{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:19:31Z","timestamp":1790230771780,"version":"4.1.0"},"reference-count":58,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s393346","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T11:55:13Z","timestamp":1676548513000},"page":"843-859","source":"Crossref","is-referenced-by-count":25,"title":["Huperzine A-Liposomes Efficiently Improve Neural Injury in the Hippocampus of Mice with Chronic Intermittent Hypoxia"],"prefix":"10.2147","volume":"Volume 18","author":[{"given":"Xin-Yue","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronghui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Xian","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui-Ling","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5274-8289","authenticated-orcid":true,"given":"Ji-Ren","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Fan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0679-0897","authenticated-orcid":true,"given":"Shan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Jing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5793-5574","authenticated-orcid":true,"given":"Yashuo","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5858-7567","authenticated-orcid":true,"given":"En-Sheng","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"S255","DOI":"10.3233\/JAD-179936","volume":"64","author":"Andrade","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"784045","DOI":"10.3389\/fncel.2021.784045","volume":"15","author":"Xu","year":"2021","journal-title":"Front Cell Neurosci"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.patbio.2014.05.015","volume":"62","author":"Gagnon","year":"2014","journal-title":"Pathol Biol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"8520967","DOI":"10.1155\/2021\/8520967","volume":"2021","author":"Zhao","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/S2213-2600(19)30198-5","volume":"7","author":"Benjafield","year":"2019","journal-title":"Lancet Respir Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1586\/17476348.2.3.349","volume":"2","author":"Lee","year":"2008","journal-title":"Expert Rev Respir Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/S2213-2600(15)00090-9","volume":"3","author":"Rosenzweig","year":"2015","journal-title":"Lancet Respir Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1089\/ars.2014.6122","volume":"23","author":"Xu","year":"2015","journal-title":"Antioxid Redox Signal"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1523\/JNEUROSCI.1359-18.2018","volume":"39","author":"Khuu","year":"2019","journal-title":"J Neurosci"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"325","DOI":"10.3233\/JAD-130419","volume":"37","author":"Shiota","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1152\/japplphysiol.00332.2022","volume":"133","author":"Marciante","year":"2022","journal-title":"J Appl Physiol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.biopsych.2021.02.973","volume":"91","author":"Kazim","year":"2022","journal-title":"Biol Psychiatry"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-022-02671-6","author":"Wang","year":"2022","journal-title":"Sleep Breath"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.nbd.2013.08.016","volume":"62","author":"Wall","year":"2014","journal-title":"Neurobiol Dis"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"7415212","DOI":"10.1155\/2019\/7415212","volume":"2019","author":"Zhao","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"117573","DOI":"10.1016\/j.lfs.2020.117573","volume":"250","author":"An","year":"2020","journal-title":"Life Sci"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1038\/s41419-021-03725-5","volume":"12","author":"Wang","year":"2021","journal-title":"Cell Death Dis"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/s41419-022-05043-w","volume":"13","author":"You","year":"2022","journal-title":"Cell Death Dis"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"e2676","DOI":"10.1038\/cddis.2017.93","volume":"8","author":"You","year":"2017","journal-title":"Cell Death Dis"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"365","DOI":"10.3390\/biom12030365","volume":"12","author":"Kwan","year":"2022","journal-title":"Biomolecules"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.cbi.2008.04.049","volume":"175","author":"Zhang","year":"2008","journal-title":"Chem Biol Interact"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1038\/aps.2016.78","volume":"37","author":"Tao","year":"2016","journal-title":"Acta Pharmacol Sin"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/j.neurobiolaging.2013.11.004","volume":"35","author":"Huang","year":"2014","journal-title":"Neurobiol Aging"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"5294","DOI":"10.3390\/molecules25225294","volume":"25","author":"Zorkina","year":"2020","journal-title":"Molecules"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"8279","DOI":"10.2147\/IJN.S340180","volume":"16","author":"Sun","year":"2021","journal-title":"Int J Nanomedicine"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.jconrel.2016.01.017","volume":"224","author":"Zhao","year":"2016","journal-title":"J Control Release"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2018.05.082","volume":"124","author":"Zhao","year":"2018","journal-title":"Free Radic Biol Med"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s12951-017-0277-2","volume":"15","author":"Guo","year":"2017","journal-title":"J Nanobiotechnology"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.2147\/IJN.S346948","volume":"17","author":"Kong","year":"2022","journal-title":"Int J Nanomedicine"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"9452","DOI":"10.1039\/C7TB01689A","volume":"5","author":"Amani","year":"2017","journal-title":"J Mater Chem B"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"11386","DOI":"10.1021\/acsanm.1c01907","volume":"4","author":"Afshari","year":"2021","journal-title":"ACS Appl Nano Mater"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"104811","DOI":"10.1016\/j.chemphyslip.2019.104811","volume":"225","author":"Wang","year":"2019","journal-title":"Chem Phys Lipids"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.neurobiolaging.2019.05.016","volume":"81","author":"Xiao","year":"2019","journal-title":"Neurobiol Aging"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1080\/13880209.2022.2043392","volume":"60","author":"Song","year":"2022","journal-title":"Pharm Biol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"3041","DOI":"10.1016\/j.xphs.2017.05.022","volume":"106","author":"Kandzija","year":"2017","journal-title":"J Pharm Sci"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1080\/10717544.2020.1797240","volume":"27","author":"Yan","year":"2020","journal-title":"Drug Deliv"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.apsb.2017.02.002","volume":"7","author":"Li","year":"2017","journal-title":"Acta Pharm Sin B"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"9217","DOI":"10.2147\/IJN.S214657","volume":"14","author":"Jiang","year":"2019","journal-title":"Int J Nanomedicine"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1111\/ejn.15635","volume":"55","author":"Huang","year":"2022","journal-title":"Eur J Neurosci"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/0896-6273(92)90245-9","volume":"9","author":"Cho","year":"1992","journal-title":"Neuron"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"4709","DOI":"10.1038\/s41467-021-25058-9","volume":"12","author":"Tian","year":"2021","journal-title":"Nat Commun"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"7130","DOI":"10.1021\/acs.jafc.2c02140","volume":"70","author":"Yan","year":"2022","journal-title":"J Agric Food Chem"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.nlm.2007.08.018","volume":"89","author":"Lu","year":"2008","journal-title":"Neurobiol Learn Mem"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.nbd.2010.05.020","volume":"40","author":"Xie","year":"2010","journal-title":"Neurobiol Dis"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"e0227834","DOI":"10.1371\/journal.pone.0227834","volume":"15","author":"Flores","year":"2020","journal-title":"PLoS One"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"8861903","DOI":"10.1155\/2020\/8861903","volume":"2020","author":"Xu","year":"2020","journal-title":"Neural Plast"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"723922","DOI":"10.3389\/fphar.2021.723922","volume":"12","author":"Li","year":"2021","journal-title":"Front Pharmacol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1038\/nn.4147","volume":"18","author":"Fei","year":"2015","journal-title":"Nat Neurosci"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"389","DOI":"10.2174\/1871527317666180525113109","volume":"17","author":"Wang","year":"2018","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"833","DOI":"10.3233\/JAD-130278","volume":"35","author":"Rispoli","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.pbb.2017.06.002","volume":"158","author":"Du","year":"2017","journal-title":"Pharmacol Biochem Behav"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1089\/ars.2016.6883","volume":"28","author":"Zhao","year":"2018","journal-title":"Antioxid Redox Signal"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.3389\/fphar.2019.01312","volume":"10","author":"De la fuente-ortega","year":"2019","journal-title":"Front Pharmacol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"5574","DOI":"10.1007\/s12035-022-02929-w","volume":"59","author":"Zhang","year":"2022","journal-title":"Mol Neurobiol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"6531","DOI":"10.3390\/molecules26216531","volume":"26","author":"Friedli","year":"2021","journal-title":"Molecules"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"38361","DOI":"10.1021\/acsomega.2c03185","volume":"7","author":"Atiya","year":"2022","journal-title":"ACS Omega"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.msec.2016.06.055","volume":"69","author":"Akhavan","year":"2016","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.carbon.2015.08.017","volume":"95","author":"Akhavan","year":"2015","journal-title":"Carbon"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=87562","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=87562","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T11:55:15Z","timestamp":1676548515000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/huperzine-a-liposomes-efficiently-improve-neural-injury-in-the-hippoca-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":58,"URL":"https:\/\/doi.org\/10.2147\/ijn.s393346","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2]]}}}