{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T10:03:36Z","timestamp":1774260216574,"version":"3.50.1"},"reference-count":72,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s582078","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T09:10:13Z","timestamp":1774257013000},"page":"1-27","source":"Crossref","is-referenced-by-count":0,"title":["Sequential Release of mRNA Complex and T Cells by a Double-Layered Implantable Scaffold for Combination Therapy of Head and Neck Squamous Cell Carcinoma"],"prefix":"10.2147","volume":"Volume 21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2298-7224","authenticated-orcid":true,"given":"Pingchuan","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1933-724X","authenticated-orcid":true,"given":"Yan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3301-2238","authenticated-orcid":true,"given":"Shan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiayu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9489-0142","authenticated-orcid":true,"given":"Xizi","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0587-9961","authenticated-orcid":true,"given":"Ke","family":"Men","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1446-0692","authenticated-orcid":true,"given":"Longjiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2026,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41572-023-00418-5","volume":"9","author":"Johnson","year":"2023","journal-title":"Nat Rev Dis Primers"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"3818","DOI":"10.1158\/0008-5472.can-24-0067","volume":"84","author":"Zhang","year":"2024","journal-title":"Cancer Res"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.oraloncology.2016.02.001","volume":"55","author":"Kraaijenga","year":"2016","journal-title":"Oral Oncol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"371","DOI":"10.4103\/0973-029x.325257","volume":"25","author":"Sahu","year":"2021","journal-title":"J Oral Maxillofac Pathol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"3838","DOI":"10.1200\/jco.2016.68.1478","volume":"34","author":"Chow","year":"2016","journal-title":"J Clin Oncol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"240","DOI":"10.3390\/ijms22010240","volume":"22","author":"Kitamura","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e000531","DOI":"10.1136\/esmoopen-2019-000531","volume":"4","author":"Iivanainen","year":"2019","journal-title":"ESMO Open"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.3389\/fimmu.2020.01721","volume":"11","author":"Qiao","year":"2020","journal-title":"Front Immunol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/s41585-021-00431-x","volume":"18","author":"Gregg","year":"2021","journal-title":"Nat Rev Urol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1166\/jbn.2020.2961","volume":"16","author":"Lei","year":"2020","journal-title":"J Biomed Nanotechnol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/gt.2017.74","volume":"24","author":"Wang","year":"2017","journal-title":"Gene Ther"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"4779","DOI":"10.2147\/ijn.s452548","volume":"19","author":"Wang","year":"2024","journal-title":"Int J Nanomed"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.oraloncology.2017.02.005","volume":"67","author":"Hanna","year":"2017","journal-title":"Oral Oncol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"3361","DOI":"10.21873\/anticanres.15823","volume":"42","author":"Kajiyama","year":"2022","journal-title":"Anticancer Res"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1001\/archotol.129.6.618","volume":"129","author":"Bray","year":"2003","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.otohns.2008.05.001","volume":"139","author":"Adappa","year":"2008","journal-title":"Otolaryngol Head Neck Surg"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1021\/acs.molpharmaceut.3c00826","volume":"21","author":"Huang","year":"2024","journal-title":"Mol Pharm"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.actbio.2025.04.031","volume":"199","author":"Zou","year":"2025","journal-title":"Acta Biomater"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.coph.2021.05.004","volume":"59","author":"Moreno","year":"2021","journal-title":"Curr Opin Pharmacol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"e007162","DOI":"10.1136\/jitc-2023-007162","volume":"11","author":"Papa","year":"2023","journal-title":"J Immunother Cancer"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e001523","DOI":"10.1136\/jitc-2020-001523","volume":"8","author":"Charap","year":"2020","journal-title":"J Immunother Cancer"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1038\/s41587-020-0462-y","volume":"38","author":"Klichinsky","year":"2020","journal-title":"Nat Biotechnol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1158\/2326-6066.cir-14-0100","volume":"3","author":"Mitchell","year":"2015","journal-title":"Cancer Immunol Res"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1158\/1078-0432.ccr-18-2722","volume":"25","author":"Stevanovi\u0107","year":"2019","journal-title":"Clin Cancer Res"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.oraloncology.2018.01.024","volume":"78","author":"Park","year":"2018","journal-title":"Oral Oncol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41408-021-00459-7","volume":"11","author":"Sterner","year":"2021","journal-title":"Blood Cancer J"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"2440","DOI":"10.1016\/j.ymthe.2017.09.010","volume":"25","author":"Rosewell Shaw","year":"2017","journal-title":"Mol Ther"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.1200\/jco.18.02424","volume":"37","author":"Doran","year":"2019","journal-title":"J Clin Oncol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/978-1-4939-2727-2_21","volume":"1317","author":"Papa","year":"2015","journal-title":"Methods Mol Biol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"2629","DOI":"10.1038\/bjc.2013.645","volume":"109","author":"Jie","year":"2013","journal-title":"Br J Cancer"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.semcancer.2018.01.008","volume":"52","author":"Solomon","year":"2018","journal-title":"Semin Cancer Biol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/s41573-019-0051-2","volume":"19","author":"Depil","year":"2020","journal-title":"Nat Rev Drug Discov"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"5211","DOI":"10.2147\/ijn.s319092","volume":"16","author":"Gao","year":"2021","journal-title":"Int J Nanomed"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/s41392-021-00830-x","volume":"6","author":"Cao","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1038\/s41563-023-01472-w","volume":"22","author":"Zhong","year":"2023","journal-title":"Nat Mater"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.ijbiomac.2021.06.084","volume":"185","author":"Chung","year":"2021","journal-title":"Int J Biol Macromol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1021\/acs.nanolett.0c05039","volume":"21","author":"Yin","year":"2021","journal-title":"Nano Lett"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"100800","DOI":"10.1016\/j.ajps.2023.100800","volume":"18","author":"Wang","year":"2023","journal-title":"Asian J Pharm Sci"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"eaay6853","DOI":"10.1126\/scitranslmed.aay6853","volume":"12","author":"Hasani-Sadrabadi","year":"2020","journal-title":"Sci Transl Med"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1700886","DOI":"10.1002\/adhm.201700886","volume":"7","author":"Li","year":"2018","journal-title":"Adv Healthc Mater"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"881544","DOI":"10.3389\/fbioe.2022.881544","volume":"10","author":"Fu","year":"2022","journal-title":"Front Bioeng Biotechnol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s13036-020-00239-0","volume":"14","author":"Abasalizadeh","year":"2020","journal-title":"J Biol Eng"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.bioactmat.2021.06.027","volume":"8","author":"Kurian","year":"2022","journal-title":"Bioact. Mater"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.tvjl.2015.11.006","volume":"210","author":"Supsavhad","year":"2016","journal-title":"Vet J"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1186\/s12967-022-03707-x","volume":"20","author":"Li","year":"2022","journal-title":"J Transl Med"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s12943-022-01572-2","volume":"21","author":"Jin","year":"2022","journal-title":"Mol Cancer"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"2721","DOI":"10.1007\/s00520-019-05060-0","volume":"28","author":"Barasch","year":"2020","journal-title":"Support Care Cancer"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s40364-025-00726-w","volume":"13","author":"Chen","year":"2025","journal-title":"Biomark Res"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"E625","DOI":"10.1002\/ijc.27435","volume":"131","author":"Furuta","year":"2012","journal-title":"Int, J, Cancer"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"8607","DOI":"10.1158\/0008-5472.can-10-0850","volume":"70","author":"Martin","year":"2010","journal-title":"Cancer Res"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1021\/acs.molpharmaceut.3c00802","volume":"21","author":"Ma","year":"2024","journal-title":"Mol Pharm"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"12317","DOI":"10.18632\/oncotarget.2640","volume":"5","author":"Tada","year":"2014","journal-title":"Oncotarget"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1038\/s41565-020-00843-7","volume":"16","author":"Zhang","year":"2021","journal-title":"Nat Nanotechnol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"11385","DOI":"10.1021\/acs.chemrev.0c01177","volume":"121","author":"Correa","year":"2021","journal-title":"Chem Rev"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"e2309591","DOI":"10.1002\/adma.202309591","volume":"36","author":"Wang","year":"2024","journal-title":"Adv Mater"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"e2210787","DOI":"10.1002\/adma.202210787","volume":"35","author":"Wu","year":"2023","journal-title":"Adv Mater"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"124825","DOI":"10.1016\/j.ijpharm.2024.124825","volume":"666","author":"Haider","year":"2024","journal-title":"Int J Pharm"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.jconrel.2022.09.010","volume":"351","author":"Chen","year":"2022","journal-title":"J Control Release"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"126221","DOI":"10.1016\/j.ijbiomac.2023.126221","volume":"251","author":"Tsai","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"4029","DOI":"10.1021\/acs.molpharmaceut.1c00461","volume":"18","author":"Li","year":"2021","journal-title":"Mol Pharm"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"3378","DOI":"10.1021\/acs.molpharmaceut.0c00451","volume":"17","author":"Lei","year":"2020","journal-title":"Mol Pharm"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"17653","DOI":"10.1021\/acsnano.5c01366","volume":"19","author":"Lei","year":"2025","journal-title":"ACS nano"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"9142","DOI":"10.1038\/s41598-021-88503-1","volume":"11","author":"Hu","year":"2021","journal-title":"Sci Rep"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"127033","DOI":"10.1016\/j.ijbiomac.2023.127033","volume":"253","author":"Xie","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"50809","DOI":"10.1021\/acsami.3c10607","volume":"15","author":"Tan","year":"2023","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s40820-021-00647-x","volume":"13","author":"Huang","year":"2021","journal-title":"Nanomicro Lett"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1056\/NEJMoa1914347","volume":"382","author":"Wang","year":"2020","journal-title":"N Engl J Med"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s13046-022-02327-z","volume":"41","author":"Pan","year":"2022","journal-title":"J Exp Clin Cancer Res"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41423-019-0306-1","volume":"17","author":"Nakamura","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.3390\/cancers14061403","volume":"14","author":"Nguyen","year":"2022","journal-title":"Cancers"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/82_2020_217","volume":"440","author":"Zeng","year":"2022","journal-title":"Curr Top Microbiol Immunol"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/113346","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/113346","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T09:10:14Z","timestamp":1774257014000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/sequential-release-of-mrna-complex-and-t-cells-by-a-double-layered-imp-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":72,"URL":"https:\/\/doi.org\/10.2147\/ijn.s582078","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]}}}