{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:16:33Z","timestamp":1778598993830,"version":"3.51.4"},"reference-count":91,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s270242","type":"journal-article","created":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T18:57:05Z","timestamp":1603047425000},"page":"7995-8018","source":"Crossref","is-referenced-by-count":41,"title":["<p>Zein\/Phospholipid Composite Nanoparticles for Successful Delivery of Gallic Acid into aHSCs: Influence of Size, Surface Charge, and Vitamin A Coupling<\/p>"],"prefix":"10.2147","volume":"Volume 15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6242-9545","authenticated-orcid":true,"given":"Shaimaa Ali Ali","family":"Radwan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walaa H","family":"El-Maadawy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7593-6001","authenticated-orcid":true,"given":"Carol","family":"Yousry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9454-7458","authenticated-orcid":true,"given":"Aliaa Nabil","family":"ElMeshad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raguia Aly","family":"Shoukri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2020,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1056\/NEJMra1504367","volume":"375","author":"Ge","year":"2016","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.bpg.2011.02.005","volume":"25","author":"Lee","year":"2011","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1055\/s-0036-1571295","volume":"36","author":"Yoon","year":"2016","journal-title":"Semin Liver Dis"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.addr.2017.05.007","volume":"121","author":"Higashi","year":"2017","journal-title":"Adv Drug Deliv Rev"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"47","DOI":"10.2174\/1573413052953110","volume":"1","author":"Vasir","year":"2005","journal-title":"Curr Nanosci"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.jconrel.2008.12.018","volume":"136","author":"Nagarwal","year":"2009","journal-title":"J Controlled Release"},{"key":"ref7","first-page":"364","volume":"3","author":"Bartneck","year":"2014","journal-title":"Hepatobiliary Surg Nutr"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"6997","DOI":"10.2147\/IJN.S145951","volume":"12","author":"Surendran","year":"2017","journal-title":"Int J Nanomedicine"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"119616","DOI":"10.1016\/j.biomaterials.2019.119616","volume":"230","author":"Fan","year":"2020","journal-title":"Biomaterials"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"7242","DOI":"10.3748\/wjg.v20.i23.7242","volume":"20","author":"Giannitrapani","year":"2014","journal-title":"World J Gastroenterol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.ejpb.2018.11.018","volume":"134","author":"Hassan","year":"2019","journal-title":"Eur J Pharm Biopharm"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.ijpharm.2010.11.025","volume":"404","author":"Lai","year":"2011","journal-title":"Int J Pharm"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1016\/j.foodchem.2006.10.054","volume":"103","author":"Ercisli","year":"2007","journal-title":"Food Chem"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1248\/bpb.30.1052","volume":"30","author":"Kim","year":"2007","journal-title":"Biol Pharm Bull"},{"key":"ref15","volume":"2018","author":"Chen","year":"2018","journal-title":"Biomed Res Int"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jtcme.2018.01.010","volume":"9","author":"El-Lakkany","year":"2019","journal-title":"J Tradit Complement Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s12013-013-9761-y","volume":"69","author":"Wang","year":"2014","journal-title":"Cell Biochem Biophys"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1007\/s11095-009-9926-y","volume":"26","author":"Kaur","year":"2009","journal-title":"Pharm Res"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.msec.2015.11.014","volume":"60","author":"Alves","year":"2016","journal-title":"Mater Sci Eng C"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1080\/10837450.2017.1344994","volume":"23","author":"Abdou","year":"2018","journal-title":"Pharm Dev Technol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1208\/s12249-013-9991-8","volume":"14","author":"Bhattacharyya","year":"2013","journal-title":"AAPS PharmSciTech"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"4691","DOI":"10.1016\/j.biomaterials.2003.10.084","volume":"25","author":"Dong","year":"2004","journal-title":"Biomaterials"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.ejps.2013.11.017","volume":"52","author":"Yang","year":"2014","journal-title":"Eur J Pharm Sci"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.colsurfb.2011.02.020","volume":"85","author":"Luo","year":"2011","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"3952","DOI":"10.1016\/j.biomaterials.2007.05.017","volume":"28","author":"Wang","year":"2007","journal-title":"Biomaterials"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.jcs.2004.12.005","volume":"41","author":"Guo","year":"2005","journal-title":"J Cereal Sci"},{"key":"ref27","first-page":"11","volume":"11","author":"Dai","year":"2016","journal-title":"PLoS One"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.jconrel.2017.09.035","volume":"266","author":"El-Mezayen","year":"2017","journal-title":"J Controlled Release"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.jconrel.2012.02.011","volume":"161","author":"Poelstra","year":"2012","journal-title":"J Controlled Release"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/nbt1396","volume":"26","author":"Sato","year":"2008","journal-title":"Nat Biotechnol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.jconrel.2018.05.032","volume":"283","author":"Qiao","year":"2018","journal-title":"J Controlled Release"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1002\/smll.201402870","volume":"11","author":"Duong","year":"2015","journal-title":"Small"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1706332","DOI":"10.1002\/adfm.201706332","volume":"28","author":"Hayashi","year":"2018","journal-title":"Adv Funct Mater"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1080\/03639045.2017.1318899","volume":"43","author":"Radwan","year":"2017","journal-title":"Drug Dev Ind Pharm"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1080\/10717544.2017.1410262","volume":"25","author":"Fahmy","year":"2018","journal-title":"Drug Deliv"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1007\/s11051-014-2285-6","volume":"16","author":"Rashidi","year":"2014","journal-title":"J Nanopart Res"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1080\/10408347.2015.1095064","volume":"46","author":"Fernandes","year":"2016","journal-title":"Crit Rev Anal Chem"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.3109\/03639045.2016.1171335","volume":"42","author":"Yousry","year":"2016","journal-title":"Drug Dev Ind Pharm"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"111121","DOI":"10.1016\/j.colsurfb.2020.111121","volume":"193","author":"Resende","year":"2020","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1166\/jbns.2015.1324","volume":"9","author":"Patil","year":"2015","journal-title":"J Bionanoscience"},{"key":"ref41","unstructured":"Pathan IK, Patel RK, Bhandari A. Standardization development and validation of spectrophotometric method for simultaneous estimation of embelin and gallic acid as individual and in combination in ayurvedic churna formulation. Asian J Pharm Clin Res. 2013;6(5):170\u2013175."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.jddst.2016.09.012","volume":"36","author":"Wang","year":"2016","journal-title":"J Drug Deliv Sci Technol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1002\/jps.2600521210","volume":"52","author":"Higuchi","year":"1963","journal-title":"J Pharm Sci"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/0378-5173(83)90064-9","volume":"15","author":"Korsmeyer","year":"1983","journal-title":"Int J Pharm"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/0378-5173(89)90306-2","volume":"57","author":"Peppas","year":"1989","journal-title":"Int J Pharm"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.ejps.2017.01.026","volume":"100","author":"Shaikh","year":"2017","journal-title":"Eur J Pharm Sci"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"3097","DOI":"10.1208\/s12249-018-1138-5","volume":"19","author":"Naseef","year":"2018","journal-title":"AAPS PharmSciTech"},{"key":"ref48","first-page":"e3917","volume":"64","author":"Shen","year":"2012","journal-title":"J Vis Exp"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1038\/nprot.2006.179","volume":"1","author":"Vichai","year":"2006","journal-title":"Nat Protoc"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1371\/journal.pone.0219752","volume":"14","author":"Boseila","year":"2019","journal-title":"PLoS One"},{"key":"ref51","first-page":"425","volume":"10","author":"Derakhshandeh","year":"2011","journal-title":"Iran J Pharm Res"},{"key":"ref52","first-page":"37","volume":"3","author":"Kardani","year":"2013","journal-title":"J Appl Pharm"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Martinotti S, Ranzato E. Scratch wound healing assay. 2019.","DOI":"10.1007\/7651_2019_259"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1111\/cpr.12195","volume":"48","author":"Siddiqui","year":"2015","journal-title":"Cell Prolif"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-020-02891-z","author":"Radwan","year":"2020","journal-title":"Pharm Res"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1016\/j.foodchem.2017.05.134","volume":"237","author":"Dai","year":"2017","journal-title":"Food Chem"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.ijpharm.2015.03.020","volume":"485","author":"Abdelbary","year":"2015","journal-title":"Int J Pharm"},{"key":"ref59","volume-title":"Pharmaceutics: The Science of Dosage Form Design","year":"2002"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.ijpharm.2013.07.032","volume":"454","author":"Zhang","year":"2013","journal-title":"Int J Pharm"},{"key":"ref61","first-page":"2810","volume":"4","author":"Dangi","year":"2013","journal-title":"Int J Pharm Life Sci"},{"key":"ref62","first-page":"2116","volume":"2","author":"Tripathi","year":"2010","journal-title":"Int J Pharm Tech Res"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1007\/s10856-013-4965-7","volume":"24","author":"Pardeshi","year":"2013","journal-title":"J Mater Sci Mater Med"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1039\/tf9393500716","volume":"35","author":"Cockbain","year":"1939","journal-title":"Trans Faraday Soc"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.jconrel.2005.06.006","volume":"107","author":"Manjunath","year":"2005","journal-title":"J Controlled Release"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1166\/jnn.2016.11671","volume":"16","author":"Silva","year":"2016","journal-title":"J Nanosci Nanotechnol"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S0927-7757(02)00404-1","volume":"214","author":"Proverbio","year":"2003","journal-title":"Colloids Surf a Physicochem Eng Asp"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.ijpharm.2005.09.023","volume":"306","author":"Guinedi","year":"2005","journal-title":"Int J Pharm"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.ijpharm.2006.03.040","volume":"319","author":"Kim","year":"2006","journal-title":"Int J Pharm"},{"key":"ref70","unstructured":"Wang JJ, Zeng ZW, Xiao RZ, et al. Recent advances of chitosan nanoparticles as drug carriers. Int J Nanomedicine. 2011;6:765."},{"key":"ref71","first-page":"035011","volume":"9","author":"Dahiya","year":"2018","journal-title":"Adv Nat Sci"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"465","DOI":"10.4103\/1735-5362.217427","volume":"12","author":"Shakiba","year":"2017","journal-title":"Res Pharm Sci"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.foodchem.2012.09.010","volume":"136","author":"Neo","year":"2013","journal-title":"Food Chem"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.foodchem.2016.04.138","volume":"210","author":"Sun","year":"2016","journal-title":"Food Chem"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ijpharm.2005.10.001","volume":"307","author":"Yanyu","year":"2006","journal-title":"Int J Pharm"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.ijpharm.2015.08.011","volume":"493","author":"Tadros","year":"2015","journal-title":"Int J Pharm"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.colsurfa.2016.08.043","volume":"508","author":"Lee","year":"2016","journal-title":"Colloids Surf a Physicochem Eng Asp"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0378-5173(01)00677-9","volume":"221","author":"Berbenni","year":"2001","journal-title":"Int J Pharm"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"4621","DOI":"10.1039\/C8FO00729B","volume":"9","author":"Jawad","year":"2018","journal-title":"Food Funct"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"S15","DOI":"10.1016\/j.jhep.2015.02.039","volume":"62","author":"Trautwein","year":"2015","journal-title":"J Hepatol"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1586\/egh.11.92","volume":"6","author":"Tacke","year":"2012","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/j.nano.2013.05.007","volume":"9","author":"Hsu","year":"2013","journal-title":"Nanomedicine"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.1021\/nn505166x","volume":"9","author":"Zhang","year":"2015","journal-title":"ACS Nano"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.jconrel.2006.04.014","volume":"114","author":"Lv","year":"2006","journal-title":"J Controlled Release"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.2147\/IJN.S154033","volume":"13","author":"Badawi","year":"2018","journal-title":"Int J Nanomedicine"},{"key":"ref86","first-page":"4395","volume":"33","author":"Hagen","year":"2013","journal-title":"Anticancer Res"},{"key":"ref87","first-page":"30","volume":"1","author":"Tang","year":"2007","journal-title":"Res J Med Sci"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s00535-016-1190-4","volume":"51","author":"Greuter","year":"2016","journal-title":"J Gastroenterol"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1111\/j.1572-0241.2005.40952.x","volume":"100","author":"C\u00e1rdenas","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1080\/10286020.2017.1384819","volume":"20","author":"Ghaznavi","year":"2018","journal-title":"J Asian Nat Prod Res"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.jfda.2017.05.001","volume":"25","author":"Asci","year":"2017","journal-title":"J Food Drug Anal"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/test.dovepress.com\/getfile.php?fileID=62651","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/test.dovepress.com\/getfile.php?fileID=62651","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T18:57:14Z","timestamp":1603047434000},"score":1,"resource":{"primary":{"URL":"https:\/\/test.dovepress.com\/zeinphospholipid-composite-nanoparticles-for-successful-delivery-of-ga-peer-reviewed-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":91,"URL":"https:\/\/doi.org\/10.2147\/ijn.s270242","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10]]}}}