{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:21:17Z","timestamp":1785212477682,"version":"3.55.0"},"reference-count":39,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s518120","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T14:50:13Z","timestamp":1751295013000},"page":"8481-8496","source":"Crossref","is-referenced-by-count":6,"title":["ROS-Responsive Nanosystem Targeted Co-Delivery YC-1 and Regorafenib to Alleviate Hypoxia Enhancing Hepatocellular Carcinoma Therapy"],"prefix":"10.2147","volume":"Volume 20","author":[{"given":"Liming","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senfeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaning","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruopeng","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongtao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binghua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7679-5386","authenticated-orcid":true,"given":"Yupeng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3389\/fonc.2020.00171","volume":"10","author":"Dasgupta","year":"2020","journal-title":"Front Oncol"},{"key":"ref3","volume":"34","author":"Gabutti","year":"2020","journal-title":"Oncology"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1097\/sla.0000000000000710","volume":"261","author":"Tabrizian","year":"2015","journal-title":"Ann Surg"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"16224","DOI":"10.1038\/s41598-018-34676-1","volume":"8","author":"Lee","year":"2018","journal-title":"Sci Rep"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1136\/gutjnl-2013-306627","volume":"63","author":"Bruix","year":"2014","journal-title":"Gut"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ctrv.2018.05.006","volume":"68","author":"Raoul","year":"2018","journal-title":"Cancer Treat Rev"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.canlet.2006.01.008","volume":"242","author":"Pang","year":"2006","journal-title":"Cancer Lett"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/978-3-319-91442-8_3","volume":"211","author":"Ettrich","year":"2018","journal-title":"Recent Results Cancer Res"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1002\/ijc.25864","volume":"129","author":"Wilhelm","year":"2011","journal-title":"Int J Cancer"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1097\/hep.0000000000000237","volume":"79","author":"Ladd","year":"2024","journal-title":"Hepatology"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.actbio.2018.05.049","volume":"75","author":"Li","year":"2018","journal-title":"Acta Biomater"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1021\/acs.bioconjchem.1c00131","volume":"32","author":"Luo","year":"2021","journal-title":"Bioconjug Chem"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.canlet.2007.03.026","volume":"255","author":"Shin","year":"2007","journal-title":"Cancer Lett"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/s43018-023-00523-0","volume":"4","author":"Shi","year":"2023","journal-title":"Nat Cancer"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/s41392-023-01513-5","volume":"8","author":"Liao","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"106400","DOI":"10.1016\/j.bioorg.2023.106400","volume":"133","author":"Ouyang","year":"2023","journal-title":"Bioorg Chem"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"114423","DOI":"10.1016\/j.biopha.2023.114423","volume":"161","author":"Li","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1124\/jpet.104.077230","volume":"312","author":"Wang","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"7010","DOI":"10.1021\/acsnano.9b02096","volume":"13","author":"Wang","year":"2019","journal-title":"ACS Nano"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/s12951-020-00694-3","volume":"18","author":"Xiong","year":"2020","journal-title":"J Nanobiotechnology"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"216106","DOI":"10.1016\/j.canlet.2023.216106","volume":"558","author":"Wu","year":"2023","journal-title":"Cancer Lett"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"12679","DOI":"10.1021\/acsnano.0c01453","volume":"14","author":"Zhou","year":"2020","journal-title":"ACS Nano"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.7150\/thno.29101","volume":"9","author":"Gao","year":"2019","journal-title":"Theranostics"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1038\/s41467-017-01050-0","volume":"8","author":"Yang","year":"2017","journal-title":"Nat Commun"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.jconrel.2015.06.002","volume":"211","author":"Fornaguera","year":"2015","journal-title":"J Control Release"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1080\/17425247.2016.1182485","volume":"13","author":"D\u2019Souza","year":"2016","journal-title":"Expert Opin Drug Deliv"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1016\/j.biomaterials.2011.11.051","volume":"33","author":"Zhao","year":"2012","journal-title":"Biomaterials"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1703674","DOI":"10.1002\/adfm.201703674","volume":"27","author":"Zhou","year":"2017","journal-title":"Adv Funct Mater"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1706945","DOI":"10.1002\/adfm.201706945","volume":"28","author":"Zhen","year":"2018","journal-title":"Adv Funct Mater"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1039\/d1ra08120a","volume":"12","author":"Yu","year":"2021","journal-title":"RSC Adv"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"17562848211016959","DOI":"10.1177\/17562848211016959","volume":"14","author":"Granito","year":"2021","journal-title":"Therap Adv Gastroenterol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.ultsonch.2018.11.005","volume":"52","author":"Modarres-Gheisari","year":"2019","journal-title":"Ultrason Sonochem"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232214063","volume":"23","author":"Wang","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"5865","DOI":"10.2147\/ijn.S86313","volume":"10","author":"Lopes","year":"2015","journal-title":"Int J Nanomed"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"e2406140","DOI":"10.1002\/adma.202406140","volume":"36","author":"Wu","year":"2024","journal-title":"Adv Mater"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"121975","DOI":"10.1016\/j.biomaterials.2022.121975","volume":"293","author":"Hao","year":"2023","journal-title":"Biomaterials"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"13129","DOI":"10.1038\/s41598-021-92480-w","volume":"11","author":"Dudas","year":"2021","journal-title":"Sci Rep"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.biocel.2006.10.002","volume":"39","author":"Hempel","year":"2007","journal-title":"Int J Biochem Cell Biol"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/104376","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/104376","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T14:50:14Z","timestamp":1751295014000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/ros-responsive-nanosystem-targeted-co-delivery-yc-1-and-regorafenib-to-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":39,"URL":"https:\/\/doi.org\/10.2147\/ijn.s518120","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}