{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:15:17Z","timestamp":1790511317521,"version":"4.1.0"},"reference-count":87,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s570887","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T16:20:12Z","timestamp":1765988412000},"page":"15167-15183","source":"Crossref","is-referenced-by-count":3,"title":["Nanozymes Targeting Redox Imbalance: A Novel Weapon for Immunomodulation and Organ Protection in Sepsis"],"prefix":"10.2147","volume":"Volume 20","author":[{"given":"Junlong","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"456","DOI":"10.3390\/epidemiologia5030032","volume":"5","author":"La Via","year":"2024","journal-title":"Epidemiologia"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1038\/s41467-023-44387-5","volume":"15","author":"Das","year":"2024","journal-title":"Nat Commun"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1186\/cc10334","volume":"15","author":"Andrades","year":"2011","journal-title":"Crit Care"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.cell.2020.11.025","volume":"184","author":"Karki","year":"2021","journal-title":"Cell"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/s41420-023-01766-7","volume":"9","author":"Cao","year":"2023","journal-title":"Cell Death Discov"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"340","DOI":"10.3390\/antiox14030340","volume":"14","author":"Dhalla","year":"2025","journal-title":"Antioxidants"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1093\/nutrit\/nuad105","volume":"82","author":"Sun","year":"2024","journal-title":"Nutr Rev"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s13054-022-03900-w","volume":"26","author":"Rosengrave","year":"2022","journal-title":"Crit Care"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1348713","DOI":"10.3389\/fcimb.2024.1348713","volume":"14","author":"Sahoo","year":"2024","journal-title":"Front Cell Infect Microbiol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"6503","DOI":"10.2147\/IJN.S431061","volume":"18","author":"Zeng","year":"2023","journal-title":"Int J Nanomed"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"2211041","DOI":"10.1002\/adma.202211041","volume":"36","author":"Zandieh","year":"2024","journal-title":"Adv Mater"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"16450","DOI":"10.1021\/acsnano.4c03425","volume":"18","author":"Yang","year":"2024","journal-title":"ACS Nano"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"102046","DOI":"10.1016\/j.redox.2021.102046","volume":"45","author":"Chen","year":"2021","journal-title":"Redox Biol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"20210267","DOI":"10.1002\/EXP.20210267","volume":"2","author":"Yang","year":"2022","journal-title":"Exploration"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"150988","DOI":"10.1016\/j.cej.2024.150988","volume":"489","author":"Xin","year":"2024","journal-title":"Chem Eng J"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"11399","DOI":"10.1002\/anie.201704904","volume":"56","author":"Soh","year":"2017","journal-title":"Angew Chem Int Ed"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"10324","DOI":"10.1021\/acsnano.0c03807","volume":"14","author":"Yim","year":"2020","journal-title":"ACS Nano"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"176354","DOI":"10.1016\/j.ejphar.2024.176354","volume":"968","author":"Li","year":"2024","journal-title":"Eur J Pharmacol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"2418683","DOI":"10.1002\/adfm.202418683","volume":"35","author":"Deng","year":"2025","journal-title":"Adv Funct Mater"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.jare.2023.02.008","volume":"55","author":"Wang","year":"2024","journal-title":"J Adv Res"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"102416","DOI":"10.1016\/j.nantod.2024.102416","volume":"58","author":"Sun","year":"2024","journal-title":"Nano Today"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"36047","DOI":"10.1021\/acsami.4c04994","volume":"16","author":"Xin","year":"2024","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"2401581","DOI":"10.1002\/adhm.202401581","volume":"14","author":"Liu","year":"2025","journal-title":"Adv Healthcare Mater"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"5108","DOI":"10.1002\/anie.201912182","volume":"59","author":"Cao","year":"2020","journal-title":"Angew Chem Int Ed"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2304002","DOI":"10.1002\/adhm.202304002","volume":"13","author":"Liu","year":"2024","journal-title":"Adv Healthcare Mater"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.jare.2023.10.011","volume":"63","author":"Jiang","year":"2024","journal-title":"J Adv Res"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"160293","DOI":"10.1016\/j.cej.2025.160293","volume":"507","author":"Che","year":"2025","journal-title":"Chem Eng J"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1515\/hsz-2013-0241","volume":"395","author":"Lugrin","year":"2014","journal-title":"Biol Chem"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","volume":"97","author":"Jomova","year":"2023","journal-title":"Arch Toxicol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"101255","DOI":"10.1016\/j.redox.2019.101255","volume":"26","author":"Breda","year":"2019","journal-title":"Redox Biol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1126\/science.aar8048","volume":"362","author":"Visnes","year":"2018","journal-title":"Science"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1086\/685547","volume":"6","author":"Bime","year":"2016","journal-title":"Pulm Circ"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1378\/chest.105.1.232","volume":"105","author":"Mathru","year":"1994","journal-title":"Chest"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1089\/ars.2021.0027","volume":"35","author":"Joffre","year":"2021","journal-title":"Antioxid Redox Signal"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s42255-025-01224-x","volume":"7","author":"Casey","year":"2025","journal-title":"Nat Metab"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/nri2725","volume":"10","author":"Tschopp","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41577-021-00656-2","volume":"22","author":"Wong","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1577105","DOI":"10.3389\/fimmu.2025.1577105","volume":"16","author":"Gao","year":"2025","journal-title":"Front Immunol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1271098","DOI":"10.3389\/fimmu.2023.1271098","volume":"14","author":"Thoppil","year":"2023","journal-title":"Front Immunol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.imbio.2018.11.010","volume":"224","author":"Rendra","year":"2019","journal-title":"Immunobiology"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"571810","DOI":"10.3389\/fphys.2020.571810","volume":"11","author":"Zhao","year":"2020","journal-title":"Front Physiol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1159\/000517855","volume":"14","author":"Surabhi","year":"2022","journal-title":"J Innate Immun"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s12929-015-0194-3","volume":"22","author":"Belikov","year":"2015","journal-title":"J Biomed Sci"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/nm.2557","volume":"18","author":"Hoetzenecker","year":"2011","journal-title":"Nat Med"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1152\/physrev.00026.2013","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol Rev"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s40779-018-0187-0","volume":"5","author":"Zhang","year":"2018","journal-title":"Mil Med Res"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s13613-021-00893-7","volume":"11","author":"Preau","year":"2021","journal-title":"Ann Intensive Care"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"832","DOI":"10.3389\/fimmu.2018.00832","volume":"9","author":"Grazioli","year":"2018","journal-title":"Front Immunol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/s41420-021-00807-3","volume":"8","author":"He","year":"2022","journal-title":"Cell Death Discov"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"7038","DOI":"10.1111\/febs.16059","volume":"289","author":"Liu","year":"2022","journal-title":"FEBS J"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"117152","DOI":"10.1016\/j.ejmech.2024.117152","volume":"283","author":"Wang","year":"2025","journal-title":"Eur J Med Chem"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"995974","DOI":"10.3389\/fimmu.2022.995974","volume":"13","author":"Gong","year":"2022","journal-title":"Front Immunol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/s41392-023-01570-w","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1954","DOI":"10.1016\/j.freeradbiomed.2012.02.037","volume":"52","author":"Laurindo","year":"2012","journal-title":"Free Radic Biol Med"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/nnano.2007.260","volume":"2","author":"Gao","year":"2007","journal-title":"Nat Nanotechnol"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"110385","DOI":"10.1016\/j.isci.2024.110385","volume":"27","author":"Guo","year":"2024","journal-title":"iScience"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"100981","DOI":"10.1016\/j.nantod.2020.100981","volume":"35","author":"Shen","year":"2020","journal-title":"Nano Today"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"101768","DOI":"10.1016\/j.nantod.2023.101768","volume":"49","author":"Zhang","year":"2023","journal-title":"Nano Today"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/s41586-025-08747-z","volume":"640","author":"Shi","year":"2025","journal-title":"Nature"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"2211151","DOI":"10.1002\/adma.202211151","volume":"36","author":"Shen","year":"2024","journal-title":"Adv Mater"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1038\/s44222-024-00205-1","volume":"2","author":"Zhang","year":"2024","journal-title":"Nat Rev Bioeng"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"2721","DOI":"10.7150\/thno.83543","volume":"13","author":"Xiang","year":"2023","journal-title":"Theranostics"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"19086","DOI":"10.1021\/jacs.3c07048","volume":"145","author":"Liu","year":"2023","journal-title":"J Am Chem Soc"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"2807","DOI":"10.1021\/acsmaterialslett.3c00906","volume":"5","author":"Yuan","year":"2023","journal-title":"ACS Mater Lett"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"4601","DOI":"10.2147\/IJN.S416049","volume":"18","author":"Zhang","year":"2023","journal-title":"Int J Nanomed"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"8685","DOI":"10.1039\/c9ra10262k","volume":"10","author":"Zhang","year":"2020","journal-title":"RSC Adv"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2147\/IJN.S338886","volume":"17","author":"Zhao","year":"2022","journal-title":"Int J Nanomed"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"2434","DOI":"10.1021\/acsmaterialslett.4c00084","volume":"6","author":"Liu","year":"2024","journal-title":"ACS Mater Lett"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"6229","DOI":"10.1021\/acsnano.3c09528","volume":"18","author":"Gu","year":"2024","journal-title":"ACS Nano"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1056\/NEJMra2403213","volume":"391","author":"Meyer","year":"2024","journal-title":"N Engl J Med"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s40779-022-00430-y","volume":"9","author":"Pei","year":"2022","journal-title":"Mil Med Res"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1186\/s12951-022-01589-1","volume":"20","author":"Wang","year":"2022","journal-title":"J Nanobiotechnol"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1186\/s13054-020-03112-0","volume":"24","author":"Huang","year":"2020","journal-title":"Crit Care"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.chest.2024.03.006","volume":"166","author":"Molinari","year":"2024","journal-title":"Chest"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"2342","DOI":"10.7150\/thno.40395","volume":"10","author":"Yu","year":"2020","journal-title":"Theranostics"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s13020-025-01103-3","volume":"20","author":"Wang","year":"2025","journal-title":"Chin Med"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"163893","DOI":"10.1016\/j.cej.2025.163893","volume":"516","author":"Guo","year":"2025","journal-title":"Chem Eng J"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"2405090","DOI":"10.1002\/adhm.202405090","volume":"14","author":"Xia","year":"2025","journal-title":"Adv Healthcare Mater"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"1504223","DOI":"10.3389\/fcimb.2025.1504223","volume":"15","author":"Guo","year":"2025","journal-title":"Front Cell Infect Microbiol"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"35013","DOI":"10.1021\/acsnano.5c04379","volume":"19","author":"Yan","year":"2025","journal-title":"ACS Nano"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/ngeo1148","volume":"4","author":"Y\u00fccel","year":"2011","journal-title":"Nat Geosci"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"2412211","DOI":"10.1002\/adma.202412211","volume":"37","author":"Ma","year":"2025","journal-title":"Adv Mater"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/s41467-023-44463-w","volume":"15","author":"Ma","year":"2024","journal-title":"Nat Commun"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1038\/s41565-025-01907-2","volume":"20","author":"Wang","year":"2025","journal-title":"Nat Nanotechnol"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"7133","DOI":"10.2147\/IJN.S516260","volume":"20","author":"Wang","year":"2025","journal-title":"Int J Nanomed"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/110073","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/110073","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T16:20:13Z","timestamp":1765988413000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/nanozymes-targeting-redox-imbalance-a-novel-weapon-for-immunomodulatio-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":87,"URL":"https:\/\/doi.org\/10.2147\/ijn.s570887","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]}}}