{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:57:57Z","timestamp":1788562677191,"version":"build-2803163510"},"reference-count":45,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s374895","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T12:30:08Z","timestamp":1663936208000},"page":"4497-4508","source":"Crossref","is-referenced-by-count":18,"title":["Combined Shikonin-Loaded MPEG-PCL Micelles Inhibits Effective Transition of Endothelial-to-Mesenchymal Cells"],"prefix":"10.2147","volume":"Volume 17","author":[{"given":"Guanglin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxu","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zejun","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxuan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiye","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3407-6666","authenticated-orcid":true,"given":"Weirong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1055\/s-0033-1350934","volume":"79","author":"And\u00fajar","year":"2013","journal-title":"Planta Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1021\/np50045a014","volume":"49","author":"Tanaka","year":"1986","journal-title":"J Nat Prod"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.ejphar.2011.02.043","volume":"658","author":"Lu","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.bbrc.2006.12.214","volume":"354","author":"Calonghi","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.3892\/or.2019.6966","volume":"41","author":"Xu","year":"2019","journal-title":"Oncol Rep"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.foodchem.2007.01.031","volume":"106","author":"Han","year":"2008","journal-title":"Food Chem"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.foodchem.2003.12.017","volume":"87","author":"Assimopoulu","year":"2004","journal-title":"Food Chem"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"570441","DOI":"10.3389\/fphys.2020.570441","volume":"11","author":"Guo","year":"2020","journal-title":"Front Physiol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1016\/j.biopha.2017.06.086","volume":"93","author":"Yang","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41401-019-0308-7","volume":"41","author":"L\u00fc","year":"2020","journal-title":"Acta Pharmacol Sin"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1002\/bmc.310","volume":"18","author":"Assimopoulou","year":"2004","journal-title":"Biomed Chromatogr"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/0378-5173(96)04634-0","volume":"141","author":"Chen","year":"1996","journal-title":"Int J Pharm"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"10834","DOI":"10.1021\/jf303153d","volume":"60","author":"Albreht","year":"2012","journal-title":"J Agric Food Chem"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"645","DOI":"10.3389\/fchem.2018.00645","volume":"6","author":"Yorulmaz Avsar","year":"2019","journal-title":"Front Chem"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1142411","DOI":"10.1080\/2331205X.2016.1142411","volume":"3","author":"Danafar","year":"2016","journal-title":"Cogent Med"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/s0168-3659(01)00299-1","volume":"73","author":"Torchilin","year":"2001","journal-title":"J Control Release"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1208\/s12249-018-1009-0","volume":"19","author":"Wei","year":"2018","journal-title":"AAPS PharmSciTech"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nri3800","volume":"15","author":"Epelman","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1586\/14779072.2016.1128828","volume":"14","author":"Gregersen","year":"2016","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/0140-6736(92)93147-f","volume":"340","author":"Celermajer","year":"1992","journal-title":"Lancet"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"294","DOI":"10.3389\/fimmu.2018.00294","volume":"9","author":"Cho","year":"2018","journal-title":"Front Immunol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1161\/CIRCRESAHA.119.314813","volume":"124","author":"Bischoff","year":"2019","journal-title":"Circ Res"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"627","DOI":"10.14202\/vetworld.2018.627-635","volume":"11","author":"Abdulkhaleq","year":"2018","journal-title":"Vet World"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"4514","DOI":"10.1172\/JCI82719","volume":"125","author":"Chen","year":"2015","journal-title":"J Clin Invest"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.cytogfr.2016.09.002","volume":"33","author":"P\u00e9rez","year":"2017","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"114716","DOI":"10.1016\/j.bcp.2021.114716","volume":"192","author":"Chen","year":"2021","journal-title":"Biochem Pharmacol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.jconrel.2004.03.026","volume":"97","author":"Sant","year":"2004","journal-title":"J Control Release"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"5527","DOI":"10.1039\/c1cc10605h","volume":"47","author":"Cai","year":"2011","journal-title":"Chem Commun (Camb)"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.colsurfb.2015.12.053","volume":"140","author":"Li","year":"2016","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"2571","DOI":"10.1039\/d0bm01599g","volume":"9","author":"Li","year":"2021","journal-title":"Biomater Sci"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.2147\/IJN.S290263","volume":"16","author":"Wang","year":"2021","journal-title":"Int J Nanomedicine"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.ijpharm.2017.05.054","volume":"533","author":"Dimchevska","year":"2017","journal-title":"Int J Pharm"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"5849","DOI":"10.2147\/IJN.S73111","volume":"9","author":"Zhao","year":"2014","journal-title":"Int J Nanomedicine"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"S91","DOI":"10.1007\/BF02493361","volume":"55","author":"Brodie","year":"2002","journal-title":"Chromatographia"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"4591","DOI":"10.2147\/IJN.S245188","volume":"15","author":"Li","year":"2020","journal-title":"Int J Nanomedicine"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.3390\/polym10101127","volume":"10","author":"Zhai","year":"2018","journal-title":"Polymers"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"110516","DOI":"10.1016\/j.biopha.2020.110516","volume":"130","author":"Kong","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.3390\/nano10122490","volume":"10","author":"Bikiaris","year":"2020","journal-title":"Nanomaterials"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/j.jconrel.2020.11.008","volume":"330","author":"Repp","year":"2021","journal-title":"J Control Release"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.jconrel.2018.08.034","volume":"287","author":"Deshantri","year":"2018","journal-title":"J Control Release"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0927-7765(99)00058-2","volume":"16","author":"Allen","year":"1999","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1080\/10837450.2018.1556689","volume":"24","author":"Zamani","year":"2019","journal-title":"Pharm Dev Technol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1007\/s11595-020-2368-4","volume":"35","author":"Liu","year":"2020","journal-title":"J Wuhan Univ Technol-Mater Sci Ed"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.jconrel.2005.10.008","volume":"110","author":"Forrest","year":"2006","journal-title":"J Control Release"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"e10675","DOI":"10.7717\/peerj.10675","volume":"9","author":"Han","year":"2021","journal-title":"PeerJ"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=84216","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=84216","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T12:30:11Z","timestamp":1663936211000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/combined-shikonin-loaded-mpeg-pcl-micelles-inhibits-effective-transiti-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":45,"URL":"https:\/\/doi.org\/10.2147\/ijn.s374895","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9]]}}}