{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:16:35Z","timestamp":1788794195345,"version":"build-2803163510"},"reference-count":55,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s259993","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T20:01:12Z","timestamp":1598385672000},"page":"6503-6518","source":"Crossref","is-referenced-by-count":31,"title":["&lt;p&gt;A Non-Lipolysis Nanoemulsion Improved Oral Bioavailability by Reducing the First-Pass Metabolism of Raloxifene, and Related Absorption Mechanisms Being Studied&lt;\/p&gt;"],"prefix":"10.2147","volume":"Volume 15","author":[{"given":"Jing-Yi","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Yun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6362-5436","authenticated-orcid":true,"given":"Chuan-Li","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Rong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ban-Yi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2841-1795","authenticated-orcid":true,"given":"Chang-Shun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ying","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1007\/s00535-016-1207-z","volume":"51","author":"Oshima","year":"2016","journal-title":"J Gastroenterol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.ejpb.2017.05.008","volume":"126","author":"Goke","year":"2018","journal-title":"Eur J Pharm Biopharm"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1615\/CritRevTherDrugCarrierSyst.2013005964","volume":"30","author":"Kumar","year":"2013","journal-title":"Crit Rev Ther Drug Carrier Syst"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.jconrel.2010.10.013","volume":"149","author":"Gao","year":"2011","journal-title":"J Control Release"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1002\/jps.2600570710","volume":"57","author":"Conway","year":"1968","journal-title":"J Pharm Sci"},{"key":"ref6","first-page":"52","volume":"48","author":"Crocker","year":"1970","journal-title":"J Endocrinol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1124\/dmd.110.033936","volume":"38","author":"Liu","year":"2010","journal-title":"Drug Metab Dispos"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"15125","DOI":"10.1007\/s11356-017-9118-y","volume":"24","author":"Balasubramani","year":"2017","journal-title":"Environ Sci Pollut R"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1007\/s11095-006-0207-8","volume":"23","author":"Kalantzi","year":"2006","journal-title":"Pharm Res"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1194\/jlr.r200012-jlr200","volume":"43","author":"Lowe","year":"2002","journal-title":"J Lipid Res"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1981.240.1.G1","volume":"240","author":"Shiau","year":"1981","journal-title":"Am J Physiol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/359159a0","volume":"359","author":"van Tilbeurgh","year":"1992","journal-title":"Nature"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1007\/s11095-006-9607-z","volume":"23","author":"Persson","year":"2006","journal-title":"Pharm Res"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1016\/j.foodchem.2013.03.050","volume":"141","author":"Salvia-Trujillo","year":"2013","journal-title":"Food Chem"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"5623","DOI":"10.2147\/IJN.S203911","volume":"14","author":"Ye","year":"2019","journal-title":"Int J Nanomed"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"917","DOI":"10.3109\/00498254.2012.683497","volume":"42","author":"Thorn","year":"2012","journal-title":"Xenobiotica"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1002\/etc.5620210407","volume":"21","author":"Teeter","year":"2002","journal-title":"Environ Toxicol Chem"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1124\/dmd.104.001883","volume":"33","author":"Jeong","year":"2005","journal-title":"Drug Metab Dispos"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1124\/dmd.30.6.694","volume":"30","author":"Kemp","year":"2002","journal-title":"Drug Metab Dispos"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.ejps.2012.11.004","volume":"48","author":"Larsen","year":"2013","journal-title":"Eur J Pharm Sci"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1124\/jpet.102.044719","volume":"305","author":"Cummins","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"12620","DOI":"10.1021\/acsami.6b01680","volume":"8","author":"Miao","year":"2016","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.colsurfb.2017.02.024","volume":"153","author":"Khatri","year":"2017","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.ejps.2004.12.006","volume":"24","author":"Dahan","year":"2005","journal-title":"Eur J Pharm Sci"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.ejps.2008.07.003","volume":"35","author":"Lind","year":"2008","journal-title":"Eur J Pharm Sci"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.nano.2011.08.016","volume":"8","author":"Zhang","year":"2012","journal-title":"Nanomedicine"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1016\/j.foodchem.2015.08.125","volume":"194","author":"Giang","year":"2016","journal-title":"Food Chem"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.ejpb.2015.04.027","volume":"93","author":"Benito-Gallo","year":"2015","journal-title":"Eur J Pharm Biopharm"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.foodchem.2012.12.060","volume":"139","author":"Zhu","year":"2013","journal-title":"Food Chem"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/0005-2744(70)90181-6","volume":"212","author":"Brockerhoff","year":"1970","journal-title":"Biochim Biophys Acta"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1016\/s0959-8049(01)00171-x","volume":"37","author":"Gelderblom","year":"2001","journal-title":"Eur J Cancer"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1081\/DDC-100000125","volume":"27","author":"Alany","year":"2001","journal-title":"Drug Dev Ind Pharm"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"3783","DOI":"10.1021\/acs.molpharmaceut.6b00594","volume":"13","author":"Khan","year":"2016","journal-title":"Mol Pharm"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1021\/acs.molpharmaceut.6b00594","volume":"60","author":"Pouton","year":"2008","journal-title":"Adv Drug Deliv Rev"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"641","DOI":"10.3390\/pharmaceutics4040641","volume":"4","author":"Larsen","year":"2012","journal-title":"Pharmaceutics"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1007\/s11095-010-0309-1","volume":"28","author":"Anton","year":"2011","journal-title":"Pharm Res"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1002\/jps.21246","volume":"97","author":"Cuine","year":"2008","journal-title":"J Pharm Sci"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nrd2197","volume":"6","author":"Porter","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"143","DOI":"10.2174\/1389200003339171","volume":"1","author":"King","year":"2000","journal-title":"Curr Drug Metab"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1124\/dmd.116.072231.41","volume":"45","author":"Vaessen","year":"2017","journal-title":"Drug Metab Dispos"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1007\/s13346-018-0514-8","volume":"8","author":"Jain","year":"2018","journal-title":"Drug Deliv Transl Res"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"E1085","DOI":"10.3390\/nano10061085","volume":"10","author":"Murthy","year":"2020","journal-title":"Nanomaterials"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1021\/acs.molpharmaceut.7b01090","volume":"15","author":"Izgelov","year":"2018","journal-title":"Mol Pharm"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.addr.2007.10.014","volume":"60","author":"Porter","year":"2008","journal-title":"Adv Drug Deliv Rev"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"841","DOI":"10.4155\/tde.13.46","volume":"4","author":"McClements","year":"2013","journal-title":"Ther Deliv"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"2447","DOI":"10.1016\/j.xphs.2017.01.001","volume":"106","author":"El-Say","year":"2017","journal-title":"J Pharm Sci"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"4733","DOI":"10.1021\/acs.molpharmaceut.8b00699","volume":"15","author":"Alskar","year":"2018","journal-title":"Mol Pharm"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"016005","DOI":"10.1088\/1478-3975\/13\/1\/016005","volume":"13","author":"Banerjee","year":"2016","journal-title":"Phys Biol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.bbrc.2006.11.135","volume":"353","author":"Harush-Frenkel","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"12386","DOI":"10.1039\/c8nr02393j","volume":"10","author":"Ho","year":"2018","journal-title":"Nanoscale"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.ejpb.2013.12.015","volume":"87","author":"Ravi","year":"2014","journal-title":"Eur J Pharm Biopharm"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.ijpharm.2015.09.014","volume":"495","author":"Makwana","year":"2015","journal-title":"Int J Pharm"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1080\/1061186X.2017.1365875","volume":"26","author":"Garg","year":"2018","journal-title":"J Drug Target"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.ejps.2011.04.011","volume":"43","author":"Sun","year":"2011","journal-title":"Eur J Pharm Sci"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1002\/ar.1091940403","volume":"194","author":"Mak","year":"1979","journal-title":"Anat Rec"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=61048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=61048","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T20:01:14Z","timestamp":1598385674000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/a-non-lipolysis-nanoemulsion-improved-oral-bioavailability-by-reducing-peer-reviewed-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":55,"URL":"https:\/\/doi.org\/10.2147\/ijn.s259993","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8]]}}}