{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T17:09:53Z","timestamp":1770829793309,"version":"3.50.1"},"reference-count":91,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s545116","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T16:15:16Z","timestamp":1770826516000},"page":"1-23","source":"Crossref","is-referenced-by-count":0,"title":["MSN Templated with L-Dopa Amide Derivatives Outperforms the Efficiency of Free-L-Dopa in Reducing Parkinson\u2019s Behavioral Dysfunction in Mice"],"prefix":"10.2147","volume":"Volume 21","author":[{"given":"M\u00f3nica","family":"Onrubia-M\u00e1rquez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6910-0494","authenticated-orcid":true,"given":"Miguel M","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Navas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Mart\u00ednez-Erro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1609-2099","authenticated-orcid":true,"given":"Victoria","family":"Morales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justine","family":"Delaval","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6719-5011","authenticated-orcid":true,"given":"Lara","family":"Merch\u00e1n-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva M\u00aa","family":"S\u00e1nchez-Robles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy A","family":"Paniagua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Rodr\u00edguez-Rivera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00fal","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Goicoechea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9091-8733","authenticated-orcid":true,"given":"Rafael","family":"Garc\u00eda-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2026,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S1474-4422(18)30499-X","volume":"18","author":"Feigin","year":"2019","journal-title":"Lancet Neurol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"8593","DOI":"10.3390\/ijms24108593","volume":"24","author":"Wen","year":"2023","journal-title":"IJMS"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fpubh.2022.952161","author":"Ding","year":"2022","journal-title":"Front Public Health"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/S1474-4422(18)30295-3","volume":"17","author":"Dorsey","year":"2018","journal-title":"Lancet Neurol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"105696","DOI":"10.1016\/j.nbd.2022.105696","volume":"168","author":"Domingues","year":"2022","journal-title":"Neurobiol Dis"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","volume":"186","author":"Wilson","year":"2023","journal-title":"Cell"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13024-018-0241-0","volume":"13","author":"Yamada","year":"2018","journal-title":"Mol Neurodegeneration"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1136\/jnnp.2004.050666","volume":"77","author":"Vaugoyeau","year":"2006","journal-title":"J Neurol Neurosurg"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neubiorev.2005.03.024","volume":"30","author":"Cools","year":"2006","journal-title":"Neurosci Biobehav Rev"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1007\/s00702-024-02825-8","volume":"131","author":"Jost","year":"2024","journal-title":"J Neural Transm"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1036068","DOI":"10.3389\/fneur.2022.1036068","volume":"13","author":"LeWitt","year":"2022","journal-title":"Front Neurol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1007\/s00702-010-0424-5","volume":"117","author":"Stacy","year":"2010","journal-title":"J Neural Transm"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"899","DOI":"10.3233\/JPD-240272","volume":"14","author":"McFarthing","year":"2024","journal-title":"JPD"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1212\/CPJ.0000000000000316","volume":"7","author":"Espay","year":"2017","journal-title":"Neur Clin Pract"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3233\/JPD-202285","volume":"11","author":"Olanow","year":"2021","journal-title":"JPD"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1002\/mds.22596","volume":"24","author":"Honig","year":"2009","journal-title":"Mov Disord"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1002\/mds.26078","volume":"30","author":"Poewe","year":"2015","journal-title":"Mov Disord"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"8592","DOI":"10.1021\/acsnano.1c00453","volume":"15","author":"Garc\u00eda-Pardo","year":"2021","journal-title":"ACS Nano"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.jconrel.2004.11.004","volume":"102","author":"Ar\u0131ca","year":"2005","journal-title":"J Control Release"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"19077","DOI":"10.1038\/s41598-024-69324-4","volume":"14","author":"Yeni","year":"2024","journal-title":"Sci Rep"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"118","DOI":"10.3390\/pharmaceutics10030118","volume":"10","author":"Narayan","year":"2018","journal-title":"Pharmaceutics"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.apsb.2018.01.007","volume":"8","author":"Zhou","year":"2018","journal-title":"Acta Pharmaceutica Sinica B"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1902634","DOI":"10.1002\/adfm.201902634","volume":"30","author":"Manzano","year":"2020","journal-title":"Adv Funct Mater"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"2860","DOI":"10.1021\/acsbiomaterials.8b00335","volume":"4","author":"Pandey","year":"2018","journal-title":"ACS Biomater Sci Eng"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"5038","DOI":"10.1002\/anie.200501819","volume":"44","author":"Giri","year":"2005","journal-title":"Angew Chem Int Ed"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"15322","DOI":"10.1021\/acsami.9b02797","volume":"11","author":"Cheng","year":"2019","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.ejpb.2003.12.007","volume":"57","author":"Charnay","year":"2004","journal-title":"Eur J Pharm Biopharm"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"16887","DOI":"10.1021\/acs.jpcc.6b06238","volume":"120","author":"Morales","year":"2016","journal-title":"J Phys Chem C"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"11635","DOI":"10.1007\/s10853-019-03708-0","volume":"54","author":"Morales","year":"2019","journal-title":"J Mater Sci"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"7996","DOI":"10.1039\/C4TB00089G","volume":"2","author":"Garc\u00eda-Mu\u00f1oz","year":"2014","journal-title":"J Mater Chem B"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"5934","DOI":"10.1002\/chem.200600226","volume":"12","author":"Vallet\u2010Reg\u00ed","year":"2006","journal-title":"Chem a Eur J"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.3390\/polym16081105","volume":"16","author":"Kovtareva","year":"2024","journal-title":"Polymers"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"8746","DOI":"10.1021\/ja301691j","volume":"134","author":"Lu","year":"2012","journal-title":"J Am Chem Soc"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.micromeso.2010.10.051","volume":"141","author":"Parambadath","year":"2011","journal-title":"Microporous Mesoporous Mater"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.ijpharm.2019.04.067","volume":"564","author":"S\u00e1bio","year":"2019","journal-title":"Int J pharm"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"673","DOI":"10.2217\/nnm.16.5","volume":"11","author":"Hoshyar","year":"2016","journal-title":"Nanomedicine"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"886981","DOI":"10.3389\/fphar.2022.886981","volume":"13","author":"Mohamed","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","volume":"20","author":"Mitchell","year":"2021","journal-title":"Nat Rev Drug Discov"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.ejpb.2010.12.024","volume":"77","author":"Ragnaill","year":"2011","journal-title":"Eur J Pharm Biopharm"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"16909","DOI":"10.1039\/D1NR03553C","volume":"13","author":"Janjua","year":"2021","journal-title":"Nanoscale"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.3390\/ijms15021812","volume":"15","author":"Hanada","year":"2014","journal-title":"IJMS"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.matlet.2015.08.015","volume":"161","author":"L\u00f3pez","year":"2015","journal-title":"Mater Lett"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.3390\/pharmaceutics13071039","volume":"13","author":"Kiss","year":"2021","journal-title":"Pharmaceutics"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"3202","DOI":"10.3390\/ma12193202","volume":"12","author":"Swar","year":"2019","journal-title":"Materials"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.4103\/1673-5374.332143","volume":"17","author":"Garcia-Munoz","year":"2022","journal-title":"Neural Regen Res"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.micromeso.2018.01.005","volume":"264","author":"Morales","year":"2018","journal-title":"Microporous Mesoporous Mater"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"7291","DOI":"10.1002\/adfm.201505073","volume":"26","author":"Morales","year":"2016","journal-title":"Adv Funct Mater"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1186\/s12951-022-01714-0","volume":"20","author":"L\u00f3pez-Ruiz","year":"2022","journal-title":"J Nanobiotechnol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"7968","DOI":"10.3390\/ijms22157968","volume":"22","author":"Martinez-Erro","year":"2021","journal-title":"IJMS"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"4178","DOI":"10.1039\/D1TB00481F","volume":"9","author":"Morales","year":"2021","journal-title":"J Mater Chem B"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"12376","DOI":"10.1021\/acsanm.4c00393","volume":"7","author":"Roman\u00ed-Cubells","year":"2024","journal-title":"ACS Appl Nano Mater"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1016\/j.dental.2025.08.004","volume":"41","author":"Jim\u00e9nez-D\u00edez","year":"2025","journal-title":"Dent Mater"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.3891\/acta.chem.scand.20-1182","volume":"20","author":"Scheline","year":"1966","journal-title":"Acta Chem Scand"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"3284","DOI":"10.1002\/adma.200601321","volume":"18","author":"Wang","year":"2006","journal-title":"Adv Mater"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S0223-5234(03)00012-6","volume":"38","author":"Di","year":"2003","journal-title":"Eur J Med Chem"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"112986","DOI":"10.1016\/j.biopha.2022.112986","volume":"150","author":"Garc\u00eda","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1038\/359710a0","volume":"359","author":"Kresge","year":"1992","journal-title":"Nature"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.3390\/biom13111658","volume":"13","author":"Pogorelov","year":"2023","journal-title":"Biomolecules"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1097\/00002826-199619010-00005","volume":"19","author":"Djaldetti","year":"1996","journal-title":"Clin Neuropharmacol"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"27","DOI":"10.4103\/0976-0105.177703","volume":"7","author":"Nair","year":"2016","journal-title":"J Basic Clin Pharm"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"e1001018","DOI":"10.1371\/journal.pmed.1001018","volume":"8","author":"Ayieko","year":"2011","journal-title":"PLoS Med"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.3791\/1376","author":"Da Concei\u00e7\u00e3o","year":"2010","journal-title":"JoVE"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"3548","DOI":"10.3390\/cells10123548","volume":"10","author":"Yu","year":"2021","journal-title":"Cells"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.bbr.2015.01.053","volume":"284","author":"Boix","year":"2015","journal-title":"Behav Brain Res"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/0006-8993(83)91129-0","volume":"264","author":"Robinson","year":"1983","journal-title":"Brain Res"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.4077\/CJP.2013.BAB125","volume":"56","author":"Liao","year":"2013","journal-title":"Chin J Physiol"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"14057","DOI":"10.1523\/JNEUROSCI.1312-15.2015","volume":"35","author":"Alvarsson","year":"2015","journal-title":"J Neurosci"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"16005","DOI":"10.1038\/s41598-017-16228-1","volume":"7","author":"Lerner","year":"2017","journal-title":"Sci Rep"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"12860","DOI":"10.1038\/s41598-019-49009-z","volume":"9","author":"Huttunen","year":"2019","journal-title":"Sci Rep"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"2523","DOI":"10.1007\/s11095-012-0966-3","volume":"30","author":"Peura","year":"2013","journal-title":"Pharm Res"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.biochi.2020.01.013","volume":"170","author":"Hachem","year":"2020","journal-title":"Biochimie"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"1801362","DOI":"10.1002\/adma.201801362","volume":"30","author":"Furtado","year":"2018","journal-title":"Adv Mater"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.jpba.2010.05.003","volume":"53","author":"Jiang","year":"2010","journal-title":"J Pharmaceut Biomed Anal"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1002\/adfm.200600578","volume":"17","author":"M\u00f6ller","year":"2017","journal-title":"Adv Funct Mater"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.micromeso.2009.11.015","volume":"132","author":"Cauda","year":"2010","journal-title":"Microporous Mesoporous Mater"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"102494","DOI":"10.1016\/j.nano.2021.102494","volume":"40","author":"Halder","year":"2022","journal-title":"Nanomed Nanotechnol Biol Med"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1046\/j.1471-4159.1995.64020825.x","volume":"64","author":"Basma","year":"1995","journal-title":"J Neurochem"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/mds.870120105","volume":"12","author":"Ziv","year":"1997","journal-title":"Mov Disord"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.8277","author":"Su","year":"2017","journal-title":"Mol Med Rep"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"3234","DOI":"10.3791\/3234","author":"Thiele","year":"2012","journal-title":"JoVE"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbr.2005.11.026","volume":"169","author":"Truong","year":"2006","journal-title":"Behav Brain Res"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s12868-019-0487-7","volume":"20","author":"Rentsch","year":"2019","journal-title":"BMC Neurosci"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.bbr.2008.01.012","volume":"189","author":"Da Cunha","year":"2008","journal-title":"Behav Brain Res"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.bbr.2015.03.058","volume":"288","author":"Bagga","year":"2015","journal-title":"Behav Brain Res"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.neures.2012.03.004","volume":"73","author":"Tronci","year":"2012","journal-title":"Neurosci Res"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"700672","DOI":"10.3389\/fnins.2021.700672","volume":"15","author":"Mottaghi","year":"2021","journal-title":"Front Neurosci"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"982218","DOI":"10.3389\/fnbeh.2022.982218","volume":"16","author":"Sun","year":"2022","journal-title":"Front Behav Neurosci"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"e34120","DOI":"10.1016\/j.heliyon.2024.e34120","volume":"10","author":"De Carvalho","year":"2024","journal-title":"Heliyon"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"11530","DOI":"10.3390\/ijms222111530","volume":"22","author":"Mendes-Pinheiro","year":"2021","journal-title":"IJMS"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/111961","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/111961","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T16:15:17Z","timestamp":1770826517000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/msn-templated-with-l-dopa-amide-derivatives-outperforms-the-efficiency-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":91,"URL":"https:\/\/doi.org\/10.2147\/ijn.s545116","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]}}}