{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:38:30Z","timestamp":1791473910035,"version":"4.3.4"},"reference-count":64,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s481917","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T11:05:12Z","timestamp":1735902312000},"page":"71-89","source":"Crossref","is-referenced-by-count":15,"title":["Hyaluronic Acid-Based Hybrid Nanoparticles as Promising Carriers for the Intranasal Administration of Dimethyl Fumarate"],"prefix":"10.2147","volume":"Volume 20","author":[{"given":"Carla","family":"Serri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7022-7705","authenticated-orcid":true,"given":"Miriam","family":"Piccioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Guarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4094-9996","authenticated-orcid":true,"given":"Pamela","family":"Santonicola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6366-3002","authenticated-orcid":true,"given":"Iriczalli","family":"Cruz-Maya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Crispi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano Pio","family":"Di Cagno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Ferraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Dalpiaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giada","family":"Botti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Giunchedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6268-8179","authenticated-orcid":true,"given":"Giovanna","family":"Rassu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0499-9419","authenticated-orcid":true,"given":"Elisabetta","family":"Gavini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1146\/annurev-pathol-052920-040318","volume":"17","author":"Rodr\u00edguez Mur\u00faa","year":"2022","journal-title":"Annu Rev Pathol Mech Dis"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.18553\/jmcp.2016.22.12.1394","volume":"22","author":"Higuera","year":"2016","journal-title":"J Manag Care Spec Pharm"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1002\/acn3.50862","volume":"6","author":"Waubant","year":"2019","journal-title":"Ann Clin Transl Neurol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e00362","DOI":"10.1002\/brb3.362","volume":"5","author":"Garg","year":"2015","journal-title":"Brain Behav"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1007\/s40263-021-00799-9","volume":"35","author":"Lategan","year":"2021","journal-title":"CNS Drugs"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.clindermatol.2008.07.001","volume":"26","author":"Yazdi","year":"2008","journal-title":"Clin Dermatol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1177\/13524585211037909","volume":"28","author":"Gold","year":"2022","journal-title":"Mult Scler J"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"103669","DOI":"10.1016\/j.msard.2022.103669","volume":"59","author":"De La Maza","year":"2022","journal-title":"Mult Scler Relat Disord"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"225","DOI":"10.15171\/apb.2018.027","volume":"8","author":"Ojha","year":"2018","journal-title":"Adv Pharm Bull"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1021\/acschemneuro.6b00428","volume":"8","author":"Kumar","year":"2017","journal-title":"ACS Chem Neurosci"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"111617","DOI":"10.1016\/j.intimp.2024.111617","volume":"129","author":"Royaei","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.36468\/pharmaceutical-sciences.535","volume":"81","author":"Ojha","year":"2019","journal-title":"Indian J Pharm Sci"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"102893","DOI":"10.1016\/j.jaut.2022.102893","volume":"132","author":"Rolfsen Ferreira Da Silva","year":"2022","journal-title":"J Autoimmun"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"3132","DOI":"10.1021\/acs.molpharmaceut.1c00366","volume":"18","author":"Clementino","year":"2021","journal-title":"Mol Pharm"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1007\/s11910-013-0394-8","volume":"13","author":"Linker","year":"2013","journal-title":"Curr Neurol Neurosci Rep"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1080\/10837450.2023.2285506","volume":"28","author":"Kumar","year":"2023","journal-title":"Pharm Dev Technol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.ejpb.2018.05.009","volume":"128","author":"Bourganis","year":"2018","journal-title":"Eur J Pharm Biopharm"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1007\/s13346-021-01086-2","volume":"12","author":"Borrajo","year":"2022","journal-title":"Drug Deliv Transl Res"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.ijpharm.2013.03.054","volume":"453","author":"Mu","year":"2013","journal-title":"Int J Pharm"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/nnano.2007.387","volume":"2","author":"Peer","year":"2007","journal-title":"Nat Nanotechnol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/nrd1632","volume":"4","author":"Torchilin","year":"2005","journal-title":"Nat Rev Drug Discov"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.ejpb.2013.07.002","volume":"85","author":"Hadinoto","year":"2013","journal-title":"Eur J Pharm Biopharm"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.ijpharm.2005.10.010","volume":"307","author":"Owensiii","year":"2006","journal-title":"Int J Pharm"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.jconrel.2011.11.019","volume":"160","author":"Gabizon","year":"2012","journal-title":"J Control Release"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"4377","DOI":"10.3390\/molecules25194377","volume":"25","author":"Mohanty","year":"2020","journal-title":"Molecules"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1111\/j.1460-9568.2008.06377.x","volume":"28","author":"Lor\u00eda","year":"2008","journal-title":"Eur J Neurosci"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.carbpol.2015.12.031","volume":"140","author":"Giarra","year":"2016","journal-title":"Carbohydr Polym"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/j.colsurfb.2019.06.044","volume":"181","author":"Serri","year":"2019","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"122496","DOI":"10.1016\/j.ijpharm.2022.122496","volume":"631","author":"Laffleur","year":"2023","journal-title":"Int J Pharm"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.colsurfb.2012.05.010","volume":"100","author":"Salama","year":"2012","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/j.ijbiomac.2019.11.066","volume":"151","author":"Vasvani","year":"2020","journal-title":"Int J Biol Macromol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s13318-017-0426-x","volume":"43","author":"Mercier","year":"2018","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1186\/1471-2164-15-1154","volume":"15","author":"Krishna","year":"2014","journal-title":"BMC Genomics"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ijpharm.2017.01.049","volume":"520","author":"Serri","year":"2017","journal-title":"Int J Pharm"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1208\/s12249-008-9153-6","volume":"9","author":"Juliano","year":"2008","journal-title":"AAPS Pharm Sci Tech"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"105419","DOI":"10.1016\/j.jddst.2024.105419","volume":"93","author":"Lombardo","year":"2024","journal-title":"J Drug Deliv Sci Technol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1002\/jssc.202001007","volume":"44","author":"Habib","year":"2021","journal-title":"J Sep Sci"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"4046","DOI":"10.1021\/acs.molpharmaceut.1c00468","volume":"18","author":"Demartis","year":"2021","journal-title":"Mol Pharm"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.ejps.2015.03.019","volume":"73","author":"Di Cagno","year":"2015","journal-title":"Eur J Pharm Sci"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"592","DOI":"10.3390\/pharmaceutics15020592","volume":"15","author":"Jacobsen","year":"2023","journal-title":"Pharmaceutics"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0165-0270(02)00033-X","volume":"116","author":"Den Berg MP","year":"2002","journal-title":"J Neurosci Methods"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1021\/mp400735c","volume":"11","author":"Dalpiaz","year":"2014","journal-title":"Mol Pharm"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1007\/BF01466734","volume":"52","author":"Felgenhauer","year":"1974","journal-title":"Klin Wochenschr"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1128\/AAC.38.9.2111","volume":"38","author":"Madu","year":"1994","journal-title":"Antimicrob Agents Chemother"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1042\/CS20210792","volume":"136","author":"Pinto","year":"2022","journal-title":"Clin Sci"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1007\/s13346-020-00891-5","volume":"12","author":"Keller","year":"2022","journal-title":"Drug Deliv Transl Res"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1007\/s40263-022-00930-4","volume":"36","author":"Lofts","year":"2022","journal-title":"CNS Drugs"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.ejpb.2017.04.011","volume":"115","author":"Esposito","year":"2017","journal-title":"Eur J Pharm Biopharm"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.colsurfb.2016.01.014","volume":"141","author":"Zeng","year":"2016","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0141-8130(94)90028-0","volume":"16","author":"Ghosh","year":"1994","journal-title":"Int J Biol Macromol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"112240","DOI":"10.1016\/j.colsurfb.2021.112240","volume":"210","author":"Della Sala","year":"2022","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.3390\/polym12081800","volume":"12","author":"Snetkov","year":"2020","journal-title":"Polymers"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.addr.2011.02.001","volume":"63","author":"Wu","year":"2011","journal-title":"Adv Drug Deliv Rev"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.ijpharm.2010.12.036","volume":"406","author":"Kovacevic","year":"2011","journal-title":"Int J Pharm"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"124216","DOI":"10.1016\/j.ijpharm.2024.124216","volume":"659","author":"Cama","year":"2024","journal-title":"Int J Pharm"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.ejpb.2008.10.009","volume":"72","author":"Horv\u00e1t","year":"2009","journal-title":"Eur J Pharm Biopharm"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1023\/A:1015894910416","volume":"08","author":"Morimoto","year":"1991","journal-title":"Pharm Res"},{"key":"ref58","unstructured":"Guidance for industry. nasal spray and inhalation solution, suspension, and spray drug products - chemistry, manufacturing, and controls documentation; 2002. Available from: https:\/\/www.fda.gov\/files\/drugs\/published\/Nasal-Spray-and-Inhalation-Solution--Suspension--and-Drug-Products.pdf. Accessed December 21, 2024."},{"key":"ref59","unstructured":"Kulkarni V, Shaw C Formulation and characterization of nasal sprays. Inhalation; 2012; Available from: https:\/\/www.inhalationmag.com\/wp-content\/uploads\/pdf\/inh_20120601_0010.pdf. Accessed December 21, 2024."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.ejpb.2008.04.025","volume":"70","author":"Mayol","year":"2008","journal-title":"Eur J Pharm Biopharm"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.ijbiomac.2020.01.235","volume":"149","author":"Oliveira Cardoso VM","year":"2020","journal-title":"Int J Biol Macromol"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"100072","DOI":"10.1016\/j.sctalk.2022.100072","volume":"4","author":"Sepulveda","year":"2022","journal-title":"Sci Talks"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.ejps.2013.01.006","volume":"48","author":"Di Cagno","year":"2013","journal-title":"Eur J Pharm Sci"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.2147\/IJN.S198353","volume":"14","author":"Mukherjee","year":"2019","journal-title":"Int J Nanomed"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/98943","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/98943","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T11:05:14Z","timestamp":1735902314000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/hyaluronic-acid-based-hybrid-nanoparticles-as-promising-carriers-for-t-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":64,"URL":"https:\/\/doi.org\/10.2147\/ijn.s481917","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]}}}