{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:23:45Z","timestamp":1791228225523,"version":"4.1.0"},"reference-count":42,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s436253","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T02:20:13Z","timestamp":1701310813000},"page":"7133-7147","source":"Crossref","is-referenced-by-count":36,"title":["A Novel pH-Responsive Iron Oxide Core-Shell Magnetic Mesoporous Silica Nanoparticle (M-MSN) System Encapsulating Doxorubicin (DOX) and Glucose Oxidase (Gox) for Pancreatic Cancer Treatment"],"prefix":"10.2147","volume":"Volume 18","author":[{"given":"Guiqiang","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyue","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengchao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0281-8749","authenticated-orcid":true,"given":"Zhichen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7996-0834","authenticated-orcid":true,"given":"Qiangqiang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongtao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liguo","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21708","volume":"72","author":"Siege","year":"2022","journal-title":"CA"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1016\/S0140-6736(20)30974-0","volume":"395","author":"Mizrahi","year":"2020","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.canlet.2020.07.041","volume":"492","author":"Shah","year":"2020","journal-title":"Cancer Lett"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/s41571-023-00746-1","volume":"20","author":"Springfeld","year":"2023","journal-title":"Nat Rev Clin Oncol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"13797","DOI":"10.1021\/acs.chemrev.0c01332","volume":"121","author":"Krissanaprasit","year":"2021","journal-title":"Chem Rev"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"6250","DOI":"10.1039\/c6cs00458j","volume":"45","author":"Liang","year":"2016","journal-title":"Chem Soc Rev"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1080\/10717544.2022.2149897","volume":"30","author":"Wang","year":"2023","journal-title":"Drug Deliv"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"120990","DOI":"10.1016\/j.biomaterials.2021.120990","volume":"275","author":"Feng","year":"2021","journal-title":"Biomaterials"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.bioactmat.2022.12.027","volume":"24","author":"Nel","year":"2023","journal-title":"Bioact Mater"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"7687","DOI":"10.2147\/IJN.S267321","volume":"15","author":"Bao","year":"2020","journal-title":"Int J Nanomed"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actbio.2022.12.013","volume":"157","author":"Raza","year":"2023","journal-title":"Acta Biomater"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1021\/acsnano.9b03978","volume":"14","author":"Xie","year":"2020","journal-title":"ACS Nano"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"2809","DOI":"10.2147\/IJN.S241055","volume":"15","author":"Grafals-Ruiz","year":"2020","journal-title":"Int J Nanomed"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e1901223","DOI":"10.1002\/adhm.201901223","volume":"9","author":"Kang","year":"2020","journal-title":"Adv Healthc Mater"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e2203915","DOI":"10.1002\/adma.202203915","volume":"34","author":"Cheng","year":"2022","journal-title":"Adv Mater"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"119303","DOI":"10.1016\/j.biomaterials.2019.119303","volume":"217","author":"Hu","year":"2019","journal-title":"Biomaterials"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"42499","DOI":"10.1021\/acsami.0c10781","volume":"12","author":"Seth","year":"2020","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"6387","DOI":"10.1021\/acsnano.2c11112","volume":"17","author":"Li","year":"2023","journal-title":"ACS Nano"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.jcis.2022.06.069","volume":"625","author":"Sagir","year":"2022","journal-title":"J Colloid Interface Sci"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"e253183","DOI":"10.1590\/1519-6984.253183","volume":"84","author":"Shosha","year":"2022","journal-title":"Braz J Biol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.jconrel.2018.09.022","volume":"289","author":"Wang","year":"2018","journal-title":"J Control Release"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"822","DOI":"10.3390\/pharmaceutics15030822","volume":"15","author":"Thirumurugan","year":"2023","journal-title":"Pharmaceutics"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"9003","DOI":"10.1021\/acsnano.2c10310","volume":"17","author":"Chen","year":"2023","journal-title":"ACS Nano"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"21759","DOI":"10.1039\/c9nr05671h","volume":"11","author":"Zhang","year":"2019","journal-title":"Nanoscale"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.actbio.2022.12.017","volume":"157","author":"Ding","year":"2023","journal-title":"Acta Biomater"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"3675","DOI":"10.1021\/acsami.1c18654","volume":"14","author":"Huo","year":"2022","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1039\/d2tb02523j","volume":"11","author":"Hao","year":"2023","journal-title":"J Mater Chem B"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.canlet.2019.04.023","volume":"455","author":"Shen","year":"2019","journal-title":"Cancer Lett"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jcis.2022.01.099","volume":"615","author":"Cheng","year":"2022","journal-title":"J Colloid Interface Sci"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1080\/10717544.2021.2018523","volume":"29","author":"Li","year":"2022","journal-title":"Drug Deliv"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"558","DOI":"10.3390\/bios12080558","volume":"12","author":"Dong","year":"2022","journal-title":"Biosensors"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12951-021-01237-0","volume":"20","author":"Wang","year":"2022","journal-title":"J Nanobiotechnol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"13985","DOI":"10.1021\/acsnano.9b05836","volume":"13","author":"Fu","year":"2019","journal-title":"ACS Nano"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.msec.2017.03.224","volume":"77","author":"Zhang","year":"2017","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"6519","DOI":"10.3390\/molecules27196519","volume":"27","author":"Li","year":"2022","journal-title":"Molecules"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"5876","DOI":"10.1039\/c8tb01731j","volume":"6","author":"Sun","year":"2018","journal-title":"J Mater Chem B"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.3390\/nano10071312","volume":"10","author":"Kim","year":"2020","journal-title":"Nanomaterials"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.3390\/nano11092455","volume":"11","author":"P\u00e9rez-Garnes","year":"2021","journal-title":"Nanomaterials"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"111124","DOI":"10.1016\/j.msec.2020.111124","volume":"115","author":"Vaz-Ramos","year":"2020","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"18462","DOI":"10.1021\/acsami.7b02457","volume":"9","author":"Cheng","year":"2017","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"6134","DOI":"10.3390\/molecules28166134","volume":"28","author":"Wang","year":"2023","journal-title":"Molecules"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"3092","DOI":"10.1021\/acsami.5b10352","volume":"8","author":"Guo","year":"2016","journal-title":"ACS Appl Mater Interfaces"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=94788","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=94788","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T02:20:15Z","timestamp":1701310815000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/a-novel-ph-responsive-iron-oxide-core-shell-magnetic-mesoporous-silica-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":42,"URL":"https:\/\/doi.org\/10.2147\/ijn.s436253","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11]]}}}