{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:37:10Z","timestamp":1790361430118,"version":"4.1.0"},"reference-count":171,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s563730","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T04:00:26Z","timestamp":1767153626000},"page":"16125-16147","source":"Crossref","is-referenced-by-count":11,"title":["Advances in PLGA-Based Drug Delivery Systems for Glioblastoma Treatment"],"prefix":"10.2147","volume":"Volume 20","author":[{"given":"Salona","family":"Roy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Alday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4820-805X","authenticated-orcid":true,"given":"Qi","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.22034\/apjcp.2017.18.1.3","volume":"18","author":"Hanif","year":"2017","journal-title":"Asian Pac J Cancer Prev"},{"key":"ref2","doi-asserted-by":"publisher","volume-title":"Glioblastoma [Internet]","year":"2017","DOI":"10.15586\/codon.glioblastoma.2017.ch8"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s41984-024-00294-5","volume":"39","author":"Sabouri","year":"2024","journal-title":"Egyptian J Neurosurg"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s11910-024-01338-x","volume":"24","author":"Narsinh","year":"2024","journal-title":"Curr Neurol Neurosci Rep"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"443","DOI":"10.3390\/cancers14020443","volume":"14","author":"Seker-Polat","year":"2022","journal-title":"Cancers"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/s41392-023-01481-w","volume":"8","author":"Wu","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"4934","DOI":"10.1038\/s41467-023-40579-1","volume":"14","author":"Cai","year":"2023","journal-title":"Nat Commun"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1403511","DOI":"10.3389\/fbioe.2024.1403511","volume":"12","author":"Lai","year":"2024","journal-title":"Front Bioeng Biotechnol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3892\/ijo.2025.5789","volume":"67","author":"Si","year":"2025","journal-title":"Int J Oncol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"843","DOI":"10.3390\/polym16060843","volume":"16","author":"Ding","year":"2024","journal-title":"Polymers"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2728","DOI":"10.3390\/pharmaceutics14122728","volume":"14","author":"Alsaab","year":"2022","journal-title":"Pharmaceutics"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1208\/s12248-021-00611-y","volume":"23","author":"Wang","year":"2021","journal-title":"AAPS J"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201701035","volume":"7","author":"Martins","year":"2018","journal-title":"Adv Healthc Mater"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.colsurfb.2017.07.038","volume":"159","author":"Mir","year":"2017","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2300424","DOI":"10.1002\/adtp.202300424","volume":"7","author":"Sharmah","year":"2024","journal-title":"Advanced Therapeutics"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.ijpharm.2012.05.068","volume":"434","author":"Lee","year":"2012","journal-title":"Int J Pharm"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"110294","DOI":"10.1016\/j.msec.2019.110294","volume":"106","author":"Lu","year":"2020","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"381","DOI":"10.3389\/fbioe.2020.00381","volume":"8","author":"Shen","year":"2020","journal-title":"Front Bioeng Biotechnol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"4988","DOI":"10.1039\/c9nr10620k","volume":"12","author":"Zhang","year":"2020","journal-title":"Nanoscale"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1039\/d1ma00600b","volume":"3","author":"Chatterjee","year":"2022","journal-title":"Mater Adv"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.3390\/mi14081647","volume":"14","author":"Kovalenko","year":"2023","journal-title":"Micromachines"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"4333","DOI":"10.3390\/ijms24054333","volume":"24","author":"Guo","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.3390\/ijms23042034","volume":"23","author":"Rocha","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"787","DOI":"10.2174\/1570159x18666200831160627","volume":"19","author":"Di Filippo","year":"2021","journal-title":"Curr Neuropharmacol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1519479","DOI":"10.3389\/fphar.2024.1519479","volume":"15","author":"Liu","year":"2025","journal-title":"Front Pharmacol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1002\/(SICI)1097-0142(19990715)86:2<325::AID-CNCR17>3.0.CO;2-S","volume":"86","author":"Menei","year":"1999","journal-title":"Cancer"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1002\/cncr.11922","volume":"100","author":"Menei","year":"2004","journal-title":"Cancer"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1227\/01.neu.0000144982.82068.a2","volume":"56","author":"Menei","year":"2005","journal-title":"Neurosurgery"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1021\/acsomega.8b02767","volume":"4","author":"K\u0131z\u0131lbey","year":"2019","journal-title":"ACS Omega"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"965789","DOI":"10.3389\/fphar.2022.965789","volume":"13","author":"Wang","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"2280800020977170","DOI":"10.1177\/2280800020977170","volume":"18","author":"Zhang","year":"2020","journal-title":"J Appl Biomater Funct Mate"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mimet.2019.05.004","volume":"162","author":"Ospina-Villa","year":"2019","journal-title":"J Microbiol Meth"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.3390\/pharmaceutics17081056","volume":"17","author":"Kobyra","year":"2025","journal-title":"Pharmaceutics"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.ejpb.2007.04.022","volume":"68","author":"Mok","year":"2008","journal-title":"Eur J Pharm Biopharm"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"4509","DOI":"10.2147\/ijn.S165184","volume":"13","author":"Ganipineni","year":"2018","journal-title":"Int J Nanomed"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s13346-020-00880-8","volume":"11","author":"Luque-Michel","year":"2021","journal-title":"Drug Deliv Transl Res"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"19516","DOI":"10.1038\/s41598-024-69888-1","volume":"14","author":"Madani","year":"2024","journal-title":"Sci Rep"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2021.644827","volume":"9","author":"Cruz","year":"2021","journal-title":"Front Chem"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"114326","DOI":"10.1016\/j.ejpb.2024.114326","volume":"200","author":"Ramalho","year":"2024","journal-title":"Eur J Pharm Biopharm"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"81001","DOI":"10.18632\/oncotarget.20944","volume":"8","author":"Huang","year":"2017","journal-title":"Oncotarget"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"110191","DOI":"10.1016\/j.msec.2019.110191","volume":"108","author":"Roberts","year":"2020","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1002\/2211-5463.13809","volume":"14","author":"Bernert","year":"2024","journal-title":"FEBS Open Bio"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.biomaterials.2017.08.036","volume":"145","author":"Ben David-Naim","year":"2017","journal-title":"Biomaterials"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"102322","DOI":"10.1016\/j.omtn.2024.102322","volume":"35","author":"Hong","year":"2024","journal-title":"Mol Ther Nucleic Acids"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1007\/s10499-025-02322-z","volume":"33","author":"Mao","year":"2025","journal-title":"Aquacult Int"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1007\/s13346-024-01693-9","volume":"15","author":"Salmasi","year":"2025","journal-title":"Drug Deliv Transl Res"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1007\/s40005-025-00751-9","author":"Kamali","year":"2025","journal-title":"J Pharmaceu Invest"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.pdpdt.2018.06.026","volume":"23","author":"Jamali","year":"2018","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1080\/10837450.2024.2448333","volume":"30","author":"Bostanc\u0131","year":"2025","journal-title":"Pharm Dev Technol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"11440","DOI":"10.1021\/acsami.6b16854","volume":"9","author":"Chopra","year":"2017","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"280","DOI":"10.4236\/jct.2013.41035","volume":"4","author":"Nikitczuk","year":"2013","journal-title":"J Cancer Ther"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"832","DOI":"10.3109\/1061186X.2015.1025077","volume":"23","author":"Wang","year":"2015","journal-title":"J Drug Target"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s12951-019-0564-1","volume":"18","author":"Jo","year":"2020","journal-title":"J Nanobiotechnology"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1021\/nn700281b","volume":"2","author":"Nehilla","year":"2008","journal-title":"ACS Nano"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"2280","DOI":"10.3762\/bjnano.10.220","volume":"10","author":"Lababidi","year":"2019","journal-title":"Beilstein J Nanotechnol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"e18318","DOI":"10.1016\/j.heliyon.2023.e18318","volume":"9","author":"Guo","year":"2023","journal-title":"Heliyon"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"19514","DOI":"10.1021\/acs.langmuir.5c02318","volume":"41","author":"Pan","year":"2025","journal-title":"Langmuir"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1007\/s11095-024-03792-1","volume":"41","author":"Neustrup","year":"2024","journal-title":"Pharm Res"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1007\/s13346-024-01644-4","volume":"15","author":"Gonz\u00e1lez-Garc\u00eda","year":"2025","journal-title":"Drug Deliv Transl Res"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"33246","DOI":"10.1039\/C9RA06279C","volume":"9","author":"Omidi","year":"2019","journal-title":"RSC Adv"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.1039\/D2LC01014C","volume":"23","author":"Kaang","year":"2023","journal-title":"Lab Chip"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"4218","DOI":"10.1039\/c9ra10857b","volume":"10","author":"Hern\u00e1ndez-Giottonini","year":"2020","journal-title":"RSC Adv"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s40204-020-00139-y","volume":"9","author":"Lagreca","year":"2020","journal-title":"Prog Biomater"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"51015","DOI":"10.3791\/51015","author":"McCall","year":"2013","journal-title":"J Vis Exp"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"187354","DOI":"10.5402\/2012\/187354","author":"Khemani","year":"2012","journal-title":"ISRN Nanotechnol"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"870","DOI":"10.3390\/pharmaceutics14040870","volume":"14","author":"Alkholief","year":"2022","journal-title":"Pharmaceutics"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"990505","DOI":"10.3389\/fphar.2022.990505","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3389\/fbioe.2020.00048","volume":"8","author":"Essa","year":"2020","journal-title":"Front Bioeng Biotechnol"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.ijpharm.2015.10.057","volume":"496","author":"Iqbal","year":"2015","journal-title":"Int J Pharm"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s41120-022-00060-7","volume":"8","author":"Alvi","year":"2022","journal-title":"AAPS Open"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"354","DOI":"10.3390\/nano12030354","volume":"12","author":"El-Hammadi","year":"2022","journal-title":"Nanomaterials"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"794601","DOI":"10.1155\/2015\/794601","author":"Sah","year":"2015","journal-title":"J. Nanomater"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.biomaterials.2006.09.047","volume":"28","author":"Cheng","year":"2007","journal-title":"Biomaterials"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.ijpharm.2017.08.064","volume":"532","author":"Mart\u00ednez Rivas","year":"2017","journal-title":"Int J Pharm"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"864","DOI":"10.3390\/nano11040864","volume":"11","author":"Niculescu","year":"2021","journal-title":"Nanomaterials"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1039\/D1NH00540E","volume":"7","author":"Cai","year":"2022","journal-title":"Nanoscale Horizons"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"094001","DOI":"10.1088\/0960-1317\/25\/9\/094001","volume":"25","author":"Ward","year":"2015","journal-title":"J Micromech Microeng"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1002\/smll.200701029","volume":"4","author":"Song","year":"2008","journal-title":"Small"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1039\/c8ra08972h","volume":"9","author":"Rezvantalab","year":"2019","journal-title":"RSC Adv"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"590","DOI":"10.3390\/pharmaceutics11110590","volume":"11","author":"Operti","year":"2019","journal-title":"Pharmaceutics"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1007\/s13204-018-0790-0","volume":"8","author":"Amoyav","year":"2018","journal-title":"Appl Nanosci"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"4810","DOI":"10.3390\/molecules28124810","volume":"28","author":"Kim","year":"2023","journal-title":"Molecules"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"2602","DOI":"10.1021\/acs.chemrev.5b00346","volume":"116","author":"Kamaly","year":"2016","journal-title":"Chem Rev"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s40005-019-00439-x","volume":"49","author":"Elmowafy","year":"2019","journal-title":"J Pharmaceu Invest"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"2401623","DOI":"10.1002\/smtd.202401623","volume":"9","author":"Wang","year":"2025","journal-title":"Small Methods"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"6053","DOI":"10.1021\/acsbiomaterials.0c01228","volume":"6","author":"Yoo","year":"2020","journal-title":"ACS Biomater Sci Eng"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1021\/acs.molpharmaceut.6b00896","volume":"14","author":"Chen","year":"2017","journal-title":"Mol Pharm"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.ijpharm.2017.12.006","volume":"536","author":"Busatto","year":"2018","journal-title":"Int J Pharm"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/S0168-3659(02)00136-0","volume":"82","author":"Berkland","year":"2002","journal-title":"J Control Release"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0168-3659(96)01469-1","volume":"43","author":"Sansdrap","year":"1997","journal-title":"J Control Release"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s12195-019-00571-6","volume":"12","author":"Garland","year":"2019","journal-title":"Cell Mol Bioeng"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.ijpharm.2005.07.031","volume":"314","author":"Klose","year":"2006","journal-title":"Int J Pharm"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1080\/09205063.2019.1659712","volume":"30","author":"Kim","year":"2019","journal-title":"J Biomater Sci Polym Ed"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.jconrel.2018.07.044","volume":"286","author":"Mylonaki","year":"2018","journal-title":"J Control Release"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.mattod.2020.02.001","volume":"37","author":"Ding","year":"2020","journal-title":"Mater Today"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.conb.2018.12.014","volume":"57","author":"Ayloo","year":"2019","journal-title":"Curr Opin Neurobiol"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/s41568-018-0005-8","volume":"18","author":"Robey","year":"2018","journal-title":"Nat Rev Cancer"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"739","DOI":"10.3389\/fonc.2020.00739","volume":"10","author":"Belykh","year":"2020","journal-title":"Front Oncol"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1021\/acsnano.3c10674","volume":"18","author":"Zha","year":"2024","journal-title":"ACS Nano"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/s41568-019-0205-x","volume":"20","author":"Arvanitis","year":"2020","journal-title":"Nat Rev Cancer"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"128","DOI":"10.2478\/jtim-2018-0025","volume":"6","author":"Michael","year":"2018","journal-title":"J Translational Internal Med"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.7150\/thno.38147","volume":"10","author":"Zhao","year":"2020","journal-title":"Theranostics"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"4217","DOI":"10.2147\/cmar.S288720","volume":"13","author":"Wang","year":"2021","journal-title":"Cancer Manag Res"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1093\/neuonc\/nox175","volume":"20","author":"Sarkaria","year":"2018","journal-title":"Neuro Oncol"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"2544","DOI":"10.3390\/ijms18122544","volume":"18","author":"Wijaya","year":"2017","journal-title":"Int J Mol Sci"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"vdad009","DOI":"10.1093\/noajnl\/vdad009","volume":"5","author":"Sharma","year":"2023","journal-title":"Neurooncol Adv"},{"key":"ref107","doi-asserted-by":"publisher","volume-title":"Glioblastoma [Internet]","year":"2017","DOI":"10.15586\/codon.glioblastoma.2017.ch16"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1080\/17425247.2024.2429702","volume":"21","author":"Khot","year":"2024","journal-title":"Expert Opin Drug Deliv"},{"key":"ref109","doi-asserted-by":"publisher","DOI":"10.3389\/fddev.2022.823412","volume":"2","author":"Pacheco","year":"2022","journal-title":"Front Drug Delivery"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"407","DOI":"10.3390\/cells14060407","volume":"14","author":"Nowacka","year":"2025","journal-title":"Cells"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1007\/s12035-020-01892-8","volume":"57","author":"Ahir","year":"2020","journal-title":"Mol Neurobiol"},{"key":"ref112","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1439","volume":"9","author":"Wadajkar","year":"2017","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13045-022-01252-0","volume":"15","author":"Jiang","year":"2022","journal-title":"J Hematol Oncol"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.ijpharm.2018.09.033","volume":"551","author":"Agarwal","year":"2018","journal-title":"Int J Pharm"},{"key":"ref115","first-page":"2894","volume":"8","author":"Choe","year":"2002","journal-title":"Clin Cancer Res"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"1336476","DOI":"10.3389\/fimmu.2024.1336476","volume":"15","author":"Collado","year":"2024","journal-title":"Front Immunol"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"116931","DOI":"10.1016\/j.bcp.2025.116931","volume":"237","author":"Dabkevi\u010di\u016bt\u0117","year":"2025","journal-title":"Biochem Pharmacol"},{"key":"ref118","first-page":"3742","volume":"11","author":"Mohiuddin","year":"2021","journal-title":"Am J Cancer Res"},{"key":"ref119","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.actbio.2025.01.050","volume":"194","author":"Xiong","year":"2025","journal-title":"Acta Biomater"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1126\/science.1203486","volume":"331","author":"Schreiber","year":"2011","journal-title":"Science"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"6273","DOI":"10.7150\/thno.76854","volume":"12","author":"Liu","year":"2022","journal-title":"Theranostics"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"6228","DOI":"10.1038\/s41467-021-26352-2","volume":"12","author":"Lain\u00e9","year":"2021","journal-title":"Nat Commun"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"4114","DOI":"10.3390\/polym13234114","volume":"13","author":"Rabha","year":"2021","journal-title":"Polymers"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1021\/acs.bioconjchem.1c00479","volume":"33","author":"Wiwatchaitawee","year":"2022","journal-title":"Bioconjug Chem"},{"key":"ref125","doi-asserted-by":"publisher","first-page":"4171","DOI":"10.1111\/jcmm.13695","volume":"22","author":"Li","year":"2018","journal-title":"J Cell Mol Med"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.ejpb.2019.10.004","volume":"145","author":"Luque-Michel","year":"2019","journal-title":"Eur J Pharm Biopharm"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"5807","DOI":"10.2147\/IJN.S119999","volume":"11","author":"Xin","year":"2016","journal-title":"Int J Nanomedicine"},{"key":"ref128","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1166\/jbn.2015.1965","volume":"11","author":"Shi","year":"2015","journal-title":"J Biomed Nanotechnol"},{"key":"ref129","doi-asserted-by":"publisher","first-page":"65339","DOI":"10.18632\/oncotarget.18689","volume":"8","author":"Bhowmik","year":"2017","journal-title":"Oncotarget"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"5897","DOI":"10.1016\/j.biomaterials.2014.03.068","volume":"35","author":"Wang","year":"2014","journal-title":"Biomaterials"},{"key":"ref131","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/s41419-023-05738-8","volume":"14","author":"Cai","year":"2023","journal-title":"Cell Death Dis"},{"key":"ref132","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1007\/s11095-021-03050-8","volume":"38","author":"Smiley","year":"2021","journal-title":"Pharm Res"},{"key":"ref133","doi-asserted-by":"publisher","first-page":"119076","DOI":"10.1016\/j.ijpharm.2020.119076","volume":"578","author":"Caban-Toktas","year":"2020","journal-title":"Int J Pharm"},{"key":"ref134","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1158\/1535-7163.Mct-22-0066","volume":"21","author":"Kannappan","year":"2022","journal-title":"Mol Cancer Ther"},{"key":"ref135","doi-asserted-by":"publisher","first-page":"9737","DOI":"10.12659\/msm.918899","volume":"25","author":"Zhang","year":"2019","journal-title":"Med Sci Monit"},{"key":"ref136","doi-asserted-by":"publisher","first-page":"8010","DOI":"10.1016\/j.biomaterials.2011.07.004","volume":"32","author":"Guo","year":"2011","journal-title":"Biomaterials"},{"key":"ref137","doi-asserted-by":"publisher","first-page":"1700709","DOI":"10.1002\/adhm.201700709","volume":"6","author":"Guan","year":"2017","journal-title":"Adv Healthc Mater"},{"key":"ref138","doi-asserted-by":"publisher","first-page":"101157","DOI":"10.1016\/j.jddst.2019.101157","volume":"53","author":"Heggannavar","year":"2019","journal-title":"J Drug Delivery Sci Technol"},{"key":"ref139","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.ijpharm.2014.12.070","volume":"479","author":"Kuo","year":"2015","journal-title":"Int J Pharm"},{"key":"ref140","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1080\/21691401.2017.1384385","volume":"46","author":"Kou","year":"2018","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"ref141","doi-asserted-by":"publisher","first-page":"563938","DOI":"10.3389\/fonc.2020.563938","volume":"10","author":"Cui","year":"2020","journal-title":"Front Oncol"},{"key":"ref142","doi-asserted-by":"publisher","first-page":"133848","DOI":"10.1016\/j.cej.2021.133848","volume":"433","author":"Yin","year":"2022","journal-title":"Chem Engine J"},{"key":"ref143","doi-asserted-by":"publisher","first-page":"290","DOI":"10.3390\/pharmaceutics15010290","volume":"15","author":"Chen","year":"2023","journal-title":"Pharmaceutics"},{"key":"ref144","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1002\/mabi.201500091","volume":"15","author":"Hao","year":"2015","journal-title":"Macromol Biosci"},{"key":"ref145","doi-asserted-by":"publisher","first-page":"4319","DOI":"10.1016\/j.biomaterials.2014.01.082","volume":"35","author":"Kang","year":"2014","journal-title":"Biomaterials"},{"key":"ref146","doi-asserted-by":"publisher","first-page":"5896","DOI":"10.1039\/C9TB01131E","volume":"7","author":"Agarwal","year":"2019","journal-title":"J Mater Chem B"},{"key":"ref147","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.colsurfb.2015.08.016","volume":"135","author":"Cantisani","year":"2015","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref148","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.1021\/acsnano.2c09033","volume":"17","author":"Ma","year":"2023","journal-title":"ACS Nano"},{"key":"ref149","doi-asserted-by":"publisher","first-page":"2301439","DOI":"10.1002\/smll.202301439","volume":"19","author":"Zhang","year":"2023","journal-title":"Small"},{"key":"ref150","doi-asserted-by":"publisher","first-page":"16592","DOI":"10.1039\/D5NR02445E","volume":"17","author":"Nikfar","year":"2025","journal-title":"Nanoscale"},{"key":"ref151","doi-asserted-by":"publisher","first-page":"145413","DOI":"10.1016\/j.cej.2023.145413","volume":"473","author":"Li","year":"2023","journal-title":"Chem Eng J"},{"key":"ref152","doi-asserted-by":"publisher","first-page":"5526","DOI":"10.3390\/ma16165526","volume":"16","author":"Dash","year":"2023","journal-title":"Materials"},{"key":"ref153","doi-asserted-by":"publisher","first-page":"32159","DOI":"10.1021\/acsami.6b10175","volume":"8","author":"Cui","year":"2016","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref154","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.ijrobp.2020.12.019","volume":"110","author":"Wei","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref155","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s11060-024-04795-z","volume":"170","author":"Zhu","year":"2024","journal-title":"J Neurooncol"},{"key":"ref156","doi-asserted-by":"publisher","first-page":"113042","DOI":"10.1016\/j.biopha.2022.113042","volume":"150","author":"Wang","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"ref157","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3390\/pharmaceutics17010087","volume":"17","author":"Akpinar Adscheid","year":"2025","journal-title":"Pharmaceutics"},{"key":"ref158","doi-asserted-by":"publisher","first-page":"276","DOI":"10.3390\/pharmaceutics14020276","volume":"14","author":"Operti","year":"2022","journal-title":"Pharmaceutics"},{"key":"ref159","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.3390\/biomedicines9121834","volume":"9","author":"Achar","year":"2021","journal-title":"Biomedicines"},{"key":"ref160","doi-asserted-by":"publisher","first-page":"eabd0772","DOI":"10.1126\/sciadv.abd0772","volume":"7","author":"Chen","year":"2021","journal-title":"Sci Adv"},{"key":"ref161","doi-asserted-by":"publisher","first-page":"9805","DOI":"10.1021\/acs.nanolett.1c02996","volume":"21","author":"Li","year":"2021","journal-title":"Nano Lett"},{"key":"ref162","doi-asserted-by":"publisher","first-page":"e09517","DOI":"10.1016\/j.heliyon.2022.e09517","volume":"8","author":"Morales","year":"2022","journal-title":"Heliyon"},{"key":"ref163","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.3390\/pharmaceutics14061189","volume":"14","author":"El Kheir","year":"2022","journal-title":"Pharmaceutics"},{"key":"ref164","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.jconrel.2024.01.053","volume":"367","author":"Xu","year":"2024","journal-title":"J Control Release"},{"key":"ref165","doi-asserted-by":"publisher","first-page":"e70213","DOI":"10.1002\/mco2.70213","volume":"6","author":"Qiu","year":"2025","journal-title":"MedComm"},{"key":"ref166","doi-asserted-by":"publisher","first-page":"17947","DOI":"10.1039\/D5NR00870K","volume":"17","author":"Bolon","year":"2025","journal-title":"Nanoscale"},{"key":"ref167","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/s41392-021-00544-0","volume":"6","author":"Huang","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"ref168","doi-asserted-by":"publisher","first-page":"100364","DOI":"10.1016\/j.mtbio.2022.100364","volume":"16","author":"Li","year":"2022","journal-title":"Mater Today Bio"},{"key":"ref169","doi-asserted-by":"publisher","first-page":"e2101536","DOI":"10.1002\/adhm.202101536","volume":"11","author":"Sheffey","year":"2022","journal-title":"Adv Healthc Mater"},{"key":"ref170","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1039\/D3TB02485G","volume":"12","author":"Habeeb","year":"2024","journal-title":"J Mater Chem B"},{"key":"ref171","doi-asserted-by":"publisher","volume-title":"Theranostics Nanomaterials in Drug Delivery","year":"2025","DOI":"10.1016\/B978-0-443-22044-9.00025-5"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/110587","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/110587","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T04:00:28Z","timestamp":1767153628000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/advances-in-plga-based-drug-delivery-systems-for-glioblastoma-treatmen-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":171,"URL":"https:\/\/doi.org\/10.2147\/ijn.s563730","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]}}}