{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:48:13Z","timestamp":1784306893675,"version":"3.55.0"},"reference-count":52,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s278885","type":"journal-article","created":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T22:22:12Z","timestamp":1613514132000},"page":"1231-1244","source":"Crossref","is-referenced-by-count":20,"title":["Iron Oxide Nanoparticles Combined with Cytosine Arabinoside Show Anti-Leukemia Stem Cell Effects on Acute Myeloid Leukemia by Regulating Reactive Oxygen Species"],"prefix":"10.2147","volume":"Volume 16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6944-5874","authenticated-orcid":true,"given":"Jun","family":"Dou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luoyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danfeng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2888-1490","authenticated-orcid":true,"given":"Hui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyang","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9722-0055","authenticated-orcid":true,"given":"Fengshu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"5278","DOI":"10.2174\/0929867326666190517114450","volume":"26","author":"Singh","year":"2019","journal-title":"Curr Med Chem"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s11864-020-00765-5","volume":"21","author":"Thol","year":"2020","journal-title":"Curr Treat Options Oncol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1021\/acs.molpharmaceut.6b01150","volume":"14","author":"Guo","year":"2017","journal-title":"Mol Pharm"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1038\/s41598-017-18932-4","volume":"8","author":"Mandal","year":"2018","journal-title":"Sci Rep"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"4309","DOI":"10.1158\/1078-0432.CCR-12-1424","volume":"19","author":"Nogueira","year":"2013","journal-title":"Clin Cancer Res"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"E532","DOI":"10.3390\/antiox9060532","volume":"9","author":"Shin","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"105450","DOI":"10.1016\/j.ejps.2020.105450","volume":"152","author":"Xiaotian","year":"2020","journal-title":"Eur J Pharm Sci"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"7856","DOI":"10.1039\/d0cs00379d","volume":"49","author":"Han","year":"2020","journal-title":"Chem Soc Rev"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.colsurfb.2017.02.004","volume":"153","author":"Srikanth Vallabani","year":"2017","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/nnano.2007.260","volume":"2","author":"Gao","year":"2007","journal-title":"Nat Nanotechnol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1039\/C6CC08542C","volume":"53","author":"Fan","year":"2016","journal-title":"Chem Commun (Camb)"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/nnano.2012.90","volume":"7","author":"Fan","year":"2012","journal-title":"Nat Nanotechnol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/nrc2981","volume":"11","author":"Cairns","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.molcel.2012.09.025","volume":"48","author":"Sena","year":"2012","journal-title":"Mol Cell"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1038\/nrd4002","volume":"12","author":"Gorrini","year":"2013","journal-title":"Nat Rev Drug Discov"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1007\/s11274-019-2742-6","volume":"35","author":"Gabrielyan","year":"2019","journal-title":"World J Microbiol Biotechnol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1111\/jam.14214","volume":"126","author":"Gabrielyan","year":"2019","journal-title":"J Appl Microbiol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"30551","DOI":"10.1021\/acsami.9b09323","volume":"11","author":"Chen","year":"2019","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1166\/jbn.2016.2269","volume":"12","author":"Li","year":"2016","journal-title":"J Biomed Nanotechnol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"e107315","DOI":"10.1371\/journal.pone.0107315","volume":"9","author":"Wani","year":"2014","journal-title":"PLoS One"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/nm0797-730","volume":"3","author":"Bonnet","year":"1997","journal-title":"Nat Med"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/84282","volume":"2","author":"Bhardwaj","year":"2001","journal-title":"Nat Immunol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/35102167","volume":"41","author":"Reya","year":"2001","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"45","DOI":"10.2217\/nnm.12.216","volume":"9","author":"Yang","year":"2014","journal-title":"Nanomedicine"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3109\/1061186X.2015.1052075","volume":"24","author":"Shi","year":"2016","journal-title":"J Drug Target"},{"key":"ref26","first-page":"528","volume":"4","author":"Dou","year":"2007","journal-title":"Cell Mol Immunol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2858","DOI":"10.1002\/stem.1795","volume":"32","author":"Zhang","year":"2014","journal-title":"Stem Cells"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"8838","DOI":"10.1073\/pnas.1320769111","volume":"111","author":"Dave","year":"2014","journal-title":"PANAS"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.jbiosc.2014.01.008","volume":"118","author":"Chen","year":"2014","journal-title":"J Biosci Bioeng"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1182\/blood-2003-09-3064","volume":"103","author":"Matsui","year":"2004","journal-title":"Blood"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s13287-018-0885-2","volume":"9","author":"Shi","year":"2018","journal-title":"Stem Cell Res Ther"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1186\/s12885-020-07119-2","volume":"20","author":"Alhuthali","year":"2020","journal-title":"BMC Cancer"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"E606","DOI":"10.3390\/antiox9070606","volume":"9","author":"Sedlic","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1002\/jcp.29128","volume":"235","author":"Li","year":"2020","journal-title":"J Cell Physiol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s13058-020-01264-z","volume":"22","author":"Li","year":"2020","journal-title":"Breast Cancer Res"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.imbio.2008.11.002","volume":"214","author":"Dou","year":"2009","journal-title":"Immunobiology"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1757-2215-7-8","volume":"7","author":"Zhang","year":"2014","journal-title":"J Ovarian Res"},{"key":"ref38","first-page":"OL1606","volume":"57 Suppl","author":"Wang","year":"2011","journal-title":"Cell Mol Biol (Noisy-Le-Grand)"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"27714","DOI":"10.18632\/oncotarget.4663","volume":"6","author":"Yang","year":"2015","journal-title":"Oncotarget"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1182\/blood.V79.8.2089.2089","volume":"79","author":"Sawyers","year":"1992","journal-title":"Blood"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2220\/biomedres.27.197","volume":"27","author":"Ouyang","year":"2006","journal-title":"Biomed Res"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.2147\/IJN.S38447","volume":"8","author":"Yang","year":"2013","journal-title":"Int J Nanomedicine"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"3333","DOI":"10.2147\/IJN.S249240","volume":"15","author":"Ayyanaar","year":"2020","journal-title":"Int J Nanomedicine"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.2147\/IJN.S194596","volume":"14","author":"Rahimi","year":"2019","journal-title":"Int J Nanomedicine"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1177\/0885328219836540","volume":"33","author":"Cheng","year":"2019","journal-title":"J Biomater Appl"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"3015","DOI":"10.1038\/emboj.2009.242","volume":"28","author":"Bensaad","year":"2009","journal-title":"EMBO J"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"2907","DOI":"10.3390\/molecules25122907","volume":"25","author":"Chen","year":"2020","journal-title":"Molecules"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1007\/s12011-019-1632-y","volume":"191","author":"Shokoofeh","year":"2019","journal-title":"Biol Trace Elem Res"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/s41467-018-08234-2","volume":"10","author":"Wu","year":"2019","journal-title":"Nat Commun"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-00649-z","author":"Cho","year":"2020","journal-title":"Cell Death Differ"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"e201900542","DOI":"10.26508\/lsa.201900542","volume":"3","author":"Benfield","year":"2020","journal-title":"Life Sci Alliance"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s13402-019-00437-z","volume":"42","author":"Gan","year":"2019","journal-title":"Cell Oncol"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=66726","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=66726","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T22:22:18Z","timestamp":1613514138000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/iron-oxide-nanoparticles-combined-with-cytosine-arabinoside-show-anti--peer-reviewed-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":52,"URL":"https:\/\/doi.org\/10.2147\/ijn.s278885","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]}}}