{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T03:50:33Z","timestamp":1787629833737,"version":"build-2736575974"},"reference-count":62,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s538737","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:25:12Z","timestamp":1758126312000},"page":"11341-11360","source":"Crossref","is-referenced-by-count":4,"title":["Nano-Emulsion Incorporating Squalene and Mn2+ Stabilized by TA\/Mn2+ Networks Enhances Subunit Vaccine Immunogenicity"],"prefix":"10.2147","volume":"Volume 20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0382-2378","authenticated-orcid":true,"given":"Kai","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanying","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1925-4337","authenticated-orcid":true,"given":"Yun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1238586","DOI":"10.3389\/fimmu.2023.1238586","volume":"14","author":"Zhang","year":"2023","journal-title":"Front Immunol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1187554","DOI":"10.3389\/fimmu.2023.1187554","volume":"14","author":"Khalili","year":"2023","journal-title":"Front Immunol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"160670","DOI":"10.1016\/j.cej.2025.160670","volume":"507","author":"Bao","year":"2025","journal-title":"Chem Eng J"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"109232","DOI":"10.1016\/j.matdes.2020.109232","volume":"197","author":"He","year":"2021","journal-title":"Mater Des"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1002\/cmdc.201200487","volume":"8","author":"Moyle","year":"2013","journal-title":"ChemMedChem"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/s41577-019-0243-3","volume":"20","author":"Mascola","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.actbio.2023.08.015","volume":"169","author":"Shrimali","year":"2023","journal-title":"Acta Biomater"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.it.2016.07.001","volume":"37","author":"Gutjahr","year":"2016","journal-title":"Trends Immunol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.jconrel.2020.06.021","volume":"326","author":"Hou","year":"2020","journal-title":"J Control Release"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1021\/acs.nanolett.2c04970","volume":"23","author":"Gao","journal-title":"Nano Lett"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1038\/s41423-021-00669-w","volume":"18","author":"Zhang","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"2303615","DOI":"10.1002\/advs.202303615","volume":"10","author":"Shi","year":"2023","journal-title":"Adv Sci"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.jconrel.2023.04.036","volume":"358","author":"Qiao","year":"2023","journal-title":"J Control Release"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1153042","DOI":"10.3389\/fimmu.2023.1153042","volume":"14","author":"Chen","year":"2023","journal-title":"Front Immunol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1002\/eji.201445133","volume":"45","author":"Yildiz","year":"2015","journal-title":"Eur J Immunol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"13322","DOI":"10.1007\/s12274-023-6295-5","volume":"16","author":"Li","year":"2023","journal-title":"Nano Res"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2000771","DOI":"10.1002\/advs.202000771","volume":"7","author":"Qin","year":"2020","journal-title":"Adv Sci"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1021\/acs.molpharmaceut.7b00800","volume":"15","author":"Huang","year":"2018","journal-title":"Mol Pharm"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/S1473-3099(21)00147-X","volume":"21","author":"Goepfert","year":"2021","journal-title":"Lancet Infect Dis"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/S0140-6736(07)61297-5","volume":"370","author":"Leroux-Roels","year":"2007","journal-title":"Lancet"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1800136","DOI":"10.1002\/mnfr.201800136","volume":"62","author":"Lou-Bonafonte","year":"2018","journal-title":"Mol Nutr Food Res"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"9116","DOI":"10.1038\/s41598-018-27455-5","volume":"8","author":"Shimizu","year":"2018","journal-title":"Sci Rep"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/0005-2760(95)00005-W","volume":"1256","author":"Kohno","year":"1995","journal-title":"Biochim Biophys Acta, Lipids Lipid Metab"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.5555\/20183375924","volume":"14","author":"Palaniyandi","year":"2018","journal-title":"Phcog Mag"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"113889","DOI":"10.1016\/j.addr.2021.113889","volume":"176","author":"Liu","year":"2021","journal-title":"Adv Drug Deliv Rev"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"e9130018","DOI":"10.26599\/NTM.2023.9130018","volume":"2","author":"Lu","year":"2023","journal-title":"Nano TransMed"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"12972","DOI":"10.1021\/acsnano.0c04197","volume":"14","author":"Han","year":"2020","journal-title":"ACS Nano"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"11709","DOI":"10.1021\/acs.jafc.1c02066","volume":"69","author":"Wu","year":"2021","journal-title":"J Agric Food Chem"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.jconrel.2024.12.054","volume":"379","author":"Janes","year":"2025","journal-title":"J Control Release"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"166","DOI":"10.2174\/0929866528666211125110701","volume":"29","author":"Cabral-Hip\u00f3lito","year":"2022","journal-title":"Protein Pept Lett"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"110590","DOI":"10.1016\/j.ygeno.2023.110590","volume":"115","author":"Zeng","year":"2023","journal-title":"Genomics"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"3601","DOI":"10.1128\/aac.00944-13","volume":"57","author":"Harris","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"e1802342","DOI":"10.1002\/smll.201802342","volume":"14","author":"Besford","year":"2018","journal-title":"Small"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"5546","DOI":"10.1002\/anie.201311136","volume":"53","author":"Guo","year":"2014","journal-title":"Angew Chem Int Ed"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1126\/science.1237265","volume":"341","author":"Ejima","year":"2013","journal-title":"Science"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"9581","DOI":"10.1038\/s41467-024-53937-4","volume":"15","author":"Feng","year":"2024","journal-title":"Nat Commun"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"106577","DOI":"10.1016\/j.ultsonch.2023.106577","volume":"99","author":"Wang","year":"2023","journal-title":"Ultrason Sonochem"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"3010","DOI":"10.4049\/jimmunol.171.6.3010","volume":"171","author":"Matsue","year":"2003","journal-title":"J Immunol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"3839","DOI":"10.1016\/j.bioactmat.2021.03.039","volume":"6","author":"Li","year":"2021","journal-title":"Bioact Mater"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1900115","DOI":"10.1002\/adtp.201900115","volume":"3","author":"Song","year":"2020","journal-title":"Adv Ther"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1704272","DOI":"10.1002\/smll.201704272","volume":"14","author":"Wang","year":"2018","journal-title":"Small"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.jdsci.2009.11.010","volume":"49","author":"Silverman","year":"2010","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"10482","DOI":"10.1021\/acsnano.2c01283","volume":"16","author":"Li","year":"2022","journal-title":"ACS Nano"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-024-01759-2","author":"Liu","year":"2024","journal-title":"Nat Nanotechnol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"3077","DOI":"10.1016\/j.biomaterials.2012.12.041","volume":"34","author":"Chen","year":"2013","journal-title":"Biomaterials"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/imm.13262","volume":"162","author":"Toor","year":"2021","journal-title":"Immunology"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.4049\/jimmunol.178.4.2396","volume":"178","author":"Krishnan","year":"2007","journal-title":"J Immunol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/s41577-023-00853-1","volume":"23","author":"Rotrosen","year":"2023","journal-title":"Nat Rev Immunol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1146\/annurev.immunol.22.012703.104702","volume":"22","author":"Sallusto","year":"2004","journal-title":"Annu Rev Immunol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"2205409","DOI":"10.1002\/adma.202205409","volume":"35","author":"Zhang","year":"2023","journal-title":"Adv Mater"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"710375","DOI":"10.3389\/fimmu.2021.710375","volume":"12","author":"Yuan","year":"2021","journal-title":"Front Immunol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"eabf1198","DOI":"10.1126\/sciimmunol.abf1198","volume":"6","author":"Iwanaga","year":"2021","journal-title":"Sci Immunol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.3389\/fimmu.2019.01400","volume":"10","author":"Auladell","year":"2019","journal-title":"Front Immunol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"486","DOI":"10.3389\/fcimb.2020.00486","volume":"10","author":"Chen","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.abb.2015.06.011","volume":"580","author":"Bonke","year":"2015","journal-title":"Arch Biochem Biophys"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.jff.2015.03.009","volume":"14","author":"C\u00e1rdeno","year":"2015","journal-title":"J Funct Foods"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"2771","DOI":"10.2174\/092986705774462987","volume":"12","author":"Blanusa","year":"2005","journal-title":"Curr Med Chem"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.neuro.2008.12.007","volume":"30","author":"Zheng","year":"2009","journal-title":"NeuroToxicology"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1097\/01.jom.0000204114.01893.3e","volume":"48","author":"Jiang","year":"2006","journal-title":"J Occup Environ Med"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"2004210","DOI":"10.1002\/adma.202004210","volume":"32","author":"Peng","year":"2020","journal-title":"Adv Mater"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"607945","DOI":"10.3389\/fimmu.2020.607945","volume":"11","author":"Baranov","year":"2021","journal-title":"Front Immunol"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"5172","DOI":"10.1039\/D2CS00848C","volume":"52","author":"Ren","year":"2023","journal-title":"Chem Soc Rev"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/107084","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/107084","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:25:13Z","timestamp":1758126313000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/nano-emulsion-incorporating-squalene-and-mn2-stabilized-by-tamn2-netwo-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":62,"URL":"https:\/\/doi.org\/10.2147\/ijn.s538737","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]}}}