{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:24:39Z","timestamp":1784899479670,"version":"3.55.0"},"reference-count":41,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s313093","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T20:46:25Z","timestamp":1623703585000},"page":"4063-4072","source":"Crossref","is-referenced-by-count":46,"title":["Clinical, Biochemical and Molecular Evaluations of Ivermectin Mucoadhesive Nanosuspension Nasal Spray in Reducing Upper Respiratory Symptoms of Mild COVID-19"],"prefix":"10.2147","volume":"Volume 16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1803-735X","authenticated-orcid":true,"given":"Zaki F","family":"Aref","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7653-0006","authenticated-orcid":true,"given":"Shamardan Ezz Eldin S","family":"Bazeed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2698-9438","authenticated-orcid":true,"given":"Mohammed H","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8984-2957","authenticated-orcid":true,"given":"Abeer S","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Rashad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab G","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida A","family":"Abdelmaksoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"El-Sayed, A., Kamel, M. Coronaviruses in humans and animals: the role of bats in viral evolution. Environ Sci Pollut Res. 2021;28:19589\u201319600. doi:10.1007\/s11356-021-12553-1","DOI":"10.1007\/s11356-021-12553-1"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1208\/s12248-007-9000-9","volume":"10","author":"Gonz\u00e1lez Canga","year":"2008","journal-title":"AAPS J"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"23138","DOI":"10.1038\/srep23138","volume":"6","author":"G\u00f6tz","year":"2016","journal-title":"Sci Rep"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1042\/BJ20120150","volume":"443","author":"Wagstaff","year":"2012","journal-title":"Biochem J"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/07391102.2020.1802345","author":"Siddiqui","year":"2020","journal-title":"J Biomol Struct Dyn"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.3390\/plants9091244","volume":"9","author":"Siddiqui","year":"2020","journal-title":"Plants"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"37707","DOI":"10.1039\/D0RA06379G","volume":"10","author":"Surti","year":"2020","journal-title":"RSC Adv"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"8835986","DOI":"10.1155\/2020\/8835986","volume":"2020","author":"Alzahrani","year":"2020","journal-title":"Stem Cells Int"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1177\/1087057110390360","volume":"16","author":"Wagstaff","year":"2011","journal-title":"J Biomol Screen"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"104787","DOI":"10.1016\/j.antiviral.2020.104787","volume":"178","author":"Caly","year":"2020","journal-title":"Antiviral Res"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.diagmicrobio.2019.03.012","volume":"95","author":"Ketkar","year":"2019","journal-title":"Diagn Microbiol Infect Dis"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"119166","DOI":"10.1016\/j.ijpharm.2020.119166","volume":"579","author":"Alshweiat","year":"2020","journal-title":"Int J Pharm"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"6459","DOI":"10.2174\/0929867326666190827151741","volume":"26","author":"Alshweiat","year":"2019","journal-title":"Curr Med Chem"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"3023","DOI":"10.21873\/invivo.12134","volume":"34","author":"Lehrer","year":"2020","journal-title":"In Vivo"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"101613","DOI":"10.1016\/j.tmaid.2020.101613","volume":"35","author":"Rodriguez-Morales","year":"2020","journal-title":"Travel Med Infect Dis"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"3","DOI":"10.35663\/amp.2020.371.909","volume":"37","author":"Rodriguez-Morales","year":"2020","journal-title":"Acta Medica Peruana"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"101604","DOI":"10.1016\/j.tmaid.2020.101604","volume":"2020","author":"Gallego","year":"2020","journal-title":"Travel Med Infect Dis"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12011-020-02546-5","author":"Abdelmaksoud","year":"2021","journal-title":"Biol Trace Elem Res"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40779-020-00245-9","volume":"7","author":"Wang","year":"2020","journal-title":"Mil Med Res"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s13613-020-00661-z","volume":"10","author":"Li","year":"2020","journal-title":"Ann Intensive Care"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.cmi.2020.04.012","volume":"26","author":"Zhang","year":"2020","journal-title":"Clin Microbiol Infect"},{"key":"ref22","unstructured":"Ministry of Health and Population. Egyptian national guidelines for COVID-19. 2020. Available online: https:\/\/hiph.alexu.edu.eg\/images\/egyptian_national_guidelines_covid-19.pdf. Accessed December 1, 2020."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.ejps.2010.04.006","volume":"40","author":"Xia","year":"2010","journal-title":"Eur J Pharm Sci"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"93","DOI":"10.21608\/AEJI.2020.93432","volume":"10","author":"Hegazy","year":"2020","journal-title":"Afro-Egypt J Infect Endem Dis"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1093\/jac\/dks147","volume":"67","author":"Mastrangelo","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.antiviral.2013.10.004","volume":"100","author":"Lundberg","year":"2013","journal-title":"Antiviral Res"},{"key":"ref27","first-page":"597","volume":"28","author":"Azeem","year":"2015","journal-title":"Pak J Pharm Sci"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"21","DOI":"10.22159\/ajpcr.2020.v13i8.38357","volume":"13","author":"Jabeen","year":"2020","journal-title":"Asian J Pharm Clin Res"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.2147\/IDR.S263489","volume":"13","author":"Ghweil","year":"2020","journal-title":"Infect Drug Resist"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.03.005","author":"Liu","year":"2020","journal-title":"J Infect"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"m1327","DOI":"10.1136\/bmj.m1327","volume":"369","author":"Mahase","year":"2020","journal-title":"BMJ"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.ijid.2020.03.017","volume":"94","author":"Yang","year":"2020","journal-title":"Int J Infect Dis"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"6267","DOI":"10.1007\/s11356-020-12165-1","volume":"28","author":"Kumar","year":"2021","journal-title":"Environ Sci Pollut Res Int"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.2147\/IDR.S261159","volume":"13","author":"Aly","year":"2020","journal-title":"Infect Drug Resist"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.dsx.2020.05.013","volume":"14","author":"Marhl","year":"2020","journal-title":"Diabetes Metab Syndr"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.dsx.2020.04.004","volume":"14","author":"Singh","year":"2020","journal-title":"Diabetes Metab Syndr"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2020\/46795.0000","author":"Shouman","year":"2021","journal-title":"J Clin Diagn Res"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3329\/jbcps.v38i0.47512","volume":"38","author":"Alam","year":"2020","journal-title":"J Bangladesh Coll Phys Surg"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.chest.2020.10.009","volume":"159","author":"Rajter","year":"2021","journal-title":"Chest"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1208\/s12249-012-9896-y","volume":"14","author":"Saindane","year":"2013","journal-title":"Aaps Pharmscitech"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"2501","DOI":"10.1016\/j.xphs.2021.01.017","volume":"110","author":"Errecalde","year":"2021","journal-title":"J Pharm Sci"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=70515","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=70515","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T20:46:39Z","timestamp":1623703599000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/clinical-biochemical-and-molecular-evaluations-of-ivermectin-mucoadhes-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":41,"URL":"https:\/\/doi.org\/10.2147\/ijn.s313093","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]}}}