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J. Med. Chem."},{"key":"ref133","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1007\/s12274-021-3686-3","volume":"15","author":"Wen","year":"2022","journal-title":"Nano Res"},{"key":"ref134","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1021\/acs.nanolett.9b04683","volume":"20","author":"Liu","year":"2020","journal-title":"Nano Lett"},{"key":"ref135","doi-asserted-by":"crossref","first-page":"e1903277","DOI":"10.1002\/adma.201903277","volume":"31","author":"Zheng","year":"2019","journal-title":"Adv Mater"},{"key":"ref136","doi-asserted-by":"crossref","first-page":"101157","DOI":"10.1016\/j.jddst.2019.101157","volume":"53","author":"Heggannavar","year":"2019","journal-title":"J Drug Deliv Sci Technol"},{"key":"ref137","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1021\/acs.molpharmaceut.8b01056","volume":"16","author":"Tao","year":"2019","journal-title":"Mol Pharm"},{"key":"ref138","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1007\/s00109-019-01843-4","volume":"97","author":"Ye","year":"2019","journal-title":"J Mol Med"},{"key":"ref139","doi-asserted-by":"crossref","first-page":"102218","DOI":"10.1016\/j.nano.2020.102218","volume":"28","author":"Wen","year":"2020","journal-title":"Nanomedicine"},{"key":"ref140","doi-asserted-by":"crossref","first-page":"2300029","DOI":"10.1002\/smll.202300029","volume":"19","author":"Martins","year":"2023","journal-title":"Small"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"6293","DOI":"10.1021\/acsnano.2c00320","volume":"16","author":"He","year":"2022","journal-title":"ACS Nano"},{"key":"ref142","doi-asserted-by":"crossref","first-page":"102673","DOI":"10.1016\/j.nano.2023.102673","volume":"50","author":"Thirumurugan","year":"2023","journal-title":"Nanomed Nanotechnol Biol Med"},{"key":"ref143","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1021\/acsnano.8b08177","volume":"13","author":"Erel-Akbaba","year":"2019","journal-title":"ACS nano"},{"key":"ref144","doi-asserted-by":"crossref","first-page":"120435","DOI":"10.1016\/j.lfs.2022.120435","volume":"296","author":"Ramalho","year":"2022","journal-title":"Life Sci"},{"key":"ref145","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.nano.2014.09.005","volume":"11","author":"Kim","year":"2015","journal-title":"Nanomedicine"},{"key":"ref146","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/jcp.25896","volume":"233","author":"Binabaj","year":"2018","journal-title":"J Cell 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