{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:34:04Z","timestamp":1791282844417,"version":"4.1.0"},"reference-count":282,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s532074","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T07:20:15Z","timestamp":1753082415000},"page":"9221-9249","source":"Crossref","is-referenced-by-count":44,"title":["Nanomedicine-Based Ophthalmic Drug Delivery Systems for the Treatment of Ocular Diseases"],"prefix":"10.2147","volume":"Volume 20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3390-7528","authenticated-orcid":true,"given":"Xin","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0384-3188","authenticated-orcid":true,"given":"Yali","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7641-8783","authenticated-orcid":true,"given":"Kangjia","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7019-7935","authenticated-orcid":true,"given":"Wenjie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8625-5367","authenticated-orcid":true,"given":"Chong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e489","DOI":"10.1016\/S2214-109X(20)30488-5","volume":"9","author":"Burton","year":"2021","journal-title":"Lancet Glob Health"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e130","DOI":"10.1016\/S2214-109X(20)30425-3","volume":"9","author":"GBD 2019 Blindness and Vision Impairment Collaborators; Vision Loss Expert Group of the Global Burden of Disease Study.","year":"2021","journal-title":"Lancet Glob Health"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1016\/j.addr.2005.09.004","volume":"57","author":"Hughes","year":"2005","journal-title":"Adv Drug Deliv Rev"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.addr.2017.09.008","volume":"126","author":"Huang","year":"2018","journal-title":"Adv Drug Deliv Rev"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.jtos.2014.01.004","volume":"12","author":"Yanez-Soto","year":"2014","journal-title":"Ocul Surf"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.3109\/03639045.2012.736515","volume":"39","author":"Achouri","year":"2013","journal-title":"Drug Dev Ind Pharm"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1016\/j.addr.2006.07.024","volume":"58","author":"Mannermaa","year":"2006","journal-title":"Adv Drug Deliv Rev"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1016\/j.drudis.2019.05.006","volume":"24","author":"Meng","year":"2019","journal-title":"Drug Discov Today"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1124\/dmd.116.069369","volume":"44","author":"Lee","year":"2016","journal-title":"Drug Metab Dispos"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.preteyeres.2010.04.001","volume":"29","author":"El Sanharawi","year":"2010","journal-title":"Prog Retin Eye Res"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.drudis.2016.10.015","volume":"22","author":"Radhakrishnan","year":"2017","journal-title":"Drug Discov Today"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/s0014-4835(03)00213-6","volume":"78","author":"Cunha-Vaz","year":"2004","journal-title":"Exp Eye Res"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/s0014-4835(77)80009-2","volume":"25","author":"Raviola","year":"1977","journal-title":"Exp Eye Res"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"3107","DOI":"10.2337\/diabetes.51.10.3107","volume":"51","author":"Hammes","year":"2002","journal-title":"Diabetes"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.exer.2007.10.013","volume":"86","author":"Motiejunaite","year":"2008","journal-title":"Exp Eye Res"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1080\/02713680600646890","volume":"31","author":"Kansara","year":"2006","journal-title":"Curr Eye Res"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/2040-2384-2-14","volume":"2","author":"Sarin","year":"2010","journal-title":"J Angiogenes Res"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"115005","DOI":"10.1016\/j.addr.2023.115005","volume":"200","author":"Kannan","year":"2023","journal-title":"Adv Drug Deliv Rev"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/j.msec.2017.12.036","volume":"92","author":"Ding","year":"2018","journal-title":"Mat Sci Eng C-Mater"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.addr.2018.01.008","volume":"126","author":"Mandal","year":"2018","journal-title":"Adv Drug Deliv Rev"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"114864","DOI":"10.1016\/j.addr.2023.114864","volume":"197","author":"Fan","year":"2023","journal-title":"Adv Drug Deliv Rev"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e00545","DOI":"10.1002\/prp2.545","volume":"7","author":"Horita","year":"2019","journal-title":"Pharmacol Res Perspe"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1167\/iovs.13-13650","volume":"55","author":"Shen","year":"2014","journal-title":"Invest Ophth Vis Sci"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.1167\/iovs.16-19204","volume":"57","author":"Park","year":"2016","journal-title":"Invest Ophth Vis Sci"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.jconrel.2020.07.031","volume":"326","author":"Ilochonwu","year":"2020","journal-title":"J Control Release"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.addr.2018.03.013","volume":"126","author":"Lau","year":"2018","journal-title":"Adv Drug Deliv Rev"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1038\/s41433-020-0770-y","volume":"34","author":"Seah","year":"2020","journal-title":"Eye"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"NP83","DOI":"10.1177\/11206721211019548","volume":"32","author":"Brambati","year":"2022","journal-title":"Eur J Ophthalmol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1136\/bjophthalmol-2015-307060","volume":"100","author":"Lee","year":"2016","journal-title":"Brit J Ophthalmol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1001\/jamaophthalmol.2015.4070","volume":"134","author":"Avery","year":"2016","journal-title":"JAMA Ophthalmol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"646708","DOI":"10.3389\/fbioe.2021.646708","volume":"9","author":"Bai","year":"2021","journal-title":"Front Bioeng Biotech"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.preteyeres.2007.01.002","volume":"26","author":"Coca-Prados","year":"2007","journal-title":"Prog Retin Eye Res"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"e2003699","DOI":"10.1002\/advs.202003699","volume":"9","author":"Tang","year":"2022","journal-title":"Adv Sci"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.3390\/polym10040425","volume":"10","author":"Vicario-de-la-torre","year":"2018","journal-title":"Polymers-Basel"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.jtos.2018.05.004","volume":"16","author":"Lin","year":"2018","journal-title":"Ocul Surf"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1080\/10717544.2018.1458923","volume":"25","author":"Yu","year":"2018","journal-title":"Drug Deliv"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.ijpharm.2019.05.018","volume":"565","author":"Liu","year":"2019","journal-title":"Int J Pharm"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"5125","DOI":"10.2147\/IJN.S192407","volume":"14","author":"Pang","year":"2019","journal-title":"Int J Nanomed"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"2515","DOI":"10.2147\/IJN.S190502","volume":"14","author":"Khames","year":"2019","journal-title":"Int J Nanomed"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"7847","DOI":"10.2147\/IJN.S340068","volume":"16","author":"Liang","year":"2021","journal-title":"Int J Nanomed"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.actbio.2021.10.047","volume":"138","author":"Sun","year":"2022","journal-title":"Acta Biomater"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1097\/ICO.0000000000000825","volume":"35","author":"Andrade","year":"2016","journal-title":"Cornea"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1111\/j.1755-3768.2009.01584.x","volume":"88","author":"Habib","year":"2010","journal-title":"Acta Ophthalmol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"e10238","DOI":"10.1002\/btm2.10238","volume":"6","author":"Josyula","year":"2021","journal-title":"Bioeng Transl Med"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"2111066","DOI":"10.1002\/adfm.202111066","volume":"32","author":"Zhu","year":"2022","journal-title":"Adv Funct Mater"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"110767","DOI":"10.1016\/j.msec.2020.110767","volume":"111","author":"Yan","year":"2020","journal-title":"Mat Sci Eng C-Mater"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"105648","DOI":"10.1016\/j.ejps.2020.105648","volume":"158","author":"El Hoffy","year":"2021","journal-title":"Eur J Pharm Sci"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.ijbiomac.2020.02.097","volume":"150","author":"Chowhan","year":"2020","journal-title":"Int J Biol Macromol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ajps.2018.04.008","volume":"14","author":"Wu","year":"2019","journal-title":"Asian J Pharm Sci"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1080\/07853890.2021.1955146","volume":"54","author":"Belamkar","year":"2022","journal-title":"Ann Med"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s13346-014-0196-9","volume":"4","author":"Wong","year":"2014","journal-title":"Drug Deliv Transl Res"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"105748","DOI":"10.1016\/j.ejps.2021.105748","volume":"160","author":"Bessone","year":"2021","journal-title":"Eur J Pharm Sci"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.actbio.2020.04.055","volume":"111","author":"Nguyen","year":"2020","journal-title":"Acta Biomater"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"9445","DOI":"10.1021\/acsami.0c18626","volume":"13","author":"Schnichels","year":"2021","journal-title":"Acs Appl Mater Inter"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.cej.2021.130498","author":"Wang","year":"2021","journal-title":"Chem Eng J"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"e1801047","DOI":"10.1002\/adhm.201801047","volume":"7","author":"Hu","year":"2018","journal-title":"Adv Healthc Mater"},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"OZURDEX\u00ae (Dexamethasone Intravitreal Implant) 0.7 mg as Initial Therapy in Pseudophakic Patients With Diabetic Macular Edema, Macular Edema Following Retinal Vein Occlusion, and Noninfectious Posterior Segment Uveitis: A Case-Based Discussion. Retina-J Ret Vit Dis. 2019;39(Suppl 1):S1\u2013S28. doi:10.1097\/01.iae.0000574292.81105.b2","DOI":"10.1097\/01.iae.0000574292.81105.b2"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"117216","DOI":"10.1016\/j.carbpol.2020.117216","volume":"253","author":"Chen","year":"2021","journal-title":"Carbohyd Polym"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1136\/bjophthalmol-2016-310044","volume":"101","author":"Zhang","year":"2017","journal-title":"Brit J Ophthalmol"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1111\/j.1600-0420.2006.00691.x","volume":"84","author":"Ruiz-Moreno","year":"2006","journal-title":"Acta Ophthalmol Scand"},{"key":"ref61","first-page":"1347\u2013F0181\u20131347","volume":"63","author":"Cleland","year":"2022","journal-title":"Invest Ophth Vis Sci"},{"key":"ref62","first-page":"218","volume":"62","author":"Wong","year":"2021","journal-title":"Invest Ophth Vis Sci"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21134658","volume":"21","author":"Yang","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1080\/17425247.2020.1783236","volume":"17","author":"Sun","year":"2020","journal-title":"Expert Opin Drug Deliv"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"3148","DOI":"10.1002\/jbm.a.35446","volume":"103","author":"Varshochian","year":"2015","journal-title":"J Biomed Mater Res A"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.actbio.2023.05.021","volume":"166","author":"Yao","year":"2023","journal-title":"Acta Biomater"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jconrel.2015.01.001","volume":"200","author":"Huu","year":"2015","journal-title":"J Control Release"},{"key":"ref68","first-page":"2698","volume":"49","author":"Lavinsky","year":"2008","journal-title":"Invest Ophth Vis Sci"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"7944","DOI":"10.1167\/iovs.11-8178","volume":"52","author":"Tanito","year":"2011","journal-title":"Invest Ophth Vis Sci"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3980\/j.issn.2222-3959.2014.01.01","volume":"7","author":"Lu","year":"2014","journal-title":"Int J OphthalmolChi"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.jphotobiol.2019.04.012","volume":"195","author":"Dong","year":"2019","journal-title":"J Photoch Photobio B"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.2337\/db08-1327","volume":"58","author":"Park","year":"2009","journal-title":"Diabetes"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"45","DOI":"10.2147\/IJN.S184574","volume":"14","author":"Rong","year":"2019","journal-title":"Int J Nanomed"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1016\/j.ophtha.2010.12.029","volume":"118","author":"Lim","year":"2011","journal-title":"Ophthalmology"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1080\/13543784.2016.1181750","volume":"25","author":"Bremond-Gignac","year":"2016","journal-title":"Expert Opin Inv Drug"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.202000181","volume":"4","author":"Cho","year":"2021","journal-title":"Adv Ther-Germany"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1080\/10717544.2018.1474967","volume":"25","author":"Mu","year":"2018","journal-title":"Drug Deliv"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1002\/smll.201303433","volume":"10","author":"Davis","year":"2014","journal-title":"Small"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.2147\/IJN.S195504","volume":"14","author":"Sun","year":"2019","journal-title":"Int J Nanomed"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1097\/IAE.0b013e3181a2f42a","volume":"29","author":"Abrishami","year":"2009","journal-title":"Retina-J Ret Vit Dis"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.ijpharm.2012.07.024","volume":"436","author":"Fujisawa","year":"2012","journal-title":"Int J Pharmaceut"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1016\/j.biomaterials.2010.11.030","volume":"32","author":"Kim","year":"2011","journal-title":"Biomaterials"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.3390\/molecules27041372","volume":"27","author":"Liu","year":"2022","journal-title":"Molecules"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.cis.2017.05.020","volume":"249","author":"Mazur","year":"2017","journal-title":"Adv Colloid Interfac"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.ejpb.2012.02.009","volume":"81","author":"Niu","year":"2012","journal-title":"Eur J Pharm Biopharm"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.colsurfb.2008.11.033","volume":"69","author":"Wang","year":"2009","journal-title":"Colloid Surf B"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1016\/j.cclet.2021.01.014","volume":"32","author":"Zeng","year":"2021","journal-title":"Chinese Chem Lett"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1016\/j.cclet.2021.01.001","volume":"32","author":"Li","year":"2021","journal-title":"Chinese Chem Lett"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"54:S131","DOI":"10.1016\/S0169-409X(02)00118-7","author":"M\u00fcller","year":"2002","journal-title":"Adv Drug Deliv Rev"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/B978-0-12-391860-4.00015-X","volume":"508","author":"Fonte","year":"2012","journal-title":"Method Enzymol"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"2","DOI":"10.2174\/157016312799304552","volume":"9","author":"Parhi","year":"2012","journal-title":"Curr Drug Discov Technol"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"e1701400","DOI":"10.1002\/adhm.201701400","volume":"7","author":"Lakshminarayanan","year":"2018","journal-title":"Adv Healthc Mater"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15061593","volume":"15","author":"Viegas","year":"2023","journal-title":"Pharmaceutics"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.nano.2015.09.004","volume":"12","author":"Beloqui","year":"2016","journal-title":"Nanomedicine-UK"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1517\/17425240802712590","volume":"6","author":"Doktorovova","year":"2009","journal-title":"Expert Opin Drug Deliv"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1021\/acs.nanolett.0c03978","volume":"21","author":"Morita","year":"2021","journal-title":"Nano Lett"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.addr.2020.09.009","volume":"156","author":"Hwang","year":"2020","journal-title":"Adv Drug Deliv Rev"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.jconrel.2005.09.034","volume":"109","author":"Gaucher","year":"2005","journal-title":"J Control Release"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.ejpb.2016.12.019","volume":"113","author":"Cagel","year":"2017","journal-title":"Eur J Pharm Biopharm"},{"key":"ref100","first-page":"2","author":"Tomalia","year":"2007","journal-title":"Handbook Nanosci Eng Technol"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1409","volume":"9","author":"Hsu","year":"2017","journal-title":"Wires Nanomed Nanobi"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"941","DOI":"10.4155\/tde.12.76","volume":"3","author":"Pearson","year":"2012","journal-title":"Ther Deliv"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"2824","DOI":"10.1039\/c1cs15242d","volume":"41","author":"Khandare","year":"2012","journal-title":"Chem Soc Rev"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"4413","DOI":"10.1167\/iovs.14-16250","volume":"56","author":"Kambhampati","year":"2015","journal-title":"Invest Ophth Vis Sci"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1016\/j.ophtha.2010.03.033","volume":"117","author":"Shen","year":"2010","journal-title":"Ophthalmology"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1111\/j.1600-0420.2007.00885.x","volume":"85","author":"Sigurdsson","year":"2007","journal-title":"Acta Ophthalmol Scand"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1097\/00006982-200506000-00017","volume":"25","author":"Kato","year":"2005","journal-title":"Retina-J Ret Vit Dis"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.biomaterials.2016.05.044","volume":"101","author":"Nance","year":"2016","journal-title":"Biomaterials"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s12974-016-0529-3","volume":"13","author":"Zhang","year":"2016","journal-title":"J Neuroinflammation"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.jconrel.2011.12.021","volume":"161","author":"Markovsky","year":"2012","journal-title":"J Control Release"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.pharmthera.2006.05.006","volume":"112","author":"Nishiyama","year":"2006","journal-title":"Pharmacol Therapeut"},{"key":"ref112","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.ejpb.2015.03.018","volume":"93","author":"Perez-Herrero","year":"2015","journal-title":"Eur J Pharm Biopharm"},{"key":"ref113","doi-asserted-by":"publisher","DOI":"10.3390\/polym16172503","volume":"16","author":"Slomkowski","year":"2024","journal-title":"Polymers-Basel"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.3390\/polym3031377","volume":"3","author":"Makadia","year":"2011","journal-title":"Polymers-Basel"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.jconrel.2012.01.043","volume":"161","author":"Danhier","year":"2012","journal-title":"J Control Release"},{"key":"ref116","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201701808","volume":"14","author":"Sanchez-Lopez","year":"2018","journal-title":"Small"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"9373","DOI":"10.2147\/IJN.S272750","volume":"15","author":"Jiang","year":"2020","journal-title":"Int J Nanomed"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.jconrel.2019.05.003","volume":"304","author":"Park","year":"2019","journal-title":"J Control Release"},{"key":"ref119","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.progpolymsci.2007.05.017","volume":"32","author":"Nair","year":"2007","journal-title":"Prog Polym Sci"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"e1990","DOI":"10.1002\/wnan.1990","volume":"16","author":"Longobardi","year":"2024","journal-title":"Wires Nanomed Nanobi"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"4433","DOI":"10.1038\/s41467-018-06981-w","volume":"9","author":"Than","year":"2018","journal-title":"Nat Commun"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"112212","DOI":"10.1016\/j.msec.2021.112212","volume":"127","author":"Fang","year":"2021","journal-title":"Mat Sci Eng C-Mater"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"055012","DOI":"10.1088\/1748-6041\/6\/5\/055012","volume":"6","author":"Skotak","year":"2011","journal-title":"Biomed Mater"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"102342","DOI":"10.1016\/j.cis.2020.102342","volume":"288","author":"Grassiri","year":"2021","journal-title":"Adv Colloid Interfac"},{"key":"ref125","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1016\/j.drudis.2019.05.037","volume":"24","author":"Chang","year":"2019","journal-title":"Drug Discov Today"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1016\/j.drudis.2019.03.022","volume":"24","author":"Arranz-Romera","year":"2019","journal-title":"Drug Discov Today"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1080\/21691401.2016.1243545","volume":"45","author":"Pandit","year":"2017","journal-title":"Artif Cell Nanomed B"},{"key":"ref128","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1167\/iovs.05-0495","volume":"47","author":"Enriquez De Salamanca","year":"2006","journal-title":"Invest Ophth Vis Sci"},{"key":"ref129","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1002\/anie.201911720","volume":"59","author":"Balijepalli","year":"2020","journal-title":"Angew Chem Int Edit"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"100036","DOI":"10.1016\/j.carpta.2021.100036","volume":"2","author":"Joseph","year":"2021","journal-title":"Carbohydr Polym Technol Appl"},{"key":"ref131","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.ijbiomac.2016.05.016","volume":"89","author":"Kalam","year":"2016","journal-title":"Int J Biol Macromol"},{"key":"ref132","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.ijbiomac.2021.12.129","volume":"200","author":"Dmour","year":"2022","journal-title":"Int J Biol Macromol"},{"key":"ref133","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.ijbiomac.2018.10.049","volume":"121","author":"Tiwari","year":"2019","journal-title":"Int J Biol Macromol"},{"key":"ref134","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1186\/s12951-023-01974-4","volume":"21","author":"Wei","year":"2023","journal-title":"J Nanobiotechnol"},{"key":"ref135","doi-asserted-by":"publisher","first-page":"28696","DOI":"10.3402\/fnr.v59.28696","volume":"59","author":"Zhang","year":"2015","journal-title":"Food Nutr Res"},{"key":"ref136","doi-asserted-by":"publisher","DOI":"10.3390\/biom9090389","volume":"9","author":"Tian","year":"2019","journal-title":"Biomolecules"},{"key":"ref137","doi-asserted-by":"publisher","first-page":"3559","DOI":"10.1021\/acsami.0c18926","volume":"13","author":"Varela-Fernandez","year":"2021","journal-title":"Acs Appl Mater Inter"},{"key":"ref138","doi-asserted-by":"publisher","first-page":"9330","DOI":"10.1021\/acsnano.7b04731","volume":"11","author":"Hu","year":"2017","journal-title":"Acs Nano"},{"key":"ref139","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1111\/aos.12744","volume":"93","author":"Shulman","year":"2015","journal-title":"Acta Ophthalmol"},{"key":"ref140","doi-asserted-by":"publisher","first-page":"8669","DOI":"10.1039\/d0cs00461h","volume":"50","author":"Wang","year":"2021","journal-title":"Chem Soc Rev"},{"key":"ref141","doi-asserted-by":"publisher","first-page":"246","DOI":"10.2174\/1872211314666191224115211","volume":"13","author":"Qamar","year":"2019","journal-title":"Recent Pat Drug Deliv Formul"},{"key":"ref142","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/nrmicro3028","volume":"11","author":"Lemire","year":"2013","journal-title":"Nat Rev Microbiol"},{"key":"ref143","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10091778","volume":"10","author":"Franco","year":"2022","journal-title":"Microorganisms"},{"key":"ref144","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1007\/s13346-021-00966-x","volume":"11","author":"Fan","year":"2021","journal-title":"Drug Deliv Transl Res"},{"key":"ref145","doi-asserted-by":"publisher","first-page":"101765","DOI":"10.1016\/j.jddst.2020.101765","volume":"57","author":"Ghafoorianfar","year":"2020","journal-title":"J Drug Deliv Sci Technol"},{"key":"ref146","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/s41467-020-20276-z","volume":"12","author":"Nguyen","year":"2021","journal-title":"Nat Commun"},{"key":"ref147","doi-asserted-by":"publisher","first-page":"400","DOI":"10.7150\/ntno.74613","volume":"6","author":"Mosleh-Shirazi","year":"2022","journal-title":"Nanotheranostics"},{"key":"ref148","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1021\/ar9001069","volume":"43","author":"Smith","year":"2010","journal-title":"Acc Chem Res"},{"key":"ref149","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1080\/1061186X.2017.1367006","volume":"26","author":"Wakaskar","year":"2018","journal-title":"J Drug Target"},{"key":"ref150","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1080\/02713683.2019.1660793","volume":"44","author":"Sarwat","year":"2019","journal-title":"Curr Eye Res"},{"key":"ref151","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1016\/j.addr.2008.03.012","volume":"60","author":"Slowing","year":"2008","journal-title":"Adv Drug Deliv Rev"},{"key":"ref152","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1002\/adma.201303123","volume":"26","author":"He","year":"2014","journal-title":"Adv Mater"},{"key":"ref153","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1039\/c6cs00495d","volume":"46","author":"Niu","year":"2017","journal-title":"Chem Soc Rev"},{"key":"ref154","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1021\/ar2000259","volume":"44","author":"Lee","year":"2011","journal-title":"Acc Chem Res"},{"key":"ref155","doi-asserted-by":"publisher","first-page":"2590","DOI":"10.1039\/c1cs15246g","volume":"41","author":"Li","year":"2012","journal-title":"Chem Soc Rev"},{"key":"ref156","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.biomaterials.2007.10.019","volume":"29","author":"Yang","year":"2008","journal-title":"Biomaterials"},{"key":"ref157","doi-asserted-by":"publisher","first-page":"6433","DOI":"10.1002\/adma.201201742","volume":"24","author":"Xing","year":"2012","journal-title":"Adv Mater"},{"key":"ref158","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1002\/pol.20210907","volume":"60","author":"Ow","year":"2022","journal-title":"J Polym Sci"},{"key":"ref159","doi-asserted-by":"publisher","first-page":"106135","DOI":"10.1016\/j.phrs.2022.106135","volume":"178","author":"Xu","year":"2022","journal-title":"Pharmacol Res"},{"key":"ref160","doi-asserted-by":"publisher","first-page":"650426","DOI":"10.3389\/fcell.2021.650426","volume":"9","author":"Song","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"ref161","doi-asserted-by":"publisher","first-page":"e1802896","DOI":"10.1002\/adma.201802896","volume":"31","author":"Yang","year":"2019","journal-title":"Adv Mater"},{"key":"ref162","doi-asserted-by":"publisher","first-page":"9988","DOI":"10.7150\/thno.64229","volume":"11","author":"Bu","year":"2021","journal-title":"Theranostics"},{"key":"ref163","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1111\/aos.14932","volume":"100","author":"Sanghani","year":"2022","journal-title":"Acta Ophthalmol"},{"key":"ref164","doi-asserted-by":"publisher","first-page":"121949","DOI":"10.1016\/j.biomaterials.2022.121949","volume":"293","author":"Rehman","year":"2023","journal-title":"Biomaterials"},{"key":"ref165","doi-asserted-by":"publisher","first-page":"6917","DOI":"10.2147\/IJN.S264498","volume":"15","author":"Zhang","year":"2020","journal-title":"Int J Nanomed"},{"key":"ref166","doi-asserted-by":"publisher","first-page":"e2105586","DOI":"10.1002\/advs.202105586","volume":"9","author":"Fan","year":"2022","journal-title":"Adv Sci"},{"key":"ref167","doi-asserted-by":"publisher","first-page":"101771","DOI":"10.1016\/j.nantod.2023.101771","volume":"49","author":"Chavda","year":"2023","journal-title":"Nano Today"},{"key":"ref168","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.biomaterials.2017.11.046","volume":"157","author":"Willem De Vries","year":"2018","journal-title":"Biomaterials"},{"key":"ref169","doi-asserted-by":"publisher","first-page":"114770","DOI":"10.1016\/j.addr.2023.114770","volume":"196","author":"Han","year":"2023","journal-title":"Adv Drug Deliv Rev"},{"key":"ref170","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul Surf"},{"key":"ref171","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul Surf"},{"key":"ref172","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.jtos.2017.05.006","volume":"15","author":"Jones","year":"2017","journal-title":"Ocul Surf"},{"key":"ref173","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1080\/08982104.2022.2086567","volume":"33","author":"Obeid","year":"2023","journal-title":"J Liposome Res"},{"key":"ref174","doi-asserted-by":"publisher","first-page":"1449283","DOI":"10.3389\/fopht.2024.1449283","volume":"4","author":"Huang","year":"2024","journal-title":"Front Ophthalmol"},{"key":"ref175","doi-asserted-by":"publisher","first-page":"3279","DOI":"10.3109\/10717544.2016.1172368","volume":"23","author":"Yavuz","year":"2016","journal-title":"Drug Deliv"},{"key":"ref176","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.2147\/IJN.S107569","volume":"11","author":"Kang","year":"2016","journal-title":"Int J Nanomed"},{"key":"ref177","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s10238-015-0345-6","volume":"16","author":"Prete","year":"2016","journal-title":"Clin Exp Med"},{"key":"ref178","doi-asserted-by":"publisher","first-page":"8281","DOI":"10.2147\/IJN.S173691","volume":"13","author":"Shen","year":"2018","journal-title":"Int J Nanomed"},{"key":"ref179","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.preteyeres.2010.03.001","volume":"29","author":"Baudouin","year":"2010","journal-title":"Prog Retin Eye Res"},{"key":"ref180","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1007\/s13346-020-00870-w","volume":"11","author":"Date","year":"2021","journal-title":"Drug Deliv Transl Re"},{"key":"ref181","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1089\/jop.2021.0127","volume":"38","author":"Polat","year":"2022","journal-title":"J Ocul Pharmacol Therap"},{"key":"ref182","doi-asserted-by":"publisher","first-page":"7825","DOI":"10.2147\/IJN.S268208","volume":"15","author":"El-Emam","year":"2020","journal-title":"Int J Nanomed"},{"key":"ref183","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1128\/AAC.37.4.633","volume":"37","author":"Cochereau-Massin","year":"1993","journal-title":"Antimicrob Agents Chemother"},{"key":"ref184","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1136\/bjo.79.6.606","volume":"79","author":"Diamond","year":"1995","journal-title":"Brit J Ophthalmol"},{"key":"ref185","doi-asserted-by":"publisher","first-page":"101242","DOI":"10.1016\/j.mtbio.2024.101242","volume":"28","author":"Zhang","year":"2024","journal-title":"Mater Today Bio"},{"key":"ref186","doi-asserted-by":"publisher","first-page":"3311","DOI":"10.2147\/IJN.S165125","volume":"13","author":"Qing","year":"2018","journal-title":"Int J Nanomed"},{"key":"ref187","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/nrd3745","volume":"11","author":"Zhang","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"ref188","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1016\/S0140-6736(23)01289-8","volume":"402","author":"Jayaram","year":"2023","journal-title":"Lancet"},{"key":"ref189","unstructured":"Timolol maleate-a new drug for glaucoma. Med Lett Drugs Ther. 1978;20(25):109\u2013110."},{"key":"ref190","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/s0161-6420(81)35072-6","volume":"88","author":"Zimmerman","year":"1981","journal-title":"Ophthalmology"},{"key":"ref191","doi-asserted-by":"publisher","first-page":"465\u201371;discussion472","DOI":"10.2165\/00002512-200219060-00005","volume":"19","author":"Waugh","year":"2002","journal-title":"Drug Aging"},{"key":"ref192","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0953-4431(97)10015-7","volume":"9","author":"Strier","year":"1997","journal-title":"Clin Eye Vision Care"},{"key":"ref193","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/00061198-199708000-00010","volume":"6","author":"Greenfield","year":"1997","journal-title":"J Glaucoma"},{"key":"ref194","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12060570","volume":"12","author":"Mazet","year":"2020","journal-title":"Pharmaceutics"},{"key":"ref195","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/j.ophtha.2022.02.021","volume":"129","author":"Ahmed","year":"2022","journal-title":"Ophthalmology"},{"key":"ref196","doi-asserted-by":"publisher","first-page":"2515841420905740","DOI":"10.1177\/2515841420905740","volume":"12","author":"Singh","year":"2020","journal-title":"Ther Adv Ophthalmol"},{"key":"ref197","first-page":"2515","volume":"35","author":"Wiederholt","year":"1994","journal-title":"Invest Ophth Vis Sci"},{"key":"ref198","doi-asserted-by":"publisher","first-page":"C1378","DOI":"10.1152\/ajpcell.00363.2007","volume":"294","author":"Dismuke","year":"2008","journal-title":"Am J Physiol-Cell Physiol"},{"key":"ref199","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1007\/s00417-002-0559-7","volume":"240","author":"Schneemann","year":"2002","journal-title":"Graef Arch Clin Exp"},{"key":"ref200","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1136\/postgradmedj-2017-134891","volume":"93","author":"Krishna","year":"2017","journal-title":"Postgrad Med J"},{"key":"ref201","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m4979","author":"Burkholder","year":"2021","journal-title":"BMJ-Brit Med J"},{"key":"ref202","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1007\/s10792-018-0984-1","volume":"39","author":"Shahab","year":"2019","journal-title":"Int Ophthalmol"},{"key":"ref203","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1159\/000318021","volume":"224","author":"Taylor","year":"2010","journal-title":"Ophthalmologica"},{"key":"ref204","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1136\/bjophthalmol-2013-303935","volume":"98","author":"Doycheva","year":"2014","journal-title":"Brit J Ophthalmol"},{"key":"ref205","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1016\/j.ophtha.2014.04.042","volume":"121","author":"Takeuchi","year":"2014","journal-title":"Ophthalmology"},{"key":"ref206","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.ophtha.2013.09.048","volume":"121","author":"Levy-Clarke","year":"2014","journal-title":"Ophthalmology"},{"key":"ref207","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.survophthal.2015.06.004","volume":"60","author":"Cordero-Coma","year":"2015","journal-title":"Surv Ophthalmol"},{"key":"ref208","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1080\/1744666X.2017.1288097","volume":"13","author":"Lamattina","year":"2017","journal-title":"Expert Rev Clin Immun"},{"key":"ref209","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1136\/annrheumdis-2011-201244","volume":"72","author":"Burmester","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"ref210","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/j.ophtha.2019.11.024","volume":"127","author":"Llorenc","year":"2020","journal-title":"Ophthalmology"},{"key":"ref211","doi-asserted-by":"publisher","first-page":"1412930","DOI":"10.3389\/fopht.2024.1412930","volume":"4","author":"Chauhan","year":"2024","journal-title":"Front Ophthalmol"},{"key":"ref212","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/S0140-6736(18)31550-2","volume":"392","author":"Mitchell","year":"2018","journal-title":"Lancet"},{"key":"ref213","doi-asserted-by":"publisher","first-page":"2606","DOI":"10.1056\/NEJMra0801537","volume":"358","author":"Jager","year":"2008","journal-title":"New Engl J Med"},{"key":"ref214","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1016\/S0140-6736(22)02609-5","volume":"401","author":"Guymer","year":"2023","journal-title":"Lancet"},{"key":"ref215","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1056\/NEJMra1909637","volume":"382","author":"Jampol","year":"2020","journal-title":"New Engl J Med"},{"key":"ref216","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.preteyeres.2007.03.002","volume":"26","author":"Schmidt-Erfurth","year":"2007","journal-title":"Prog Retin Eye Res"},{"key":"ref217","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/s0039-6257(00)00158-2","volume":"45","author":"Schmidt-Erfurth","year":"2000","journal-title":"Surv Ophthalmol"},{"key":"ref218","first-page":"3900","volume":"64","author":"Wu","year":"2023","journal-title":"Invest Ophth Vis Sci"},{"key":"ref219","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.exer.2016.02.010","volume":"145","author":"Giddabasappa","year":"2016","journal-title":"Exp Eye Res"},{"key":"ref220","doi-asserted-by":"publisher","first-page":"1082497","DOI":"10.1155\/2019\/1082497","volume":"2019","author":"Leng","year":"2019","journal-title":"Media Inflam"},{"key":"ref221","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.biopha.2018.09.049","volume":"108","author":"Chen","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"ref222","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1002\/jcb.27599","volume":"120","author":"Chen","year":"2019","journal-title":"J Cell Biochem"},{"key":"ref223","doi-asserted-by":"publisher","first-page":"4676","DOI":"10.1021\/mp400487f","volume":"10","author":"Yandrapu","year":"2013","journal-title":"Mol Pharm"},{"key":"ref224","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.ejps.2013.07.014","volume":"50","author":"Varshochian","year":"2013","journal-title":"Eur J Pharm Sci"},{"key":"ref225","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.canlet.2012.08.018","volume":"328","author":"Fagiani","year":"2013","journal-title":"Cancer Lett"},{"key":"ref226","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.molmed.2012.10.010","volume":"19","author":"Koh","year":"2013","journal-title":"Trends Mol Med"},{"key":"ref227","doi-asserted-by":"publisher","first-page":"5140521","DOI":"10.1155\/2019\/5140521","volume":"2019","author":"Whitehead","year":"2019","journal-title":"J Diabetes Res"},{"key":"ref228","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1038\/sj.gt.3302230","volume":"11","author":"Nambu","year":"2004","journal-title":"Gene Ther"},{"key":"ref229","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1167\/iovs.14-13897","volume":"55","author":"Lee","year":"2014","journal-title":"Invest Ophth Vis Sci"},{"key":"ref230","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.devcel.2007.10.019","volume":"14","author":"Gavard","year":"2008","journal-title":"Dev Cell"},{"key":"ref231","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1096\/fj.02-0634rev","volume":"17","author":"Duff","year":"2003","journal-title":"FASEB J"},{"key":"ref232","first-page":"2283","volume":"31","author":"Nassiri","year":"2011","journal-title":"Anticancer Res"},{"key":"ref233","doi-asserted-by":"publisher","first-page":"e2304626","DOI":"10.1002\/adhm.202304626","volume":"13","author":"Zhou","year":"2024","journal-title":"Adv Healthc Mater"},{"key":"ref234","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1056\/NEJMra1005073","volume":"366","author":"Antonetti","year":"2012","journal-title":"New Engl J Med"},{"key":"ref235","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/S0140-6736(09)62124-3","volume":"376","author":"Cheung","year":"2010","journal-title":"Lancet"},{"key":"ref236","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.ophtha.2009.06.051","volume":"117","author":"Klein","year":"2010","journal-title":"Ophthalmology"},{"key":"ref237","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1111\/ceo.12696","volume":"44","author":"Ting","year":"2016","journal-title":"Clin Exp Ophthalmol"},{"key":"ref238","doi-asserted-by":"publisher","first-page":"16012","DOI":"10.1038\/nrdp.2016.12","volume":"2","author":"Wong","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"ref239","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.preteyeres.2015.08.001","volume":"51","author":"Stitt","year":"2016","journal-title":"Prog Retin Eye Res"},{"key":"ref240","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1167\/iovs.10-5285","volume":"52","author":"Chang-Lin","year":"2011","journal-title":"Invest Ophth Vis Sci"},{"key":"ref241","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1007\/s00592-017-1010-1","volume":"54","author":"Querques","year":"2017","journal-title":"Acta Diabetol"},{"key":"ref242","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s00592-019-01435-1","volume":"57","author":"Borrelli","year":"2020","journal-title":"Acta Diabetol"},{"key":"ref243","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s00592-018-1117-z","volume":"55","author":"Iglicki","year":"2018","journal-title":"Acta Diabetol"},{"key":"ref244","doi-asserted-by":"crossref","first-page":"675\u20137,679","DOI":"10.4321\/S0365-66912006001200002","volume":"81","author":"Cardillo","year":"2006","journal-title":"Arch Soc Esp Oftalmol"},{"key":"ref245","first-page":"3886","volume":"47","author":"Cardillo","year":"2006","journal-title":"Invest Ophthalmol Visual Sci"},{"key":"ref246","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e499","author":"Kiire","year":"2012","journal-title":"BMJ"},{"key":"ref247","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e8373","author":"Chong","year":"2012","journal-title":"BMJ"},{"key":"ref248","doi-asserted-by":"publisher","first-page":"1694187","DOI":"10.1155\/2018\/1694187","volume":"2018","author":"Lu","year":"2018","journal-title":"J Ophthalmol"},{"key":"ref249","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.2147\/OPTH.S40350","volume":"8","author":"Triantafylla","year":"2014","journal-title":"Clin Ophthalmol"},{"key":"ref250","doi-asserted-by":"publisher","first-page":"376","DOI":"10.2174\/1566524014666140128114414","volume":"14","author":"Zhang","year":"2014","journal-title":"Curr Mol Med"},{"key":"ref251","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.2337\/db07-0982","volume":"57","author":"Zhang","year":"2008","journal-title":"Diabetes"},{"key":"ref252","doi-asserted-by":"publisher","first-page":"257","DOI":"10.3109\/09273948.2013.767353","volume":"21","author":"Salek","year":"2013","journal-title":"Ocul Immunol Inflamm"},{"key":"ref253","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s10792-013-9829-0","volume":"34","author":"Li","year":"2014","journal-title":"Int Ophthalmol"},{"key":"ref254","doi-asserted-by":"publisher","first-page":"149","DOI":"10.2174\/138945011794182746","volume":"12","author":"Becerra","year":"2011","journal-title":"Curr Drug Targets"},{"key":"ref255","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1046\/j.1442-9071.2001.00407.x","volume":"29","author":"Penfold","year":"2001","journal-title":"Clin Exp Ophthalmol"},{"key":"ref256","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/eye.2010.196","volume":"25","author":"Wang","year":"2011","journal-title":"Eye"},{"key":"ref257","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1111\/1440-1681.12099","volume":"40","author":"Mccarthy","year":"2013","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"ref258","doi-asserted-by":"publisher","first-page":"e7945","DOI":"10.1371\/journal.pone.0007945","volume":"4","author":"Ma","year":"2009","journal-title":"PLoS One"},{"key":"ref259","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/S0002-9440(10)65138-3","volume":"155","author":"Blaauwgeers","year":"1999","journal-title":"Am J Pathol"},{"key":"ref260","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.ejpb.2015.02.013","volume":"95","author":"Kambhampati","year":"2015","journal-title":"Eur J Pharm Biopharm"},{"key":"ref261","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1097\/IAE.0b013e3181bdfa43","volume":"30","author":"Soheilian","year":"2010","journal-title":"Retina-J Ret Vit Dis"},{"key":"ref262","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1136\/archdischild-2016-310532","volume":"102","author":"Solebo","year":"2017","journal-title":"Arch Dis Child"},{"key":"ref263","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1016\/S0140-6736(13)60178-6","volume":"382","author":"Hellstrom","year":"2013","journal-title":"Lancet"},{"key":"ref264","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1111\/dmcn.15468","volume":"65","author":"Dammann","year":"2023","journal-title":"Dev Med Child Neurol"},{"key":"ref265","doi-asserted-by":"publisher","first-page":"278","DOI":"10.18433\/j3dp43","volume":"17","author":"Almeida","year":"2014","journal-title":"J Pharm Pharm Sci"},{"key":"ref266","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.jconrel.2011.11.022","volume":"160","author":"Hagigit","year":"2012","journal-title":"J Control Release"},{"key":"ref267","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1016\/j.ijbiomac.2018.05.113","volume":"116","author":"Liu","year":"2018","journal-title":"Int J Biol Macromol"},{"key":"ref268","doi-asserted-by":"publisher","first-page":"683","DOI":"10.2217\/nnm-2016-0379","volume":"12","author":"Joseph","year":"2017","journal-title":"Nanomedicine-UK"},{"key":"ref269","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1473","volume":"10","author":"Bisht","year":"2018","journal-title":"Wires Nanomed Nanobi"},{"key":"ref270","doi-asserted-by":"publisher","first-page":"2282","DOI":"10.1039\/c8bm00471d","volume":"6","author":"Petrou","year":"2018","journal-title":"Biomater Sci UK"},{"key":"ref271","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1006\/exer.2000.0952","volume":"72","author":"Winkler","year":"2001","journal-title":"Exp Eye Res"},{"key":"ref272","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jconrel.2013.01.018","volume":"167","author":"Xu","year":"2013","journal-title":"J Control Release"},{"key":"ref273","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jconrel.2010.08.028","volume":"148","author":"Ranta","year":"2010","journal-title":"J Control Release"},{"key":"ref274","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.jconrel.2020.11.053","volume":"329","author":"Chaw","year":"2021","journal-title":"J Control Release"},{"key":"ref275","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1016\/j.jconrel.2012.01.019","volume":"161","author":"Bochot","year":"2012","journal-title":"J Control Release"},{"key":"ref276","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.addr.2007.04.009","volume":"59","author":"Date","year":"2007","journal-title":"Adv Drug Deliv Rev"},{"key":"ref277","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1021\/cr900232t","volume":"110","author":"Villaraza","year":"2010","journal-title":"Chem Rev"},{"key":"ref278","doi-asserted-by":"publisher","DOI":"10.3390\/polym14050951","volume":"14","author":"Darie-Nita","year":"2022","journal-title":"Polymers-Basel"},{"key":"ref279","doi-asserted-by":"publisher","first-page":"1802289","DOI":"10.1002\/advs.201802289","volume":"6","author":"Zhu","year":"2019","journal-title":"Adv Sci"},{"key":"ref280","doi-asserted-by":"publisher","first-page":"6497","DOI":"10.2147\/IJN.S329831","volume":"16","author":"Zhang","year":"2021","journal-title":"Int J Nanomed"},{"key":"ref281","doi-asserted-by":"publisher","first-page":"857","DOI":"10.2174\/138920021131400107","volume":"14","author":"Li","year":"2013","journal-title":"Curr Drug Metab"},{"key":"ref282","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.tox.2014.11.003","volume":"327","author":"Wilson","year":"2015","journal-title":"Toxicology"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/105000","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/105000","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T07:20:21Z","timestamp":1753082421000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/nanomedicine-based-ophthalmic-drug-delivery-systems-for-the-treatment--peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":282,"URL":"https:\/\/doi.org\/10.2147\/ijn.s532074","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}