{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:30:42Z","timestamp":1792290642830,"version":"4.4.0"},"reference-count":62,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s510937","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T15:40:10Z","timestamp":1752507610000},"page":"8993-9017","source":"Crossref","is-referenced-by-count":13,"title":["Protective Effects of GalNac-Modified Red Blood Cell-Derived Extracellular Vesicles Against Liver Diseases"],"prefix":"10.2147","volume":"Volume 20","author":[{"given":"Xiaofang","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9298-3961","authenticated-orcid":true,"given":"Gensheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1002\/hep.27406","volume":"60","author":"Wang","year":"2014","journal-title":"Hepatology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1083780","DOI":"10.3389\/fimmu.2022.1083780","volume":"13","author":"Gong","year":"2023","journal-title":"Front Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1056\/NEJMc1614962","volume":"376","author":"Wijdicks","year":"2017","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/978-3-319-48382-5_19","volume":"960","author":"Engin","year":"2017","journal-title":"Adv Exp Med Biol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1080\/13880209.2022.2117828","volume":"60","author":"Song","year":"2022","journal-title":"Pharm Biol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"156522","DOI":"10.1016\/j.phymed.2025.156522","volume":"139","author":"Ma","year":"2025","journal-title":"Phytomedicine"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1002\/ptr.6417","volume":"33","author":"Wang","year":"2019","journal-title":"Phytother Res"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"155771","DOI":"10.1016\/j.metabol.2023.155771","volume":"152","author":"Ishteyaque","year":"2024","journal-title":"Metabolism"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1002\/hep.23249","volume":"51","author":"Quiles-Perez","year":"2010","journal-title":"Hepatology"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"107567","DOI":"10.1016\/j.phrs.2024.107567","volume":"211","author":"Leng","year":"2025","journal-title":"Pharmacol Res"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1124\/jpet.117.243105","volume":"364","author":"Huang","year":"2018","journal-title":"J Pharmacol Exp Ther"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1126\/science.abg6155","volume":"373","author":"Segel","year":"2021","journal-title":"Science"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e2109256118","DOI":"10.1073\/pnas.2109256118","volume":"118","author":"Dilliard","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1021\/acscentsci.1c00146","volume":"7","author":"Zhou","year":"2021","journal-title":"ACS Cent Sci"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/0092-8674(80)90371-2","volume":"22","author":"Baenziger","year":"1980","journal-title":"Cell"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"3360","DOI":"10.1038\/s41467-020-16991-2","volume":"11","author":"Arbier-Torres","year":"2020","journal-title":"Nat Commun"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"8796","DOI":"10.1093\/nar\/gku531","volume":"42","author":"Prakash","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1038\/nbt.2612","volume":"31","author":"Gilleron","year":"2013","journal-title":"Nat Biotechnol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/nrm.2017.125","volume":"19","author":"van Niel","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.addr.2020.04.004","volume":"159","author":"Elsharkasy","year":"2020","journal-title":"Adv Drug Deliv Rev"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"2798","DOI":"10.3390\/biomedicines11102798","volume":"11","author":"Ma","year":"2023","journal-title":"Biomedicines"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.1038\/s41467-018-04791-8","volume":"9","author":"Usman","year":"2018","journal-title":"Nat Commun"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.jhep.2007.10.014","volume":"48","author":"Lu","year":"2008","journal-title":"J Hepatol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.ebiom.2018.08.054","volume":"36","author":"Liu","year":"2018","journal-title":"EBioMedicine"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/978-1-59745-019-5_13","volume":"633","author":"Li","year":"2010","journal-title":"Methods Mol Biol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1093\/abbs\/gmt143","volume":"46","author":"Chang","year":"2014","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"4124","DOI":"10.1172\/JCI94495","volume":"127","author":"Cheng","year":"2017","journal-title":"J Clin Invest"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1002\/hep.1840170118","volume":"17","author":"Higaki","year":"1993","journal-title":"Hepatology"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.jpha.2021.06.007","volume":"12","author":"Li","year":"2022","journal-title":"J Pharm Anal"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1038\/s41589-021-00770-1","volume":"17","author":"Ahn","year":"2021","journal-title":"Nat Chem Biol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"e12030","DOI":"10.1002\/jev2.12030","volume":"10","author":"Zhang","year":"2020","journal-title":"J Extracell Vesicles"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"101412","DOI":"10.1016\/j.redox.2019.101412","volume":"30","author":"Li","year":"2020","journal-title":"Redox Biol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.cmet.2012.06.016","volume":"16","author":"Bai","year":"2012","journal-title":"Cell Metab"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.jhep.2016.08.024","volume":"66","author":"Gariani","year":"2017","journal-title":"J Hepatol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"e12153","DOI":"10.1002\/jev2.12153","volume":"10","author":"Fei","year":"2021","journal-title":"J Extracell Vesicles"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.jconrel.2021.09.025","volume":"339","author":"Gandhi","year":"2021","journal-title":"J Control Release"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1089\/nat.2018.0736","volume":"28","author":"Springer","year":"2018","journal-title":"Nucleic Acid Ther"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1021\/acs.bioconjchem.0c00060","volume":"31","author":"Glazier","year":"2020","journal-title":"Bioconjug Chem"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.omtn.2016.12.003","volume":"6","author":"Huang","year":"2017","journal-title":"Mol Ther Nucleic Acids"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41392-020-0207-x","volume":"5","author":"Hu","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.omtn.2022.06.005","volume":"29","author":"Godinho","year":"2022","journal-title":"Mol Ther Nucleic Acids"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1093\/toxsci\/kfac067","volume":"189","author":"Rider","year":"2022","journal-title":"Toxicol Sci"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"20884","DOI":"10.1039\/C9NR02791B","volume":"11","author":"Luo","year":"2019","journal-title":"Nanoscale"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1080\/19420862.2017.1373924","volume":"9","author":"Bon","year":"2017","journal-title":"MAbs"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"102667","DOI":"10.1016\/j.nano.2023.102667","volume":"50","author":"Ellipilli","year":"2023","journal-title":"Nanomedicine"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1016\/j.bmc.2019.04.019","volume":"27","author":"Zhang","year":"2019","journal-title":"Bioorg Med Chem"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/s41392-020-0187-x","volume":"5","author":"Tang","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1111\/jgh.13065","volume":"30","author":"Tu","year":"2015","journal-title":"J Gastroenterol Hepatol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"3288","DOI":"10.7150\/thno.68667","volume":"12","author":"Jayasinghe","year":"2022","journal-title":"Theranostics"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.gene.2012.12.009","volume":"532","author":"Elton","year":"2013","journal-title":"Gene"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s13018-021-02886-5","volume":"17","author":"Li","year":"2022","journal-title":"J Orthop Surg Res"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1111\/jcmm.16107","volume":"25","author":"Li","year":"2021","journal-title":"J Cell Mol Med"},{"key":"ref54","first-page":"2115","volume":"7","author":"Shen","year":"2015","journal-title":"Am J Transl Res"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"115591","DOI":"10.1016\/j.bcp.2023.115591","volume":"213","author":"Prasad Panda","year":"2023","journal-title":"Biochem Pharmacol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"10224","DOI":"10.3390\/ijms231810224","volume":"23","author":"Hao","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1146\/annurev.cellbio.23.090506.123319","volume":"23","author":"Piper","year":"2007","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1091\/mbc.11.2.467","volume":"11","author":"Bucci","year":"2000","journal-title":"Mol Biol Cell"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3390\/cells5030034","volume":"5","author":"Guerra","year":"2016","journal-title":"Cells"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.devcel.2014.10.007","volume":"31","author":"Gillingham","year":"2014","journal-title":"Dev Cell"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"153","DOI":"10.3390\/ijms22010153","volume":"22","author":"Thangaraju","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.2174\/1389557523666230221145844","volume":"23","author":"Negi","year":"2023","journal-title":"Mini Rev Med Chem"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/104832","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/104832","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T15:40:12Z","timestamp":1752507612000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/protective-effects-of-galnac-modified-red-blood-cell-derived-extracell-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":62,"URL":"https:\/\/doi.org\/10.2147\/ijn.s510937","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}