{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:50:21Z","timestamp":1792709421142,"version":"4.5.0"},"reference-count":129,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s565558","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T12:20:14Z","timestamp":1765455614000},"page":"14935-14953","source":"Crossref","is-referenced-by-count":16,"title":["Key Clinical Frontiers of mRNA Loaded Lipid Nanoparticles in Cancer Vaccines"],"prefix":"10.2147","volume":"Volume 20","author":[{"given":"Lili","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meipin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0362-3826","authenticated-orcid":true,"given":"Dingchao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41392-022-00950-y","volume":"7","author":"Fang","year":"2022","journal-title":"Signal Trans Targeted Ther"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1038\/s41587-022-01294-2","volume":"40","author":"Barbier","year":"2022","journal-title":"Nature Biotechnol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1038\/s41573-024-01042-y","volume":"23","author":"Pardi","year":"2024","journal-title":"Nat Rev Drug Discov"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1126\/science.abn7591","volume":"375","author":"Muik","year":"2022","journal-title":"Science"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1056\/NEJMc2113468","volume":"385","author":"Falsey","year":"2021","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1056\/NEJMoa2113017","volume":"385","author":"El Sahly","year":"2021","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1056\/NEJMoa2115463","volume":"386","author":"Dickerman","year":"2022","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"eabj0299","DOI":"10.1126\/science.abj0299","volume":"373","author":"Corbett","year":"2021","journal-title":"Science"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"eabj9853","DOI":"10.1126\/science.abj9853","volume":"374","author":"Mateus","year":"2021","journal-title":"Science"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"eadg1036","DOI":"10.1126\/sciadv.adg1036","volume":"9","author":"Kon","year":"2023","journal-title":"Sci Adv"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"eads1328","DOI":"10.1126\/sciimmunol.ads1328","volume":"10","author":"Aunins","year":"2025","journal-title":"Sci Immunol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1016\/j.jconrel.2024.11.007","volume":"376","author":"Wu","year":"2024","journal-title":"J Control Release"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1186\/s12951-022-01478-7","volume":"20","author":"Kiaie","year":"2022","journal-title":"J Nanobiotechnol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"5800","DOI":"10.1038\/s41467-024-50087-5","volume":"15","author":"Dong","year":"2024","journal-title":"Nat Commun"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/s41551-023-01082-6","volume":"9","author":"Li","year":"2025","journal-title":"Nat Biomed Eng"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"e2309472120","DOI":"10.1073\/pnas.2309472120","volume":"120","author":"Chen","year":"2023","journal-title":"Proc Natl Acad Sci"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"102715","DOI":"10.1016\/j.jaut.2021.102715","volume":"124","author":"Kannan","year":"2021","journal-title":"J Autoimmun"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41579-022-00713-0","volume":"20","author":"Lamers","year":"2022","journal-title":"Nat Rev Microbiol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1126\/science.adn4955","volume":"386","author":"Alameh","year":"2024","journal-title":"Science"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"eabn3464","DOI":"10.1126\/scitranslmed.abn3464","volume":"15","author":"Ramos da Silva","year":"2023","journal-title":"Sci Trans Med"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/S0140-6736(23)02268-7","volume":"403","author":"Weber","year":"2024","journal-title":"Lancet"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1158\/1538-7445.AM2025-855","volume":"85","author":"Lu","year":"2025","journal-title":"Cancer Res"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"LBA9512","DOI":"10.1200\/JCO.2024.42.17_suppl.LBA9512","volume":"42","author":"Weber","year":"2024","journal-title":"Am Soc Clin Oncol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"TPS9616","DOI":"10.1200\/JCO.2024.42.16_suppl.TPS9616","volume":"42","author":"Weber","year":"2024","journal-title":"Am Soc Clin Oncol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/s41591-024-03334-7","volume":"31","author":"Lopez","year":"2025","journal-title":"Nat Med"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/s41586-023-06063-y","volume":"618","author":"Rojas","year":"2023","journal-title":"Nature"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00262-025-03992-7","volume":"74","author":"Nguyen","year":"2025","journal-title":"Cancer Immunol Immunother"},{"key":"ref28","author":"Textor","year":"2024","journal-title":"BMJ Spec J"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"3484","DOI":"10.1039\/D2TB02782H","volume":"11","author":"Zhou","year":"2023","journal-title":"J Mat Chem B"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"19550","DOI":"10.1021\/acsnano.3c05635","volume":"17","author":"Liu","year":"2023","journal-title":"ACS nano"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.jconrel.2024.03.016","volume":"368","author":"Jiang","year":"2024","journal-title":"J Control Release"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"2198","DOI":"10.1038\/s41467-025-57149-2","volume":"16","author":"Xue","year":"2025","journal-title":"Nat Commun"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"e2307800120","DOI":"10.1073\/pnas.2307800120","volume":"121","author":"Chatterjee","year":"2024","journal-title":"Proc Natl Acad Sci"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"101011","DOI":"10.1016\/j.ajps.2024.101011","volume":"20","author":"Yang","year":"2024","journal-title":"Asian J Pharm Sci"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.jconrel.2024.11.010","volume":"377","author":"Binici","year":"2025","journal-title":"J Control Release"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"2209624","DOI":"10.1002\/adma.202209624","volume":"35","author":"Lam","year":"2023","journal-title":"Adv Mater"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1038\/s41563-024-01961-6","volume":"23","author":"Gong","year":"2024","journal-title":"Nature Mater"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.2147\/IJN.S452896","volume":"19","author":"da Silva","year":"2024","journal-title":"Int J Nanomed"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s43556-024-00222-x","volume":"5","author":"Weerarathna","year":"2024","journal-title":"Mol Biomed"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"e117","DOI":"10.1016\/S2352-3018(23)00264-3","volume":"11","author":"Nkolola","year":"2024","journal-title":"Lancet HIV"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1016\/j.vaccine.2021.03.038","volume":"39","author":"Rosa","year":"2021","journal-title":"Vaccine"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s12929-024-01000-1","volume":"31","author":"Zhang","year":"2024","journal-title":"J Biomed Sci"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.trsl.2021.11.009","volume":"242","author":"Whitley","year":"2022","journal-title":"Transl Res"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"e2303567120","DOI":"10.1073\/pnas.2303567120","volume":"120","author":"Shepherd","year":"2023","journal-title":"Proc Natl Acad Sci"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"113879","DOI":"10.1016\/j.jconrel.2025.113879","volume":"384","author":"Simonsen","year":"2025","journal-title":"J Control Release"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"2338785","DOI":"10.1080\/14686996.2024.2338785","volume":"25","author":"Homma","year":"2024","journal-title":"Sci Technol Adv Mater"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"4001","DOI":"10.1021\/acs.accounts.1c00500","volume":"54","author":"Qiu","year":"2021","journal-title":"Acc Chem Res"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.tips.2021.03.002","volume":"42","author":"Patel","year":"2021","journal-title":"Trends Pharmacol Sci"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"113906","DOI":"10.1016\/j.jconrel.2025.113906","volume":"384","author":"Ge","year":"2025","journal-title":"J Control Release"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"e2301067120","DOI":"10.1073\/pnas.2301067120","volume":"120","author":"Zheng","year":"2023","journal-title":"Proc Natl Acad Sci"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"2404510","DOI":"10.1002\/adfm.202404510","volume":"34","author":"Liu","year":"2024","journal-title":"Adv Funct Mater"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1021\/acs.molpharmaceut.2c00033","volume":"19","author":"Ferraresso","year":"2022","journal-title":"Mol Pharmaceut"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"10829","DOI":"10.1021\/acsnano.4c14098","volume":"19","author":"Carucci","year":"2025","journal-title":"ACS nano"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.1021\/acs.jpcb.1c10903","volume":"126","author":"Stelter","year":"2022","journal-title":"J Phys Chem A"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"114030","DOI":"10.1016\/j.jconrel.2025.114030","volume":"385","author":"Miyasaki","year":"2025","journal-title":"J Control Release"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"e3642","DOI":"10.1002\/jgm.3642","volume":"26","author":"Tafech","year":"2024","journal-title":"J Gene Med"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"3061","DOI":"10.1021\/acs.molpharmaceut.4c01543","volume":"22","author":"Barros","year":"2025","journal-title":"Mol Pharmaceut"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.actbio.2022.09.065","volume":"154","author":"Patel","year":"2022","journal-title":"Acta Biomater"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"121570","DOI":"10.1016\/j.biomaterials.2022.121570","volume":"286","author":"Ripoll","year":"2022","journal-title":"Biomaterials"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.bbrc.2021.03.073","volume":"555","author":"Koide","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.jconrel.2023.06.027","volume":"360","author":"Takata","year":"2023","journal-title":"J Control Release"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"10804","DOI":"10.1038\/s41467-024-55072-6","volume":"15","author":"Wang","year":"2024","journal-title":"Nat Commun"},{"key":"ref63","first-page":"1","author":"Witten","year":"2024","journal-title":"Nature Biotechnol"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"6305","DOI":"10.1038\/s41467-024-50619-z","volume":"15","author":"Xu","year":"2024","journal-title":"Nat Commun"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1038\/s41563-024-01867-3","volume":"23","author":"Li","year":"2024","journal-title":"Nature Mater"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.jconrel.2022.02.017","volume":"344","author":"Maeki","year":"2022","journal-title":"J Control Release"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"101703","DOI":"10.1016\/j.mtbio.2025.101703","volume":"32","author":"Xie","year":"2025","journal-title":"Mater Today Bio"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"2303444","DOI":"10.1002\/adhm.202303444","volume":"13","author":"Carvalho","year":"2024","journal-title":"Adv Healthcare Mater"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"2400815","DOI":"10.1002\/smll.202400815","volume":"20","author":"Eygeris","year":"2024","journal-title":"Small"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"125520","DOI":"10.1016\/j.ijpharm.2025.125520","volume":"675","author":"Wu","year":"2025","journal-title":"Int J Pharm"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"123730","DOI":"10.1016\/j.memsci.2025.123730","volume":"719","author":"Javidanbardan","year":"2025","journal-title":"J Membr Sci"},{"key":"ref72","unstructured":"Batista DAV. A study on lipid nanoparticle synthesis by microfluifics and its PAT methods. 2024."},{"key":"ref73","unstructured":"Grau-Carbonell A, Wang Y, Verbeek M, et al. Real-time process control in nanodispersion manufacturing via continuous nanoparticle size monitoring."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1080\/14760584.2024.2354251","volume":"23","author":"Hu","year":"2024","journal-title":"Expert Rev Vaccines"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.3390\/pr10091783","volume":"10","author":"Schmidt","year":"2022","journal-title":"Processes"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"12797","DOI":"10.3390\/ijms252312797","volume":"25","author":"Niazi","year":"2024","journal-title":"Int J Mol Sci"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.3390\/jpm14111092","volume":"14","author":"Ramadan","year":"2024","journal-title":"J Personalized Med"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"2303261","DOI":"10.1002\/adma.202303261","volume":"35","author":"Zong","year":"2023","journal-title":"Adv Mater"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"e2207841119","DOI":"10.1073\/pnas.2207841119","volume":"119","author":"Chen","year":"2022","journal-title":"Proc Natl Acad Sci"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/s41571-024-00902-1","volume":"21","author":"Sayour","year":"2024","journal-title":"Nat Rev Clin Oncol"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"5659","DOI":"10.1038\/s41467-024-50093-7","volume":"15","author":"Su","year":"2024","journal-title":"Nat Commun"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1038\/s41467-024-45422-9","volume":"15","author":"Xue","year":"2024","journal-title":"Nat Commun"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"23466","DOI":"10.1021\/acsnano.3c05341","volume":"17","author":"Zeng","year":"2023","journal-title":"ACS nano"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1016\/j.ymthe.2023.02.009","volume":"31","author":"Yu","year":"2023","journal-title":"Mol Ther"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/s41541-023-00751-6","volume":"8","author":"Zhang","year":"2023","journal-title":"Npj Vaccines"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"100324","DOI":"10.1016\/j.ijpx.2025.100324","volume":"9","author":"de Castilla","year":"2025","journal-title":"Int J Pharm X"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"2400643","DOI":"10.1002\/smll.202400643","volume":"20","author":"Yazdi","year":"2024","journal-title":"Small"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"102068","DOI":"10.1016\/j.omtn.2023.102068","volume":"34","author":"Radloff","year":"2023","journal-title":"Mol Ther Nucleic Acids"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1021\/acs.bioconjchem.3c00329","volume":"34","author":"Debnath","year":"2023","journal-title":"Bioconjugate Chem"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/s41596-022-00755-x","volume":"18","author":"Wang","year":"2023","journal-title":"Nat Protocols"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"2501914","DOI":"10.1002\/adhm.202501914","volume":"14","author":"Xu","year":"2025","journal-title":"Adv Healthcare Mater"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"2403366","DOI":"10.1002\/adhm.202403366","volume":"14","author":"Yoo","year":"2025","journal-title":"Adv Healthcare Mater"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.jconrel.2023.04.005","volume":"357","author":"Huayamares","year":"2023","journal-title":"J Control Release"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.3390\/ph18071042","volume":"18","author":"Zhao","year":"2025","journal-title":"Pharmaceuticals"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1021\/acs.molpharmaceut.1c00579","volume":"19","author":"R\u00f8ise","year":"2021","journal-title":"Mol Pharmaceut"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"479","DOI":"10.3390\/pharmaceutics17040479","volume":"17","author":"Li","year":"2025","journal-title":"Pharmaceutics"},{"key":"ref97","volume-title":"Transdermal Applications of Minimally Invasive Drug Delivery Systems: Current Trends and Future Perspectives","year":"2025"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.jconrel.2023.11.008","volume":"364","author":"Tang","year":"2023","journal-title":"J Control Release"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"4122","DOI":"10.1039\/D5MD00084J","volume":"16","author":"Kimura","year":"2025","journal-title":"RSC Med Chemistry"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"102506","DOI":"10.1016\/j.cbpa.2024.102506","volume":"81","author":"Grau","year":"2024","journal-title":"Curr Opin Chem Biol"},{"key":"ref101","author":"Omo-Lamai","year":"2024","journal-title":"BioRxiv"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"4678","DOI":"10.1039\/D3NR05570A","volume":"16","author":"Nandi","year":"2024","journal-title":"Nanoscale"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jconrel.2024.08.016","volume":"374","author":"Barbieri","year":"2024","journal-title":"J Control Release"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1038\/s41551-023-01030-4","volume":"7","author":"Rhym","year":"2023","journal-title":"Nat Biomed Eng"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/S1470-2045(24)00100-1","volume":"25","author":"Machiels","year":"2024","journal-title":"Lancet Oncol"},{"key":"ref106","first-page":"1","author":"Sethna","year":"2025","journal-title":"Nature"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"4176","DOI":"10.3390\/cancers15164176","volume":"15","author":"Mooradian","year":"2023","journal-title":"Cancers"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1158\/2159-8290.CD-25-0300","volume":"15","author":"Martini","year":"2025","journal-title":"Cancer Discovery"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1097\/XCS.0000000000000939","volume":"238","author":"Angeli-Pahim","year":"2024","journal-title":"J Am College Surg"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"113865","DOI":"10.1016\/j.jconrel.2025.113865","volume":"384","author":"Yang","year":"2025","journal-title":"J Control Release"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"TPS3641","DOI":"10.1200\/JCO.2022.40.16_suppl.TPS3641","volume":"40","author":"Kopetz","year":"2022","journal-title":"Am Soc Clin Oncol"},{"key":"ref112","unstructured":"B. announces positive topline Phase. results for mRNA immunotherapy candidate BNT111 in patients with advanced melanoma."},{"key":"ref113","doi-asserted-by":"publisher","first-page":"962","DOI":"10.2174\/0115680096360059250131075456","volume":"25","author":"Hussain","year":"2025","journal-title":"Curr Cancer Drug Targets"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1038\/s41416-020-0785-y","volume":"122","author":"Gridelli","year":"2020","journal-title":"Br J Cancer"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"100267","DOI":"10.1016\/j.iotech.2022.100267","volume":"16","author":"Klinghammer","year":"2022","journal-title":"Immuno-Oncol Technol"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"TPS3635","DOI":"10.1200\/JCO.2022.40.16_suppl.TPS3635","volume":"40","author":"Hecht","year":"2022","journal-title":"Am Soc Clin Oncol"},{"key":"ref117","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2025.43.4_suppl.LBA13","volume":"43","author":"Hecht","year":"2025","journal-title":"Am Soc Clin Oncol"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"e009352","DOI":"10.1136\/jitc-2024-009352","volume":"13","author":"Eigentler","year":"2025","journal-title":"J ImmunoTher Cancer"},{"key":"ref119","first-page":"1075","volume":"72","author":"Lutz","year":"2023","journal-title":"Immunotherapy"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"S96","DOI":"10.1016\/j.jtho.2021.01.063","volume":"16","author":"Nagasaka","year":"2021","journal-title":"J Thorac Oncol"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"2301515","DOI":"10.1002\/adhm.202301515","volume":"12","author":"Hamilton","year":"2023","journal-title":"Adv Healthcare Mater"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"e008977","DOI":"10.1136\/jitc-2024-008977","volume":"12","author":"Moon","year":"2024","journal-title":"J ImmunoTher Cancer"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"7604","DOI":"10.1021\/jacs.4c16987","volume":"147","author":"Baimanov","year":"2025","journal-title":"J Am Chem Soc"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1038\/s41467-023-37328-9","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat Commun"},{"key":"ref125","volume-title":"A PROGRESS TOWARDS UNDERSTANDING THE IMPACT OF STRESS FACTORS ON MRNA LIPID NANO-PARTICLE CRITICAL QUALITY ATTRIBUTES","year":"2024"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"2401252","DOI":"10.1002\/adhm.202401252","volume":"13","author":"Bi","year":"2024","journal-title":"Adv Healthcare Mater"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"430","DOI":"10.3390\/pharmaceutics14020430","volume":"14","author":"Kis","year":"2022","journal-title":"Pharmaceutics"},{"key":"ref128","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/9781118971147.ch16","author":"Elder","year":"2017","journal-title":"ICH Quality Guidelines"},{"key":"ref129","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1208\/s12248-022-00685-2","volume":"24","author":"Verch","year":"2022","journal-title":"AAPS J"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/109830","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/109830","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T12:20:17Z","timestamp":1765455617000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/key-clinical-frontiers-of-mrna-loaded-lipid-nanoparticles-in-cancer-va-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":129,"URL":"https:\/\/doi.org\/10.2147\/ijn.s565558","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]}}}