{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:16:34Z","timestamp":1791299794054,"version":"4.1.0"},"reference-count":86,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s415968","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T22:20:10Z","timestamp":1690323610000},"page":"4121-4142","source":"Crossref","is-referenced-by-count":39,"title":["Sorafenib-Loaded PLGA Carriers for Enhanced Drug Delivery and Cellular Uptake in Liver Cancer Cells"],"prefix":"10.2147","volume":"Volume 18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2701-8353","authenticated-orcid":true,"given":"Tania Mariastella","family":"Caputo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9903-1717","authenticated-orcid":true,"given":"Angela Maria","family":"Cusano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Principe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Cicatiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Celetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Aliberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Micco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menotti","family":"Ruvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Tagliamonte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concetta","family":"Ragone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Minopoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9768-2997","authenticated-orcid":true,"given":"Maria Vincenza","family":"Carriero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Buonaguro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Cusano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"5464","DOI":"10.7150\/thno.54822","volume":"11","author":"Kong","year":"2021","journal-title":"Theranostics"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1056\/NEJMra1713263","volume":"380","author":"Villanueva","year":"2019","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41572-020-00240-3","volume":"7","author":"Llovet","year":"2021","journal-title":"Nat Rev Dis Prim"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2952","DOI":"10.1093\/annonc\/mdt294","volume":"24","author":"Hourdequin","year":"2013","journal-title":"Ann Oncol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.msec.2016.01.063","volume":"62","author":"Krukiewicz","year":"2016","journal-title":"Mater Sci Eng C"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s12032-017-1053-8","volume":"34","author":"Miyahara","year":"2017","journal-title":"Med Oncol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"597","DOI":"10.2217\/nnm.10.35","volume":"5","author":"Dong","year":"2010","journal-title":"Nanomedicine"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1021\/acsabm.2c00002","volume":"5","author":"Khan","year":"2022","journal-title":"ACS Appl Bio Mater"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.jpha.2022.12.001","volume":"13","author":"Lu","year":"2023","journal-title":"J Pharm Anal"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1007\/s11307-016-0964-7","volume":"18","author":"Silva","year":"2016","journal-title":"Mol Imaging Biol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.1002\/adfm.201504899","volume":"26","author":"Feng","year":"2016","journal-title":"Adv Funct Mater"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.3109\/10717544.2015.1055619","volume":"23","author":"Wang","year":"2016","journal-title":"Drug Deliv"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1080\/10717544.2022.2027573","volume":"29","author":"Liu","year":"2022","journal-title":"Drug Deliv"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.ijpharm.2017.04.073","volume":"528","author":"Gupta","year":"2017","journal-title":"Int J Pharm"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2978","DOI":"10.1073\/pnas.1418494112","volume":"112","author":"Wei","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"295","DOI":"10.2217\/nnm-2016-0382","volume":"12","author":"Zhu","year":"2017","journal-title":"Nanomedicine"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.colsurfb.2016.05.029","volume":"145","author":"Yu","year":"2016","journal-title":"Colloids Surf B"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jconrel.2021.11.010","volume":"341","author":"Hasannia","year":"2022","journal-title":"J Control Release"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.jare.2022.02.014","volume":"43","author":"Li","year":"2023","journal-title":"J Adv Res"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"2100227","DOI":"10.1002\/adfm.202100227","volume":"31","author":"Li","year":"2021","journal-title":"Adv Funct Mater"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1602225","DOI":"10.1002\/smll.201602225","volume":"13","author":"Yao","year":"2017","journal-title":"Small"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"14746","DOI":"10.1039\/C7DT02274C","volume":"46","author":"Wang","year":"2017","journal-title":"Dalt Trans"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1021\/acsnano.1c08485","volume":"16","author":"Chen","year":"2022","journal-title":"ACS Nano"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1021\/acs.molpharmaceut.8b00810","volume":"16","author":"Sztandera","year":"2019","journal-title":"Mol Pharm"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.3390\/nano9101423","volume":"9","author":"Lee","year":"2019","journal-title":"Nanomaterials"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"112254","DOI":"10.1016\/j.colsurfb.2021.112254","volume":"210","author":"Miranda","year":"2022","journal-title":"Colloids Surf B"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.actbio.2019.11.027","volume":"102","author":"Zhi","year":"2020","journal-title":"Acta Biomater"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1080\/10717544.2017.1399300","volume":"24","author":"Zhao","year":"2017","journal-title":"Drug Deliv"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1002\/jcp.26899","volume":"234","author":"Mohajeri","year":"2018","journal-title":"J Cell Physiol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"189","DOI":"10.3390\/nano7070189","volume":"7","author":"Watermann","year":"2017","journal-title":"Nanomaterials"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"5365","DOI":"10.1039\/d1cs00659b","volume":"51","author":"Vallet-Reg\u00ed","year":"2022","journal-title":"Chem Soc Rev"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"10664","DOI":"10.1021\/acsami.7b19549","volume":"10","author":"Hua","year":"2018","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.molmed.2015.01.001","volume":"21","author":"Xu","year":"2015","journal-title":"Trends Mol Med"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"eaax3931","DOI":"10.1126\/sciadv.aax3931","volume":"6","author":"Dancy","year":"2020","journal-title":"Sci Adv"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1208\/s12248-021-00611-y","volume":"23","author":"Wang","year":"2021","journal-title":"AAPS J"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1080\/10717544.2021.1938756","volume":"28","author":"Su","year":"2021","journal-title":"Drug Deliv"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jhep.2018.03.019","volume":"69","author":"Galle","year":"2018","journal-title":"J Hepatol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1056\/NEJMoa0708857","volume":"359","author":"Llovet","year":"2008","journal-title":"N Engl J Med"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.jhep.2008.09.001","volume":"49","author":"Galle","year":"2008","journal-title":"J Hepatol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1038\/aps.2017.5","volume":"38","author":"Zhu","year":"2017","journal-title":"Acta Pharmacol Sin"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1016\/S0140-6736(18)30207-1","volume":"391","author":"Kudo","year":"2018","journal-title":"Lancet"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1056\/NEJMoa1915745","volume":"382","author":"Finn","year":"2020","journal-title":"N Engl J Med"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"11851","DOI":"10.1158\/0008-5472.CAN-06-1377","volume":"66","author":"Liu","year":"2006","journal-title":"Cancer Res"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1016\/S0140-6736(03)14964-1","volume":"362","author":"Llovet","year":"2003","journal-title":"Lancet"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1002\/hep.24199","volume":"53","author":"Bruix","year":"2011","journal-title":"Hepatology"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"7099","DOI":"10.1158\/0008-5472.CAN-04-1443","volume":"64","author":"Wilhelm","year":"2004","journal-title":"Cancer Res"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/s00280-006-0393-4","volume":"59","author":"Chang","year":"2007","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1053\/j.gastro.2021.12.276","volume":"162","author":"Su","year":"2022","journal-title":"Gastroenterology"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.jceh.2019.07.012","volume":"9","author":"Doycheva","year":"2019","journal-title":"J Clin Exp Hepatol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"4565","DOI":"10.1016\/j.biomaterials.2014.02.024","volume":"35","author":"Zhang","year":"2014","journal-title":"Biomaterials"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.jpba.2009.02.008","volume":"49","author":"Blanchet","year":"2009","journal-title":"J Pharm Biomed Anal"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"212851","DOI":"10.1016\/j.bioadv.2022.212851","volume":"137","author":"Rahiminezhad","year":"2022","journal-title":"Biomater Adv"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"489","DOI":"10.3390\/pharmaceutics11100489","volume":"11","author":"Feczk\u00f3","year":"2019","journal-title":"Pharmaceutics"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"895","DOI":"10.3390\/polym10080895","volume":"10","author":"Babos","year":"2018","journal-title":"Polymers"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1080\/00914037.2018.1429434","volume":"67","author":"Khan","year":"2018","journal-title":"Int J Polym Mater Polym Biomater"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1002\/jps.24318","volume":"104","author":"Liu","year":"2015","journal-title":"J Pharm Sci"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"3231","DOI":"10.1039\/c3nr05647c","volume":"6","author":"Liu","year":"2014","journal-title":"Nanoscale"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/1556-276X-7-91","volume":"7","author":"Kim","year":"2012","journal-title":"Nanoscale Res Lett"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1016\/j.nano.2014.05.011","volume":"10","author":"Malarvizhi","year":"2014","journal-title":"Biol Med"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1016\/j.nano.2016.01.017","volume":"12","author":"Zhang","year":"2016","journal-title":"Biol Med"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"50147","DOI":"10.1002\/app.50147","volume":"138","author":"Caputo","year":"2021","journal-title":"J Appl Polym Sci"},{"key":"ref62","first-page":"1214","volume":"23","author":"Caputo","year":"2021","journal-title":"Curr Pharm Biotechnol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"15998","DOI":"10.1016\/j.matpr.2018.05.044","volume":"5","author":"Giannouli","year":"2018","journal-title":"Mater Today"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"109818","DOI":"10.1016\/j.eurpolymj.2020.109818","volume":"134","author":"Maity","year":"2020","journal-title":"Eur Polym J"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/aps.2014.122","volume":"36","author":"Wei","year":"2015","journal-title":"Acta Pharmacol Sin"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.3390\/s18072101","volume":"18","author":"Carotenuto","year":"2018","journal-title":"Sensors"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/nphoton.2006.96","volume":"1","author":"Monat","year":"2007","journal-title":"Nat Photonics"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/nphoton.2011.206","volume":"5","author":"Fan","year":"2011","journal-title":"Nat Photonics"},{"key":"ref69","volume":"2022","author":"Sui","year":"2022","journal-title":"Biophotonics Congr Biomed Opt"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"3244","DOI":"10.1002\/adfm.201505260","volume":"26","author":"Nazari","year":"2016","journal-title":"Adv Funct Mater"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.sna.2014.04.013","volume":"214","author":"Wang","year":"2014","journal-title":"Sens Actuator a Phys"},{"key":"ref72","first-page":"012112","volume":"711","author":"Yang","year":"2020","journal-title":"Mater Sci Eng"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"2738","DOI":"10.1364\/AO.50.002738","volume":"50","author":"Caldas","year":"2011","journal-title":"Appl Opt"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"34011","DOI":"10.1364\/OE.27.034011","volume":"27","author":"Gao","year":"2019","journal-title":"Opt Express"},{"key":"ref75","doi-asserted-by":"crossref","unstructured":"Silva GE, Caldas P, Santos JC, et al. All-fiber sensor based on a metallic coated hybrid LPG-FBG structure for thermal characterization of materials. In: 23rd International Conference on Optical Fibre Sensors. SPIE; 2014:241\u2013244.","DOI":"10.1117\/12.2059655"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"2592","DOI":"10.1109\/JSEN.2019.2891044","volume":"19","author":"Liu","year":"2019","journal-title":"IEEE Sens J"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"24521","DOI":"10.1364\/OE.25.024521","volume":"25","author":"Zhang","year":"2017","journal-title":"Opt Express"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"3373","DOI":"10.1109\/JLT.2019.2916572","volume":"37","author":"Liu","year":"2019","journal-title":"J Light Technol"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"27028","DOI":"10.1364\/OE.399774","volume":"28","author":"Wang","year":"2020","journal-title":"Opt Express"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s41120-022-00060-7","volume":"8","author":"Alvi","year":"2022","journal-title":"AAPS Open"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"4218","DOI":"10.1039\/C9RA10857B","volume":"10","author":"Hern\u00e1ndez-Giottonini","year":"2020","journal-title":"RSC Adv"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201701035","volume":"7","author":"Martins","year":"2018","journal-title":"Adv Healthc Mater"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"121","DOI":"10.2217\/nnm.13.191","volume":"9","author":"Toy","year":"2014","journal-title":"Nanomedicine"},{"key":"ref84","first-page":"1884","volume":"17","author":"Zhou","year":"2017","journal-title":"Anticancer Agents Med Chem"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1126\/science.8128245","volume":"263","author":"Gref","year":"1994","journal-title":"Science"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.2147\/IJN.S19491","volume":"6","author":"Jeong","year":"2011","journal-title":"Int J Nanomedicine"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=91488","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=91488","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T22:20:19Z","timestamp":1690323619000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/sorafenib-loaded-plga-carriers-for-enhanced-drug-delivery-and-cellular-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":86,"URL":"https:\/\/doi.org\/10.2147\/ijn.s415968","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7]]}}}