{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T06:17:34Z","timestamp":1793859454518,"version":"4.6.1"},"reference-count":54,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s544429","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T14:30:11Z","timestamp":1764599411000},"page":"14313-14328","source":"Crossref","is-referenced-by-count":3,"title":["Comparative Evaluation of Nano-Assemblies From Shaoyao Gancao Decoction on Paeoniflorin Bioavailability"],"prefix":"10.2147","volume":"Volume 20","author":[{"given":"Chengying","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinling","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoying","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangchen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianzhan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4473-4607","authenticated-orcid":true,"given":"Baode","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"156053","DOI":"10.1016\/j.phymed.2024.156053","volume":"135","author":"Wu","year":"2024","journal-title":"Phytomedicine"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"670054","DOI":"10.3389\/fphar.2021.670054","volume":"12","author":"Chang","year":"2021","journal-title":"Front Pharmacol"},{"key":"ref3","first-page":"6311","volume":"23","author":"Ding","year":"2024","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1707122","DOI":"10.1155\/2022\/1707122","volume":"2022","author":"Lu","year":"2022","journal-title":"Mediators Inflamm"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"110505","DOI":"10.1016\/j.biopha.2020.110505","volume":"130","author":"Zhou","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"ref6","author":"Takeda","year":"1995","journal-title":"J Pharm Pharmacol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1254\/jjp.88.250","volume":"3","author":"Chen","year":"2002","journal-title":"Jpn J Pharmacol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1016\/j.fct.2006.07.003","volume":"12","author":"Yoshida","year":"2006","journal-title":"Food Chem Toxicol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.taap.2013.12.015","volume":"275","author":"Li","year":"2014","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1016\/j.foodchem.2012.07.061","volume":"4","author":"Hou","year":"2012","journal-title":"Food Chem"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.jep.2013.06.049","volume":"2","author":"Xu","year":"2013","journal-title":"J Ethnopharmacol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1080\/13880209.2019.1651876","volume":"1","author":"Sun","year":"2019","journal-title":"Pharm Biol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1007\/s11418-016-1049-2","volume":"1","author":"He","year":"2017","journal-title":"J Nat Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"5476","DOI":"10.1039\/D4RA07212J","volume":"7","author":"Fang","year":"2025","journal-title":"RSC Adv"},{"key":"ref15","first-page":"1288","volume":"6","author":"Dong","year":"2024","journal-title":"J Tradit Chin Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.3390\/molecules27103268","volume":"10","author":"Gao","year":"2022","journal-title":"Molecules"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"128","DOI":"10.3390\/pharmaceutics12020128","volume":"2","author":"Zhao","year":"2020","journal-title":"Pharmaceutics"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1080\/03639045.2020.1862178","volume":"2","author":"Shen","year":"2021","journal-title":"Drug Dev Ind Pharm"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"9354","DOI":"10.1021\/acs.jafc.9b03208","volume":"33","author":"Zhou","year":"2019","journal-title":"J Agric Food Chem"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"128235","DOI":"10.1016\/j.ijbiomac.2023.128235","volume":"255","author":"Wang","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.jconrel.2024.03.029","volume":"369","author":"Liu","year":"2024","journal-title":"J Control Release"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"5279","DOI":"10.1007\/s12274-022-5199-0","volume":"16","author":"Li","year":"2023","journal-title":"Nano Res"},{"key":"ref23","unstructured":"Dong YY. Study on the Absorption Mechanism of Glycyrrhizin Protein-Paeoniflorin Nanoparticles in Shaoyao Gancao Decoction. Master\u2019s Thesis, China Academy of Chinese Medical Sciences, 2024."},{"key":"ref24","first-page":"2190","volume":"9","author":"Shen","year":"2021","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref25","first-page":"3099","volume":"9","author":"He","year":"2025","journal-title":"Zhong Cao Yao"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"3521","DOI":"10.2147\/IJN.S135749","volume":"12","author":"Zhang","year":"2017","journal-title":"Int J Nanomed"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.2147\/IJN.S357541","volume":"17","author":"Sun","year":"2022","journal-title":"Int J Nanomed"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.3390\/molecules22111867","volume":"11","author":"Kuang","year":"2017","journal-title":"Molecules"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"775","DOI":"10.3109\/00498254.2015.1121553","volume":"9","author":"Yang","year":"2016","journal-title":"Xenobiotica"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1023\/A:1016065715308","volume":"9","author":"Fagerholm","year":"1996","journal-title":"Pharm Res"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1111\/j.2042-7158.1997.tb06084.x","volume":"7","author":"Lennern\u00e4s","year":"1997","journal-title":"J Pharm Pharmacol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.ejps.2012.12.025","volume":"4-5","author":"Reis","year":"2013","journal-title":"Eur J Pharm Sci"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"132157","DOI":"10.1016\/j.foodchem.2022.132157","volume":"380","author":"Buecker","year":"2022","journal-title":"Food Chem"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/nnano.2014.208","volume":"11","author":"Chung","year":"2014","journal-title":"Nat Nanotechnol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"6297","DOI":"10.2147\/IJN.S323685","volume":"16","author":"Zhao","year":"2021","journal-title":"Int J Nanomed"},{"key":"ref36","unstructured":"Guo Q. Exploring the material basis of compatibility of Shaoyao-Gancao medicine pairs based on protein self-assembly. Master\u2019s Thesis, China Academy of Chinese Medical Sciences, 2022."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"120546","DOI":"10.1016\/j.ijpharm.2021.120546","volume":"601","author":"You","year":"2021","journal-title":"Int J Pharm"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.jcis.2021.03.101","volume":"598","author":"Tucker","year":"2021","journal-title":"J Colloid Interface Sci"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"4337","DOI":"10.3390\/molecules20034337","volume":"3","author":"Yang","year":"2015","journal-title":"Molecules"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10837450.2025.2591746","author":"Wang","year":"2025","journal-title":"Pharm Dev Technol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"3371","DOI":"10.3390\/molecules23123371","volume":"12","author":"Cui","year":"2018","journal-title":"Molecules"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"9195","DOI":"10.2147\/IJN.S474287","volume":"19","author":"Kang","year":"2024","journal-title":"Int J Nanomed"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/fcp.12594","volume":"1","author":"Liu","year":"2021","journal-title":"Fundam Clin Pharmacol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2015.01.014","volume":"1-2","author":"Lozoya-Agullo","year":"2015","journal-title":"Int J Pharm"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"711","DOI":"10.3389\/fphar.2020.00711","volume":"11","author":"Yao","year":"2020","journal-title":"Front Pharmacol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.ijpharm.2019.01.047","volume":"559","author":"Selyutina","year":"2019","journal-title":"Int J Pharm"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.2147\/IJN.S505427","volume":"20","author":"Zheng","year":"2025","journal-title":"Int J Nanomed"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.3390\/pharmaceutics15071816","volume":"7","author":"He","year":"2023","journal-title":"Pharmaceutics"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1186\/s12951-024-02930-6","volume":"1","author":"Wang","year":"2024","journal-title":"J Nanobiotechnology"},{"key":"ref50","first-page":"436","volume":"1","author":"Shen","year":"2017","journal-title":"Nanoscale"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s41232-018-0072-y","volume":"38","author":"Nakamura","year":"2018","journal-title":"Inflamm Regen"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1400739","DOI":"10.3389\/fimmu.2024.1400739","volume":"15","author":"Castillo","year":"2024","journal-title":"Front Immunol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1007\/s11095-006-9100-8","volume":"12","author":"Liu","year":"2006","journal-title":"Pharm Res"},{"key":"ref54","unstructured":"Shen CY. Study on the identification of self-assembled nanoparticles from Shaoyao Gancao Decoction and its effect on compatibility. Master\u2019s Thesis, Chengdu University of Traditional Chinese Medicine, 2021."}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/109445","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/109445","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T14:30:14Z","timestamp":1764599414000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/comparative-evaluation-of-nano-assemblies-from-shaoyao-gancao-decoctio-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":54,"URL":"https:\/\/doi.org\/10.2147\/ijn.s544429","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]}}}