{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:03:45Z","timestamp":1788264225939,"version":"build-2803163510"},"reference-count":50,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s281029","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T16:41:18Z","timestamp":1608223278000},"page":"10331-10347","source":"Crossref","is-referenced-by-count":40,"title":["<p>The Synergistic Effect of Hyperthermia and Chemotherapy in Magnetite Nanomedicine-Based Lung Cancer Treatment<\/p>"],"prefix":"10.2147","volume":"Volume 15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4881-0040","authenticated-orcid":true,"given":"Shu-Jyuan","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Huan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Jium","family":"Shieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Cheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,12]]},"reference":[{"key":"ref1","first-page":"4989","volume":"9","author":"Shi","year":"2015","journal-title":"Drug Des Devel Ther"},{"key":"ref2","first-page":"189","volume":"1856","author":"Lemjabbar-Alaoui","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"220","DOI":"10.3322\/caac.21149","volume":"62","author":"Siegel","year":"2012","journal-title":"CA Cancer J Clin"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","volume":"740","author":"Dasari","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"ref5","first-page":"2","volume":"16","author":"Aisner","year":"1989","journal-title":"Semin Oncol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"8769","DOI":"10.2147\/IJN.S226254","volume":"14","author":"Khafaji","year":"2019","journal-title":"Int J Nanomedicine"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"195","DOI":"10.2217\/nnm-2016-0315","volume":"12","author":"Sudha","year":"2017","journal-title":"Nanomedicine (Lond)"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"11631","DOI":"10.1158\/0008-5472.CAN-05-1093","volume":"65","author":"Mamot","year":"2005","journal-title":"Cancer Res"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.jconrel.2005.09.039","volume":"109","author":"Park","year":"2005","journal-title":"J Control Release"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"18584","DOI":"10.1039\/C5NR05067G","volume":"7","author":"Jang","year":"2015","journal-title":"Nanoscale"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1002\/smll.201002300","volume":"7","author":"Ferris","year":"2011","journal-title":"Small"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"6323","DOI":"10.1002\/anie.200460800","volume":"43","author":"Nasongkla","year":"2004","journal-title":"Angew Chem Int Ed Engl"},{"key":"ref13","first-page":"1949","volume":"6","author":"Goren","year":"2000","journal-title":"Clin Cancer Res"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1021\/bc9004798","volume":"21","author":"Yang","year":"2010","journal-title":"Bioconjug Chem"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.3390\/ijms16011772","volume":"16","author":"Wong","year":"2015","journal-title":"Int J Mol Sci"},{"key":"ref16","first-page":"1","volume":"1","author":"Zwicke","year":"2012","journal-title":"Nano Rev"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1056\/NEJM199308123290708","volume":"329","author":"Simon","year":"1993","journal-title":"N Engl J Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1080\/02656736.2016.1262064","volume":"33","author":"Tan","year":"2017","journal-title":"Int J Hyperthermia"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.ctrv.2016.09.016","volume":"50","author":"Datta","year":"2016","journal-title":"Cancer Treat Rev"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.addr.2009.11.002","volume":"62","author":"Veiseh","year":"2010","journal-title":"Adv Drug Deliv Rev"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"14656","DOI":"10.1021\/acsami.6b02616","volume":"8","author":"Thorat","year":"2016","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"5168","DOI":"10.1002\/adma.201002219","volume":"22","author":"Liong","year":"2010","journal-title":"Adv Mater"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"8009","DOI":"10.1038\/ncomms9009","volume":"6","author":"Muthana","year":"2015","journal-title":"Nat Commun"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"4216","DOI":"10.1021\/ja900790v","volume":"131","author":"Xu","year":"2009","journal-title":"J Am Chem Soc"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"3818","DOI":"10.1002\/adfm.201504185","volume":"26","author":"Huang","year":"2016","journal-title":"Adv Funct Mater"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jcis.2016.11.014","volume":"490","author":"Mashhadi Malekzadeh","year":"2017","journal-title":"J Colloid Interface Sci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/B978-0-12-813855-7.00006-4","author":"Inozemtseva","year":"2018","journal-title":"Nanotechnol Biosensors"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1080\/02656730802104757","volume":"24","author":"Thiesen","year":"2008","journal-title":"Int J Hyperthermia"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"7234","DOI":"10.1021\/ja102489q","volume":"132","author":"Hu","year":"2010","journal-title":"J Am Chem Soc"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"6808","DOI":"10.1021\/acsnano.7b01762","volume":"11","author":"Tong","year":"2017","journal-title":"ACS Nano"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1080\/02656730110095609","volume":"18","author":"Moroz","year":"2002","journal-title":"Int J Hyperthermia"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1111\/j.1349-7006.1998.tb03283.x","volume":"89","author":"Yanase","year":"1998","journal-title":"Jpn J Cancer Res"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1002\/ijc.21061","volume":"116","author":"Tanaka","year":"2005","journal-title":"Int J Cancer"},{"key":"ref34","first-page":"51","volume":"10","author":"Granov","year":"2003","journal-title":"Vestn Ross Akad Med Nau"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.colsurfb.2015.10.014","volume":"136","author":"Fang","year":"2015","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1039\/C7TB03206D","volume":"6","author":"Xue","year":"2018","journal-title":"J Mater Chem B"},{"key":"ref37","first-page":"205","volume":"52","author":"Gholami","year":"2020","journal-title":"Drug Metab Rev"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0065-3233(08)60065-0","volume":"37","author":"Peters","year":"1985","journal-title":"Adv Protein Chem"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"6383","DOI":"10.1021\/acsnano.8b06542","volume":"13","author":"Albarqi","year":"2019","journal-title":"ACS Nano"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"102","DOI":"10.2310\/7290.2010.00037","volume":"10","author":"Mehrmohammadi","year":"2011","journal-title":"Mol Imaging"},{"key":"ref41","first-page":"86","volume":"45","author":"Boven","year":"1985","journal-title":"Cancer Res"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.ijbiomac.2016.06.014","volume":"91","author":"Hashad","year":"2016","journal-title":"Int J Biol Macromol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1002\/chir.20203","volume":"17","author":"Akasaka","year":"2005","journal-title":"Chirality"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.colsurfb.2018.10.043","volume":"173","author":"Tu","year":"2019","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"3801","DOI":"10.1039\/C6TB00778C","volume":"4","author":"Ishay","year":"2016","journal-title":"J Mater Chem B"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1080\/02656730110116713","volume":"18","author":"Rabin","year":"2002","journal-title":"Int J Hyperthermia"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"345101","DOI":"10.1088\/0957-4484\/22\/34\/345101","volume":"22","author":"Giustini","year":"2011","journal-title":"Nanotechnology"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1021\/acssensors.8b00785","volume":"3","author":"Chen","year":"2018","journal-title":"ACS Sens"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.lungcan.2017.09.002","volume":"113","author":"Kato","year":"2017","journal-title":"Lung Cancer"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1080\/02841860152703454","volume":"40","author":"Marinho","year":"2001","journal-title":"Acta Oncol"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=64968","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=64968","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T16:41:22Z","timestamp":1608223282000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/the-synergistic-effect-of-hyperthermia-and-chemotherapy-in-magnetite-n-peer-reviewed-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":50,"URL":"https:\/\/doi.org\/10.2147\/ijn.s281029","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12]]}}}