{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:43:27Z","timestamp":1783485807945,"version":"3.55.0"},"reference-count":59,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s388234","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T08:31:42Z","timestamp":1670315502000},"page":"6031-6046","source":"Crossref","is-referenced-by-count":13,"title":["Combined Ibuprofen-Nanoconjugate Micelles with E-Selectin for Effective Sunitinib Anticancer Therapy"],"prefix":"10.2147","volume":"Volume 17","author":[{"given":"Xianhu","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunrong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8154-6221","authenticated-orcid":true,"given":"Zhipeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0365-1151","authenticated-orcid":true,"given":"Yong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9195-7972","authenticated-orcid":true,"given":"Shangcong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,12]]},"reference":[{"key":"ref1","volume-title":"Focus on Kidney Cancer Research","year":"2005"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1093\/annonc\/mdw186","volume":"27","author":"Scelo","year":"2016","journal-title":"Ann Oncol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/sj.ki.5000065","volume":"69","author":"Weiss","year":"2006","journal-title":"Kidney Int"},{"key":"ref4","first-page":"263","volume":"15","author":"Thoma","year":"2018","journal-title":"Nat Rev Urol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/nrclinonc.2009.94","volume":"6","author":"Chen","year":"2009","journal-title":"Nat Rev Clin Oncol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1056\/NEJMc1811532","volume":"379","author":"Bex","year":"2018","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1093\/annonc\/mdx014","volume":"28","author":"Bex","year":"2017","journal-title":"Ann Oncol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1016\/j.cmet.2021.08.012","volume":"33","author":"Wei","year":"2021","journal-title":"Cell Metab"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.eururo.2021.06.009","volume":"80","author":"Mejean","year":"2021","journal-title":"Eur Urol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/nrurol.2017.36","volume":"14","author":"Czarnecka","year":"2017","journal-title":"Nat Rev Urol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1093\/annonc\/mdp291","volume":"21","author":"Blay","year":"2010","journal-title":"Ann Oncol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1016\/S0140-6736(07)61865-0","volume":"370","author":"Chu","year":"2007","journal-title":"Lancet"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e27","DOI":"10.1056\/NEJMicm1309906","volume":"370","author":"Brzezniak","year":"2014","journal-title":"N Engl J Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"3137","DOI":"10.1093\/annonc\/mds145","volume":"23","author":"Poprach","year":"2012","journal-title":"Ann Oncol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1093\/annonc\/mdn389","volume":"19","author":"Lacouture","year":"2008","journal-title":"Ann Oncol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.addr.2020.09.009","volume":"156","author":"Hwang","year":"2020","journal-title":"Adv Drug Deliver Rev"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.jconrel.2014.05.001","volume":"190","author":"Duncan","year":"2014","journal-title":"J Control Release"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.jconrel.2021.02.016","volume":"332","author":"Ghosh","year":"2021","journal-title":"J Control Release"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.jconrel.2021.02.031","volume":"332","author":"Ghezzi","year":"2021","journal-title":"J Control Release"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"4629","DOI":"10.7150\/thno.72465","volume":"12","author":"Zhang","year":"2022","journal-title":"Theranostics"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.3389\/fimmu.2019.01713","volume":"10","author":"Schulz","year":"2019","journal-title":"Front Immunol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"6638","DOI":"10.1158\/0008-5472.CAN-06-0661","volume":"66","author":"Jain","year":"2006","journal-title":"Cancer Res"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1158\/1078-0432.CCR-09-0788","volume":"16","author":"Menter","year":"2010","journal-title":"Clin Cancer Res"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1476-4598-3-7","volume":"3","author":"St-Germain","year":"2004","journal-title":"Mol Cancer"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1053\/j.gastro.2009.01.010","volume":"136","author":"Young","year":"2009","journal-title":"Gastroenterology"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1172\/JCI119400","volume":"99","author":"Sheng","year":"1997","journal-title":"J Clin Invest"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"4735","DOI":"10.1038\/s41388-018-0318-9","volume":"37","author":"Garg","year":"2018","journal-title":"Oncogene"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"11127","DOI":"10.1073\/pnas.1410432111","volume":"111","author":"Zhang","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"4597","DOI":"10.1038\/onc.2017.82","volume":"36","author":"Ko","year":"2017","journal-title":"Oncogene"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1002\/ijc.1376","volume":"93","author":"Rozic","year":"2001","journal-title":"Int J Cancer"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1053\/j.gastro.2021.09.059","volume":"161","author":"Wang","year":"2021","journal-title":"Gastroenterology"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.ctrv.2004.01.001","volume":"30","author":"Scartozzi","year":"2004","journal-title":"Cancer Treat Rev"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1016\/S0140-6736(89)91869-2","volume":"2","author":"Doogan","year":"1989","journal-title":"Lancet"},{"key":"ref34","first-page":"559","volume":"13","author":"Harris","year":"2005","journal-title":"Oncol Rep"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.7150\/thno.19571","volume":"7","author":"Hu","year":"2017","journal-title":"Theranostics"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.tips.2021.09.002","volume":"42","author":"Lunemann","year":"2021","journal-title":"Trends Pharmacol Sci"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120780","volume":"272","author":"Grun","year":"2021","journal-title":"Biomaterials"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"11532","DOI":"10.1002\/anie.201406685","volume":"53","author":"Wang","year":"2014","journal-title":"Angew Chem Int Edit"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"7591","DOI":"10.1021\/acsnano.9b00467","volume":"13","author":"Yongvongsoontorn","year":"2019","journal-title":"Acs Nano"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.actbio.2022.01.004","volume":"141","author":"Song","year":"2022","journal-title":"Acta Biomater"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"117719","DOI":"10.1016\/j.carbpol.2021.117719","volume":"258","author":"Jafari","year":"2021","journal-title":"Carbohydr Polym"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"120432","DOI":"10.1016\/j.biomaterials.2020.120432","volume":"266","author":"Liang","year":"2021","journal-title":"Biomaterials"},{"key":"ref43","first-page":"1","volume":"401","author":"Zhang","year":"2021","journal-title":"J Hazard Mater"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.jhazmat.2018.11.111","volume":"366","author":"Abbasi Kajani","year":"2019","journal-title":"J Hazard Mater"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1186\/s12951-022-01422-9","volume":"20","author":"Zhu","year":"2022","journal-title":"J Nanobiotechnology"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.biomaterials.2018.01.004","volume":"159","author":"Song","year":"2018","journal-title":"Biomaterials"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/s41467-021-27750-2","volume":"13","author":"Xu","year":"2022","journal-title":"Nat Commun"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"5427","DOI":"10.1021\/acsnano.1c09367","volume":"16","author":"Bazylinska","year":"2022","journal-title":"Acs Nano"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.biomaterials.2009.09.060","volume":"31","author":"Huang","year":"2010","journal-title":"Biomaterials"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.jconrel.2022.06.060","volume":"349","author":"Zang","year":"2022","journal-title":"J Control Release"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"103520","DOI":"10.1016\/j.jddst.2022.103520","volume":"74","author":"Li Yanfeng","year":"2022","journal-title":"J Drug Deliv Sci Technol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1158\/1078-0432.CCR-09-0583","volume":"16","author":"Daneau","year":"2010","journal-title":"Clin Cancer Res"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/1476-4598-9-43","volume":"9","author":"Liu","year":"2010","journal-title":"Mol Cancer"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.immuni.2007.04.011","volume":"26","author":"Zarbock","year":"2007","journal-title":"Immunity"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1080\/10717544.2022.2055225","volume":"29","author":"Li","year":"2022","journal-title":"Drug Deliv"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1039\/D2TB00197G","volume":"10","author":"Zang","year":"2022","journal-title":"J Mater Chem B"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"2510","DOI":"10.1158\/1078-0432.CCR-04-1776","volume":"11","author":"Dudderidge","year":"2005","journal-title":"Clin Cancer Res"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.2967\/jnumed.111.091629","volume":"52","author":"Blankenberg","year":"2011","journal-title":"J Nucl Med"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jconrel.2020.03.023","volume":"322","author":"Wang","year":"2020","journal-title":"J Control Release"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=85931","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=85931","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T08:31:47Z","timestamp":1670315507000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/combined-ibuprofen-nanoconjugate-micelles-with-e-selectin-for-effectiv-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":59,"URL":"https:\/\/doi.org\/10.2147\/ijn.s388234","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12]]}}}