{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:56:52Z","timestamp":1791928612357,"version":"4.3.4"},"reference-count":47,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s557902","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T16:30:12Z","timestamp":1765384212000},"page":"14911-14933","source":"Crossref","is-referenced-by-count":4,"title":["Hepatocyte-Targeted Epicatechin Nanoparticles Promote Autophagy and Enhance Mitochondrial Function in Metabolic Dysfunction-Associated Steatotic Liver Disease"],"prefix":"10.2147","volume":"Volume 20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9731-5620","authenticated-orcid":true,"given":"Daewon","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeji","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solji","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyubae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam-Kyung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Eun","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junguee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Seok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Kyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongdae","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8029-2004","authenticated-orcid":true,"given":"Hwan-Woo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1093\/cvr\/cvad095","volume":"119","author":"Grander","year":"2023","journal-title":"Cardiovasc Res"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1053\/j.gastro.2019.11.312","volume":"158","author":"Eslam","year":"2020","journal-title":"Gastroenterology"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119220","volume":"271","author":"Gerges","year":"2021","journal-title":"Life Sci"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"4539","DOI":"10.3748\/wjg.v13.i34.4539","volume":"13","author":"Duvnjak","year":"2007","journal-title":"World J Gastroenterol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1146\/annurev-pathol-020117-043617","volume":"13","author":"Arab","year":"2018","journal-title":"Annu Rev Pathol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.livres.2018.09.004","volume":"2","author":"Khambu","year":"2018","journal-title":"Liver Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1126\/science.290.5497.1717","volume":"290","author":"Klionsky","year":"2000","journal-title":"Science"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.4161\/15548627.2014.984268","volume":"10","author":"Park","year":"2014","journal-title":"Autophagy"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1681\/ASN.2016070731","volume":"28","author":"Yamamoto","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"24131","DOI":"10.1074\/jbc.M702824200","volume":"282","author":"Pankiv","year":"2007","journal-title":"J Biol Chem"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1146\/annurev.nutr.27.061406.093749","volume":"27","author":"Mizushima","year":"2007","journal-title":"Annu Rev Nutr"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S0002-9440(10)64369-6","volume":"160","author":"Zatloukal","year":"2002","journal-title":"Am J Pathol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"4","DOI":"10.21037\/tgh-20-125","volume":"6","author":"Prasun","year":"2021","journal-title":"Transl Gastroenterol Hepatol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1186\/s12967-023-04367-1","volume":"21","author":"Zheng","year":"2023","journal-title":"J Transl Med"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"7303","DOI":"10.1021\/jf034728l","volume":"51","author":"Ikeda","year":"2003","journal-title":"J Agric Food Chem"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1017\/S000711452300209X","volume":"131","author":"Connolly","year":"2024","journal-title":"Br J Nutr"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1055\/s-2000-8599","volume":"66","author":"Zhu","year":"2000","journal-title":"Planta Med"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201700303","volume":"61","author":"Cheng","year":"2017","journal-title":"Mol Nutr Food Res"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"67","DOI":"10.2217\/nnm-2022-0261","volume":"18","author":"Athanasopoulou","year":"2023","journal-title":"Nanomedicine"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biomaterials.2019.01.008","volume":"197","author":"Lee","year":"2019","journal-title":"Biomaterials"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1016\/j.nano.2016.01.013","volume":"12","author":"Park","year":"2016","journal-title":"Nanomedicine"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"3008","DOI":"10.1021\/acs.biomac.5b00906","volume":"16","author":"Thapa","year":"2015","journal-title":"Biomacromolecules"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1111\/jphp.12430","volume":"67","author":"Mistry","year":"2015","journal-title":"J Pharm Pharmacol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s40824-023-00342-5","volume":"27","author":"Kim","year":"2023","journal-title":"Biomater Res"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-022-00737-9","author":"Han","year":"2022","journal-title":"Exp Mol Med"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"4834","DOI":"10.1038\/ncomms5834","volume":"5","author":"Park","year":"2014","journal-title":"Nature Communications"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1302227","volume":"14","author":"Han","year":"2023","journal-title":"Front Pharmacol"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231710055","volume":"23","author":"Chen","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.657389","volume":"9","author":"Ramos","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"e1179","DOI":"10.1038\/cddis.2014.162","volume":"5","author":"Gonzalez-Rodriguez","year":"2014","journal-title":"Cell Death Dis"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"3239","DOI":"10.1039\/c3tb20406e","volume":"1","author":"Yue","year":"2013","journal-title":"J Mater Chem B"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1615\/critrevtherdrugcarriersyst.2013006475","volume":"30","author":"Hines","year":"2013","journal-title":"Crit Rev Ther Drug Carrier Syst"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1039\/d4md00652f","volume":"16","author":"Ramirez-Cortes","year":"2025","journal-title":"RSC Med Chem"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.jconrel.2015.02.022","volume":"203","author":"D\u2019Souza","year":"2015","journal-title":"J Control Release"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1021\/jm00009a014","volume":"38","author":"Biessen","year":"1995","journal-title":"J Med Chem"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"3574","DOI":"10.1021\/acs.biomac.1c00649","volume":"22","author":"Sharma","year":"2021","journal-title":"Biomacromolecules"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"6053","DOI":"10.1021\/acsbiomaterials.0c01228","volume":"6","author":"Yoo","year":"2020","journal-title":"ACS Biomater Sci Eng"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1186\/s12943-025-02410-x","volume":"24","author":"Kesharwani","year":"2025","journal-title":"Mol Cancer"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.970292","volume":"13","author":"Fang","year":"2022","journal-title":"Front Physiol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"e61020","DOI":"10.1371\/journal.pone.0061020","volume":"8","author":"Decuypere","year":"2013","journal-title":"PLoS One"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1111\/jgh.16272","volume":"38","author":"Marcondes-de-Castro","year":"2023","journal-title":"J Gastroenterol Hepatol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s11658-016-0031-z","volume":"21","author":"Liu","year":"2016","journal-title":"Cell Mol Biol Lett"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1002\/hep.29742","volume":"68","author":"Cho","year":"2018","journal-title":"Hepatology"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.3389\/fphar.2018.01459","volume":"9","author":"Zhang","year":"2018","journal-title":"Front Pharmacol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"20567","DOI":"10.1073\/pnas.0810611105","volume":"105","author":"Kim","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.bcp.2018.11.020","volume":"160","author":"Grattagliano","year":"2019","journal-title":"Biochem Pharmacol"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1463187","volume":"15","author":"Deng","year":"2024","journal-title":"Front Pharmacol"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/109799","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/109799","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T16:30:13Z","timestamp":1765384213000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/hepatocyte-targeted-epicatechin-nanoparticles-promote-autophagy-and-en-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":47,"URL":"https:\/\/doi.org\/10.2147\/ijn.s557902","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]}}}