{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:33:32Z","timestamp":1790253212889,"version":"4.1.0"},"reference-count":34,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s323208","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T18:20:16Z","timestamp":1630693216000},"page":"6171-6182","source":"Crossref","is-referenced-by-count":32,"title":["Celastrol Niosome Hydrogel Has Anti-Inflammatory Effect on Skin Keratinocytes and Circulation without Systemic Drug Exposure in Psoriasis Mice"],"prefix":"10.2147","volume":"Volume 16","author":[{"given":"Fen","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengshuang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghua","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4555-2143","authenticated-orcid":true,"given":"Ying","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,9]]},"reference":[{"key":"ref1","unstructured":"Michalek IM, Loring B, John SM, Global report on psoriasis. World Health Organization; 2016."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s12016-016-8535-x","volume":"50","author":"Deng","year":"2016","journal-title":"Clin Rev Allergy Immunol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"16082","DOI":"10.1038\/nrdp.2016.82","volume":"2","author":"Greb","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.jconrel.2020.12.019","volume":"330","author":"Amani","year":"2021","journal-title":"J Control Release"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.3389\/fimmu.2018.01549","volume":"9","author":"Albanesi","year":"2018","journal-title":"Front Immunol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.immuni.2016.06.021","volume":"45","author":"Zhang","year":"2016","journal-title":"Immunity"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/1346-8138.15184","volume":"47","author":"Wang","year":"2020","journal-title":"J Dermatol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/S0140-6736(14)61909-7","volume":"386","author":"Boehncke","year":"2015","journal-title":"Lancet"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1080\/17425247.2016.1188801","volume":"13","author":"Hoffman","year":"2016","journal-title":"Expert Opin Drug Deliv"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1146\/annurev-med-042915-103905","volume":"68","author":"Kim","year":"2017","journal-title":"Annu Rev Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1111\/jdv.13614","volume":"30","author":"Wu","year":"2016","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.jaad.2008.12.032","volume":"60","author":"Menter","year":"2009","journal-title":"J Am Acad Dermatol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.ijpharm.2018.11.024","volume":"554","author":"Gu","year":"2019","journal-title":"Int J Pharm"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0889-857X(05)70118-6","volume":"26","author":"Tao","year":"2000","journal-title":"Rheumatic Dis Clin North America"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"443","DOI":"10.4103\/0366-6999.151069","volume":"128","author":"Wu","year":"2015","journal-title":"Chin Med J (Engl)"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"S585","DOI":"10.1080\/21691401.2018.1503599","volume":"46","author":"Kang","year":"2018","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.canlet.2010.10.025","volume":"303","author":"Kannaiyan","year":"2011","journal-title":"Cancer Lett"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.clim.2015.01.011","volume":"157","author":"Astry","year":"2015","journal-title":"Clin Immunol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3109\/07357900903095664","volume":"28","author":"Zhu","year":"2010","journal-title":"Cancer Invest"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.ijpharm.2017.10.053","volume":"535","author":"Freag","year":"2018","journal-title":"Int J Pharm"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.cis.2012.08.002","volume":"183\u2013184","author":"Mahale","year":"2012","journal-title":"Adv Colloid Interface Sci"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.apsb.2011.09.002","volume":"1","author":"Kumar","year":"2011","journal-title":"Acta Pharmaceutica Sinica B"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.ijpharm.2015.03.020","volume":"485","author":"Abdelbary","year":"2015","journal-title":"Int J Pharm"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"110352","DOI":"10.1016\/j.colsurfb.2019.110352","volume":"182","author":"Meng","year":"2019","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.jconrel.2017.03.385","volume":"254","author":"Sun","year":"2017","journal-title":"J Control Release"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"5836","DOI":"10.4049\/jimmunol.0802999","volume":"182","author":"van der Fits","year":"2009","journal-title":"J Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1080\/01926230600867743","volume":"34","author":"Cesta","year":"2006","journal-title":"Toxicol Pathol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"109398","DOI":"10.1016\/j.biopha.2019.109398","volume":"119","author":"Weng","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"101847","DOI":"10.1016\/j.jddst.2020.101847","volume":"59","author":"Algahtani","year":"2020","journal-title":"J Drug Deliv Sci Technol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"848","DOI":"10.3390\/nano10050848","volume":"10","author":"Algahtani","year":"2020","journal-title":"Nanomaterials (Basel)"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1080\/08982104.2016.1224897","volume":"27","author":"Jacob","year":"2017","journal-title":"J Liposome Res"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.it.2014.11.003","volume":"36","author":"Chang","year":"2015","journal-title":"Trends Immunol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.clindermatol.2007.08.013","volume":"25","author":"Albanesi","year":"2007","journal-title":"Clin Dermatol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.jconrel.2016.05.017","volume":"246","author":"Boakye","year":"2017","journal-title":"J Control Release"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=73315","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=73315","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T18:20:21Z","timestamp":1630693221000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/celastrol-niosome-hydrogel-has-anti-inflammatory-effect-on-skin-kerati-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":34,"URL":"https:\/\/doi.org\/10.2147\/ijn.s323208","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9]]}}}