{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T06:10:08Z","timestamp":1775715008959,"version":"3.50.1"},"reference-count":29,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s287806","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T21:17:37Z","timestamp":1614719857000},"page":"1775-1787","source":"Crossref","is-referenced-by-count":23,"title":["A Carrier-Free Folate Receptor-Targeted Ursolic Acid\/Methotrexate Nanodelivery System for Synergetic Anticancer Therapy"],"prefix":"10.2147","volume":"Volume 16","author":[{"given":"Jin-Shuai","family":"Lan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Hong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui-Feng","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2442-8613","authenticated-orcid":true,"given":"Tong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney JY","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2021,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1158\/1055-9965.EPI-10-0437","volume":"19","author":"Jemal","year":"2010","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"179","DOI":"10.3109\/1061186X.2015.1051049","volume":"24","author":"Kumari","year":"2016","journal-title":"J Drug Target"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.3390\/ijms21103483","volume":"21","author":"Kozminski","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1007\/s00280-012-2062-0","volume":"71","author":"Abolmaali","year":"2013","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.det.2015.05.009","volume":"33","author":"Wood","year":"2015","journal-title":"Dermatol Clin"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1021\/acs.molpharmaceut.8b01335","volume":"16","author":"Zhang","year":"2019","journal-title":"Mol Pharm"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.msec.2017.07.036","volume":"81","author":"Ji","year":"2017","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"33894","DOI":"10.1038\/srep33894","volume":"6","author":"Zhu","year":"2016","journal-title":"Sci Rep"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1634\/theoncologist.2015-0164","volume":"21","author":"Howar","year":"2016","journal-title":"Oncologist"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.ijpharm.2015.04.014","volume":"487","author":"Ren","year":"2015","journal-title":"Int J Pharm"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"3547","DOI":"10.2147\/IJN.S79892","volume":"10","author":"Feng","year":"2015","journal-title":"Int J Nanomed"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1016\/j.drudis.2016.06.018","volume":"21","author":"Fumagalli","year":"2016","journal-title":"Drug Discov Today"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3389\/fbioe.2020.00127","volume":"8","author":"Yadav","year":"2020","journal-title":"Front Bioeng Biotechnol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"6827","DOI":"10.1021\/acsami.9b18443","volume":"12","author":"Wang","year":"2020","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1080\/14686996.2018.1553108","volume":"20","author":"Ariga","year":"2019","journal-title":"Sci Technol Adv Mater"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"614","DOI":"10.3390\/ma12040614","volume":"12","author":"Lu","year":"2019","journal-title":"Materials"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.ejmech.2016.01.026","volume":"111","author":"Dar","year":"2016","journal-title":"Eur J Med Chem"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1177\/1535370215616195","volume":"241","author":"Zhang","year":"2016","journal-title":"Exp Biol Med"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1080\/01480545.2016.1209680","volume":"40","author":"Bacanli","year":"2017","journal-title":"Drug Chem Toxicol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"3495","DOI":"10.1021\/acs.bioconjchem.8b00657","volume":"29","author":"Li","year":"2018","journal-title":"Bioconjug Chem"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"43508","DOI":"10.1021\/acsami.7b14755","volume":"9","author":"Guo","year":"2017","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.ijbiomac.2018.11.095","volume":"123","author":"Oliyaei","year":"2019","journal-title":"Int J Biol Macromol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"9121","DOI":"10.1039\/C7TB02562A","volume":"5","author":"Jiang","year":"2017","journal-title":"J Mater Chem B"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1080\/21691401.2018.1561457","volume":"47","author":"Jain","year":"2019","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"147","DOI":"10.2174\/2211738506666180706121515","volume":"6","author":"Fornaguera","year":"2018","journal-title":"Pharm Nanotechnol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"2582","DOI":"10.1021\/acs.langmuir.6b00302","volume":"32","author":"Liu","year":"2016","journal-title":"Langmuir"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2761","DOI":"10.1007\/s00018-017-2496-y","volume":"74","author":"Peppicelli","year":"2017","journal-title":"Cell Mol Life Sci"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"6780","DOI":"10.1021\/acs.biochem.8b00607","volume":"57","author":"Nogueira","year":"2018","journal-title":"Biochemistry"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.colsurfb.2018.07.013","volume":"170","author":"Soe","year":"2018","journal-title":"Colloids Surf B Biointerfaces"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=67299","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=67299","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T21:17:40Z","timestamp":1614719860000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/a-carrier-free-folate-receptor-targeted-ursolic-acidmethotrexate-nanod-peer-reviewed-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":29,"URL":"https:\/\/doi.org\/10.2147\/ijn.s287806","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3]]}}}