{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:57:21Z","timestamp":1792601841125,"version":"4.5.0"},"reference-count":165,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s463939","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T11:10:14Z","timestamp":1716549014000},"page":"4735-4757","source":"Crossref","is-referenced-by-count":28,"title":["Stimuli-Responsive Delivery Systems for Intervertebral Disc Degeneration"],"prefix":"10.2147","volume":"Volume 19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6094-9857","authenticated-orcid":true,"given":"Jianing","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7207-4009","authenticated-orcid":true,"given":"Yuexin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qirui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3823-9984","authenticated-orcid":true,"given":"Yulong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2024,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/s0140-6736(16)30970-9","volume":"389","author":"Maher","year":"2017","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/s0140-6736(21)00733-9","volume":"398","author":"Knezevic","year":"2021","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/j.joca.2015.03.028","volume":"23","author":"Vergroesen","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s40824-017-0106-6","volume":"21","author":"van Uden","year":"2017","journal-title":"Biomater Res"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Global, regional. and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1789\u20131858. doi:10.1016\/s0140-6736(18)32279-7","DOI":"10.1016\/S0140-6736(18)32279-7"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"208","DOI":"10.3390\/ijms24010208","volume":"24","author":"Mohd Isa","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nrrheum.2013.160","volume":"10","author":"Risbud","year":"2014","journal-title":"Nat Rev Rheumatol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"421","DOI":"10.5455\/medarh.2019.73.421-424","volume":"73","author":"Kos","year":"2019","journal-title":"Med Arch"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.arr.2007.08.001","volume":"6","author":"Zhao","year":"2007","journal-title":"Ageing Res Rev"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1242\/dmm.006403","volume":"4","author":"Smith","year":"2011","journal-title":"Dis Model Mech"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1111\/os.13254","volume":"14","author":"Xin","year":"2022","journal-title":"Orthop Surg"},{"key":"ref12","first-page":"1","volume":"21","author":"Wu","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"27","DOI":"10.7150\/thno.48987","volume":"11","author":"Kamali","year":"2021","journal-title":"Theranostics"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"6235400","DOI":"10.1155\/2022\/6235400","volume":"2022","author":"Esquijarosa Hechavarria","year":"2022","journal-title":"Pain Res Manag"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1007\/s00586-004-0687-3","volume":"13","author":"Aunoble","year":"2004","journal-title":"Eur Spine J"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1097\/00024720-200308000-00009","volume":"16","author":"van Ooij","year":"2003","journal-title":"J Spinal Disord Tech"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1097\/01.bsd.0000159035.35365.df","volume":"18","author":"Shim","year":"2005","journal-title":"J Spinal Disord Tech"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1153019","DOI":"10.3389\/fbioe.2023.1153019","volume":"11","author":"Huang","year":"2023","journal-title":"Front Bioeng Biotechnol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1077028","DOI":"10.3389\/fbioe.2022.1077028","volume":"10","author":"Liu","year":"2022","journal-title":"Front Bioeng Biotechnol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"211","DOI":"10.3390\/gels8040211","volume":"8","author":"Ligorio","year":"2022","journal-title":"Gels"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"e2102530","DOI":"10.1002\/adhm.202102530","volume":"11","author":"Mohd Isa","year":"2022","journal-title":"Adv Healthc Mater"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"121941","DOI":"10.1016\/j.ijpharm.2022.121941","volume":"624","author":"Le Moal","year":"2022","journal-title":"Int J Pharm"},{"key":"ref23","volume-title":"The Intervertebral Disc: Molecular and Structural Studies of the Disc in Health and Disease","year":"2014"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.jmbbm.2017.01.037","volume":"69","author":"Newell","year":"2017","journal-title":"J Mech Behav Biomed Mater"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1002\/ar.1092200402","volume":"220","author":"Humzah","year":"1988","journal-title":"Anat Rec"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/bjs.1800650126","volume":"65","author":"Kessel","year":"2005","journal-title":"Br J Surg"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1002\/ca.22316","volume":"27","author":"D\u2019Antoni","year":"2014","journal-title":"Clin Anat"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"6815","DOI":"10.1038\/s41598-021-86334-8","volume":"11","author":"Stein","year":"2021","journal-title":"Sci Rep"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s00441-019-03136-1","volume":"379","author":"Molladavoodi","year":"2020","journal-title":"Cell Tissue Res"},{"key":"ref30","first-page":"1","volume":"120","author":"Maroudas","year":"1975","journal-title":"J Anat"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1302\/0301-620X.52B2.371","volume":"52","author":"Souter","year":"1970","journal-title":"J Bone Joint Surg Br"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/nyas.13964","volume":"1442","author":"Torre","year":"2019","journal-title":"Ann N Y Acad Sci"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"e0144497","DOI":"10.1371\/journal.pone.0144497","volume":"11","author":"van den Akker","year":"2016","journal-title":"PLoS One"},{"key":"ref34","volume-title":"Spinal Anatomy: Modern Concepts","year":"2020"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1093\/rheumatology\/ket303","volume":"53","author":"Lv","year":"2014","journal-title":"Rheumatology"},{"key":"ref36","first-page":"435","volume":"22","author":"Maarof","year":"2011","journal-title":"Biomed Res"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1136\/annrheumdis-2020-219515","volume":"80","author":"Morris","year":"2021","journal-title":"Ann Rheumatic Dis"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s00586-006-0088-x","volume":"15","author":"Chen","year":"2006","journal-title":"Eur Spine J"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1097\/00007632-199912010-00009","volume":"24","author":"Guilak","year":"1999","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/j.0021-8782.2004.00352.x","volume":"205","author":"Hunter","year":"2004","journal-title":"J Anat"},{"key":"ref41","first-page":"1","volume":"2019","author":"Taylor","year":"2019","journal-title":"Biology Intervertebral Disc"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"e52020","DOI":"10.1371\/journal.pone.0052020","volume":"7","author":"Tang","year":"2012","journal-title":"PLoS One"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"C621","DOI":"10.1152\/ajpcell.00538.2006","volume":"293","author":"Agrawal","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1007\/s00586-013-2798-1","volume":"22","author":"Moon","year":"2013","journal-title":"Eur Spine J"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s00586-006-0170-4","volume":"15","author":"Moore","year":"2006","journal-title":"Eur Spine J"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/00007632-198103000-00006","volume":"6","author":"Inoue","year":"1981","journal-title":"Spine"},{"key":"ref47","unstructured":"Standring S. Gray\u2019s anatomy: the anatomical basis of clinical practice; 2015."},{"key":"ref48","first-page":"1","volume":"2019","author":"Crock","year":"2019","journal-title":"The Biology of the Intervertebral Disc"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1016\/j.jbiomech.2010.01.023","volume":"43","author":"Shirazi-Adl","year":"2010","journal-title":"J Biomech"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1093\/pm\/pnab070","volume":"22","author":"Groh","year":"2021","journal-title":"Pain Med"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1097\/00007632-199512150-00005","volume":"20","author":"Roberts","year":"1995","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"90","DOI":"10.3389\/fbioe.2018.00090","volume":"6","author":"Chu","year":"2018","journal-title":"Front Bioeng Biotechnol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/s0945-053x(01)00125-1","volume":"20","author":"Hayes","year":"2001","journal-title":"Matrix Biol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1007\/s00586-010-1378-x","volume":"19","author":"Rutges","year":"2010","journal-title":"Eur Spine J"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1039\/c6bm00863a","volume":"5","author":"Chuah","year":"2017","journal-title":"Biomater Sci"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.actbio.2022.05.054","volume":"148","author":"Yu","year":"2022","journal-title":"Acta Biomater"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1097\/01.brs.0000192682.87267.2a","volume":"31","author":"Miyamoto","year":"2006","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.joca.2015.11.022","volume":"24","author":"Pratsinis","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"S326","DOI":"10.1007\/s00586-006-0127-7","volume":"15","author":"Roughley","year":"2006","journal-title":"Eur Spine J"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1097\/00007632-199106000-00008","volume":"16","author":"Brinckmann","year":"1991","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.1007\/s00586-014-3450-4","volume":"23","author":"Vergroesen","year":"2014","journal-title":"Eur Spine J"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1053\/j.semss.2005.06.001","volume":"17","author":"Singh","year":"2005","journal-title":"Sem Spine Surg"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"2631","DOI":"10.1097\/00007632-200212010-00002","volume":"27","author":"Boos","year":"2002","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1097\/00007632-199605150-00006","volume":"21","author":"Antoniou","year":"1996","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref65","first-page":"1","volume":"2000","author":"Urban","year":"2000","journal-title":"Am Zool"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1038\/ncomms2226","volume":"3","author":"Sakai","year":"2012","journal-title":"Nat Commun"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"R94","DOI":"10.1186\/ar4274","volume":"15","author":"Quero","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"R126","DOI":"10.1186\/ar2793","volume":"11","author":"Richardson","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.bbrc.2013.02.034","volume":"433","author":"Purmessur","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.spinee.2012.02.027","volume":"13","author":"Vo","year":"2013","journal-title":"Spine J"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1302\/0301-620x.90b10.20910","volume":"90","author":"Hadjipavlou","year":"2008","journal-title":"J Bone Joint Surg Br"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"39738","DOI":"10.1074\/jbc.M111.264549","volume":"286","author":"Wang","year":"2011","journal-title":"J Biol Chem"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1007\/s005860050217","volume":"9","author":"Moore","year":"2000","journal-title":"Eur Spine J Apr"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"442","DOI":"10.21037\/atm.2018.10.61","volume":"6","author":"Che-Nordin","year":"2018","journal-title":"Ann Transl Med"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1111\/j.1469-7580.2012.01551.x","volume":"221","author":"Adams","year":"2012","journal-title":"J Anat"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1097\/01.brs.0000261561.12944.ff","volume":"32","author":"Kuisma","year":"2007","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"838","DOI":"10.3174\/ajnr.A0925","volume":"29","author":"Rahme","year":"2008","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"6460","DOI":"10.3390\/ijms23126460","volume":"23","author":"Cost\u0103chescu","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/978-1-0716-1237-8_12","volume":"2270","author":"Khalil","year":"2021","journal-title":"Methods Mol Biol"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1002\/jor.25136","volume":"40","author":"Hiyama","year":"2022","journal-title":"J Orthop Res"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"5601593","DOI":"10.1155\/2017\/5601593","volume":"2017","author":"Feng","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1186\/s13075-015-0834-8","volume":"17","author":"Suzuki","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"e13448","DOI":"10.1111\/cpr.13448","volume":"56","author":"Wang","year":"2023","journal-title":"Cell Prolif"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.actbio.2023.01.020","volume":"158","author":"Zhang","year":"2023","journal-title":"Acta Biomater"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"147","DOI":"10.7150\/thno.47723","volume":"11","author":"Zheng","year":"2021","journal-title":"Theranostics"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"13651","DOI":"10.1073\/pnas.1518540112","volume":"112","author":"Zhang","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001464","volume":"4","author":"Bagno","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3389\/fphys.2014.00259","volume":"5","author":"Czikora","year":"2014","journal-title":"Front Physiol"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s12951-023-01856-9","volume":"21","author":"Yu","year":"2023","journal-title":"J Nanobiotechnology"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"e1901186","DOI":"10.1002\/adhm.201901186","volume":"9","author":"Bai","year":"2020","journal-title":"Adv Healthc Mater"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.cca.2020.04.016","volume":"508","author":"Zhang","year":"2020","journal-title":"Clin Chim Acta"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1002\/jor.24639","volume":"38","author":"Zhang","year":"2020","journal-title":"J Orthop Res"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"91","DOI":"10.12336\/biomatertransl.2021.02.003","volume":"2","author":"Peng","year":"2021","journal-title":"Biomater Transl"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1002\/art.27443","volume":"62","author":"Maurer","year":"2010","journal-title":"Arthritis Rheum"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1681\/asn.2010121308","volume":"22","author":"Qin","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1681\/asn.2011010055","volume":"23","author":"Wang","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1016\/j.biochi.2013.03.010","volume":"95","author":"He","year":"2013","journal-title":"Biochimie"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1016\/j.ajpath.2013.08.027","volume":"183","author":"Ramdas","year":"2013","journal-title":"Am J Pathol"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"e1800623","DOI":"10.1002\/adhm.201800623","volume":"7","author":"Feng","year":"2018","journal-title":"Adv Healthc Mater"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"7306","DOI":"10.3390\/ijms23137306","volume":"23","author":"Bhujel","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/nrrheum.2015.13","volume":"11","author":"Sakai","year":"2015","journal-title":"Nat Rev Rheumatol"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.bioactmat.2022.07.024","volume":"21","author":"Xia","year":"2023","journal-title":"Bioact Mater"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/nrd2425","volume":"6","author":"Szab\u00f3","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"27474","DOI":"10.1021\/acsami.6b06466","volume":"8","author":"Wu","year":"2016","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nrd4433","volume":"14","author":"Wallace","year":"2015","journal-title":"Nat Rev Drug Discov"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1039\/c8tb02566e","volume":"7","author":"Zheng","year":"2019","journal-title":"J Mater Chem B"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s00586-003-0582-3","volume":"12","author":"Razaq","year":"2003","journal-title":"Eur Spine J"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1097\/00003086-199308000-00050","volume":"293","author":"Kitano","year":"1993","journal-title":"Clin Orthop Relat Res"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"37360","DOI":"10.1038\/srep37360","volume":"6","author":"Gilbert","year":"2016","journal-title":"Sci Rep"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"e1004","DOI":"10.1002\/jsp2.1004","volume":"1","author":"Hodson","year":"2018","journal-title":"JOR Spine"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"111493","DOI":"10.1016\/j.matdes.2022.111493","volume":"225","author":"Ding","year":"2023","journal-title":"Mater Des"},{"key":"ref112","doi-asserted-by":"publisher","first-page":"7773609","DOI":"10.1155\/2023\/7773609","volume":"2023","author":"Wang","year":"2023","journal-title":"Oxid Med Cell Longev"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"122132","DOI":"10.1016\/j.biomaterials.2023.122132","volume":"298","author":"Wang","year":"2023","journal-title":"Biomaterials"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1021\/bm100046n","volume":"11","author":"Mortisen","year":"2010","journal-title":"Biomacromolecules"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"3697","DOI":"10.1021\/nl403733z","volume":"14","author":"Barhoumi","year":"2014","journal-title":"Nano Lett"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"6332","DOI":"10.1002\/anie.201101007","volume":"50","author":"Kono","year":"2011","journal-title":"Angew Chem Int Ed Engl"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.eurpolymj.2016.11.029","volume":"88","author":"Osawa","year":"2017","journal-title":"Eur Polym J"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.biomaterials.2009.09.027","volume":"31","author":"Yang","year":"2010","journal-title":"Biomaterials"},{"key":"ref119","doi-asserted-by":"publisher","first-page":"E167","DOI":"10.1002\/term.1667","volume":"9","author":"Malonzo","year":"2015","journal-title":"J Tissue Eng Regen Med"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1021\/bm800051m","volume":"9","author":"Sahoo","year":"2008","journal-title":"Biomacromolecules"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"118828","DOI":"10.1016\/j.carbpol.2021.118828","volume":"277","author":"Guo","year":"2022","journal-title":"Carbohydr Polym"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"S4108","DOI":"10.21037\/jtd.2018.09.143","volume":"10","author":"Amin","year":"2018","journal-title":"J Thorac Dis"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.cca.2015.09.011","volume":"450","author":"Wang","year":"2015","journal-title":"Clin Chim Acta"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1007\/s10753-020-01254-5","volume":"43","author":"Lin","year":"2020","journal-title":"Inflammation"},{"key":"ref125","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.21037\/atm-20-6595","volume":"8","author":"Huang","year":"2020","journal-title":"Ann Transl Med"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/nrg3763","volume":"15","author":"Yin","year":"2014","journal-title":"Nat Rev Genet"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.ijpharm.2013.03.028","volume":"448","author":"Calejo","year":"2013","journal-title":"Int J Pharm"},{"key":"ref128","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1021\/bm201637e","volume":"13","author":"Wong","year":"2012","journal-title":"Biomacromolecules"},{"key":"ref129","doi-asserted-by":"publisher","first-page":"E525","DOI":"10.1097\/BRS.0b013e31817c561b","volume":"33","author":"Zhang","year":"2008","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"R172","DOI":"10.1186\/ar2861","volume":"11","author":"Zhang","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"ref131","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1023\/b:pham.0000026436.62869.9c","volume":"21","author":"Tyagi","year":"2004","journal-title":"Pharm Res"},{"key":"ref132","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/s0168-3659(99)00194-7","volume":"63","author":"Jeong","year":"2000","journal-title":"J Control Release"},{"key":"ref133","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1023\/a:1023887203111","volume":"20","author":"Li","year":"2003","journal-title":"Pharm Res"},{"key":"ref134","doi-asserted-by":"publisher","first-page":"2000863","DOI":"10.1002\/advs.202000863","volume":"7","author":"Lee","year":"2020","journal-title":"Adv Sci (Weinh)"},{"key":"ref135","doi-asserted-by":"publisher","first-page":"4584","DOI":"10.1021\/jacs.6b08313","volume":"139","author":"Karimi","year":"2017","journal-title":"J Am Chem Soc"},{"key":"ref136","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1002\/term.2841","volume":"13","author":"Chen","year":"2019","journal-title":"J Tissue Eng Regen Med"},{"key":"ref137","doi-asserted-by":"publisher","first-page":"R67","DOI":"10.1186\/ar4505","volume":"16","author":"Clarke","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"ref138","doi-asserted-by":"publisher","first-page":"3695","DOI":"10.1002\/art.27710","volume":"62","author":"Minogue","year":"2010","journal-title":"Arthritis Rheum"},{"key":"ref139","doi-asserted-by":"publisher","first-page":"3463","DOI":"10.1016\/j.actbio.2014.04.027","volume":"10","author":"Kumar","year":"2014","journal-title":"Acta Biomater"},{"key":"ref140","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/978-1-4939-3148-4_16","volume":"1372","author":"Endo-Takahashi","year":"2016","journal-title":"Methods Mol Biol"},{"key":"ref141","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.addr.2013.12.010","volume":"72","author":"Sirsi","year":"2014","journal-title":"Adv Drug Deliv Rev"},{"key":"ref142","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.ultsonch.2016.11.002","volume":"36","author":"Liao","year":"2017","journal-title":"Ultrason Sonochem"},{"key":"ref143","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1126\/science.243.4897.1499-a","volume":"243","author":"Ultrasound","year":"1989","journal-title":"Science"},{"key":"ref144","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/s0168-3659(02)00262-6","volume":"84","author":"Marin","year":"2002","journal-title":"J Control Release"},{"key":"ref145","doi-asserted-by":"publisher","first-page":"104782","DOI":"10.1016\/j.ultsonch.2019.104782","volume":"60","author":"Mannaris","year":"2020","journal-title":"Ultrason Sonochem"},{"key":"ref146","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/s0168-3659(02)00203-1","volume":"83","author":"Husseini","year":"2002","journal-title":"J Control Release"},{"key":"ref147","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.addr.2013.11.008","volume":"72","author":"Lentacker","year":"2014","journal-title":"Adv Drug Deliv Rev"},{"key":"ref148","doi-asserted-by":"publisher","first-page":"1536012118778216","DOI":"10.1177\/1536012118778216","volume":"17","author":"Zullino","year":"2018","journal-title":"Mol Imaging"},{"key":"ref149","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1016\/j.nano.2015.12.361","volume":"12","author":"Wang","year":"2016","journal-title":"Nanomedicine"},{"key":"ref150","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1109\/tuffc.2016.2613991","volume":"64","author":"Mulvana","year":"2017","journal-title":"IEEE Trans Ultrason Ferroelectr Freq Control"},{"key":"ref151","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3109\/1061186x.2014.954119","volume":"23","author":"Ahmed","year":"2015","journal-title":"J Drug Target"},{"key":"ref152","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1023\/a:1020178304031","volume":"22","author":"Ulrich","year":"2002","journal-title":"Biosci Rep"},{"key":"ref153","doi-asserted-by":"publisher","first-page":"5439","DOI":"10.1021\/acsnano.1c09505","volume":"16","author":"Zhuang","year":"2022","journal-title":"ACS Nano"},{"key":"ref154","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.2217\/nnm-2018-0019","volume":"13","author":"Shen","year":"2018","journal-title":"Nanomedicine"},{"key":"ref155","doi-asserted-by":"publisher","first-page":"15","DOI":"10.22203\/eCM.v017a02","volume":"17","author":"Kobayashi","year":"2009","journal-title":"Eur Cell Mater"},{"key":"ref156","doi-asserted-by":"publisher","first-page":"E248","DOI":"10.1097\/brs.0000000000001220","volume":"41","author":"Zhang","year":"2016","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref157","doi-asserted-by":"publisher","DOI":"10.1117\/12.2255761","volume":"10066","author":"Horne","year":"2017","journal-title":"Proc SPIE Int Soc Opt Eng"},{"key":"ref158","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3109\/03008207.2015.1016609","volume":"56","author":"Chen","year":"2015","journal-title":"Connect Tissue Res"},{"key":"ref159","doi-asserted-by":"publisher","first-page":"7099","DOI":"10.1039\/c3cs60058k","volume":"42","author":"Th\u00e9venot","year":"2013","journal-title":"Chem Soc Rev"},{"key":"ref160","doi-asserted-by":"publisher","first-page":"5647","DOI":"10.1039\/c2cc31563g","volume":"48","author":"Bringas","year":"2012","journal-title":"Chem Commun"},{"key":"ref161","doi-asserted-by":"publisher","first-page":"2558","DOI":"10.1021\/nn205023w","volume":"6","author":"Hu","year":"2012","journal-title":"ACS Nano"},{"key":"ref162","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1002\/adfm.200701210","volume":"1186","author":"Hu","year":"2008","journal-title":"Adv Funct Mater"},{"key":"ref163","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1002\/adma.200800193","volume":"20","author":"Hu","year":"2008","journal-title":"Adv Mater"},{"key":"ref164","doi-asserted-by":"publisher","first-page":"E221","DOI":"10.1097\/BSD.0b013e31827caeb7","volume":"26","author":"Okada","year":"2013","journal-title":"J Spinal Disord Tech"},{"key":"ref165","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1039\/C2PY20089A","volume":"3","author":"Louguet","year":"2012","journal-title":"Polym Chem"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=99413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=99413","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T11:10:29Z","timestamp":1716549029000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/stimuli-responsive-delivery-systems-for-intervertebral-disc-degenerati-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":165,"URL":"https:\/\/doi.org\/10.2147\/ijn.s463939","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5]]}}}