{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:26:59Z","timestamp":1781069219802,"version":"3.54.1"},"reference-count":35,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s318124","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T19:10:11Z","timestamp":1632165011000},"page":"6441-6453","source":"Crossref","is-referenced-by-count":15,"title":["Farnesylthiosalicylic Acid-Loaded Albumin Nanoparticle Alleviates Renal Fibrosis by Inhibiting Ras\/Raf1\/p38 Signaling Pathway"],"prefix":"10.2147","volume":"Volume 16","author":[{"given":"Hui","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinhui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiandan","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingnan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guorong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"s03","DOI":"10.1590\/1806-9282.66.S1.3","volume":"66","author":"Ammirati","year":"2020","journal-title":"Rev Assoc Med Bras"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.kint.2016.04.012","volume":"90","author":"Hallan","year":"2016","journal-title":"Kidney Int"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1146\/annurev-physiol-022516-034227","volume":"80","author":"Humphreys","year":"2018","journal-title":"Annu Rev Physiol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.tem.2016.06.004","volume":"27","author":"Lovisa","year":"2016","journal-title":"Trends Endocrinol Metab"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1038\/ki.2009.346","volume":"76","author":"Tan","year":"2009","journal-title":"Kidney Int"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/cr.2009.5","volume":"19","author":"Xu","year":"2009","journal-title":"Cell Res"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/s41586-019-1897-5","volume":"577","author":"Su","year":"2020","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1038\/nrd4281","volume":"13","author":"Samatar","year":"2014","journal-title":"Nat Rev Drug Discov"},{"key":"ref9","first-page":"341","volume":"18","author":"Rodr\u00edguez-Pe\u00f1a","year":"2005","journal-title":"J Nephrol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/ki.2009.498","volume":"77","author":"Grande","year":"2010","journal-title":"Kidney Int"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"14010","DOI":"10.1038\/s41598-019-50422-7","volume":"9","author":"Newbury","year":"2019","journal-title":"Sci Rep"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3389\/fcell.2015.00088","volume":"3","author":"Gaestel","year":"2015","journal-title":"Front Cell Dev Biol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"22263","DOI":"10.1074\/jbc.270.38.22263","volume":"270","author":"Marom","year":"1995","journal-title":"J Biol Chem"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"15047","DOI":"10.1038\/cddiscovery.2015.47","volume":"1","author":"Menachem","year":"2015","journal-title":"Cell Death Discov"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/s0168-8278(99)80318-3","volume":"31","author":"Reif","year":"1999","journal-title":"J Hepatol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.jhep.2004.04.010","volume":"41","author":"Reif","year":"2004","journal-title":"J Hepatol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1097\/01.asn.0000057543.55318.8b","volume":"14","author":"Clarke","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/s41577-019-0269-6","volume":"20","author":"Irvine","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.jconrel.2011.07.031","volume":"157","author":"Elzoghby","year":"2012","journal-title":"J Control Release"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1586\/ecp.11.7","volume":"4","author":"Montero","year":"2011","journal-title":"Expert Rev Clin Pharmacol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"3767","DOI":"10.2147\/DDDT.S88023","volume":"9","author":"Kundranda","year":"2015","journal-title":"Drug Des Devel Ther"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1038\/s41467-017-00834-8","volume":"8","author":"Guo","year":"2017","journal-title":"Nat Commun"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1021\/bc500292j","volume":"25","author":"Zhang","year":"2014","journal-title":"Bioconjug Chem"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1021\/bc300608h","volume":"24","author":"Zhang","year":"2013","journal-title":"Bioconjug Chem"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.jconrel.2020.01.017","volume":"320","author":"Li","year":"2020","journal-title":"J Control Release"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"4467","DOI":"10.1038\/s41467-020-18304-z","volume":"11","author":"Li","year":"2020","journal-title":"Nat Commun"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1038\/ki.2009.86","volume":"75","author":"Chevalier","year":"2009","journal-title":"Kidney Int"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s41232-017-0048-3","volume":"37","author":"Sato","year":"2017","journal-title":"Inflamm Regen"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/nrneph.2016.48","volume":"12","author":"Meng","year":"2016","journal-title":"Nat Rev Nephrol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1038\/s41467-019-09329-0","volume":"10","author":"Chen","year":"2019","journal-title":"Nat Commun"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.nano.2005.12.003","volume":"2","author":"Reis","year":"2006","journal-title":"Nanomedicine"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"6656","DOI":"10.1073\/pnas.1103573108","volume":"108","author":"Choi","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1002\/smll.200800003","volume":"5","author":"Schipper","year":"2009","journal-title":"Small"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.1097\/01.ASN.0000139478.03463.D9","volume":"15","author":"Lahdenkari","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1016\/j.yexcr.2006.03.008","volume":"312","author":"Martinez-Salgado","year":"2006","journal-title":"Exp Cell Res"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=73875","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=73875","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T19:10:14Z","timestamp":1632165014000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/farnesylthiosalicylic-acid-loaded-albumin-nanoparticle-alleviates-rena-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":35,"URL":"https:\/\/doi.org\/10.2147\/ijn.s318124","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9]]}}}