{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:05:50Z","timestamp":1790888750262,"version":"4.1.0"},"reference-count":191,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s560983","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T11:20:12Z","timestamp":1773919212000},"page":"1-38","source":"Crossref","is-referenced-by-count":14,"title":["Tumor Microenvironment-Responsive Nanomedicine: Monitoring and Modulating the Tumor Microenvironment for Precision Cancer Therapy"],"prefix":"10.2147","volume":"Volume 21","author":[{"given":"Jiejie","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.15252\/embr.201439246","volume":"15","author":"Pickup","year":"2014","journal-title":"EMBO Rep"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/s41577-020-00490-y","volume":"21","author":"Veglia","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/s41568-020-00329-7","volume":"21","author":"Cox","year":"2021","journal-title":"Nat Rev Cancer"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.cell.2016.06.028","volume":"166","author":"Nieto","year":"2016","journal-title":"Cell"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41571-020-0403-1","volume":"18","author":"Derynck","year":"2021","journal-title":"Nat Rev Clin Oncol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/s41577-019-0127-6","volume":"19","author":"DeNardo","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/s41568-018-0038-z","volume":"18","author":"Hamidi","year":"2018","journal-title":"Nat Rev Cancer"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"4557","DOI":"10.1158\/0008-5472.CAN-18-3962","volume":"79","author":"Hinshaw","year":"2019","journal-title":"Cancer Res"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1101\/gad.314617.118","volume":"32","author":"Gonzalez","year":"2018","journal-title":"Genes Dev"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/j.cell.2009.10.027","volume":"139","author":"Levental","year":"2009","journal-title":"Cell"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1200\/JCO.2012.46.3653","volume":"31","author":"Jain","year":"2013","journal-title":"J Clin Oncol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e2412017","DOI":"10.1002\/advs.202412017","volume":"12","author":"Xiong","year":"2025","journal-title":"Adv Sci Weinh Baden-Wurtt Ger"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"111708","DOI":"10.1016\/j.biopha.2021.111708","volume":"139","author":"Rawat","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"297","DOI":"10.3324\/haematol.2019.229781","volume":"105","author":"Yakoub-Agha","year":"2020","journal-title":"Haematologica"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1038\/d41586-024-03830-3","volume":"635","author":"Eisenstein","year":"2024","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1158\/2159-8290.CD-15-1545","volume":"6","author":"Chen","year":"2016","journal-title":"Cancer Discov"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/nrc2622","volume":"9","author":"Nguyen","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.cell.2012.01.021","volume":"148","author":"Semenza","year":"2012","journal-title":"Cell"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/cr.2016.151","volume":"27","author":"Tanaka","year":"2017","journal-title":"Cell Res"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.ccell.2023.02.014","volume":"41","author":"Tay","year":"2023","journal-title":"Cancer Cell"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1038\/nrc2442","volume":"8","author":"Bergers","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"ref24","first-page":"2497","volume":"60","author":"Netti","year":"2000","journal-title":"Cancer Res"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"2516","DOI":"10.1038\/ncomms3516","volume":"4","author":"Chauhan","year":"2013","journal-title":"Nat Commun"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/imr.12528","volume":"276","author":"Allard","year":"2017","journal-title":"Immunol Rev"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1172\/JCI67313","volume":"124","author":"Deng","year":"2014","journal-title":"J Clin Invest"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1158\/1078-0432.CCR-14-1554","volume":"21","author":"Wang","year":"2015","journal-title":"Clin Cancer Res"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1158\/0008-5472.CAN-12-2233","volume":"73","author":"Cox","year":"2013","journal-title":"Cancer Res"},{"key":"ref30","first-page":"987","volume":"54","author":"Gabizon","year":"1994","journal-title":"Cancer Res"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"7794","DOI":"10.1200\/JCO.2005.04.937","volume":"23","author":"Gradishar","year":"2005","journal-title":"J Clin Oncol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"e000573","DOI":"10.1136\/bmjonc-2024-000573","volume":"4","author":"Gabizon","year":"2025","journal-title":"BMJ Oncol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/s12943-025-02368-w","volume":"24","author":"Abdullah","year":"2025","journal-title":"Mol Cancer"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"e2103836","DOI":"10.1002\/advs.202103836","volume":"9","author":"Peng","year":"2022","journal-title":"Adv Sci"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/nrc1074","volume":"3","author":"Longley","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"16014","DOI":"10.1038\/natrevmats.2016.14","volume":"1","author":"Wilhelm","year":"2016","journal-title":"Nat Rev Mater"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"114776","DOI":"10.1016\/j.addr.2023.114776","volume":"196","author":"Meagher","year":"2023","journal-title":"Adv Drug Deliv Rev"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"216397","DOI":"10.1016\/j.canlet.2023.216397","volume":"574","author":"Xu","year":"2023","journal-title":"Cancer Lett"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1080\/17425247.2023.2221026","volume":"20","author":"Di Filippo","year":"2023","journal-title":"Expert Opin Drug Deliv"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.jconrel.2022.12.051","volume":"354","author":"Zhang","year":"2023","journal-title":"J Control Release"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.jconrel.2024.07.001","volume":"372","author":"Iqbal","year":"2024","journal-title":"J Control Release"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"7149","DOI":"10.1038\/s41467-021-27485-0","volume":"12","author":"Li","year":"2021","journal-title":"Nat Commun"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"449","DOI":"10.3390\/pharmaceutics16040449","volume":"16","author":"Bodn\u00e1r","year":"2024","journal-title":"Pharmaceutics"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"984","DOI":"10.3390\/pharmaceutics17080984","volume":"17","author":"Xu","year":"2025","journal-title":"Pharmaceutics"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00775-022-01981-0","volume":"28","author":"Anand","year":"2023","journal-title":"J Biol Inorg Chem"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"e2302902","DOI":"10.1002\/adhm.202302902","volume":"13","author":"Abousalman-Rezvani","year":"2024","journal-title":"Adv Healthc Mater"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"121395","DOI":"10.1016\/j.ijpharm.2021.121395","volume":"613","author":"Mojarad-Jabali","year":"2022","journal-title":"Int J Pharm"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"e2304654","DOI":"10.1002\/adma.202304654","volume":"35","author":"Sela","year":"2023","journal-title":"Adv Mater"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"279","DOI":"10.3390\/pharmaceutics14020279","volume":"14","author":"Ramalho","year":"2022","journal-title":"Pharmaceutics"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"e2306463","DOI":"10.1002\/advs.202306463","volume":"11","author":"Dang","year":"2024","journal-title":"Adv Sci Weinh Baden-Wurtt Ger"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1007\/s13346-022-01266-8","volume":"13","author":"Bigdeli","year":"2023","journal-title":"Drug Deliv Transl Res"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"22793","DOI":"10.1021\/acsnano.4c08486","volume":"18","author":"Su","year":"2024","journal-title":"ACS Nano"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.3390\/pharmaceutics15071855","volume":"15","author":"Sikhondze","year":"2023","journal-title":"Pharmaceutics"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"9221","DOI":"10.2147\/IJN.S532074","volume":"20","author":"Lin","year":"2025","journal-title":"Int J Nanomed"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"847901","DOI":"10.3389\/fbioe.2022.847901","volume":"10","author":"Xiong","year":"2022","journal-title":"Front Bioeng Biotechnol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"2506","DOI":"10.1016\/j.apsb.2021.10.022","volume":"12","author":"Xia","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1039\/D2BM01719A","volume":"11","author":"Zeeshan","year":"2023","journal-title":"Biomater Sci"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"124899","DOI":"10.1016\/j.ijpharm.2024.124899","volume":"667","author":"Al Yabhouni","year":"2024","journal-title":"Int J Pharm"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"122740","DOI":"10.1016\/j.ijpharm.2023.122740","volume":"638","author":"Abdi","year":"2023","journal-title":"Int J Pharm"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.jconrel.2024.06.017","volume":"371","author":"Dong","year":"2024","journal-title":"J Control Release"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.apsb.2022.03.026","volume":"13","author":"Luo","year":"2023","journal-title":"Acta Pharm Sin B"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.jconrel.2022.03.007","volume":"345","author":"Chen","year":"2022","journal-title":"J Control Release"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1186\/s12951-025-03572-y","volume":"23","author":"Yuan","year":"2025","journal-title":"J Nanobiotechnol"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"e70647","DOI":"10.1002\/hsr2.70647","volume":"8","author":"Fard","year":"2025","journal-title":"Health Sci Rep"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"e2403409","DOI":"10.1002\/smll.202403409","volume":"20","author":"Wu","year":"2024","journal-title":"Small"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"12460","DOI":"10.1186\/s13045-023-01460-2","volume":"16","author":"Li","year":"2023","journal-title":"J Hematol Oncol"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1158\/1078-0432.CCR-20-2839","volume":"27","author":"Fontana","year":"2021","journal-title":"Clin Cancer Res"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"121258","DOI":"10.1016\/j.biomaterials.2021.121258","volume":"280","author":"Pallar\u00e8s","year":"2022","journal-title":"Biomaterials"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s42003-020-0817-4","volume":"3","author":"Palanikumar","year":"2020","journal-title":"Commun Biol"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"936","DOI":"10.3390\/polym14050936","volume":"14","author":"AlSawaftah","year":"2022","journal-title":"Polymers"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"125931","DOI":"10.1016\/j.ijpharm.2025.125931","volume":"682","author":"Tapponi","year":"2025","journal-title":"Int J Pharm"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"e1614","DOI":"10.1002\/wnan.1614","volume":"12","author":"Wang","year":"2020","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1186\/s12967-025-07277-6","volume":"23","author":"Li","year":"2025","journal-title":"J Transl Med"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/s41467-024-55658-0","volume":"16","author":"Zou","year":"2025","journal-title":"Nat Commun"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"e2409790","DOI":"10.1002\/advs.202409790","volume":"12","author":"Wu","year":"2025","journal-title":"Adv Sci Weinh Baden-Wurtt Ger"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.3390\/polym17081010","volume":"17","author":"Hou","year":"2025","journal-title":"Polymers"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.bioactmat.2022.09.025","volume":"22","author":"Wang","year":"2023","journal-title":"Bioact Mater"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"5474","DOI":"10.1021\/acsbiomaterials.4c00388","volume":"10","author":"Li","year":"2024","journal-title":"ACS Biomater Sci Eng"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"113985","DOI":"10.1016\/j.addr.2021.113985","volume":"178","author":"Borys","year":"2021","journal-title":"Adv Drug Deliv Rev"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1158\/1078-0432.CCR-16-2433","volume":"24","author":"Tak","year":"2018","journal-title":"Clin Cancer Res"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"193","DOI":"10.2217\/hep-2016-0005","volume":"3","author":"Lencioni","year":"2016","journal-title":"Hepatic Oncol"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1080\/17425247.2022.2099834","volume":"19","author":"Chaudhry","year":"2022","journal-title":"Expert Opin Drug Deliv"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.jcis.2025.01.146","volume":"685","author":"Chen","year":"2025","journal-title":"J Colloid Interface Sci"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"7987","DOI":"10.2147\/IJN.S526497","volume":"20","author":"Sun","year":"2025","journal-title":"Int J Nanomed"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.1080\/17435889.2025.2555507","volume":"20","author":"Raza","year":"2025","journal-title":"Nanomedicine"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.actbio.2025.02.045","volume":"196","author":"Li","year":"2025","journal-title":"Acta Biomater"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1038\/s41467-025-57190-1","volume":"16","author":"Wang","year":"2025","journal-title":"Nat Commun"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"e2408980","DOI":"10.1002\/smll.202408980","volume":"21","author":"Chen","year":"2025","journal-title":"Small Weinh Bergstr Ger"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"54","DOI":"10.15212\/AMM-2023-0003","volume":"2","author":"Li","year":"2023","journal-title":"Acta Mater Med"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/s12943-025-02357-z","volume":"24","author":"Sabit","year":"2025","journal-title":"Mol Cancer"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"e13567","DOI":"10.1002\/advs.202513567","volume":"12","author":"Huang","year":"2025","journal-title":"Adv Sci Weinh Baden-Wurtt Ger"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"e2303597","DOI":"10.1002\/advs.202303597","volume":"10","author":"Zhou","year":"2023","journal-title":"Adv Sci"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"5195","DOI":"10.7150\/thno.45017","volume":"10","author":"Ding","year":"2020","journal-title":"Theranostics"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"18187","DOI":"10.1021\/acs.analchem.4c04366","volume":"96","author":"Zhao","year":"2024","journal-title":"Anal Chem"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1002\/1878-0261.12876","volume":"15","author":"Wang","year":"2021","journal-title":"Mol Oncol"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"16287","DOI":"10.1021\/acsami.4c17502","volume":"17","author":"Lin","year":"2025","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"3635","DOI":"10.1039\/d4nr04014g","volume":"17","author":"Duffield","year":"2025","journal-title":"Nanoscale"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s40580-024-00428-3","volume":"11","author":"Lyu","year":"2024","journal-title":"Nano Converg"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/s41377-024-01718-5","volume":"14","author":"Chang","year":"2025","journal-title":"Light Sci Appl"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"344256","DOI":"10.1016\/j.aca.2025.344256","volume":"1366","author":"Nizio\u0142","year":"2025","journal-title":"Anal Chim Acta"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1021\/acsnano.4c11505","volume":"19","author":"Wang","year":"2025","journal-title":"ACS Nano"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"11604","DOI":"10.1021\/acsnano.4c18470","volume":"19","author":"Lin","year":"2025","journal-title":"ACS Nano"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"8459","DOI":"10.1039\/D0TB01211D","volume":"8","author":"Zong","year":"2020","journal-title":"J Mater Chem B"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"115555","DOI":"10.1016\/j.celrep.2025.115555","volume":"44","author":"Liu","year":"2025","journal-title":"Cell Rep"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"e1804890","DOI":"10.1002\/smll.201804890","volume":"15","author":"Abate","year":"2019","journal-title":"Small Weinh Bergstr Ger"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1186\/s12967-024-05616-7","volume":"22","author":"Rivandi","year":"2024","journal-title":"J Transl Med"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"4147","DOI":"10.7150\/thno.108705","volume":"15","author":"Zhang","year":"2025","journal-title":"Theranostics"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"8909","DOI":"10.7150\/thno.61651","volume":"11","author":"Wang","year":"2021","journal-title":"Theranostics"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"17736","DOI":"10.1039\/D5SC04436G","volume":"16","author":"Lu","year":"2025","journal-title":"Chem Sci"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"10503","DOI":"10.2147\/IJN.S529003","volume":"20","author":"Zhu","year":"2025","journal-title":"Int J Nanomed"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"4481","DOI":"10.7150\/thno.108880","volume":"15","author":"Sun","year":"2025","journal-title":"Theranostics"},{"key":"ref112","doi-asserted-by":"publisher","first-page":"5141","DOI":"10.2147\/IJN.S417944","volume":"18","author":"Liu","year":"2023","journal-title":"Int J Nanomed"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"8054","DOI":"10.1038\/s41467-025-63311-7","volume":"16","author":"Ding","year":"2025","journal-title":"Nat Commun"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"9859","DOI":"10.7150\/thno.65771","volume":"11","author":"Jia","year":"2021","journal-title":"Theranostics"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"5934","DOI":"10.1021\/ja100254m","volume":"132","author":"Osborne","year":"2010","journal-title":"J Am Chem Soc"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.bioactmat.2024.03.022","volume":"37","author":"Feng","year":"2024","journal-title":"Bioact Mater"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"122971","DOI":"10.1016\/j.biomaterials.2024.122971","volume":"315","author":"Xie","year":"2025","journal-title":"Biomaterials"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"e2307794","DOI":"10.1002\/smll.202307794","volume":"20","author":"Liu","year":"2024","journal-title":"Small Weinh Bergstr Ger"},{"key":"ref119","doi-asserted-by":"publisher","first-page":"122386","DOI":"10.1016\/j.biomaterials.2023.122386","volume":"303","author":"Chen","year":"2023","journal-title":"Biomaterials"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"e2406870","DOI":"10.1002\/smll.202406870","volume":"21","author":"Liu","year":"2025","journal-title":"Small Weinh Bergstr Ger"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"2779","DOI":"10.7150\/ijbs.95484","volume":"20","author":"Liang","year":"2024","journal-title":"Int J Biol Sci"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.jconrel.2024.03.057","volume":"369","author":"Pan","year":"2024","journal-title":"J Control Release"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"121533","DOI":"10.1016\/j.biomaterials.2022.121533","volume":"284","author":"Dai","year":"2022","journal-title":"Biomaterials"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"102190","DOI":"10.1016\/j.mtbio.2025.102190","volume":"34","author":"Wu","year":"2025","journal-title":"Mater Today Bio"},{"key":"ref125","doi-asserted-by":"publisher","first-page":"535460","DOI":"10.2147\/IJN.S535460","volume":"20","author":"Zhao","year":"2025","journal-title":"Int J Nanomed"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.bioactmat.2023.10.023","volume":"32","author":"Fang","year":"2024","journal-title":"Bioact Mater"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"4354","DOI":"10.1021\/acs.nanolett.3c04706","volume":"24","author":"Theivendran","year":"2024","journal-title":"Nano Lett"},{"key":"ref128","doi-asserted-by":"publisher","first-page":"e2310673","DOI":"10.1002\/adma.202310673","volume":"36","author":"Sun","year":"2024","journal-title":"Adv Mater"},{"key":"ref129","doi-asserted-by":"publisher","first-page":"e202402107","DOI":"10.1002\/advs.202402107","volume":"11","author":"Cui","year":"2024","journal-title":"Adv Sci Weinh Baden-Wurtt Ger"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"1802070","DOI":"10.1002\/advs.201802070","volume":"6","author":"Chen","year":"2019","journal-title":"Adv Sci Weinh Baden-Wurtt Ger"},{"key":"ref131","doi-asserted-by":"publisher","first-page":"e1983","DOI":"10.1002\/wnan.1983","volume":"16","author":"Agarwal","year":"2024","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"key":"ref132","doi-asserted-by":"publisher","first-page":"e1793","DOI":"10.1002\/wnan.1793","volume":"14","author":"Zhu","year":"2022","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"key":"ref133","doi-asserted-by":"publisher","first-page":"1700474","DOI":"10.1002\/advs.201700474","volume":"5","author":"Wu","year":"2018","journal-title":"Adv Sci"},{"key":"ref134","doi-asserted-by":"publisher","first-page":"6334","DOI":"10.7150\/thno.59342","volume":"11","author":"Wei","year":"2021","journal-title":"Theranostics"},{"key":"ref135","doi-asserted-by":"publisher","first-page":"3204","DOI":"10.1039\/C4TB00103F","volume":"2","author":"Chen","year":"2014","journal-title":"J Mater Chem B"},{"key":"ref136","doi-asserted-by":"publisher","first-page":"e2001117","DOI":"10.1002\/adhm.202001117","volume":"9","author":"Wang","year":"2020","journal-title":"Adv Healthc Mater"},{"key":"ref137","doi-asserted-by":"publisher","first-page":"3489","DOI":"10.1021\/acs.molpharmaceut.9b00332","volume":"16","author":"Cheng","year":"2019","journal-title":"Mol Pharm"},{"key":"ref138","doi-asserted-by":"publisher","first-page":"15001","DOI":"10.1021\/acsami.7b19797","volume":"10","author":"Tang","year":"2018","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref139","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s12951-023-01820-7","volume":"21","author":"Yuan","year":"2023","journal-title":"J Nanobiotechnol"},{"key":"ref140","doi-asserted-by":"publisher","first-page":"e218","DOI":"10.1002\/mco2.218","volume":"4","author":"Nong","year":"2023","journal-title":"MedComm"},{"key":"ref141","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/s41392-024-02082-x","volume":"10","author":"Chen","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"ref142","doi-asserted-by":"publisher","first-page":"115390","DOI":"10.1016\/j.intimp.2025.115390","volume":"164","author":"Yan","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"ref143","doi-asserted-by":"publisher","first-page":"122695","DOI":"10.1016\/j.biomaterials.2024.122695","volume":"311","author":"Zhang","year":"2024","journal-title":"Biomaterials"},{"key":"ref144","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1158\/0008-5472.CAN-17-1352","volume":"78","author":"Waitkus","year":"2018","journal-title":"Cancer Res"},{"key":"ref145","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1016\/j.bbrc.2018.03.079","volume":"498","author":"Ma","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"ref146","doi-asserted-by":"publisher","first-page":"122778","DOI":"10.1016\/j.biomaterials.2024.122778","volume":"313","author":"Wang","year":"2025","journal-title":"Biomaterials"},{"key":"ref147","doi-asserted-by":"publisher","first-page":"e202308254","DOI":"10.1002\/adma.202308254","volume":"36","author":"Dong","year":"2024","journal-title":"Adv Mater"},{"key":"ref148","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s13045-025-01717-y","volume":"18","author":"Hu","year":"2025","journal-title":"J Hematol Oncol"},{"key":"ref149","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/s41419-024-06697-4","volume":"15","author":"Mai","year":"2024","journal-title":"Cell Death Dis"},{"key":"ref150","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s40164-025-00647-2","volume":"14","author":"Zhang","year":"2025","journal-title":"Exp Hematol Oncol"},{"key":"ref151","doi-asserted-by":"publisher","first-page":"e000000","DOI":"10.1097\/HEP.0000000000001545","volume":"82","author":"Minini","year":"2025","journal-title":"Hepatology"},{"key":"ref152","doi-asserted-by":"publisher","first-page":"102385","DOI":"10.1016\/j.mtbio.2025.102385","volume":"35","author":"Deng","year":"2025","journal-title":"Mater Today Bio"},{"key":"ref153","doi-asserted-by":"publisher","first-page":"15578","DOI":"10.1021\/acs.analchem.2c01341","volume":"94","author":"Hou","year":"2022","journal-title":"Anal Chem"},{"key":"ref154","doi-asserted-by":"publisher","first-page":"119671","DOI":"10.1016\/j.carbpol.2022.119671","volume":"291","author":"Wang","year":"2022","journal-title":"Carbohydr Polym"},{"key":"ref155","doi-asserted-by":"publisher","first-page":"5394","DOI":"10.1021\/acs.nanolett.9b01900","volume":"19","author":"Wei","year":"2019","journal-title":"Nano Lett"},{"key":"ref156","doi-asserted-by":"publisher","first-page":"4808","DOI":"10.1039\/D3TB00568B","volume":"11","author":"Jia","year":"2023","journal-title":"J Mater Chem B"},{"key":"ref157","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.jconrel.2025.02.026","volume":"380","author":"Zhang","year":"2025","journal-title":"J Control Release"},{"key":"ref158","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s12951-021-00824-5","volume":"19","author":"Xu","year":"2021","journal-title":"J Nanobiotechnol"},{"key":"ref159","doi-asserted-by":"publisher","first-page":"2969","DOI":"10.3390\/ijms26072969","volume":"26","author":"Ailioaie","year":"2025","journal-title":"Int J Mol Sci"},{"key":"ref160","doi-asserted-by":"publisher","first-page":"1903341","DOI":"10.1002\/advs.201903341","volume":"7","author":"You","year":"2020","journal-title":"Adv Sci"},{"key":"ref161","doi-asserted-by":"publisher","first-page":"10786","DOI":"10.1039\/D4TB00281D","volume":"12","author":"Javid","year":"2024","journal-title":"J Mater Chem B"},{"key":"ref162","doi-asserted-by":"publisher","first-page":"121831","DOI":"10.1016\/j.ijpharm.2022.121831","volume":"622","author":"Singh","year":"2022","journal-title":"Int J Pharm"},{"key":"ref163","doi-asserted-by":"publisher","first-page":"15548","DOI":"10.1021\/jacs.5b10748","volume":"137","author":"Gale","year":"2015","journal-title":"J Am Chem Soc"},{"key":"ref164","doi-asserted-by":"publisher","first-page":"2629","DOI":"10.1186\/s12951-024-02629-8","volume":"22","author":"Huang","year":"2024","journal-title":"J Nanobiotechnol"},{"key":"ref165","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1111\/j.1365-2990.2004.00557.x","volume":"30","author":"Neuwelt","year":"2004","journal-title":"Neuropathol Appl Neurobiol"},{"key":"ref166","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/nature22341","volume":"546","author":"Kamerkar","year":"2017","journal-title":"Nature"},{"key":"ref167","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.jconrel.2011.06.001","volume":"153","author":"Bae","year":"2011","journal-title":"J Control Release"},{"key":"ref168","doi-asserted-by":"publisher","first-page":"6305","DOI":"10.1038\/s41467-024-50619-z","volume":"15","author":"Xu","year":"2024","journal-title":"Nat Commun"},{"key":"ref169","doi-asserted-by":"publisher","first-page":"10804","DOI":"10.1038\/s41467-024-55072-6","volume":"15","author":"Wang","year":"2024","journal-title":"Nat Commun"},{"key":"ref170","doi-asserted-by":"publisher","first-page":"e000000","DOI":"10.1016\/j.apsb.2025.05.014","volume":"15","author":"Wei","year":"2025","journal-title":"Acta Pharm Sin B"},{"key":"ref171","doi-asserted-by":"publisher","first-page":"e03138","DOI":"10.1002\/advs.202503138","volume":"12","author":"Wang","year":"2025","journal-title":"Adv Sci Weinh Baden-Wurtt Ger"},{"key":"ref172","doi-asserted-by":"publisher","first-page":"2589","DOI":"10.1021\/acssensors.4c03051","volume":"10","author":"Nguyen","year":"2025","journal-title":"ACS Sens"},{"key":"ref173","doi-asserted-by":"publisher","first-page":"e2412187","DOI":"10.1002\/adma.202412187","volume":"37","author":"Ren","year":"2025","journal-title":"Adv Mater"},{"key":"ref174","doi-asserted-by":"publisher","first-page":"e2403866","DOI":"10.1002\/adhm.202403866","volume":"14","author":"Jiang","year":"2025","journal-title":"Adv Healthc Mater"},{"key":"ref175","doi-asserted-by":"publisher","first-page":"3265","DOI":"10.1021\/acsnano.4c11686","volume":"19","author":"Tran","year":"2025","journal-title":"ACS Nano"},{"key":"ref176","doi-asserted-by":"publisher","first-page":"4049","DOI":"10.1038\/s41467-024-48437-4","volume":"15","author":"Wu","year":"2024","journal-title":"Nat Commun"},{"key":"ref177","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1021\/acssensors.4c03572","volume":"10","author":"Xu","year":"2025","journal-title":"ACS Sens"},{"key":"ref178","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3390\/nano15020117","volume":"15","author":"Chow","year":"2025","journal-title":"Nanomaterials"},{"key":"ref179","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s12645-021-00099-3","volume":"12","author":"Klapproth","year":"2021","journal-title":"Cancer Nanotechnol"},{"key":"ref180","doi-asserted-by":"publisher","first-page":"951","DOI":"10.3390\/biomedicines13040951","volume":"13","author":"Huhulea","year":"2025","journal-title":"Biomedicines"},{"key":"ref181","doi-asserted-by":"publisher","first-page":"5801","DOI":"10.1021\/acs.molpharmaceut.5c01062","volume":"22","author":"Piotrowska","year":"2025","journal-title":"Mol Pharm"},{"key":"ref182","doi-asserted-by":"publisher","first-page":"7086","DOI":"10.1039\/D5NA00390C","volume":"7","author":"Bhatt","year":"2025","journal-title":"Nanoscale Adv"},{"key":"ref183","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1038\/s41565-024-01673-7","volume":"19","author":"Mendes","year":"2024","journal-title":"Nat Nanotechnol"},{"key":"ref184","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.3390\/pharmaceutics16101306","volume":"16","author":"Tikhonov","year":"2024","journal-title":"Pharmaceutics"},{"key":"ref185","doi-asserted-by":"publisher","first-page":"33","DOI":"10.12336\/biomatertransl.2024.01.004","volume":"5","author":"Guo","year":"2024","journal-title":"Biomater Transl"},{"key":"ref186","doi-asserted-by":"publisher","first-page":"e70025","DOI":"10.1002\/wnan.70025","volume":"17","author":"Sundaram","year":"2025","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"key":"ref187","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.matt.2023.01.012","volume":"6","author":"Shao","year":"2023","journal-title":"Matter"},{"key":"ref188","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.1038\/s41467-025-57770-1","volume":"16","author":"Wang","year":"2025","journal-title":"Nat Commun"},{"key":"ref189","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/s41565-024-01811-1","volume":"20","author":"Heinen","year":"2025","journal-title":"Nat Nanotechnol"},{"key":"ref190","doi-asserted-by":"publisher","first-page":"22594","DOI":"10.1039\/D5NR02301G","volume":"17","author":"Denman","year":"2025","journal-title":"Nanoscale"},{"key":"ref191","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.3390\/pharmaceutics17081074","volume":"17","author":"Fu","year":"2025","journal-title":"Pharmaceutics"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/113213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/113213","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T11:20:35Z","timestamp":1773919235000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/tumor-microenvironment-responsive-nanomedicine-monitoring-and-modulati-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":191,"URL":"https:\/\/doi.org\/10.2147\/ijn.s560983","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]}}}