{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:39:52Z","timestamp":1790883592832,"version":"4.1.0"},"reference-count":82,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s402418","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T07:40:25Z","timestamp":1680075625000},"page":"1615-1630","source":"Crossref","is-referenced-by-count":30,"title":["Effects of PEG-Linker Chain Length of Folate-Linked Liposomal Formulations on Targeting Ability and Antitumor Activity of Encapsulated Drug"],"prefix":"10.2147","volume":"Volume 18","author":[{"given":"Chaemin","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuseon","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kioh","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8448-0491","authenticated-orcid":true,"given":"Patihul","family":"Husni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sehwa","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Gon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Seong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9099-9230","authenticated-orcid":true,"given":"Yu Seok","family":"Youn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4379-7238","authenticated-orcid":true,"given":"Kyung Taek","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40005-020-00473-0","volume":"50","author":"Atlihan-Gundogdu","year":"2020","journal-title":"J Pharm Investig"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s40005-019-00459-7","volume":"50","author":"Tran","year":"2020","journal-title":"J Pharm Investig"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40005-021-00527-x","volume":"51","author":"Gupta","year":"2021","journal-title":"J Pharm Investig"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s40005-022-00601-y","volume":"2022","author":"Ha","year":"2022","journal-title":"J Pharm Investig"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2885","DOI":"10.1039\/C2CS15260F","volume":"41","author":"Doane","year":"2012","journal-title":"Chem Soc Rev"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1038\/nbt1006-1211","volume":"24","author":"Wagner","year":"2006","journal-title":"Nat Biotechnol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s40005-020-00504-w","volume":"51","author":"Kiio","year":"2021","journal-title":"J Pharm Investig"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s40005-016-0291-7","volume":"47","author":"Hoang","year":"2017","journal-title":"J Pharm Investig"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s40005-017-0320-1","volume":"47","author":"Son","year":"2017","journal-title":"J Pharm Investig"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"3181","DOI":"10.1021\/cr940351u","volume":"99","author":"Uhrich","year":"1999","journal-title":"Chem Rev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s40005-019-00448-w","volume":"50","author":"Cho","year":"2020","journal-title":"J Pharm Investig"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s40005-022-00573-z","volume":"52","author":"Shinn","year":"2022","journal-title":"J Pharm Investig"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2013.00143","volume":"4","author":"Hua","year":"2013","journal-title":"Front Pharmacol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"293","DOI":"10.3390\/pharmaceutics11060293","volume":"11","author":"Lim","year":"2019","journal-title":"Pharmaceutics"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.colsurfb.2015.09.034","volume":"136","author":"Nogueira","year":"2015","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.jconrel.2016.01.039","volume":"225","author":"Patil","year":"2016","journal-title":"J Control Release"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.ijpharm.2005.12.043","volume":"312","author":"Sadzuka","year":"2006","journal-title":"Int J Pharm"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s40005-021-00548-6","volume":"52","author":"Hegde","year":"2022","journal-title":"J Pharm Investig"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"419","DOI":"10.2165\/00003088-200342050-00002","volume":"42","author":"Gabizon","year":"2003","journal-title":"Clin Pharmacokinet"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1080\/10717540600814402","volume":"13","author":"Hamidi","year":"2006","journal-title":"Drug Deliv"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.ijpharm.2011.09.045","volume":"421","author":"Muthu","year":"2011","journal-title":"Int J Pharm"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"11","DOI":"10.2147\/IJN.S124701","volume":"13","author":"Singh","year":"2018","journal-title":"Int J Nanomedicine"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.tibtech.2013.09.007","volume":"32","author":"Noble","year":"2014","journal-title":"Trends Biotechnol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.ijpharm.2007.06.010","volume":"346","author":"Suzuki","year":"2008","journal-title":"Int J Pharm"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.actbio.2018.01.038","volume":"70","author":"Zhang","year":"2018","journal-title":"Acta Biomaterialia"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"523","DOI":"10.2217\/nnm.10.23","volume":"5","author":"Nie","year":"2010","journal-title":"Nanomedicine"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.canlet.2013.02.020","volume":"335","author":"Biswas","year":"2013","journal-title":"Cancer Lett"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"9246","DOI":"10.1016\/j.biomaterials.2012.09.027","volume":"33","author":"Jiang","year":"2012","journal-title":"Biomaterials"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1039\/C3PP25384H","volume":"12","author":"Moret","year":"2013","journal-title":"Photochem Photobiol Sci"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"475101","DOI":"10.1088\/0957-4484\/21\/47\/475101","volume":"21","author":"Sun","year":"2010","journal-title":"Nanotechnology"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/s40005-022-00583-x","volume":"52","author":"Sahu","year":"2022","journal-title":"J Pharm Investig"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.1158\/0008-5472.CAN-12-3526","volume":"73","author":"LeBeau","year":"2013","journal-title":"Cancer Res"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.ijpharm.2006.02.027","volume":"316","author":"Wu","year":"2006","journal-title":"Int J Pharm"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s40005-021-00553-9","volume":"52","author":"Shim","year":"2022","journal-title":"J Pharm Investig"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1021\/nn900002m","volume":"3","author":"Farokhzad","year":"2009","journal-title":"ACS Nano"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/nrc1566","volume":"5","author":"Ferrari","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"ref37","first-page":"6551","volume":"9","author":"Gabizon","year":"2003","journal-title":"Clin Cancer Res"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"746","DOI":"10.7150\/thno.10732","volume":"5","author":"Saw","year":"2015","journal-title":"Theranostics"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"2935","DOI":"10.1021\/nn305663e","volume":"7","author":"Stefanick","year":"2013","journal-title":"ACS Nano"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1021\/bi962148u","volume":"36","author":"Kirpotin","year":"1997","journal-title":"Biochemistry"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"369","DOI":"10.2174\/156720105774370159","volume":"2","author":"Sapra","year":"2005","journal-title":"Curr Drug Deliv"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"8161","DOI":"10.1158\/1078-0432.CCR-08-0159","volume":"14","author":"Yamada","year":"2008","journal-title":"Clin Cancer Res"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s40005-022-00559-x","volume":"52","author":"Bakhtiar","year":"2022","journal-title":"J Pharm Investig"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.addr.2012.09.020","volume":"64","author":"Lu","year":"2012","journal-title":"Adv Drug Deliv Rev"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jconrel.2016.09.010","volume":"243","author":"Marshalek","year":"2016","journal-title":"J Control Release"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12951-016-0201-1","volume":"14","author":"Muralidharan","year":"2016","journal-title":"J Nanobiotechnology"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"72","DOI":"10.3390\/ph10030072","volume":"10","author":"Siwowska","year":"2017","journal-title":"Pharmaceuticals"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s12645-022-00120-3","volume":"13","author":"Mirzaghavami","year":"2022","journal-title":"Cancer Nanotechnol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1006\/mgme.2000.3034","volume":"70","author":"Chango","year":"2000","journal-title":"Mol Genet Metab"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0168-3659(97)00236-8","volume":"53","author":"Wang","year":"1998","journal-title":"J Control Release"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.colsurfb.2015.11.018","volume":"140","author":"Chen","year":"2016","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"015008","DOI":"10.1088\/2043-6254\/aa5982","volume":"8","author":"Nho","year":"2017","journal-title":"Adv Nat Sci Nanosci Nanotechnol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1021\/bc9801124","volume":"10","author":"Gabizon","year":"1999","journal-title":"Bioconjug Chem"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2011\/160967","volume":"2011","author":"Kawano","year":"2011","journal-title":"J Drug Deliv"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3109\/10611861003733953","volume":"19","author":"Riviere","year":"2011","journal-title":"J Drug Target"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1016\/j.addr.2004.01.011","volume":"56","author":"Gabizon","year":"2004","journal-title":"Adv Drug Deliv Rev"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.ijpharm.2014.08.019","volume":"474","author":"Qu","year":"2014","journal-title":"Int J Pharm"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"5437","DOI":"10.2147\/IJN.S315619","volume":"16","author":"Park","year":"2021","journal-title":"Int J Nanomedicine"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jconrel.2009.05.036","volume":"139","author":"Zucker","year":"2009","journal-title":"J Control Release"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.3109\/10717544.2015.1040527","volume":"23","author":"Yuan","year":"2016","journal-title":"Drug Deliv"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12272-021-01365-z","volume":"45","author":"Park","year":"2022","journal-title":"Arch Pharm Res"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"102345","DOI":"10.1016\/j.nano.2020.102345","volume":"32","author":"Hwang","year":"2021","journal-title":"Nanomedicine"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1211\/0022357991772079","volume":"51","author":"Epps","year":"1999","journal-title":"J Pharm Pharmacol"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s12272-021-01324-8","volume":"44","author":"Wang","year":"2021","journal-title":"Arch Pharm Res"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1007\/s12272-022-01380-8","volume":"45","author":"Nam","year":"2022","journal-title":"Arch Pharm Res"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1007\/s12272-021-01364-0","volume":"45","author":"Lee","year":"2022","journal-title":"Arch Pharm Res"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1016\/j.bbamem.2006.12.013","volume":"1768","author":"Dos Santos","year":"2007","journal-title":"Biochimica et Biophysica Acta"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/pharmaceutics9020012","volume":"9","author":"Bulbake","year":"2017","journal-title":"Pharmaceutics"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.jconrel.2004.03.007","volume":"97","author":"Hattori","year":"2004","journal-title":"J Control Release"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1080\/10611860802201464","volume":"16","author":"Ohguchi","year":"2008","journal-title":"J Drug Target"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1158\/1078-0432.CCR-04-1129","volume":"11","author":"Shiokawa","year":"2005","journal-title":"Clin Cancer Res"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.ijpharm.2005.12.032","volume":"311","author":"Hinrichs","year":"2006","journal-title":"Int J Pharm"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.ijpharm.2007.12.030","volume":"356","author":"Xiang","year":"2008","journal-title":"Int J Pharm"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1111\/j.1745-7254.2005.00537.x","volume":"26","author":"Fang","year":"2005","journal-title":"Acta Pharmacol Sin"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"5751","DOI":"10.1016\/j.biomaterials.2009.07.021","volume":"30","author":"Kim","year":"2009","journal-title":"Biomaterials"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1158\/1535-7163.MCT-05-0543","volume":"5","author":"Shmeeda","year":"2006","journal-title":"Mol Cancer Ther"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"980","DOI":"10.3389\/fphar.2018.00980","volume":"9","author":"Wang","year":"2018","journal-title":"Front Pharmacol"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1002\/cbic.201600092","volume":"17","author":"Xing","year":"2016","journal-title":"Chembiochem"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"3193","DOI":"10.1039\/B606930D","author":"Cavalli","year":"2006","journal-title":"Chem Comm"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"5746","DOI":"10.1039\/C0CC00784F","volume":"46","author":"Kumar","year":"2010","journal-title":"Chem Comm"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.1021\/bc3005057","volume":"23","author":"Feldborg","year":"2012","journal-title":"Bioconjug Chem"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"4200","DOI":"10.1021\/acs.molpharmaceut.5b00399","volume":"12","author":"Kang","year":"2015","journal-title":"Mol Pharm"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=88568","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=88568","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T07:40:31Z","timestamp":1680075631000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/effects-of-peg-linker-chain-length-of-folate-linked-liposomal-formulat-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":82,"URL":"https:\/\/doi.org\/10.2147\/ijn.s402418","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3]]}}}