{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:27:10Z","timestamp":1792160830992,"version":"4.4.0"},"reference-count":177,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s524695","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T11:30:24Z","timestamp":1756899024000},"page":"10831-10855","source":"Crossref","is-referenced-by-count":15,"title":["Phytochemicals in Bone Therapy: Exploring Natural Alternatives for Bone Health"],"prefix":"10.2147","volume":"Volume 20","author":[{"given":"Hiba","family":"Abdelnabi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8956-6048","authenticated-orcid":true,"given":"Sahar","family":"Mohsin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"184","DOI":"10.3390\/DDC3010011","volume":"3","author":"Chaachouay","year":"2024","journal-title":"Drugs Drug Candidates"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"xvii","DOI":"10.1016\/B978-0-12-805257-0.00001-6","author":"Galanakis","year":"2017","journal-title":"Nutraceutical Funct Food Components Eff Innov Process Tech"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/01635580903191585","volume":"62","author":"Huang","year":"2009","journal-title":"Nutr Cancer"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/S00425-018-3056-X","volume":"249","author":"Tetali","year":"2019","journal-title":"Planta"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/B978-0-12-813374-3.00003-X","author":"Mukherjee","year":"2019","journal-title":"Qual Control Eval Herb Drugs"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"4224","DOI":"10.2174\/0929867324666170830113755","volume":"25","author":"Palazzolo","year":"2017","journal-title":"Curr Med Chem"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1080\/21691401.2018.1457039","volume":"46","author":"Dadwal","year":"2018","journal-title":"Cells Nanomed Biotechnol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"189","DOI":"10.2174\/187231309788166398","volume":"3","author":"Feng","year":"2009","journal-title":"Curr Chem Biol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.3390\/ANI12151946","volume":"12","author":"Bienko","year":"2022","journal-title":"Anim"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"728","DOI":"10.3390\/bioengineering9120728","volume":"9","author":"Bhushan","year":"2022","journal-title":"Bioengineering"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/J.ACTBIO.2021.02.034","volume":"126","author":"Bose","year":"2021","journal-title":"Acta Biomater"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"3876957","DOI":"10.1155\/2019\/3876957","volume":"2019","author":"Mohsin","year":"2019","journal-title":"J Diabetes Res"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-53487-6","volume":"9","author":"Mohsin","year":"2019","journal-title":"Sci Rep"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e16278","DOI":"10.7717\/PEERJ.16278","volume":"11","author":"Mohsin","year":"2023","journal-title":"PeerJ"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"101773","DOI":"10.1016\/J.BERH.2022.101773","volume":"36","author":"Baker","year":"2022","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"601618","DOI":"10.3389\/FMED.2020.601618","volume":"7","author":"Llorente","year":"2020","journal-title":"Front Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"638727","DOI":"10.1155\/2013\/638727","volume":"2013","author":"Gorka","year":"2013","journal-title":"Int J Endocrinol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1210\/ME.2007-0033","volume":"21","author":"Bassett","year":"2007","journal-title":"Mol Endocrinol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1080\/14712598.2019.1618266","volume":"19","author":"Mohsin","year":"2019","journal-title":"Expert Opin Biol Ther"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.4065\/83.9.1032","volume":"83","author":"Drake","year":"2008","journal-title":"Mayo Clin Proc"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"216","DOI":"10.3390\/CELLS12020216","volume":"12","author":"Azam","year":"2023","journal-title":"Cells"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1177\/0963689721993776","author":"Zhang","year":"2021","journal-title":"Cell Transplant"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"4925","DOI":"10.3390\/IJMS24054925","volume":"24","author":"Derwich","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"2995","DOI":"10.2174\/1381612054865019","volume":"11","author":"Sawynok","year":"2005","journal-title":"Curr Pharm Des"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1515\/ZNC-2021-0018","volume":"76","author":"Abdelnabi","year":"2021","journal-title":"Zeitschrift fur Naturforsch - Sect C J Biosci"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/B978-0-12-416003-3.00022-6","volume":"65","author":"Nagaoka","year":"2012","journal-title":"Adv Food Nutr Res"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/J.JOCA.2006.06.008","volume":"15","author":"Varghese","year":"2007","journal-title":"Osteoarthr Cartil"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"S20","DOI":"10.1097\/BOT.0000000000000978","volume":"31","author":"Schemitsch","year":"2017","journal-title":"J Orthop Trauma"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1097\/BOT.0B013E318224CAF0","volume":"25","author":"Nauth","year":"2011","journal-title":"J Orthop Trauma"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"114","DOI":"10.4161\/ORG.23306","volume":"8","author":"Roberts","year":"2012","journal-title":"Organogenesis"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.1007\/S10856-014-5240-2","volume":"25","author":"Campana","year":"2014","journal-title":"J Mater Sci Mater Med"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"39","DOI":"10.4236\/njgc.2018.83004","volume":"08","author":"Leteve","year":"2018","journal-title":"New J Glas Ceram"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.bioactmat.2017.05.007","volume":"2","author":"Wang","year":"2017","journal-title":"Bioact Mater"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.gendis.2014.07.005","volume":"1","author":"Wang","year":"2014","journal-title":"Genes Dis"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"a021899","DOI":"10.1101\/CSHPERSPECT.A021899","volume":"8","author":"Katagiri","year":"2016","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1900084","DOI":"10.1002\/BIOT.201900084","volume":"14","author":"Arriaga","year":"2019","journal-title":"Biotechnol J"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41413-024-00342-8","volume":"12","author":"Hu","year":"2024","journal-title":"Bone Res"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"2872","DOI":"10.1016\/J.LFS.2005.11.004","volume":"78","author":"Cai","year":"2006","journal-title":"Life Sci"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"8185","DOI":"10.1021\/JF402222V","volume":"61","author":"Wu","year":"2013","journal-title":"J Agric Food Chem"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/J.BMCL.2004.10.081","volume":"15","author":"Modak","year":"2005","journal-title":"Bioorg Med Chem Lett"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1016\/J.FREERADBIOMED.2005.08.009","volume":"39","author":"Melidou","year":"2005","journal-title":"Free Radic Biol Med"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"135645","DOI":"10.1016\/J.FOODCHEM.2023.135645","volume":"414","author":"de Melo","year":"2023","journal-title":"Food Chem"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/J.JTCME.2016.05.005","volume":"7","author":"Amalraj","year":"2016","journal-title":"J Tradit Complement Med"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"104284","DOI":"10.1016\/J.PHRS.2019.104284","volume":"146","author":"Z\u00e1le\u0161\u00e1k","year":"2019","journal-title":"Pharmacol Res"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.3389\/FPHAR.2016.00292","volume":"7","author":"Ain","year":"2016","journal-title":"Front Pharmacol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"102379","DOI":"10.1016\/J.PBI.2023.102379","volume":"74","author":"Bui","year":"2023","journal-title":"Curr Opin Plant Biol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/978-981-13-9566-6_5","volume":"15","author":"Laghezza Masci","year":"2019","journal-title":"Microorg Sustain"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"100217","DOI":"10.1016\/J.FOCHX.2022.100217","volume":"13","author":"Masyita","year":"2022","journal-title":"Food Chem X"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat Rev Drug Discov"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1023\/A:1016473601633","volume":"19","author":"Yu","year":"2002","journal-title":"Pharm Res"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"120301","DOI":"10.1016\/J.LFS.2022.120301","volume":"291","author":"Khan","year":"2022","journal-title":"Life Sci"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"2595","DOI":"10.1515\/NTREV-2022-0148","volume":"11","author":"Campora","year":"2022","journal-title":"Nanotechnol Rev"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/J.MIMET.2019.03.017","volume":"160","author":"Dave","year":"2019","journal-title":"J Microbiol Methods"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/J.ADDR.2009.11.008","volume":"62","author":"Fadeel","year":"2010","journal-title":"Adv Drug Deliv Rev"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1500223","DOI":"10.1002\/ADVS.201500223","volume":"3","author":"Ehlerding","year":"2016","journal-title":"Adv Sci"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.3389\/FPHAR.2018.01401","volume":"9","author":"Maiti","year":"2019","journal-title":"Front Pharmacol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"273","DOI":"10.3390\/PHARMACEUTICS16020273","volume":"16","author":"Hassan","year":"2024","journal-title":"Pharm"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1093\/RB\/RBAD025","author":"Zhou","year":"2023","journal-title":"Regen Biomater"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S12951-024-02352-4","volume":"22","author":"Yang","year":"2024","journal-title":"J Nanobiotechnology"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1007\/S11427-023-2454-9","volume":"67","author":"Qin","year":"2024","journal-title":"Sci China Life Sci"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-79734-9","volume":"11","author":"Ma","year":"2021","journal-title":"Sci Rep"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"e52463","DOI":"10.1002\/APP.52463","volume":"139","author":"Dehghan","year":"2022","journal-title":"J Appl Polym Sci"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/J.IJBIOMAC.2022.07.054","volume":"217","author":"Soltani","year":"2022","journal-title":"Int J Biol Macromol"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1007\/S12663-022-01829-9","volume":"23","author":"Tanideh","year":"2022","journal-title":"J Maxillofac Oral Surg"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"103339","DOI":"10.1016\/J.MTCOMM.2022.103339","volume":"31","author":"Khodabandeh","year":"2022","journal-title":"Mater Today Commun"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"155155","DOI":"10.1016\/J.PHYMED.2023.155155","volume":"122","author":"Raina","year":"2024","journal-title":"Phytomedicine"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1021\/ACSPTSCI.3C00356","volume":"7","author":"Tripathi","year":"2024","journal-title":"ACS Pharmacol Transl Sci"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"112139","DOI":"10.1016\/j.yexcr.2020.112139","volume":"394","author":"Deng","year":"2020","journal-title":"Exp Cell Res"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"855393","DOI":"10.3389\/FPHAR.2022.855393","volume":"13","author":"Ding","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/J.JGR.2020.05.003","volume":"44","author":"Kang","year":"2020","journal-title":"J Ginseng Res"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1016\/J.BBRC.2017.11.200","volume":"495","author":"Kim","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"113999","DOI":"10.1016\/J.JEP.2021.113999","volume":"273","author":"Sanap","year":"2021","journal-title":"J Ethnopharmacol"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1208\/S12248-012-9432-8","volume":"15","author":"Gupta","year":"2012","journal-title":"AAPS J"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"111074","DOI":"10.1016\/J.MCE.2020.111074","volume":"520","author":"Liu","year":"2021","journal-title":"Mol Cell Endocrinol"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.3892\/mmr.2017.6752","volume":"16","author":"Sekiguchi","year":"2017","journal-title":"Mol Med Rep"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2018.3506","author":"Ding","year":"2018","journal-title":"Int J Mol Med"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"136094","DOI":"10.1016\/J.IJBIOMAC.2024.136094","volume":"280","author":"Sohrabi","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"2639","DOI":"10.1002\/PTR.7010","volume":"35","author":"Wang","year":"2021","journal-title":"Phyther Res"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"2506","DOI":"10.1021\/ACSBIOMATERIALS.9B00254\/","volume":"5","author":"Chen","year":"2019","journal-title":"ACS Biomater Sci Eng"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"10573","DOI":"10.1021\/ACSANM.4C01020","volume":"7","author":"Xu","year":"2024","journal-title":"ACS Appl Nano Mater"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/4178021","volume":"2018","author":"Pang","year":"2018","journal-title":"Biomed Res Int"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"213249","DOI":"10.1016\/J.BIOADV.2022.213249","volume":"145","author":"Kamal","year":"2023","journal-title":"Biomater Adv"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"97613","DOI":"10.1039\/C6RA17141A","volume":"6","author":"Ahmad","year":"2016","journal-title":"RSC Adv"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/J.ACTBIO.2015.12.013","volume":"32","author":"Forte","year":"2016","journal-title":"Acta Biomater"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.3390\/ANTIBIOTICS10101170","volume":"10","author":"Preethi","year":"2021","journal-title":"Antibiot"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1016\/J.JFMA.2021.01.024","volume":"120","author":"Huang","year":"2021","journal-title":"J Formos Med Assoc"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"32955","DOI":"10.1021\/ACSAMI.8B08119","volume":"10","author":"Song","year":"2018","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"112570","DOI":"10.1016\/J.BIOPHA.2021.112570","volume":"146","author":"Ren","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"2170","DOI":"10.1002\/JBM.A.37753","volume":"112","author":"Dai","year":"2024","journal-title":"J Biomed Mater Res Part A"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"111045","DOI":"10.1016\/J.MATDES.2022.111045","volume":"222","author":"Han","year":"2022","journal-title":"Mater Des"},{"key":"ref91","first-page":"4313","volume":"10","author":"Yuan","year":"2018","journal-title":"Am J Transl Res"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"4738","DOI":"10.1007\/S10924-023-02913-Y","volume":"31","author":"Al-Musawi","year":"2023","journal-title":"J Polym Environ"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"124826","DOI":"10.1016\/J.IJPHARM.2024.124826","volume":"666","author":"Jafarbeglou","year":"2024","journal-title":"Int J Pharm"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"4140","DOI":"10.3390\/POLYM13234140\/S1","volume":"13","author":"Shaban","year":"2021","journal-title":"Polymers"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/J.BIOPHA.2018.08.131","volume":"108","author":"Xie","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"633","DOI":"10.15625\/1811-4989\/18\/4\/15311","volume":"18","author":"Minh","year":"2020","journal-title":"Vietnam J Biotechnol"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1515\/NTREV-2020-0046","volume":"9","author":"Hu","year":"2020","journal-title":"Nanotechnol Rev"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1093\/RB\/RBAB022","volume":"8","author":"Wang","year":"2021","journal-title":"Regen Biomater"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/J.INTIMP.2015.05.014","volume":"28","author":"Zhou","year":"2015","journal-title":"Int Immunopharmacol"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"10263","DOI":"10.2147\/IJN.S475320","volume":"19","author":"Ming","year":"2024","journal-title":"Int J Nanomed"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"15403","DOI":"10.3390\/IJMS242015403","volume":"24","author":"Chen","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/J.BIOPHA.2017.08.001","volume":"94","author":"Adil","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"112562","DOI":"10.1016\/J.BIOPHA.2021.112562","volume":"146","author":"Londzin","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/J.EJPHAR.2019.02.026","volume":"851","author":"Zhang","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1002\/PAT.5549","volume":"33","author":"Ehterami","year":"2022","journal-title":"Polym Adv Technol"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"3667","DOI":"10.3390\/NU14173667","volume":"14","author":"Gu","year":"2022","journal-title":"Nutr"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"34387","DOI":"10.1074\/jbc.M211386200","volume":"278","author":"Lee","year":"2003","journal-title":"J Biol Chem"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/J.BBRC.2010.12.099","volume":"404","author":"Jang","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"32941","DOI":"10.1074\/jbc.M403344200","volume":"279","author":"Peng","year":"2004","journal-title":"J Biol Chem"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1158\/1541-7786.MCR-06-0218","volume":"5","author":"Kim","year":"2007","journal-title":"Mol Cancer Res"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/J.JFF.2019.04.048","volume":"58","author":"Li","year":"2019","journal-title":"J Funct Foods"},{"key":"ref112","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1080\/03639045.2017.1291666","volume":"43","author":"Bhalekar","year":"2017","journal-title":"Drug Dev Ind Pharm"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"104937","DOI":"10.1016\/J.YEXMP.2024.104937","volume":"140","author":"Gholijani","year":"2024","journal-title":"Exp Mol Pathol"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"105188","DOI":"10.1016\/J.JDDST.2023.105188","volume":"91","author":"Oliveira","year":"2024","journal-title":"J Drug Deliv Sci Technol"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S13018-023-03642-7","volume":"18","author":"Qi","year":"2023","journal-title":"J Orthop Surg Res"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"17184","DOI":"10.1021\/ACSAMI.9B01218\/","volume":"11","author":"Sarkar","year":"2019","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/J.MTCHEM.2018.03.005","volume":"8","author":"Bose","year":"2018","journal-title":"Mater Today Chem"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/J.JOB.2023.12.004","volume":"66","author":"Senthil","year":"2024","journal-title":"J Oral Biosci"},{"key":"ref119","doi-asserted-by":"publisher","first-page":"3297","DOI":"10.1007\/S00784-018-2755-9","volume":"23","author":"Guimaraes-Stabili","year":"2019","journal-title":"Clin Oral Investig"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.3390\/ANTIOX10121987","volume":"10","author":"Carnovali","year":"2021","journal-title":"Antioxidants"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"113563","DOI":"10.1016\/J.COLSURFB.2023.113563","volume":"231","author":"Bose","year":"2023","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"31542","DOI":"10.1021\/ACSAMI.1C08775","volume":"13","author":"Tan","year":"2021","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/J.BIOACTMAT.2021.09.028","volume":"11","author":"Khodaei","year":"2022","journal-title":"Bioact Mater"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"116364","DOI":"10.1016\/J.BIOPHA.2024.116364","volume":"173","author":"Zhang","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"ref125","doi-asserted-by":"publisher","first-page":"739326","DOI":"10.3389\/FPHAR.2021.739326","volume":"12","author":"Xie","year":"2021","journal-title":"Front Pharmacol"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"842014","DOI":"10.3389\/FBIOE.2022.842014","volume":"10","author":"Wang","year":"2022","journal-title":"Front Bioeng Biotechnol"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"104396","DOI":"10.1016\/J.JDDST.2023.104396","volume":"83","author":"Moorthy","year":"2023","journal-title":"J Drug Deliv Sci Technol"},{"key":"ref128","doi-asserted-by":"publisher","first-page":"102666","DOI":"10.1016\/J.JDDST.2021.102666","volume":"64","author":"Gupta","year":"2021","journal-title":"J Drug Deliv Sci Technol"},{"key":"ref129","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-023-39505-8","volume":"13","author":"Ranjbar","year":"2023","journal-title":"Sci Rep"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"116717","DOI":"10.1016\/J.BIOPHA.2024.116717","volume":"175","author":"Lee","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"ref131","doi-asserted-by":"publisher","first-page":"118143","DOI":"10.1016\/J.LFS.2020.118143","volume":"258","author":"Nie","year":"2020","journal-title":"Life Sci"},{"key":"ref132","doi-asserted-by":"publisher","first-page":"174954","DOI":"10.1016\/J.EJPHAR.2022.174954","volume":"927","author":"Gan","year":"2022","journal-title":"Eur J Pharmacol"},{"key":"ref133","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/J.IJPHARM.2019.04.056","volume":"564","author":"Pleguezuelos-Villa","year":"2019","journal-title":"Int J Pharm"},{"key":"ref134","doi-asserted-by":"publisher","first-page":"976","DOI":"10.3390\/BIOLOGY12070976","volume":"12","author":"Gu","year":"2023","journal-title":"Biol"},{"key":"ref135","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1016\/J.CRFS.2022.05.002","volume":"5","author":"Wang","year":"2022","journal-title":"Curr Res Food Sci"},{"key":"ref136","doi-asserted-by":"publisher","first-page":"155282","DOI":"10.1016\/J.PHYMED.2023.155282","volume":"124","author":"Deng","year":"2024","journal-title":"Phytomedicine"},{"key":"ref137","doi-asserted-by":"publisher","first-page":"1028932","DOI":"10.3389\/FPHAR.2022.1028932","volume":"13","author":"He","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref138","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.3390\/MA16062206","volume":"16","author":"Swain","year":"2023","journal-title":"Mater"},{"key":"ref139","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1208\/S12249-016-0536-9","volume":"18","author":"Li","year":"2017","journal-title":"AAPS Pharm Sci Tech"},{"key":"ref140","doi-asserted-by":"publisher","first-page":"117905","DOI":"10.1016\/J.CARBPOL.2021.117905","volume":"261","author":"Demeyer","year":"2021","journal-title":"Carbohydr Polym"},{"key":"ref141","doi-asserted-by":"publisher","first-page":"124208","DOI":"10.1016\/J.IJBIOMAC.2023.124208","volume":"239","author":"Wang","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"ref142","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2023.2173338","volume":"30","author":"Adin","year":"2023","journal-title":"Drug Deliv"},{"key":"ref143","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/S12038-021-00206-X","volume":"46","author":"Nair","year":"2021","journal-title":"J Biosci"},{"key":"ref144","doi-asserted-by":"publisher","first-page":"102049","DOI":"10.1016\/J.MTCOMM.2021.102049","volume":"26","author":"Kashte","year":"2021","journal-title":"Mater Today Commun"},{"key":"ref145","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1177\/0883911518793913","volume":"33","author":"Tamburaci","year":"2018","journal-title":"J Bioact Compat Polym"},{"key":"ref146","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1177\/0883911519894667","volume":"35","author":"Kashte","year":"2020","journal-title":"J Bioact Compat Polym"},{"key":"ref147","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1016\/J.CARBPOL.2011.09.094","volume":"87","author":"Soumya","year":"2012","journal-title":"Carbohydr Polym"},{"key":"ref148","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/S10856-023-06739-X\/FIGURES\/9","volume":"34","author":"Liao","year":"2023","journal-title":"J Mater Sci Mater Med"},{"key":"ref149","doi-asserted-by":"publisher","first-page":"123110","DOI":"10.1016\/J.IJPHARM.2023.123110","volume":"642","author":"Gupta","year":"2023","journal-title":"Int J Pharm"},{"key":"ref150","doi-asserted-by":"publisher","first-page":"103945","DOI":"10.1016\/J.JMBBM.2020.103945","volume":"111","author":"Robertson","year":"2020","journal-title":"J Mech Behav Biomed Mater"},{"key":"ref151","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S43088-024-00463-3","volume":"13","author":"Prabhu","year":"2024","journal-title":"Beni-Suef Univ J Basic Appl Sci"},{"key":"ref152","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.3390\/APP14041512","volume":"14","author":"Aggarwal","year":"2024","journal-title":"Appl Sci"},{"key":"ref153","doi-asserted-by":"publisher","first-page":"3194","DOI":"10.1021\/ACSABM.9B00077","volume":"2","author":"Banerjee","year":"2019","journal-title":"ACS Appl Bio Mater"},{"key":"ref154","doi-asserted-by":"publisher","first-page":"2576","DOI":"10.3390\/APP10072576","volume":"10","author":"Donate","year":"2020","journal-title":"Appl Sci"},{"key":"ref155","doi-asserted-by":"publisher","first-page":"e20180103","DOI":"10.1590\/1678-7757-2018-0103","volume":"27","author":"Soares","year":"2019","journal-title":"J Appl Oral Sci"},{"key":"ref156","doi-asserted-by":"publisher","first-page":"12964","DOI":"10.1021\/ACSAMI.1C19617","volume":"14","author":"Bose","year":"2022","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref157","doi-asserted-by":"publisher","first-page":"11941","DOI":"10.2147\/IJN.S483091","volume":"19","author":"Xie","year":"2024","journal-title":"Int J Nanomed"},{"key":"ref158","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1002\/JPER.19-0228","volume":"91","author":"Kim","year":"2020","journal-title":"J Periodontol"},{"key":"ref159","doi-asserted-by":"publisher","first-page":"105766","DOI":"10.1016\/J.ARABJC.2024.105766","volume":"17","author":"Izadyari Aghmiuni","year":"2024","journal-title":"Arab J Chem"},{"key":"ref160","doi-asserted-by":"publisher","first-page":"514","DOI":"10.3390\/PH16040514","volume":"16","author":"Aguayo-Morales","year":"2023","journal-title":"Pharm"},{"key":"ref161","doi-asserted-by":"publisher","first-page":"45343","DOI":"10.1002\/APP.45343","volume":"134","author":"Khakestani","year":"2017","journal-title":"J Appl Polym Sci"},{"key":"ref162","doi-asserted-by":"publisher","first-page":"055015","DOI":"10.1088\/1748-605X\/AB8835","volume":"15","author":"Qayoom","year":"2020","journal-title":"Biomed Mater"},{"key":"ref163","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3390\/MOLECULES28010086","volume":"28","author":"Priyadarshini","year":"2022","journal-title":"Mol"},{"key":"ref164","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1007\/S43450-023-00429-Z","volume":"33","author":"Ju","year":"2023","journal-title":"Rev Bras Farmacogn"},{"key":"ref165","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1016\/j.biopha.2018.06.119","volume":"107","author":"Tang","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"ref166","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3389\/fphar.2021.734539","author":"Wang","year":"2021","journal-title":"Front Pharmacol"},{"key":"ref167","doi-asserted-by":"publisher","first-page":"258","DOI":"10.3390\/PH14030258","volume":"14","author":"Han","year":"2021","journal-title":"Pharm"},{"key":"ref168","doi-asserted-by":"publisher","first-page":"655","DOI":"10.3934\/MICROBIOL.2018.4.655","volume":"4","author":"Johnston","year":"2018","journal-title":"AIMS Microbiol"},{"key":"ref169","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3389\/fmats.2020.610889","author":"Arango-Ospina","year":"2021","journal-title":"Front Mater"},{"key":"ref170","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1002\/jbm.b.35283","volume":"111","author":"Robertson","year":"2023","journal-title":"J Biomed Mater Res Part B Appl Biomater"},{"key":"ref171","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1016\/j.ijbiomac.2019.09.228","volume":"146","author":"Thangavelu","year":"2020","journal-title":"Int J Biol Macromol"},{"key":"ref172","doi-asserted-by":"publisher","first-page":"101018","DOI":"10.1016\/J.JAFR.2024.101018","volume":"15","author":"Batool","year":"2024","journal-title":"J Agric Food Res"},{"key":"ref173","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3390\/MD20010020","volume":"20","author":"Mohammadpour","year":"2021","journal-title":"Mar Drugs"},{"key":"ref174","doi-asserted-by":"publisher","first-page":"112320","DOI":"10.1016\/J.MSEC.2021.112320","volume":"128","author":"Unalan","year":"2021","journal-title":"Mater Sci Eng C"},{"key":"ref175","doi-asserted-by":"publisher","first-page":"103850","DOI":"10.1016\/J.ARABJC.2022.103850","volume":"15","author":"Ali","year":"2022","journal-title":"Arab J Chem"},{"key":"ref176","doi-asserted-by":"publisher","first-page":"34447","DOI":"10.1021\/ACSOMEGA.1C04608\/","volume":"6","author":"Sadek","year":"2021","journal-title":"ACS Omega"},{"key":"ref177","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.3390\/POLYM16101428","volume":"16","author":"Li","year":"2024","journal-title":"Polym"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/106539","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/106539","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T11:30:25Z","timestamp":1756899025000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/phytochemicals-in-bone-therapy-exploring-natural-alternatives-for-bone-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":177,"URL":"https:\/\/doi.org\/10.2147\/ijn.s524695","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]}}}