{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:17:35Z","timestamp":1791919055040,"version":"4.3.4"},"reference-count":75,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s463750","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T07:30:11Z","timestamp":1722843011000},"page":"7945-7961","source":"Crossref","is-referenced-by-count":5,"title":["Virgin Coconut Oil-based Nanostructured Lipid Carrier Improves the Hypolipidemic Effect of Rosuvastatin"],"prefix":"10.2147","volume":"Volume 19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8051-1614","authenticated-orcid":true,"given":"Tamer","family":"Shehata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2684-4186","authenticated-orcid":true,"given":"Bandar","family":"Aldhubiab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba","family":"Elsewedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2024,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"574111","DOI":"10.3389\/fpubh.2020.574111","volume":"8","author":"Budreviciute","year":"2020","journal-title":"Front Public Health"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s10654-016-0219-6","volume":"32","author":"Lin","year":"2017","journal-title":"Eur j epidemiol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"4782344","DOI":"10.1155\/2022\/4782344","volume":"2022","author":"Mosca","year":"2022","journal-title":"J Nutr Metab"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.amjcard.2012.04.062","volume":"110","author":"Vodnala","year":"2012","journal-title":"Am j Cardiol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"15","DOI":"10.35772\/ghm.2020.01078","volume":"3","author":"Yanai","year":"2021","journal-title":"Glob Health Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3390\/pharma3010009","volume":"3","author":"Kayani","year":"2024","journal-title":"Pharmacoepidemiology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s12944-020-01204-y","volume":"19","author":"Hedayatnia","year":"2020","journal-title":"Lipids Health Dis"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"S236","DOI":"10.4103\/2230-8210.104048","volume":"16","author":"Rajagopal","year":"2012","journal-title":"Indian J Endocrinol Metab"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.3390\/biomedicines10051090","volume":"10","author":"Dayar","year":"2022","journal-title":"Biomedicines"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1586\/14779072.1.4.495","volume":"1","author":"Rosenson","year":"2003","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1016\/j.ijbiomac.2017.10.086","volume":"107","author":"Hirpara","year":"2018","journal-title":"Int J Biol Macromol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1080\/1061186x.2016.1191080","volume":"25","author":"Rizwanullah","year":"2017","journal-title":"J Drug Target"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"2160","DOI":"10.3390\/nano12132160","volume":"12","author":"Elsewedy","year":"2022","journal-title":"Nanomaterials"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"275","DOI":"10.3390\/pharmaceutics11060275","volume":"11","author":"Elsayed","year":"2019","journal-title":"Pharmaceutics"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.5604\/17322693.1177169","volume":"69","author":"Zdrojewicz","year":"2015","journal-title":"Postepy Hig Med Dosw"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"100239","DOI":"10.1016\/j.mtbio.2022.100239","volume":"14","author":"Xie","year":"2022","journal-title":"Mater Today Bio"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2202391","DOI":"10.1002\/adhm.202202391","volume":"12","author":"Su","year":"2023","journal-title":"Adv Healthcare Mater"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.bmt.2023.09.001","volume":"5","author":"Elumalai","year":"2024","journal-title":"Biomed Technol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.ifset.2013.03.002","volume":"19","author":"Tamjidi","year":"2013","journal-title":"Innovative Food Sci Emerg Technol"},{"key":"ref20","volume-title":"Nanocarriers for Controlled Release and Target Delivery of Bioactive Compounds","year":"2024"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"305","DOI":"10.15171\/apb.2015.043","volume":"5","author":"Naseri","year":"2015","journal-title":"Adv Pharm Bull"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"813","DOI":"10.3109\/1061186X.2012.716845","volume":"20","author":"Iqbal","year":"2012","journal-title":"J Drug Targeting"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"6929","DOI":"10.3390\/molecules26226929","volume":"26","author":"Rodrigues da Silva","year":"2021","journal-title":"Molecules"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"11160","DOI":"10.1038\/s41598-019-47486-w","volume":"9","author":"Guilherme","year":"2019","journal-title":"Sci Rep"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1080\/02652048.2017.1284276","volume":"34","author":"Cortesi","year":"2017","journal-title":"J Microencapsul"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.colsurfb.2017.11.064","volume":"162","author":"Fathi","year":"2018","journal-title":"Colloids Surf B"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1093\/toxsci\/kfr198","volume":"123","author":"Abdel-Rahman","year":"2011","journal-title":"Toxicol Sci"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/s1995-7645(11)60078-3","volume":"4","author":"DebMandal","year":"2011","journal-title":"Asian Pac J Trop Med"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"e02612","DOI":"10.1016\/j.heliyon.2019.e02612","volume":"5","author":"Widianingrum","year":"2019","journal-title":"Heliyon"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3109\/13880200903062614","volume":"48","author":"Intahphuak","year":"2010","journal-title":"Pharm Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"185","DOI":"10.4025\/actascihealthsci.v38i2.28775","volume":"38","author":"Santana","year":"2016","journal-title":"Acta Sci Health Sci"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.clinbiochem.2004.04.010","volume":"37","author":"Nevin","year":"2004","journal-title":"Clin Biochem"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"406","DOI":"10.22159\/ajpcr.2018.v11i10.27476","volume":"11","author":"Margata","year":"2018","journal-title":"Asian J Pharm Clin Res"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"564","DOI":"10.3390\/nu15030564","volume":"15","author":"Setyawati","year":"2023","journal-title":"Nutrients"},{"key":"ref35","first-page":"02","volume":"4","author":"Caesario","year":"2021","journal-title":"metabolism"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/7251562","volume":"2017","author":"Chinwong","year":"2017","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Sinaga FA, Samosir A, Sinaga R, Ayu E, Manalu N, Ginting A Effect of aerobic exercise and supplementation virgin coconut oil on lipid profile. InProceedings of Journal of Physics: Conference Series; 2021:p. 012128.","DOI":"10.1088\/1742-6596\/1811\/1\/012128"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1080\/15376516.2017.1320458","volume":"27","author":"Illam","year":"2017","journal-title":"Toxicol Mech Methods"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"262","DOI":"10.3390\/gels8050262","volume":"8","author":"Shehata","year":"2022","journal-title":"Gels"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"111919","DOI":"10.1016\/j.biopha.2021.111919","volume":"141","author":"Agrawal","year":"2021","journal-title":"Biomed Pharmacothe"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.3390\/life12071011","volume":"12","author":"Elsewedy","year":"2022","journal-title":"Life"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.3390\/polym14122436","volume":"14","author":"Elsewedy","year":"2022","journal-title":"Polymers"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"103322","DOI":"10.1016\/j.jddst.2022.103322","volume":"71","author":"Haroun","year":"2022","journal-title":"J Drug Delivery Sci Technol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.micron.2011.07.014","volume":"43","author":"Klang","year":"2012","journal-title":"Micron"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.2147\/dddt.s169522","volume":"12","author":"Li","year":"2018","journal-title":"Drug Des Devel Ther"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"907","DOI":"10.3390\/pr10050907","volume":"10","author":"Shehata","year":"2022","journal-title":"Processes"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"3670","DOI":"10.3390\/plants12213670","volume":"12","author":"Elsewedy","year":"2023","journal-title":"Plants"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"102277","DOI":"10.1016\/j.jddst.2020.102277","volume":"61","author":"Shehata","year":"2021","journal-title":"J Drug Delivery Sci Technol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"R233","DOI":"10.1152\/ajpregu.00097.2005","volume":"290","author":"Bhatt","year":"2006","journal-title":"Am J Physiol Regulatory Integr Comp Physiol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"492","DOI":"10.3390\/ph15040492","volume":"15","author":"Inam","year":"2022","journal-title":"Pharmaceuticals"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.toxlet.2003.07.004","volume":"150","author":"Burdock","year":"2004","journal-title":"Toxicol Lett"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"446","DOI":"10.34172\/apb.2023.056","volume":"13","author":"Khan","year":"2023","journal-title":"Adv Pharm Bull"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"100084","DOI":"10.1016\/j.jafr.2020.100084","volume":"2","author":"Nobari Azar","year":"2020","journal-title":"J Agric Food Res"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"531","DOI":"10.3390\/pharmaceutics13040531","volume":"13","author":"Ortiz","year":"2021","journal-title":"Pharmaceutics"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.3390\/pharmaceutics14091806","volume":"14","author":"Franceschinis","year":"2022","journal-title":"Pharmaceutics"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"101096","DOI":"10.1016\/j.addma.2020.101096","volume":"33","author":"Zhang","year":"2020","journal-title":"Addit Manuf"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.3390\/pharmaceutics12121223","volume":"12","author":"Sarheed","year":"2020","journal-title":"Pharmaceutics"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.ejpb.2010.05.003","volume":"76","author":"Rahman","year":"2010","journal-title":"Eur J Pharm Biopharm"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"178","DOI":"10.3390\/pharmaceutics13020178","volume":"13","author":"Ghanem","year":"2021","journal-title":"Pharmaceutics"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"5314","DOI":"10.1016\/j.jmrt.2019.08.052","volume":"8","author":"Gholamhosseinzadeh","year":"2019","journal-title":"J Mater Res Technol"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.jsps.2019.03.002","volume":"27","author":"Butt","year":"2019","journal-title":"Saudi Pharm J"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.1080\/10826076.2013.828305","volume":"37","author":"Mostafa","year":"2014","journal-title":"J Liquid Chromatogr Related Technol"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"122006","DOI":"10.1016\/j.ijpharm.2022.122006","volume":"624","author":"Zewail","year":"2022","journal-title":"Int J Pharm"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1080\/10717544.2017.1337823","volume":"24","author":"Elmowafy","year":"2017","journal-title":"Drug Delivery"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.ejpb.2013.12.015","volume":"87","author":"Ravi","year":"2014","journal-title":"Eur J Pharm Biopharm"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s40360-020-0393-8","volume":"21","author":"Ahmed","year":"2020","journal-title":"BMC Pharmacol Toxicol"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"12003","DOI":"10.3390\/ijms222112003","volume":"22","author":"Chudoba","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s13205-020-2132-7","volume":"10","author":"Baskararaj","year":"2020","journal-title":"3 Biotech"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"672","DOI":"10.3390\/molecules21050672","volume":"21","author":"Choi","year":"2016","journal-title":"Molecules"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.3390\/pharmaceutics14051034","volume":"14","author":"Marathe","year":"2022","journal-title":"Pharmaceutics"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.atherosclerosis.2006.11.028","volume":"194","author":"Saito","year":"2007","journal-title":"Atherosclerosis"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"10447","DOI":"10.1021\/acs.jafc.8b04080","volume":"66","author":"Lee","year":"2018","journal-title":"J Agric Food Chem"},{"key":"ref73","unstructured":"Salil G, Rajamohan T Hypolipidemic and antiperoxidative effect of coconut protein in hypercholesterolemic rats; 2001."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"4224","DOI":"10.1016\/j.sjbs.2021.06.060","volume":"28","author":"Alatawi","year":"2021","journal-title":"Saudi J Biol Sci"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"54","DOI":"10.5530\/ijper.52.1.6","volume":"52","author":"Shehata","year":"2018","journal-title":"Indian J Pharm Educ Res"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/94766","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/94766","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T07:30:18Z","timestamp":1722843018000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/virgin-coconut-oil-based-nanostructured-lipid-carrier-improves-the-hyp-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":75,"URL":"https:\/\/doi.org\/10.2147\/ijn.s463750","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]}}}