ejpb.2012.10.014","volume":"83","author":"Sasaki","year":"2013","journal-title":"Eur J Pharm Biopharm"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/S0168-3659(02)00146-3","volume":"82","author":"Ruel-Gariepy","year":"2002","journal-title":"J Control Release"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.ijbiomac.2016.10.035","volume":"94","author":"Tan","year":"2017","journal-title":"Int J Biol Macromol"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"123","DOI":"10.2147\/IJN.S25468","volume":"7","author":"Natarajan","year":"2012","journal-title":"Int J Nanomedicine"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1148\/radiol.2292020500","volume":"229","author":"Li","year":"2003","journal-title":"Radiology"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/sj.gt.3301678","volume":"9","author":"Taniyama","year":"2002","journal-title":"Gene Ther"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/nrd1417","volume":"3","author":"Lindner","year":"2004","journal-title":"Nat Rev Drug Discov"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0378-5173(02)00044-3","volume":"237","author":"Mizoue","year":"2002","journal-title":"Int J Pharm"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.ijpharm.2011.11.001","volume":"422","author":"Sugano","year":"2012","journal-title":"Int J Pharm"},{"key":"ref97","first-page":"205","volume":"15","author":"Kouchak","year":"2016","journal-title":"Iran J Pharm Res"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1080\/03639045.2017.1386196","volume":"44","author":"Kouchak","year":"2018","journal-title":"Drug Dev Ind Pharm"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.ijpharm.2018.07.012","volume":"548","author":"Fahmy","year":"2018","journal-title":"Int J Pharm"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s13346-014-0196-9","volume":"4","author":"Wong","year":"2014","journal-title":"Drug Deliv Transl Res"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.cis.2012.08.002","volume":"183\u2013184","author":"Mahale","year":"2012","journal-title":"Adv Colloid Interface Sci"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1081\/DDC-120003445","volume":"28","author":"Kaur","year":"2002","journal-title":"Drug Dev Ind Pharm"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1007\/s00417-010-1383-0","volume":"248","author":"Kaur","year":"2010","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.ijpharm.2004.10.026","volume":"290","author":"Aggarwal","year":"2005","journal-title":"Int J Pharm"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ijpharm.2007.01.019","volume":"338","author":"Aggarwal","year":"2007","journal-title":"Int J Pharm"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijpharm.2003.09.016","volume":"269","author":"Kaur","year":"2004","journal-title":"Int J Pharm"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"34379","DOI":"10.1074\/jbc.M105250200","volume":"276","author":"Liu","year":"2001","journal-title":"J Biol Chem"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.jconrel.2008.12.018","volume":"136","author":"Nagarwal","year":"2009","journal-title":"J Control Release"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jconrel.2012.10.010","volume":"165","author":"Jung","year":"2013","journal-title":"J Control Release"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3109\/02652048609049580","volume":"3","author":"Harmia","year":"1986","journal-title":"J Microencapsul"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.msec.2016.10.017","volume":"71","author":"Rathod","year":"2017","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"ref112","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.3109\/03639045.2013.814061","volume":"40","author":"Singh","year":"2014","journal-title":"Drug Dev Ind Pharm"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.ejps.2009.07.008","volume":"38","author":"Nanjwade","year":"2009","journal-title":"Eur J Pharm Sci"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.ejmech.2009.10.017","volume":"45","author":"Spataro","year":"2010","journal-title":"Eur J Med Chem"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.jconrel.2004.09.015","volume":"102","author":"Vandamme","year":"2005","journal-title":"J Control Release"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1089\/jop.2012.0197","volume":"29","author":"Yang","year":"2013","journal-title":"J Ocul Pharmacol Ther"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"2966","DOI":"10.1021\/acs.molpharmaceut.6b00182","volume":"13","author":"Bravo-Osuna","year":"2016","journal-title":"Mol Pharm"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1007\/s10544-010-9417-2","volume":"12","author":"Chen","year":"2010","journal-title":"Biomed Microdevices"},{"key":"ref119","first-page":"51","volume":"46","author":"Weinreb","year":"1992","journal-title":"J Parenter Sci Technol"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0002-9394(14)76990-9","volume":"110","author":"Weinreb","year":"1990","journal-title":"Am J Ophthalmol"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3109\/10837450903002165","volume":"15","author":"Ranpise","year":"2010","journal-title":"Pharm Dev Technol"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1016\/j.addr.2005.07.005","volume":"57","author":"Ludwig","year":"2005","journal-title":"Adv Drug Deliv Rev"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"645","DOI":"10.3109\/10611861003622552","volume":"18","author":"Laza-Knoerr","year":"2010","journal-title":"J Drug Target"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1517\/17425247.2010.497536","volume":"7","author":"Granero","year":"2010","journal-title":"Expert Opin Drug Deliv"},{"key":"ref125","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.ejpb.2010.07.005","volume":"76","author":"Jansook","year":"2010","journal-title":"Eur J Pharm Biopharm"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3389\/fphar.2018.00091","volume":"9","author":"Wang","year":"2018","journal-title":"Front Pharmacol"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.ejpb.2015.04.032","volume":"95","author":"Rodriguez-Aller","year":"2015","journal-title":"Eur J Pharm Biopharm"},{"key":"ref128","doi-asserted-by":"publisher","first-page":"295","DOI":"10.2147\/ijn.s595","volume":"3","author":"Junghanns","year":"2008","journal-title":"Int J Nanomedicine"},{"key":"ref129","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1208\/s12249-013-9997-2","volume":"14","author":"Wu","year":"2013","journal-title":"AAPS PharmSciTech"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.ijpharm.2014.03.048","volume":"467","author":"Tuomela","year":"2014","journal-title":"Int J Pharm"},{"key":"ref131","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.ijbiomac.2018.11.217","volume":"124","author":"Orasugh","year":"2019","journal-title":"Int J Biol Macromol"},{"key":"ref132","doi-asserted-by":"publisher","first-page":"44229","DOI":"10.1038\/srep44229","volume":"7","author":"Ikuta","year":"2017","journal-title":"Sci Rep"},{"key":"ref133","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nnano.2011.209","volume":"7","author":"Mochalin","year":"2011","journal-title":"Nat Nanotechnol"},{"key":"ref134","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/S0142-9612(00)00237-4","volume":"22","author":"Lloyd","year":"2001","journal-title":"Biomaterials"},{"key":"ref135","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.supflu.2008.08.015","volume":"47","author":"Cocero","year":"2009","journal-title":"J Supercrit Fluid"},{"key":"ref136","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.3390\/ma11071125","volume":"11","author":"Choi","year":"2018","journal-title":"Materials (Basel)"},{"key":"ref137","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.jconrel.2012.06.017","volume":"162","author":"Peng","year":"2012","journal-title":"J Control Release"},{"key":"ref138","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1016\/j.biomaterials.2011.10.076","volume":"33","author":"Jung","year":"2012","journal-title":"Biomaterials"},{"key":"ref139","doi-asserted-by":"publisher","first-page":"292","DOI":"10.3109\/10611860903450023","volume":"18","author":"Wadhwa","year":"2010","journal-title":"J Drug Target"},{"key":"ref140","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/nrd3745","volume":"11","author":"Zhang","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"ref141","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.survophthal.2009.04.006","volume":"54","author":"Liang","year":"2009","journal-title":"Surv Ophthalmol"},{"key":"ref142","doi-asserted-by":"publisher","first-page":"14997","DOI":"10.1038\/ncomms14997","volume":"8","author":"Kim","year":"2017","journal-title":"Nat Commun"},{"key":"ref143","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1111\/j.1755-3768.2008.01404.x","volume":"87","author":"Leonardi","year":"2009","journal-title":"Acta Ophthalmol"},{"key":"ref144","doi-asserted-by":"publisher","first-page":"875","DOI":"10.2147\/OPTH.S109708","volume":"11","author":"Dunbar","year":"2017","journal-title":"Clin Ophthalmol"},{"key":"ref145","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/17434440.2020.1761788","author":"Enders","year":"2020","journal-title":"Expert Rev Med Devices"},{"key":"ref146","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1097\/IJG.0b013e318237caa2","volume":"22","author":"Salim","year":"2013","journal-title":"J Glaucoma"},{"key":"ref147","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1586\/erd.10.40","volume":"7","author":"Peng","year":"2010","journal-title":"Expert Rev Med Devices"},{"key":"ref148","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.jcrs.2015.02.002","volume":"41","author":"Spierer","year":"2015","journal-title":"J Cataract Refract Surg"},{"key":"ref149","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.1016\/j.jcrs.2014.03.034","volume":"40","author":"Masket","year":"2014","journal-title":"J Cataract Refract Surg"},{"key":"ref150","doi-asserted-by":"publisher","first-page":"238","DOI":"10.4103\/ijo.IJO_758_17","volume":"66","author":"Barliya","year":"2018","journal-title":"Indian J Ophthalmol"},{"key":"ref151","first-page":"79","volume":"9","author":"Preethi","year":"2017","journal-title":"Int J Pharm Pharm Sci"},{"key":"ref152","doi-asserted-by":"publisher","first-page":"757","DOI":"10.2147\/OPTH.S102181","volume":"10","author":"Perera","year":"2016","journal-title":"Clin Ophthalmol"},{"key":"ref153","unstructured":"A Phase 2 study evaluating safety and efficacy of the latanoprost punctal plug delivery system (L-PPDS) in subjects with ocular hypertension (OH) or open-angle glaucoma (OAG). 2019. https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2358808. Accessed June 11, 2020."},{"key":"ref154","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.2147\/OPTH.S134562","volume":"11","author":"Park","year":"2017","journal-title":"Clin Ophthalmol"},{"key":"ref155","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1109\/IEMBS.2006.260147","volume":"1","author":"Pan","year":"2006","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"ref156","doi-asserted-by":"publisher","first-page":"e67404","DOI":"10.1371\/journal.pone.0067404","volume":"8","author":"Paschalis","year":"2013","journal-title":"PLoS One"},{"key":"ref157","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1109\/TBME.2011.2179031","volume":"59","author":"Maleki","year":"2012","journal-title":"IEEE Trans Biomed Eng"},{"key":"ref158","doi-asserted-by":"publisher","first-page":"2394","DOI":"10.1007\/s10439-015-1309-4","volume":"43","author":"Harake","year":"2015","journal-title":"Ann Biomed Eng"},{"key":"ref159","volume":"2","author":"Abu-Hassan","year":"2014","journal-title":"J Ocul Biol"},{"key":"ref160","first-page":"17","author":"Gong","year":"2016","journal-title":"Glaucoma res clin adv"},{"key":"ref161","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s40135-019-00203-2","volume":"7","author":"Castro","year":"2019","journal-title":"Curr Ophthalmol Rep"},{"key":"ref162","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.2147\/CIA.S47350","volume":"8","author":"Hu","year":"2013","journal-title":"Clin Interv Aging"},{"key":"ref163","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3389\/fbioe.2019.00135","volume":"7","author":"Mobaraki","year":"2019","journal-title":"Front Bioeng Biotechnol"},{"key":"ref164","first-page":"714","volume":"21","author":"Alvarado","year":"1981","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref165","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/eye.1987.38","volume":"1","author":"Grierson","year":"1987","journal-title":"Eye (Lond)"},{"key":"ref166","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1167\/iovs.12-11056","volume":"54","author":"Du","year":"2013","journal-title":"Investophthalmol visual sci"},{"key":"ref167","doi-asserted-by":"publisher","first-page":"12251","DOI":"10.1038\/s41598-018-30834-7","volume":"8","author":"Snider","year":"2018","journal-title":"Sci Rep"},{"key":"ref168","doi-asserted-by":"crossref","first-page":"1803239","DOI":"10.1002\/smll.201803239","volume":"14","author":"Dillinger","year":"2018","journal-title":"Small"},{"key":"ref169","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.biomaterials.2015.06.034","volume":"65","author":"Dautriche","year":"2015","journal-title":"Biomaterials"},{"key":"ref170","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.biotechadv.2014.04.012","volume":"32","author":"Dautriche","year":"2014","journal-title":"Biotechnol adv"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1002\/bit.25899","volume":"113","author":"Torrejon","year":"2016","journal-title":"Biotechnol bioeng"},{"key":"ref172","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.actbio.2019.09.032","volume":"100","author":"Waduthanthri","year":"2019","journal-title":"Acta biomater"},{"key":"ref173","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/jps.20629","volume":"96","author":"Ward","year":"2007","journal-title":"J pharm sci"},{"key":"ref174","author":"Jiang","year":"2007","journal-title":""},{"key":"ref175","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jconrel.2011.06.023","volume":"156","author":"Checa-Casalengua","year":"2011","journal-title":"J Control Rel"},{"key":"ref176","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejps.2017.02.037","volume":"103","author":"Garc\u00eda-Caballero","year":"2017","journal-title":"Eur J Pharm Sci"},{"key":"ref177","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/bit.21822","volume":"100","author":"Nkansah","year":"2008","journal-title":"Biotechnol bioeng"},{"key":"ref178","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1002\/sctm.18-0263","volume":"8","author":"Eastlake","year":"2019","journal-title":"Stem Cells Transl Med"},{"key":"ref179","doi-asserted-by":"publisher","first-page":"13654","DOI":"10.1073\/pnas.0402129101","volume":"101","author":"Ooto","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref180","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1634\/stemcells.2006-0724","volume":"25","author":"Lawrence","year":"2007","journal-title":"Stem Cells"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=60388","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=60388","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T22:17:15Z","timestamp":1596665835000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/potential-therapeutic-usage-of-nanomedicine-for-glaucoma-treatment-peer-reviewed-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":180,"URL":"https:\/\/doi.org\/10.2147\/ijn.s254792","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8]]}}}