{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:41:15Z","timestamp":1790098875050,"version":"4.0.1"},"reference-count":154,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s555555","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:05:26Z","timestamp":1780459526000},"page":"1-32","source":"Crossref","is-referenced-by-count":3,"title":["Bridging Preclinical and Clinical Gaps in Ocular Therapeutics: Hydrogel Drug Delivery and 3D Tissue Models"],"prefix":"10.2147","volume":"Volume 21","author":[{"given":"Jaleh","family":"Barar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anali","family":"Aliakbari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadollah","family":"Omidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,6]]},"reference":[{"key":"ref1","unstructured":"World Health Organization. Blindness and Visual Impairment; 2023."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e130","DOI":"10.1016\/S2214-109X(20)30425-3","volume":"9","author":"Blindness","year":"2021","journal-title":"Lancet Glob Health"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Vision Loss Expert Group of the Global Burden of Disease S, Blindness GBD, Vision Impairment C. Global estimates on the number of people blind or visually impaired by diabetic retinopathy: a meta-analysis from 2000 to 2020. Eye. 2024;38(11):2047\u20132057. doi:10.1038\/s41433-024-03101-5.","DOI":"10.1038\/s41433-024-03101-5"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Vision Loss Expert Group of the Global Burden of Disease S, Blindness GBD, Vision Impairment C. Global estimates on the number of people blind or visually impaired by cataract: a meta-analysis from 2000 to 2020. Eye. 2024;38(11):2156\u20132172. doi:10.1038\/s41433-024-02961-1.","DOI":"10.1038\/s41433-024-02961-1"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Vision Loss Expert Group of the Global Burden of Disease S, Blindness GBD, Vision Impairment C. Global estimates on the number of people blind or visually impaired by Uncorrected Refractive Error: a meta-analysis from 2000 to 2020. Eye. 2024;38(11):2083\u20132101. doi:10.1038\/s41433-024-03106-0.","DOI":"10.1038\/s41433-024-03106-0"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1016\/j.ophtha.2021.04.027","volume":"128","author":"Teo","year":"2021","journal-title":"Ophthalmology"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Blindness GBD, Vision Impairment C, Vision Loss Expert Group of the Global Burden of Disease S. Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the right to sight: an analysis for the global burden of disease study. Lancet Glob Health. 2021;9(2):e144\u2013e160. doi:10.1016\/S2214-109X(20)30489-7.","DOI":"10.1016\/S2214-109X(20)30489-7"},{"key":"ref8","unstructured":"International Agency for the Prevention of B. Vision Atlas. 2020."},{"key":"ref9","first-page":"238","volume":"4","author":"Barar","year":"2009","journal-title":"J Ophthalmic Vis Res"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1517\/17425247.5.5.567","volume":"5","author":"Barar","year":"2008","journal-title":"Expert Opin Drug Deliv"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"49","DOI":"10.15171\/bi.2016.07","volume":"6","author":"Barar","year":"2016","journal-title":"Bioimpacts"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1442-9071.2010.02363.x","volume":"38","author":"Willoughby","year":"2010","journal-title":"Clin Exp Ophthalmol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1097\/IAE.0b013e3180307271","volume":"27","author":"Scott","year":"2007","journal-title":"Retina"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.3928\/23258160-20210518-04","volume":"52","author":"Patel","year":"2021","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.ophtha.2023.12.033","volume":"131","author":"Israilevich","year":"2024","journal-title":"Ophthalmology"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1186\/s12886-025-04093-w","volume":"25","author":"Comcali","year":"2025","journal-title":"BMC Ophthalmol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"145647","DOI":"10.1016\/j.ijbiomac.2025.145647","volume":"320","author":"Lotfi","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"114739","DOI":"10.1016\/j.ejpb.2025.114739","volume":"213","author":"Marandi","year":"2025","journal-title":"Eur J Pharm Biopharm"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.ijbiomac.2020.04.274","volume":"159","author":"Pakzad","year":"2020","journal-title":"Int J Biol Macromol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"126536","DOI":"10.1016\/j.ijpharm.2025.126536","author":"Liao","year":"2025","journal-title":"Int J Pharm"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"159","DOI":"10.15171\/bi.2015.31","volume":"5","author":"Fathi","year":"2015","journal-title":"Bioimpacts"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"101814","DOI":"10.1016\/j.mtbio.2025.101814","volume":"32","author":"Xue","year":"2025","journal-title":"Mater Today Bio"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30030457","volume":"30","author":"Ribeiro","year":"2025","journal-title":"Molecules"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"124899","DOI":"10.1016\/j.ijpharm.2024.124899","volume":"667","author":"Al Yabhouni","year":"2024","journal-title":"Int J Pharm"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/978-3-030-28471-8_7","volume":"1186","author":"Boutin","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"110068","DOI":"10.1016\/j.exer.2024.110068","volume":"247","author":"Ma","year":"2024","journal-title":"Exp Eye Res"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/j.drudis.2018.01.047","volume":"23","author":"Agrahari","year":"2018","journal-title":"Drug Discov Today"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"e1900001","DOI":"10.1002\/mabi.201900001","volume":"19","author":"Lin","year":"2019","journal-title":"Macromol Biosci"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1081\/ddc-120006428","volume":"28","author":"Soppimath","year":"2002","journal-title":"Drug Dev Indust Pharm"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1007\/s13346-018-0504-x","volume":"8","author":"Kabiri","year":"2018","journal-title":"Drug Deliv Transl Res"},{"key":"ref31","volume-title":"The Eye Book: A Complete Guide to Eye Disorders and Health","year":"2021"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1007\/s10792-018-0955-6","volume":"39","author":"Deepthi","year":"2019","journal-title":"Int Ophthalmol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"183","DOI":"10.4103\/joco.joco_116_25","volume":"37","author":"Li","year":"2025","journal-title":"J Curr Ophthalmol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1080\/17425247.2017.1343297","volume":"14","author":"Moreno","year":"2017","journal-title":"Expert Opin Drug Deliv"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"e232","DOI":"10.1111\/aos.14212","volume":"98","author":"Lu","year":"2020","journal-title":"Acta Ophthalmol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"126009","DOI":"10.1016\/j.ijpharm.2025.126009","volume":"683","author":"Sahu","year":"2025","journal-title":"Int J Pharm"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"3377","DOI":"10.1039\/d1tb00263e","volume":"9","author":"Wang","year":"2021","journal-title":"J Mater Chem B"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1517\/14656566.2014.914492","volume":"15","author":"Colligris","year":"2014","journal-title":"Expert Opinion Pharmacother"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.18240\/ijo.2019.10.15","volume":"12","author":"Elhusseiny","year":"2019","journal-title":"Int J Ophthalmol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1167\/iovs.07-0635","volume":"49","author":"Khanal","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.3390\/gels8120816","volume":"8","author":"Li","year":"2022","journal-title":"Gels"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1111\/ceo.14113","volume":"50","author":"Cabrera-Aguas","year":"2022","journal-title":"Clin Exp Ophthalmol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.jtos.2021.08.007","volume":"28","author":"Stapleton","year":"2023","journal-title":"Ocul Surf"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.4103\/IJO.IJO_3289_25","author":"Gupta","year":"2026","journal-title":"Ind J Ophthalmol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1717056","DOI":"10.3389\/fmed.2026.1717056","volume":"13","author":"Han","year":"2026","journal-title":"Front Med"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-025-02130-4","volume":"75","author":"Chen","year":"2026","journal-title":"Inflamm Res"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000001219","author":"Zhang","year":"2026","journal-title":"Curr Opin Ophthalmol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"6095","DOI":"10.1038\/s41598-026-36134-9","volume":"16","author":"Jin","year":"2026","journal-title":"Sci Rep"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-026-04721-z","author":"Aune","year":"2026","journal-title":"BMC Ophthalmol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"101324","DOI":"10.1016\/j.preteyeres.2024.101324","volume":"107","author":"Karuntu","year":"2025","journal-title":"Prog Retin Eye Res"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.3390\/vision9010007","volume":"9","author":"Janaky","year":"2025","journal-title":"Vision"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000004475","author":"Mihalache","year":"2025","journal-title":"Retina"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0169-409X(94)90044-2","volume":"14","author":"Visor","year":"1994","journal-title":"Adv Drug Delivery Rev"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"S36","DOI":"10.1097\/IJG.0000000000000107","volume":"23","author":"Coca-Prados","year":"2014","journal-title":"J Glaucoma"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/s0014-4835(77)80009-2","volume":"25 Suppl","author":"Raviola","year":"1977","journal-title":"Exp Eye Res"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/s0002-9394(98)00436-x","volume":"127","author":"Toris","year":"1999","journal-title":"Am J Ophthalmol"},{"key":"ref57","first-page":"3145","volume":"32","author":"Brubaker","year":"1991","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1002\/jps.2600660222","volume":"66","author":"Conrad","year":"1977","journal-title":"J Pharm Sci"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s13619-025-00228-y","volume":"14","author":"Zhou","year":"2025","journal-title":"Cell Regen"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1055\/a-2063-8957","volume":"240","author":"Braunger","year":"2023","journal-title":"Klin Monbl Augenheilkd"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1089\/jop.2024.0153","volume":"41","author":"Sarkar","year":"2025","journal-title":"J Ocul Pharmacol Ther"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1080\/17434440.2018.1435271","volume":"15","author":"Garaszczuk","year":"2018","journal-title":"Expert Rev Med Devices"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1124\/dmd.113.052704","volume":"41","author":"Chen","year":"2013","journal-title":"Drug Metab Dispos"},{"key":"ref64","first-page":"1","volume":"287","author":"Barar","year":"2013","journal-title":"Nanomed Drug Delivery"},{"key":"ref65","volume-title":"Nanotechnology in Health Care","year":"2012"},{"key":"ref66","volume-title":"Nanoengineered Biomaterials for Advanced Drug Delivery","year":"2020"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"299","DOI":"10.4103\/ijmm.IJMM_19_443","volume":"37","author":"Ray","year":"2019","journal-title":"Ind J Med Microbiol"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"14982","DOI":"10.1039\/d5tb01575h","volume":"13","author":"Sabbagh","year":"2025","journal-title":"J Mater Chem B"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"112212","DOI":"10.1016\/j.msec.2021.112212","volume":"127","author":"Fang","year":"2021","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1002\/jps.23390","volume":"102","author":"Lu","year":"2013","journal-title":"J Pharm Sci"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"150","DOI":"10.3109\/10717544.2010.522612","volume":"18","author":"Xu","year":"2011","journal-title":"Drug Deliv"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"34194","DOI":"10.1038\/srep34194","volume":"6","author":"Lee","year":"2016","journal-title":"Sci Rep"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1039\/c9bm01582e","volume":"8","author":"Varela-Garcia","year":"2020","journal-title":"Biomater Sci"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.drudis.2007.10.021","volume":"13","author":"Sahoo","year":"2008","journal-title":"Drug Discov Today"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"7","DOI":"10.5681\/bi.2011.003","volume":"1","author":"Nakhlband","year":"2011","journal-title":"Bioimpacts"},{"key":"ref76","first-page":"1","volume":"43","author":"Omidi","year":"2012","journal-title":"Nanotechnol Health Care"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1208\/s12249-023-02516-9","volume":"24","author":"Ahmed","year":"2023","journal-title":"AAPS PharmSciTech"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"292","DOI":"10.3390\/gels9040292","volume":"9","author":"Wu","year":"2023","journal-title":"Gels"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"278","DOI":"10.18433\/j3dp43","volume":"17","author":"Almeida","year":"2014","journal-title":"J Pharm Pharm Sci"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/978-1-62703-475-3_18","volume":"1028","author":"Bharali","year":"2013","journal-title":"Methods Mol Biol"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1167\/tvst.11.5.16","volume":"11","author":"Fardous","year":"2022","journal-title":"Transl Vis Sci Technol"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.3390\/gels10090589","volume":"10","author":"Arabpour","year":"2024","journal-title":"Gels"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"e2407340","DOI":"10.1002\/advs.202407340","volume":"12","author":"Qi","year":"2025","journal-title":"Adv Sci"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"228","DOI":"10.3389\/fbioe.2020.00228","volume":"8","author":"Lynch","year":"2020","journal-title":"Front Bioeng Biotechnol"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.jconrel.2019.05.034","volume":"306","author":"Cooper","year":"2019","journal-title":"J Control Release"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"132086","DOI":"10.1016\/j.ijbiomac.2024.132086","volume":"269","author":"Yu","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1177\/0885328211406563","volume":"27","author":"Chen","year":"2012","journal-title":"J Biomater Appl"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"122486","DOI":"10.1016\/j.carbpol.2024.122486","volume":"343","author":"Dmour","year":"2024","journal-title":"Carbohydr Polym"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"3056","DOI":"10.1002\/jbm.a.34976","volume":"102","author":"Widjaja","year":"2014","journal-title":"J Biomed Mater Res A"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1002\/jps.23777","volume":"103","author":"Lu","year":"2014","journal-title":"J Pharm Sci"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.3109\/03639041003680826","volume":"36","author":"Gao","year":"2010","journal-title":"Drug Dev Ind Pharm"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"116","DOI":"10.4103\/0975-1483.63144","volume":"2","author":"Shastri","year":"2010","journal-title":"J Young Pharm"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1111\/ceo.14570","volume":"53","author":"Liu","year":"2025","journal-title":"Clin Exp Ophthalmol"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1208\/s12249-025-03212-6","volume":"27","author":"Yang","year":"2025","journal-title":"AAPS PharmSciTech"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.ijbiomac.2021.03.017","volume":"180","author":"Cheng","year":"2021","journal-title":"Int J Biol Macromol"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"104385","DOI":"10.1016\/j.jddst.2023.104385","volume":"83","author":"Ghanavi","year":"2023","journal-title":"J Drug Delivery Sci Technol"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1167\/tvst.9.13.34","volume":"9","author":"Schulz","year":"2020","journal-title":"Transl Vis Sci Technol"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"146319","DOI":"10.1016\/j.ijbiomac.2025.146319","volume":"321","author":"Kurl","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"145356","DOI":"10.1016\/j.ijbiomac.2025.145356","volume":"319","author":"Li","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"1632889","DOI":"10.3389\/fmed.2025.1632889","volume":"12","author":"Xiao","year":"2025","journal-title":"Front Med"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"132740","DOI":"10.1016\/j.ijbiomac.2024.132740","volume":"273","author":"Ge","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s12896-025-01056-3","volume":"25","author":"Shajari","year":"2025","journal-title":"BMC Biotechnol"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"3365","DOI":"10.1007\/s10856-008-3486-2","volume":"19","author":"Liu","year":"2008","journal-title":"J Mater Sci Mater Med"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"686","DOI":"10.7205\/MILMED-D-13-00360","volume":"179","author":"Chae","year":"2014","journal-title":"Mil Med"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1016\/j.actbio.2009.02.008","volume":"5","author":"Maia","year":"2009","journal-title":"Acta Biomater"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"7909","DOI":"10.1021\/acs.biomac.5c01399","volume":"26","author":"An","year":"2025","journal-title":"Biomacromolecules"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"213496","DOI":"10.1016\/j.bioadv.2023.213496","volume":"151","author":"Zhang","year":"2023","journal-title":"Biomater Adv"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"107346","DOI":"10.1016\/j.ejps.2025.107346","volume":"217","author":"Block","year":"2026","journal-title":"Eur J Pharm Sci"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1080\/0265204031000093591","volume":"20","author":"De","year":"2003","journal-title":"J Microencapsul"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"103988","DOI":"10.1016\/j.jddst.2022.103988","author":"Dalei","year":"2022","journal-title":"J Drug Delivery Sci Technol"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"e202200628","DOI":"10.1002\/asia.202200628","volume":"17","author":"Wong","year":"2022","journal-title":"Chem Asian J"},{"key":"ref112","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1016\/j.biomaterials.2009.10.010","volume":"31","author":"Anumolu","year":"2010","journal-title":"Biomaterials"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1016\/j.actbio.2010.11.013","volume":"7","author":"Pritchard","year":"2011","journal-title":"Acta Biomater"},{"key":"ref114","doi-asserted-by":"publisher","DOI":"10.3390\/gels10030193","volume":"10","author":"Villapiano","year":"2024","journal-title":"Gels"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.ijbiomac.2022.11.021","volume":"223","author":"Bhattacharjee","year":"2022","journal-title":"Int J Biol Macromol"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"51805","DOI":"10.1021\/acsami.5c12778","volume":"17","author":"Liu","year":"2025","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"e2404835","DOI":"10.1002\/advs.202404835","volume":"12","author":"Gong","year":"2025","journal-title":"Adv Sci"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.ijbiomac.2019.01.122","volume":"128","author":"Fathi","year":"2019","journal-title":"Int J Biol Macromol"},{"key":"ref119","doi-asserted-by":"publisher","first-page":"e04578","DOI":"10.1002\/adhm.202504578","author":"Nie","year":"2025","journal-title":"Adv Healthc Mater"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"4307","DOI":"10.1016\/s0142-9612(02)00175-8","volume":"23","author":"Nguyen","year":"2002","journal-title":"Biomaterials"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"146451","DOI":"10.1016\/j.ijbiomac.2025.146451","volume":"321","author":"Cheruvu","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1021\/acs.biomac.5b01526","volume":"17","author":"Zhang","year":"2016","journal-title":"Biomacromolecules"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1007\/s12015-017-9740-6","volume":"13","author":"Prina","year":"2017","journal-title":"Stem Cell Rev Rep"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/nature05024","volume":"442","author":"Dong","year":"2006","journal-title":"Nature"},{"key":"ref125","doi-asserted-by":"publisher","DOI":"10.3390\/polym13040642","volume":"13","author":"Hsu","year":"2021","journal-title":"Polymers"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1021\/acs.molpharmaceut.1c00831","volume":"19","author":"Das","year":"2022","journal-title":"Mol Pharm"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1167\/tvst.8.1.12","volume":"8","author":"Liu","year":"2019","journal-title":"Transl Vis Sci Technol"},{"key":"ref128","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.ajps.2018.08.002","volume":"14","author":"Yu","year":"2019","journal-title":"Asian J Pharm Sci"},{"key":"ref129","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.carbpol.2016.02.080","volume":"144","author":"Cheng","year":"2016","journal-title":"Carbohydr Polym"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3109\/10717544.2014.903535","volume":"23","author":"Luo","year":"2016","journal-title":"Drug Deliv"},{"key":"ref131","doi-asserted-by":"publisher","first-page":"e100632","DOI":"10.1371\/journal.pone.0100632","volume":"9","author":"Xi","year":"2014","journal-title":"PLoS One"},{"key":"ref132","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1080\/02713683.2017.1302590","volume":"42","author":"Osswald","year":"2017","journal-title":"Curr Eye Res"},{"key":"ref133","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1080\/02713683.2018.1533983","volume":"44","author":"Liu","year":"2019","journal-title":"Curr Eye Res"},{"key":"ref134","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1021\/acsbiomaterials.9b01800","volume":"6","author":"Yu","year":"2020","journal-title":"ACS Biomater Sci Eng"},{"key":"ref135","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.carbpol.2012.12.033","volume":"93","author":"Glisoni","year":"2013","journal-title":"Carbohydr Polym"},{"key":"ref136","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.colsurfb.2018.01.051","volume":"164","author":"Zhang","year":"2018","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref137","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.jconrel.2023.07.052","volume":"361","author":"Ilochonwu","year":"2023","journal-title":"J Control Release"},{"key":"ref138","doi-asserted-by":"publisher","first-page":"e13704","DOI":"10.1111\/cpr.13704","volume":"57","author":"Wan","year":"2024","journal-title":"Cell Prolif"},{"key":"ref139","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/978-1-0716-2010-6_16","volume":"2434","author":"Hau","year":"2022","journal-title":"Methods Mol Biol"},{"key":"ref140","doi-asserted-by":"publisher","DOI":"10.3390\/cells11213429","volume":"11","author":"Arthur","year":"2022","journal-title":"Cells"},{"key":"ref141","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.slasd.2021.11.002","volume":"27","author":"Rodboon","year":"2022","journal-title":"SLAS Discov"},{"key":"ref142","doi-asserted-by":"publisher","DOI":"10.3390\/cells12202478","volume":"12","author":"Duot","year":"2023","journal-title":"Cells"},{"key":"ref143","doi-asserted-by":"publisher","DOI":"10.1101\/2023.07.12.548679","author":"Duot","year":"2023","journal-title":"bioRxiv"},{"key":"ref144","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1089\/jop.2018.0139","volume":"36","author":"Wright","year":"2020","journal-title":"J Ocul Pharmacol Ther"},{"key":"ref145","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201700028","volume":"7","author":"Chung","year":"2018","journal-title":"Adv Healthc Mater"},{"key":"ref146","doi-asserted-by":"publisher","first-page":"3314","DOI":"10.1167\/iovs.15-16728","volume":"56","author":"Chan","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref147","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/aos.13982","volume":"97","author":"Lu","year":"2019","journal-title":"Acta Ophthalmol"},{"key":"ref148","doi-asserted-by":"publisher","first-page":"114229","DOI":"10.1016\/j.jconrel.2025.114229","volume":"387","author":"Li","year":"2025","journal-title":"J Control Release"},{"key":"ref149","doi-asserted-by":"publisher","first-page":"eadt8775","DOI":"10.1126\/sciadv.adt8775","volume":"11","author":"Yang","year":"2025","journal-title":"Sci Adv"},{"key":"ref150","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15051484","volume":"15","author":"Rafael","year":"2023","journal-title":"Pharmaceutics"},{"key":"ref151","doi-asserted-by":"publisher","first-page":"101767","DOI":"10.1016\/j.mtbio.2025.101767","volume":"32","author":"Ibeas Moreno","year":"2025","journal-title":"Mater Today Bio"},{"key":"ref152","doi-asserted-by":"publisher","first-page":"e46188","DOI":"10.7554\/eLife.46188","volume":"8","author":"Achberger","year":"2019","journal-title":"eLife"},{"key":"ref153","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1038\/s41596-023-00814-x","volume":"18","author":"Gabriel","year":"2023","journal-title":"Nat Protoc"},{"key":"ref154","doi-asserted-by":"publisher","first-page":"5533","DOI":"10.1364\/BOE.532258","volume":"15","author":"Zuo","year":"2024","journal-title":"Biomed Opt Express"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/115918","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/115918","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:05:35Z","timestamp":1780459535000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/bridging-preclinical-and-clinical-gaps-in-ocular-therapeutics-hydrogel-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":154,"URL":"https:\/\/doi.org\/10.2147\/ijn.s555555","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]}}}